Amino acid dipepetide frequency for Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.753AlaAla: 5.753 ± 0.034	1.343AlaCys: 1.343 ± 0.011	3.039AlaAsp: 3.039 ± 0.016	4.325AlaGlu: 4.325 ± 0.027	2.516AlaPhe: 2.516 ± 0.014	4.115AlaGly: 4.115 ± 0.023	1.496AlaHis: 1.496 ± 0.011	2.797AlaIle: 2.797 ± 0.016	3.316AlaLys: 3.316 ± 0.019	6.442AlaLeu: 6.442 ± 0.026	1.568AlaMet: 1.568 ± 0.012	2.185AlaAsn: 2.185 ± 0.012	3.13AlaPro: 3.13 ± 0.022	2.763AlaGln: 2.763 ± 0.018	2.989AlaArg: 2.989 ± 0.015	5.193AlaSer: 5.193 ± 0.02	3.414AlaThr: 3.414 ± 0.018	4.936AlaVal: 4.936 ± 0.02	0.664AlaTrp: 0.664 ± 0.007	1.584AlaTyr: 1.584 ± 0.012	0.001AlaXaa: 0.001 ± 0.0
Cys	1.278CysAla: 1.278 ± 0.012	0.766CysCys: 0.766 ± 0.008	1.21CysAsp: 1.21 ± 0.014	1.289CysGlu: 1.289 ± 0.014	1.111CysPhe: 1.111 ± 0.009	1.741CysGly: 1.741 ± 0.02	0.708CysHis: 0.708 ± 0.008	1.115CysIle: 1.115 ± 0.009	1.296CysLys: 1.296 ± 0.012	2.382CysLeu: 2.382 ± 0.017	0.522CysMet: 0.522 ± 0.006	0.959CysAsn: 0.959 ± 0.011	1.337CysPro: 1.337 ± 0.015	1.093CysGln: 1.093 ± 0.014	1.352CysArg: 1.352 ± 0.011	2.303CysSer: 2.303 ± 0.018	1.306CysThr: 1.306 ± 0.013	1.721CysVal: 1.721 ± 0.014	0.347CysTrp: 0.347 ± 0.005	0.714CysTyr: 0.714 ± 0.008	0.001CysXaa: 0.001 ± 0.0
Asp	2.847AspAla: 2.847 ± 0.017	1.184AspCys: 1.184 ± 0.012	2.954AspAsp: 2.954 ± 0.021	3.586AspGlu: 3.586 ± 0.02	2.203AspPhe: 2.203 ± 0.013	3.516AspGly: 3.516 ± 0.023	1.156AspHis: 1.156 ± 0.009	2.735AspIle: 2.735 ± 0.013	2.68AspLys: 2.68 ± 0.014	4.874AspLeu: 4.874 ± 0.023	1.272AspMet: 1.272 ± 0.01	1.95AspAsn: 1.95 ± 0.016	2.721AspPro: 2.721 ± 0.016	1.839AspGln: 1.839 ± 0.011	2.631AspArg: 2.631 ± 0.019	4.238AspSer: 4.238 ± 0.022	2.6AspThr: 2.6 ± 0.015	3.219AspVal: 3.219 ± 0.017	0.693AspTrp: 0.693 ± 0.007	1.568AspTyr: 1.568 ± 0.012	0.001AspXaa: 0.001 ± 0.0
Glu	4.445GluAla: 4.445 ± 0.026	1.272GluCys: 1.272 ± 0.013	4.12GluAsp: 4.12 ± 0.023	6.977GluGlu: 6.977 ± 0.046	1.969GluPhe: 1.969 ± 0.012	3.908GluGly: 3.908 ± 0.019	1.436GluHis: 1.436 ± 0.012	2.936GluIle: 2.936 ± 0.016	4.687GluLys: 4.687 ± 0.028	5.939GluLeu: 5.939 ± 0.031	1.704GluMet: 1.704 ± 0.013	2.794GluAsn: 2.794 ± 0.016	2.578GluPro: 2.578 ± 0.018	2.886GluGln: 2.886 ± 0.018	3.956GluArg: 3.956 ± 0.023	4.132GluSer: 4.132 ± 0.018	3.341GluThr: 3.341 ± 0.017	4.188GluVal: 4.188 ± 0.017	0.732GluTrp: 0.732 ± 0.007	1.655GluTyr: 1.655 ± 0.011	0.002GluXaa: 0.002 ± 0.0
Phe	2.038PheAla: 2.038 ± 0.012	1.14PheCys: 1.14 ± 0.01	1.862PheAsp: 1.862 ± 0.012	1.91PheGlu: 1.91 ± 0.011	1.982PhePhe: 1.982 ± 0.016	2.314PheGly: 2.314 ± 0.016	1.111PheHis: 1.111 ± 0.011	2.242PheIle: 2.242 ± 0.014	1.991PheLys: 1.991 ± 0.013	4.347PheLeu: 4.347 ± 0.02	0.893PheMet: 0.893 ± 0.007	1.627PheAsn: 1.627 ± 0.012	1.915PhePro: 1.915 ± 0.014	1.679PheGln: 1.679 ± 0.012	1.941PheArg: 1.941 ± 0.012	3.703PheSer: 3.703 ± 0.018	2.528PheThr: 2.528 ± 0.013	2.467PheVal: 2.467 ± 0.014	0.517PheTrp: 0.517 ± 0.006	1.391PheTyr: 1.391 ± 0.01	0.002PheXaa: 0.002 ± 0.0
Gly	3.801GlyAla: 3.801 ± 0.026	1.314GlyCys: 1.314 ± 0.012	3.101GlyAsp: 3.101 ± 0.017	4.055GlyGlu: 4.055 ± 0.023	2.532GlyPhe: 2.532 ± 0.016	4.95GlyGly: 4.95 ± 0.036	1.625GlyHis: 1.625 ± 0.012	2.709GlyIle: 2.709 ± 0.015	3.713GlyLys: 3.713 ± 0.021	5.446GlyLeu: 5.446 ± 0.027	1.468GlyMet: 1.468 ± 0.009	2.546GlyAsn: 2.546 ± 0.015	2.967GlyPro: 2.967 ± 0.034	2.604GlyGln: 2.604 ± 0.016	3.444GlyArg: 3.444 ± 0.021	5.386GlySer: 5.386 ± 0.024	3.376GlyThr: 3.376 ± 0.016	3.976GlyVal: 3.976 ± 0.02	0.801GlyTrp: 0.801 ± 0.007	1.911GlyTyr: 1.911 ± 0.014	0.002GlyXaa: 0.002 ± 0.0
His	1.345HisAla: 1.345 ± 0.009	0.833HisCys: 0.833 ± 0.01	0.968HisAsp: 0.968 ± 0.008	1.205HisGlu: 1.205 ± 0.009	1.176HisPhe: 1.176 ± 0.009	1.535HisGly: 1.535 ± 0.012	1.052HisHis: 1.052 ± 0.012	1.416HisIle: 1.416 ± 0.01	1.335HisLys: 1.335 ± 0.01	2.826HisLeu: 2.826 ± 0.016	0.717HisMet: 0.717 ± 0.01	1.059HisAsn: 1.059 ± 0.009	1.574HisPro: 1.574 ± 0.012	1.229HisGln: 1.229 ± 0.011	1.616HisArg: 1.616 ± 0.012	2.456HisSer: 2.456 ± 0.017	1.713HisThr: 1.713 ± 0.014	1.502HisVal: 1.502 ± 0.011	0.361HisTrp: 0.361 ± 0.005	0.903HisTyr: 0.903 ± 0.008	0.001HisXaa: 0.001 ± 0.0
Ile	2.632IleAla: 2.632 ± 0.016	1.277IleCys: 1.277 ± 0.01	2.17IleAsp: 2.17 ± 0.014	2.418IleGlu: 2.418 ± 0.013	2.117IlePhe: 2.117 ± 0.016	2.403IleGly: 2.403 ± 0.014	1.422IleHis: 1.422 ± 0.012	2.722IleIle: 2.722 ± 0.018	2.72IleLys: 2.72 ± 0.017	4.643IleLeu: 4.643 ± 0.018	1.149IleMet: 1.149 ± 0.009	2.096IleAsn: 2.096 ± 0.013	2.508IlePro: 2.508 ± 0.015	2.235IleGln: 2.235 ± 0.013	2.504IleArg: 2.504 ± 0.013	3.992IleSer: 3.992 ± 0.017	3.011IleThr: 3.011 ± 0.017	2.75IleVal: 2.75 ± 0.018	0.536IleTrp: 0.536 ± 0.007	1.578IleTyr: 1.578 ± 0.013	0.001IleXaa: 0.001 ± 0.0
Lys	3.71LysAla: 3.71 ± 0.021	1.166LysCys: 1.166 ± 0.012	3.193LysAsp: 3.193 ± 0.017	4.615LysGlu: 4.615 ± 0.027	1.69LysPhe: 1.69 ± 0.01	3.209LysGly: 3.209 ± 0.019	1.499LysHis: 1.499 ± 0.012	2.677LysIle: 2.677 ± 0.015	4.515LysLys: 4.515 ± 0.031	5.111LysLeu: 5.111 ± 0.025	1.505LysMet: 1.505 ± 0.011	2.438LysAsn: 2.438 ± 0.016	2.908LysPro: 2.908 ± 0.021	2.581LysGln: 2.581 ± 0.017	3.374LysArg: 3.374 ± 0.018	3.83LysSer: 3.83 ± 0.018	3.314LysThr: 3.314 ± 0.017	3.659LysVal: 3.659 ± 0.018	0.617LysTrp: 0.617 ± 0.008	1.627LysTyr: 1.627 ± 0.012	0.002LysXaa: 0.002 ± 0.0
Leu	6.017LeuAla: 6.017 ± 0.028	2.505LeuCys: 2.505 ± 0.017	4.786LeuAsp: 4.786 ± 0.023	6.19LeuGlu: 6.19 ± 0.034	3.837LeuPhe: 3.837 ± 0.019	5.153LeuGly: 5.153 ± 0.022	2.782LeuHis: 2.782 ± 0.018	4.24LeuIle: 4.24 ± 0.018	5.796LeuLys: 5.796 ± 0.027	10.355LeuLeu: 10.355 ± 0.044	2.174LeuMet: 2.174 ± 0.013	3.782LeuAsn: 3.782 ± 0.018	5.182LeuPro: 5.182 ± 0.023	5.291LeuGln: 5.291 ± 0.026	5.504LeuArg: 5.504 ± 0.025	8.454LeuSer: 8.454 ± 0.034	5.455LeuThr: 5.455 ± 0.019	5.619LeuVal: 5.619 ± 0.022	1.132LeuTrp: 1.132 ± 0.011	2.79LeuTyr: 2.79 ± 0.016	0.003LeuXaa: 0.003 ± 0.0
Met	1.865MetAla: 1.865 ± 0.014	0.54MetCys: 0.54 ± 0.006	1.366MetAsp: 1.366 ± 0.009	1.862MetGlu: 1.862 ± 0.012	0.957MetPhe: 0.957 ± 0.009	1.389MetGly: 1.389 ± 0.011	0.519MetHis: 0.519 ± 0.006	0.979MetIle: 0.979 ± 0.009	1.516MetLys: 1.516 ± 0.01	2.172MetLeu: 2.172 ± 0.014	0.699MetMet: 0.699 ± 0.007	0.949MetAsn: 0.949 ± 0.007	1.067MetPro: 1.067 ± 0.011	0.974MetGln: 0.974 ± 0.01	1.19MetArg: 1.19 ± 0.01	1.882MetSer: 1.882 ± 0.012	1.311MetThr: 1.311 ± 0.009	1.561MetVal: 1.561 ± 0.011	0.286MetTrp: 0.286 ± 0.004	0.689MetTyr: 0.689 ± 0.007	0.001MetXaa: 0.001 ± 0.0
Asn	2.186AsnAla: 2.186 ± 0.012	0.974AsnCys: 0.974 ± 0.011	1.748AsnAsp: 1.748 ± 0.012	2.118AsnGlu: 2.118 ± 0.014	1.556AsnPhe: 1.556 ± 0.011	2.742AsnGly: 2.742 ± 0.018	1.036AsnHis: 1.036 ± 0.01	2.319AsnIle: 2.319 ± 0.013	2.333AsnLys: 2.333 ± 0.016	3.836AsnLeu: 3.836 ± 0.017	1.076AsnMet: 1.076 ± 0.009	1.928AsnAsn: 1.928 ± 0.012	2.249AsnPro: 2.249 ± 0.012	1.732AsnGln: 1.732 ± 0.013	2.011AsnArg: 2.011 ± 0.014	3.268AsnSer: 3.268 ± 0.017	2.362AsnThr: 2.362 ± 0.014	2.408AsnVal: 2.408 ± 0.015	0.483AsnTrp: 0.483 ± 0.006	1.241AsnTyr: 1.241 ± 0.011	0.001AsnXaa: 0.001 ± 0.0
Pro	3.748ProAla: 3.748 ± 0.022	1.091ProCys: 1.091 ± 0.013	2.722ProAsp: 2.722 ± 0.016	3.547ProGlu: 3.547 ± 0.022	1.871ProPhe: 1.871 ± 0.014	3.784ProGly: 3.784 ± 0.037	1.477ProHis: 1.477 ± 0.013	1.926ProIle: 1.926 ± 0.012	2.467ProLys: 2.467 ± 0.017	4.707ProLeu: 4.707 ± 0.024	0.983ProMet: 0.983 ± 0.01	1.917ProAsn: 1.917 ± 0.012	4.715ProPro: 4.715 ± 0.042	2.467ProGln: 2.467 ± 0.018	2.538ProArg: 2.538 ± 0.015	5.113ProSer: 5.113 ± 0.026	2.926ProThr: 2.926 ± 0.019	3.588ProVal: 3.588 ± 0.018	0.566ProTrp: 0.566 ± 0.007	1.5ProTyr: 1.5 ± 0.012	0.002ProXaa: 0.002 ± 0.0
Gln	2.987GlnAla: 2.987 ± 0.019	1.044GlnCys: 1.044 ± 0.011	2.15GlnAsp: 2.15 ± 0.013	3.245GlnGlu: 3.245 ± 0.02	1.403GlnPhe: 1.403 ± 0.01	2.533GlnGly: 2.533 ± 0.016	1.336GlnHis: 1.336 ± 0.01	1.991GlnIle: 1.991 ± 0.013	2.625GlnLys: 2.625 ± 0.017	4.397GlnLeu: 4.397 ± 0.024	1.148GlnMet: 1.148 ± 0.01	1.798GlnAsn: 1.798 ± 0.012	2.338GlnPro: 2.338 ± 0.017	3.012GlnGln: 3.012 ± 0.031	2.934GlnArg: 2.934 ± 0.017	3.367GlnSer: 3.367 ± 0.017	2.509GlnThr: 2.509 ± 0.013	2.789GlnVal: 2.789 ± 0.014	0.546GlnTrp: 0.546 ± 0.006	1.273GlnTyr: 1.273 ± 0.011	0.001GlnXaa: 0.001 ± 0.0
Arg	3.266ArgAla: 3.266 ± 0.017	1.336ArgCys: 1.336 ± 0.015	2.799ArgAsp: 2.799 ± 0.016	3.676ArgGlu: 3.676 ± 0.02	2.06ArgPhe: 2.06 ± 0.013	3.289ArgGly: 3.289 ± 0.023	1.554ArgHis: 1.554 ± 0.012	2.445ArgIle: 2.445 ± 0.013	3.485ArgLys: 3.485 ± 0.016	5.23ArgLeu: 5.23 ± 0.023	1.262ArgMet: 1.262 ± 0.01	2.15ArgAsn: 2.15 ± 0.013	2.685ArgPro: 2.685 ± 0.016	2.532ArgGln: 2.532 ± 0.014	4.004ArgArg: 4.004 ± 0.023	4.278ArgSer: 4.278 ± 0.025	2.8ArgThr: 2.8 ± 0.014	3.315ArgVal: 3.315 ± 0.017	0.693ArgTrp: 0.693 ± 0.009	1.655ArgTyr: 1.655 ± 0.012	0.001ArgXaa: 0.001 ± 0.0
Ser	5.395SerAla: 5.395 ± 0.02	2.184SerCys: 2.184 ± 0.018	4.196SerAsp: 4.196 ± 0.021	4.702SerGlu: 4.702 ± 0.021	3.406SerPhe: 3.406 ± 0.016	5.414SerGly: 5.414 ± 0.026	2.291SerHis: 2.291 ± 0.015	3.471SerIle: 3.471 ± 0.016	3.995SerLys: 3.995 ± 0.021	8.432SerLeu: 8.432 ± 0.03	1.758SerMet: 1.758 ± 0.011	3.016SerAsn: 3.016 ± 0.017	5.412SerPro: 5.412 ± 0.031	3.717SerGln: 3.717 ± 0.023	4.288SerArg: 4.288 ± 0.02	9.695SerSer: 9.695 ± 0.053	4.7SerThr: 4.7 ± 0.02	5.532SerVal: 5.532 ± 0.022	1.039SerTrp: 1.039 ± 0.009	2.298SerTyr: 2.298 ± 0.016	0.004SerXaa: 0.004 ± 0.001
Thr	4.011ThrAla: 4.011 ± 0.017	1.536ThrCys: 1.536 ± 0.018	2.852ThrAsp: 2.852 ± 0.015	3.644ThrGlu: 3.644 ± 0.017	2.318ThrPhe: 2.318 ± 0.014	3.787ThrGly: 3.787 ± 0.016	1.508ThrHis: 1.508 ± 0.012	2.59ThrIle: 2.59 ± 0.015	2.745ThrLys: 2.745 ± 0.014	5.508ThrLeu: 5.508 ± 0.022	1.219ThrMet: 1.219 ± 0.009	2.048ThrAsn: 2.048 ± 0.013	3.42ThrPro: 3.42 ± 0.022	2.336ThrGln: 2.336 ± 0.012	2.462ThrArg: 2.462 ± 0.013	4.724ThrSer: 4.724 ± 0.024	3.256ThrThr: 3.256 ± 0.021	4.307ThrVal: 4.307 ± 0.021	0.704ThrTrp: 0.704 ± 0.008	1.557ThrTyr: 1.557 ± 0.011	0.002ThrXaa: 0.002 ± 0.0
Val	4.083ValAla: 4.083 ± 0.02	1.948ValCys: 1.948 ± 0.014	3.142ValAsp: 3.142 ± 0.016	3.909ValGlu: 3.909 ± 0.016	2.994ValPhe: 2.994 ± 0.018	3.529ValGly: 3.529 ± 0.018	1.674ValHis: 1.674 ± 0.012	3.258ValIle: 3.258 ± 0.017	3.678ValLys: 3.678 ± 0.018	6.309ValLeu: 6.309 ± 0.024	1.579ValMet: 1.579 ± 0.011	2.503ValAsn: 2.503 ± 0.015	3.132ValPro: 3.132 ± 0.015	2.7ValGln: 2.7 ± 0.015	3.269ValArg: 3.269 ± 0.016	5.436ValSer: 5.436 ± 0.021	4.092ValThr: 4.092 ± 0.021	4.455ValVal: 4.455 ± 0.022	0.796ValTrp: 0.796 ± 0.008	1.949ValTyr: 1.949 ± 0.013	0.003ValXaa: 0.003 ± 0.0
Trp	0.682TrpAla: 0.682 ± 0.007	0.277TrpCys: 0.277 ± 0.005	0.668TrpAsp: 0.668 ± 0.008	0.758TrpGlu: 0.758 ± 0.008	0.506TrpPhe: 0.506 ± 0.006	0.665TrpGly: 0.665 ± 0.009	0.29TrpHis: 0.29 ± 0.004	0.647TrpIle: 0.647 ± 0.008	0.762TrpLys: 0.762 ± 0.007	1.252TrpLeu: 1.252 ± 0.011	0.368TrpMet: 0.368 ± 0.005	0.541TrpAsn: 0.541 ± 0.006	0.438TrpPro: 0.438 ± 0.006	0.484TrpGln: 0.484 ± 0.006	0.751TrpArg: 0.751 ± 0.007	0.986TrpSer: 0.986 ± 0.01	0.732TrpThr: 0.732 ± 0.007	0.744TrpVal: 0.744 ± 0.007	0.206TrpTrp: 0.206 ± 0.004	0.391TrpTyr: 0.391 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.479TyrAla: 1.479 ± 0.011	0.823TyrCys: 0.823 ± 0.009	1.421TyrAsp: 1.421 ± 0.013	1.623TyrGlu: 1.623 ± 0.01	1.391TyrPhe: 1.391 ± 0.011	1.75TyrGly: 1.75 ± 0.012	0.846TyrHis: 0.846 ± 0.008	1.667TyrIle: 1.667 ± 0.013	1.583TyrLys: 1.583 ± 0.012	2.834TyrLeu: 2.834 ± 0.015	0.709TyrMet: 0.709 ± 0.007	1.319TyrAsn: 1.319 ± 0.01	1.379TyrPro: 1.379 ± 0.012	1.27TyrGln: 1.27 ± 0.01	1.755TyrArg: 1.755 ± 0.013	2.509TyrSer: 2.509 ± 0.015	1.788TyrThr: 1.788 ± 0.012	1.698TyrVal: 1.698 ± 0.01	0.427TyrTrp: 0.427 ± 0.007	1.1TyrTyr: 1.1 ± 0.009	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.0	0.002XaaCys: 0.002 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.002XaaPhe: 0.002 ± 0.0	0.002XaaGly: 0.002 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.002XaaLeu: 0.002 ± 0.0	0.003XaaMet: 0.003 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.002XaaArg: 0.002 ± 0.0	0.002XaaSer: 0.002 ± 0.0	0.002XaaThr: 0.002 ± 0.0	0.002XaaVal: 0.002 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	1.994XaaXaa: 1.994 ± 0.151

Statistics based on 31886 proteins (14967379 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---