Amino acid dipepetide frequency for Maize rough dwarf virus (MRDV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.974AlaAla: 1.974 ± 0.644
0.493AlaCys: 0.493 ± 0.271
3.208AlaAsp: 3.208 ± 0.955
2.467AlaGlu: 2.467 ± 0.513
2.467AlaPhe: 2.467 ± 0.411
0.987AlaGly: 0.987 ± 0.458
0.74AlaHis: 0.74 ± 0.314
1.974AlaIle: 1.974 ± 0.552
2.714AlaLys: 2.714 ± 0.781
3.701AlaLeu: 3.701 ± 0.656
1.234AlaMet: 1.234 ± 0.572
4.441AlaAsn: 4.441 ± 1.537
2.221AlaPro: 2.221 ± 0.586
1.48AlaGln: 1.48 ± 0.546
0.74AlaArg: 0.74 ± 0.464
3.454AlaSer: 3.454 ± 0.727
1.974AlaThr: 1.974 ± 0.433
2.467AlaVal: 2.467 ± 0.724
0.247AlaTrp: 0.247 ± 0.209
2.714AlaTyr: 2.714 ± 0.622
0.0AlaXaa: 0.0 ± 0.0
Cys
1.234CysAla: 1.234 ± 0.675
0.493CysCys: 0.493 ± 0.307
1.234CysAsp: 1.234 ± 0.495
0.74CysGlu: 0.74 ± 0.515
1.48CysPhe: 1.48 ± 0.435
0.493CysGly: 0.493 ± 0.31
0.493CysHis: 0.493 ± 0.269
0.74CysIle: 0.74 ± 0.375
0.493CysLys: 0.493 ± 0.271
1.974CysLeu: 1.974 ± 0.465
0.0CysMet: 0.0 ± 0.0
0.493CysAsn: 0.493 ± 0.321
0.493CysPro: 0.493 ± 0.325
0.493CysGln: 0.493 ± 0.304
1.48CysArg: 1.48 ± 0.572
1.48CysSer: 1.48 ± 0.567
0.987CysThr: 0.987 ± 0.355
1.974CysVal: 1.974 ± 0.716
0.0CysTrp: 0.0 ± 0.0
0.493CysTyr: 0.493 ± 0.365
0.0CysXaa: 0.0 ± 0.0
Asp
4.688AspAla: 4.688 ± 0.967
0.493AspCys: 0.493 ± 0.27
5.181AspAsp: 5.181 ± 0.92
4.441AspGlu: 4.441 ± 0.939
4.688AspPhe: 4.688 ± 0.82
2.714AspGly: 2.714 ± 0.718
1.234AspHis: 1.234 ± 0.447
4.935AspIle: 4.935 ± 0.755
4.194AspLys: 4.194 ± 0.985
5.922AspLeu: 5.922 ± 0.763
0.987AspMet: 0.987 ± 0.491
2.221AspAsn: 2.221 ± 1.207
2.714AspPro: 2.714 ± 0.826
1.48AspGln: 1.48 ± 0.419
3.454AspArg: 3.454 ± 0.681
3.948AspSer: 3.948 ± 1.083
1.48AspThr: 1.48 ± 0.388
4.935AspVal: 4.935 ± 0.965
0.74AspTrp: 0.74 ± 0.44
3.948AspTyr: 3.948 ± 0.942
0.0AspXaa: 0.0 ± 0.0
Glu
1.974GluAla: 1.974 ± 1.004
0.987GluCys: 0.987 ± 0.341
1.727GluAsp: 1.727 ± 0.58
4.441GluGlu: 4.441 ± 0.931
2.714GluPhe: 2.714 ± 0.726
1.48GluGly: 1.48 ± 0.517
2.221GluHis: 2.221 ± 0.588
4.935GluIle: 4.935 ± 1.441
4.935GluLys: 4.935 ± 1.165
6.908GluLeu: 6.908 ± 0.736
1.727GluMet: 1.727 ± 0.788
3.701GluAsn: 3.701 ± 1.186
1.48GluPro: 1.48 ± 0.641
1.48GluGln: 1.48 ± 0.428
2.467GluArg: 2.467 ± 0.552
3.948GluSer: 3.948 ± 0.998
2.961GluThr: 2.961 ± 0.672
5.675GluVal: 5.675 ± 0.674
0.987GluTrp: 0.987 ± 0.393
2.467GluTyr: 2.467 ± 0.582
0.0GluXaa: 0.0 ± 0.0
Phe
3.208PheAla: 3.208 ± 0.599
0.493PheCys: 0.493 ± 0.314
6.662PheAsp: 6.662 ± 1.319
3.701PheGlu: 3.701 ± 0.813
2.714PhePhe: 2.714 ± 1.039
3.701PheGly: 3.701 ± 0.509
1.727PheHis: 1.727 ± 0.54
3.208PheIle: 3.208 ± 0.415
3.948PheLys: 3.948 ± 0.777
6.168PheLeu: 6.168 ± 1.602
1.234PheMet: 1.234 ± 0.457
3.948PheAsn: 3.948 ± 0.957
1.727PhePro: 1.727 ± 0.557
1.48PheGln: 1.48 ± 0.507
1.974PheArg: 1.974 ± 0.709
4.194PheSer: 4.194 ± 0.757
3.948PheThr: 3.948 ± 1.032
3.454PheVal: 3.454 ± 0.445
0.247PheTrp: 0.247 ± 0.209
1.234PheTyr: 1.234 ± 0.413
0.0PheXaa: 0.0 ± 0.0
Gly
1.974GlyAla: 1.974 ± 0.838
0.74GlyCys: 0.74 ± 0.317
2.961GlyAsp: 2.961 ± 0.693
2.714GlyGlu: 2.714 ± 0.64
2.467GlyPhe: 2.467 ± 0.692
1.234GlyGly: 1.234 ± 0.412
1.48GlyHis: 1.48 ± 0.719
2.714GlyIle: 2.714 ± 0.723
3.454GlyLys: 3.454 ± 0.583
3.454GlyLeu: 3.454 ± 0.932
0.247GlyMet: 0.247 ± 0.221
1.974GlyAsn: 1.974 ± 0.747
0.247GlyPro: 0.247 ± 0.214
0.247GlyGln: 0.247 ± 0.209
2.221GlyArg: 2.221 ± 0.635
2.467GlySer: 2.467 ± 0.851
2.714GlyThr: 2.714 ± 0.739
2.467GlyVal: 2.467 ± 0.598
0.74GlyTrp: 0.74 ± 0.317
1.727GlyTyr: 1.727 ± 0.466
0.0GlyXaa: 0.0 ± 0.0
His
1.48HisAla: 1.48 ± 0.451
0.0HisCys: 0.0 ± 0.0
2.467HisAsp: 2.467 ± 0.473
2.467HisGlu: 2.467 ± 0.704
1.48HisPhe: 1.48 ± 0.6
1.234HisGly: 1.234 ± 0.688
1.234HisHis: 1.234 ± 0.575
1.974HisIle: 1.974 ± 0.45
0.987HisLys: 0.987 ± 0.29
4.688HisLeu: 4.688 ± 0.799
0.247HisMet: 0.247 ± 0.242
1.727HisAsn: 1.727 ± 0.819
0.74HisPro: 0.74 ± 0.297
1.48HisGln: 1.48 ± 0.473
0.247HisArg: 0.247 ± 0.243
2.714HisSer: 2.714 ± 0.839
0.74HisThr: 0.74 ± 0.428
2.221HisVal: 2.221 ± 0.58
0.247HisTrp: 0.247 ± 0.201
1.234HisTyr: 1.234 ± 0.478
0.0HisXaa: 0.0 ± 0.0
Ile
2.467IleAla: 2.467 ± 0.576
0.987IleCys: 0.987 ± 0.555
5.181IleAsp: 5.181 ± 0.911
3.454IleGlu: 3.454 ± 1.032
3.948IlePhe: 3.948 ± 0.842
3.208IleGly: 3.208 ± 0.55
1.974IleHis: 1.974 ± 0.518
3.948IleIle: 3.948 ± 1.136
5.922IleLys: 5.922 ± 1.083
6.908IleLeu: 6.908 ± 2.001
2.221IleMet: 2.221 ± 0.724
3.454IleAsn: 3.454 ± 0.718
3.208IlePro: 3.208 ± 0.772
1.234IleGln: 1.234 ± 0.381
2.714IleArg: 2.714 ± 0.609
7.402IleSer: 7.402 ± 1.501
5.428IleThr: 5.428 ± 0.839
2.467IleVal: 2.467 ± 0.858
0.247IleTrp: 0.247 ± 0.214
2.961IleTyr: 2.961 ± 0.771
0.0IleXaa: 0.0 ± 0.0
Lys
2.961LysAla: 2.961 ± 1.151
0.987LysCys: 0.987 ± 0.499
2.714LysAsp: 2.714 ± 1.029
3.454LysGlu: 3.454 ± 1.436
2.221LysPhe: 2.221 ± 0.475
1.974LysGly: 1.974 ± 0.413
1.974LysHis: 1.974 ± 0.904
5.675LysIle: 5.675 ± 0.972
3.948LysLys: 3.948 ± 0.845
7.402LysLeu: 7.402 ± 1.388
2.221LysMet: 2.221 ± 0.514
2.961LysAsn: 2.961 ± 0.975
1.974LysPro: 1.974 ± 0.562
2.714LysGln: 2.714 ± 0.725
2.961LysArg: 2.961 ± 0.419
3.948LysSer: 3.948 ± 0.998
4.935LysThr: 4.935 ± 1.008
5.428LysVal: 5.428 ± 1.103
0.74LysTrp: 0.74 ± 0.303
3.208LysTyr: 3.208 ± 1.021
0.0LysXaa: 0.0 ± 0.0
Leu
2.961LeuAla: 2.961 ± 0.805
2.221LeuCys: 2.221 ± 0.716
6.662LeuAsp: 6.662 ± 1.406
6.908LeuGlu: 6.908 ± 0.535
6.415LeuPhe: 6.415 ± 1.062
5.922LeuGly: 5.922 ± 1.318
2.714LeuHis: 2.714 ± 0.594
6.415LeuIle: 6.415 ± 1.198
8.636LeuLys: 8.636 ± 1.02
10.609LeuLeu: 10.609 ± 2.461
3.208LeuMet: 3.208 ± 0.606
10.363LeuAsn: 10.363 ± 1.855
2.714LeuPro: 2.714 ± 0.598
2.221LeuGln: 2.221 ± 0.568
4.935LeuArg: 4.935 ± 0.847
11.35LeuSer: 11.35 ± 1.724
5.181LeuThr: 5.181 ± 0.891
5.922LeuVal: 5.922 ± 1.338
0.493LeuTrp: 0.493 ± 0.34
3.454LeuTyr: 3.454 ± 0.849
0.0LeuXaa: 0.0 ± 0.0
Met
0.74MetAla: 0.74 ± 0.363
0.74MetCys: 0.74 ± 0.36
1.727MetAsp: 1.727 ± 0.572
0.0MetGlu: 0.0 ± 0.0
1.974MetPhe: 1.974 ± 0.39
0.987MetGly: 0.987 ± 0.453
0.74MetHis: 0.74 ± 0.347
2.467MetIle: 2.467 ± 0.916
1.727MetLys: 1.727 ± 0.516
2.714MetLeu: 2.714 ± 0.845
0.987MetMet: 0.987 ± 0.425
1.727MetAsn: 1.727 ± 0.428
0.247MetPro: 0.247 ± 0.221
0.247MetGln: 0.247 ± 0.209
0.987MetArg: 0.987 ± 0.513
2.467MetSer: 2.467 ± 0.652
2.221MetThr: 2.221 ± 0.85
0.987MetVal: 0.987 ± 0.292
0.0MetTrp: 0.0 ± 0.0
1.48MetTyr: 1.48 ± 0.764
0.0MetXaa: 0.0 ± 0.0
Asn
1.974AsnAla: 1.974 ± 0.456
1.234AsnCys: 1.234 ± 0.389
3.701AsnAsp: 3.701 ± 0.871
2.714AsnGlu: 2.714 ± 0.83
3.701AsnPhe: 3.701 ± 1.05
2.221AsnGly: 2.221 ± 0.724
3.454AsnHis: 3.454 ± 1.241
3.208AsnIle: 3.208 ± 0.803
2.714AsnLys: 2.714 ± 0.505
9.623AsnLeu: 9.623 ± 2.286
0.987AsnMet: 0.987 ± 0.413
2.961AsnAsn: 2.961 ± 1.06
2.221AsnPro: 2.221 ± 0.83
1.48AsnGln: 1.48 ± 0.516
2.467AsnArg: 2.467 ± 0.764
5.181AsnSer: 5.181 ± 1.12
4.194AsnThr: 4.194 ± 1.088
4.935AsnVal: 4.935 ± 1.205
0.247AsnTrp: 0.247 ± 0.237
3.701AsnTyr: 3.701 ± 1.028
0.0AsnXaa: 0.0 ± 0.0
Pro
0.987ProAla: 0.987 ± 0.469
1.234ProCys: 1.234 ± 0.481
1.234ProAsp: 1.234 ± 0.396
1.974ProGlu: 1.974 ± 0.632
1.727ProPhe: 1.727 ± 0.433
1.727ProGly: 1.727 ± 0.495
0.493ProHis: 0.493 ± 0.296
1.974ProIle: 1.974 ± 0.718
1.727ProLys: 1.727 ± 0.461
3.208ProLeu: 3.208 ± 1.148
0.987ProMet: 0.987 ± 0.424
3.701ProAsn: 3.701 ± 1.092
0.74ProPro: 0.74 ± 0.47
0.74ProGln: 0.74 ± 0.354
0.247ProArg: 0.247 ± 0.209
4.688ProSer: 4.688 ± 0.893
1.727ProThr: 1.727 ± 0.691
2.467ProVal: 2.467 ± 0.509
0.0ProTrp: 0.0 ± 0.0
0.987ProTyr: 0.987 ± 0.481
0.0ProXaa: 0.0 ± 0.0
Gln
0.74GlnAla: 0.74 ± 0.388
0.247GlnCys: 0.247 ± 0.209
0.493GlnAsp: 0.493 ± 0.328
1.727GlnGlu: 1.727 ± 0.586
2.714GlnPhe: 2.714 ± 0.512
0.493GlnGly: 0.493 ± 0.271
0.247GlnHis: 0.247 ± 0.201
2.221GlnIle: 2.221 ± 0.549
1.727GlnLys: 1.727 ± 0.474
3.701GlnLeu: 3.701 ± 1.171
0.987GlnMet: 0.987 ± 0.464
0.74GlnAsn: 0.74 ± 0.34
0.74GlnPro: 0.74 ± 0.325
0.247GlnGln: 0.247 ± 0.237
2.467GlnArg: 2.467 ± 1.078
1.234GlnSer: 1.234 ± 0.483
3.208GlnThr: 3.208 ± 0.843
1.48GlnVal: 1.48 ± 0.46
0.247GlnTrp: 0.247 ± 0.243
0.987GlnTyr: 0.987 ± 0.35
0.0GlnXaa: 0.0 ± 0.0
Arg
1.974ArgAla: 1.974 ± 0.617
0.493ArgCys: 0.493 ± 0.442
2.714ArgAsp: 2.714 ± 0.504
2.221ArgGlu: 2.221 ± 0.867
3.208ArgPhe: 3.208 ± 0.646
1.234ArgGly: 1.234 ± 0.338
1.48ArgHis: 1.48 ± 0.625
3.208ArgIle: 3.208 ± 0.839
3.208ArgLys: 3.208 ± 0.912
4.688ArgLeu: 4.688 ± 1.28
1.48ArgMet: 1.48 ± 0.592
1.727ArgAsn: 1.727 ± 0.721
0.987ArgPro: 0.987 ± 0.47
2.221ArgGln: 2.221 ± 0.611
2.467ArgArg: 2.467 ± 0.884
2.714ArgSer: 2.714 ± 1.285
2.714ArgThr: 2.714 ± 0.475
1.974ArgVal: 1.974 ± 0.703
0.247ArgTrp: 0.247 ± 0.201
1.48ArgTyr: 1.48 ± 0.653
0.0ArgXaa: 0.0 ± 0.0
Ser
4.194SerAla: 4.194 ± 1.448
2.221SerCys: 2.221 ± 0.7
4.935SerAsp: 4.935 ± 0.984
4.935SerGlu: 4.935 ± 1.235
4.441SerPhe: 4.441 ± 0.967
1.234SerGly: 1.234 ± 0.332
2.467SerHis: 2.467 ± 0.704
8.389SerIle: 8.389 ± 1.691
4.194SerLys: 4.194 ± 0.644
10.363SerLeu: 10.363 ± 1.426
1.727SerMet: 1.727 ± 0.56
5.181SerAsn: 5.181 ± 1.349
2.961SerPro: 2.961 ± 0.848
2.221SerGln: 2.221 ± 0.611
3.948SerArg: 3.948 ± 0.961
9.869SerSer: 9.869 ± 2.123
4.935SerThr: 4.935 ± 1.239
4.935SerVal: 4.935 ± 0.721
0.0SerTrp: 0.0 ± 0.0
4.688SerTyr: 4.688 ± 1.532
0.0SerXaa: 0.0 ± 0.0
Thr
2.714ThrAla: 2.714 ± 0.604
1.234ThrCys: 1.234 ± 0.516
3.948ThrAsp: 3.948 ± 1.063
3.701ThrGlu: 3.701 ± 0.805
2.467ThrPhe: 2.467 ± 0.812
1.727ThrGly: 1.727 ± 0.408
0.493ThrHis: 0.493 ± 0.301
3.701ThrIle: 3.701 ± 0.771
2.467ThrLys: 2.467 ± 0.737
7.649ThrLeu: 7.649 ± 0.949
2.221ThrMet: 2.221 ± 1.191
3.454ThrAsn: 3.454 ± 0.689
1.234ThrPro: 1.234 ± 0.618
1.727ThrGln: 1.727 ± 0.524
2.221ThrArg: 2.221 ± 0.824
6.168ThrSer: 6.168 ± 1.335
3.208ThrThr: 3.208 ± 1.341
3.948ThrVal: 3.948 ± 0.551
0.493ThrTrp: 0.493 ± 0.427
1.974ThrTyr: 1.974 ± 0.571
0.0ThrXaa: 0.0 ± 0.0
Val
2.714ValAla: 2.714 ± 0.936
0.493ValCys: 0.493 ± 0.321
2.714ValAsp: 2.714 ± 0.59
4.194ValGlu: 4.194 ± 0.978
5.428ValPhe: 5.428 ± 1.324
2.467ValGly: 2.467 ± 0.679
1.727ValHis: 1.727 ± 0.684
4.935ValIle: 4.935 ± 0.682
4.194ValLys: 4.194 ± 1.152
5.922ValLeu: 5.922 ± 0.817
1.48ValMet: 1.48 ± 0.503
4.441ValAsn: 4.441 ± 1.173
3.454ValPro: 3.454 ± 0.661
2.221ValGln: 2.221 ± 0.756
3.454ValArg: 3.454 ± 0.804
5.181ValSer: 5.181 ± 1.228
3.208ValThr: 3.208 ± 0.983
4.194ValVal: 4.194 ± 0.892
0.0ValTrp: 0.0 ± 0.0
1.974ValTyr: 1.974 ± 0.569
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.247TrpCys: 0.247 ± 0.201
0.247TrpAsp: 0.247 ± 0.237
0.987TrpGlu: 0.987 ± 0.542
0.247TrpPhe: 0.247 ± 0.201
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.987TrpLys: 0.987 ± 0.43
0.247TrpLeu: 0.247 ± 0.221
0.0TrpMet: 0.0 ± 0.0
0.74TrpAsn: 0.74 ± 0.357
0.247TrpPro: 0.247 ± 0.209
0.493TrpGln: 0.493 ± 0.296
0.0TrpArg: 0.0 ± 0.0
0.987TrpSer: 0.987 ± 0.554
0.247TrpThr: 0.247 ± 0.201
0.247TrpVal: 0.247 ± 0.209
0.0TrpTrp: 0.0 ± 0.0
0.493TrpTyr: 0.493 ± 0.299
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.74TyrAla: 0.74 ± 0.402
1.234TyrCys: 1.234 ± 0.515
4.688TyrAsp: 4.688 ± 0.873
2.221TyrGlu: 2.221 ± 0.5
2.467TyrPhe: 2.467 ± 0.781
3.208TyrGly: 3.208 ± 0.881
2.714TyrHis: 2.714 ± 0.752
2.467TyrIle: 2.467 ± 0.89
2.221TyrLys: 2.221 ± 1.004
3.454TyrLeu: 3.454 ± 1.056
0.987TyrMet: 0.987 ± 0.584
2.961TyrAsn: 2.961 ± 0.721
2.221TyrPro: 2.221 ± 0.594
0.74TyrGln: 0.74 ± 0.47
0.987TyrArg: 0.987 ± 0.367
4.441TyrSer: 4.441 ± 1.115
0.74TyrThr: 0.74 ± 0.264
2.221TyrVal: 2.221 ± 0.824
0.493TyrTrp: 0.493 ± 0.402
1.234TyrTyr: 1.234 ± 0.381
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (4054 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski