Amino acid dipepetide frequency for bacterium 1XD42-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.223AlaAla: 7.223 ± 0.094
1.129AlaCys: 1.129 ± 0.025
3.635AlaAsp: 3.635 ± 0.047
4.507AlaGlu: 4.507 ± 0.054
3.226AlaPhe: 3.226 ± 0.047
5.592AlaGly: 5.592 ± 0.063
1.139AlaHis: 1.139 ± 0.026
4.842AlaIle: 4.842 ± 0.051
4.865AlaLys: 4.865 ± 0.056
7.333AlaLeu: 7.333 ± 0.067
2.295AlaMet: 2.295 ± 0.04
2.425AlaAsn: 2.425 ± 0.034
2.372AlaPro: 2.372 ± 0.041
2.757AlaGln: 2.757 ± 0.048
3.014AlaArg: 3.014 ± 0.037
4.142AlaSer: 4.142 ± 0.046
2.798AlaThr: 2.798 ± 0.045
5.833AlaVal: 5.833 ± 0.058
0.616AlaTrp: 0.616 ± 0.018
2.703AlaTyr: 2.703 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.04CysAla: 1.04 ± 0.026
0.313CysCys: 0.313 ± 0.015
0.747CysAsp: 0.747 ± 0.019
0.834CysGlu: 0.834 ± 0.023
0.758CysPhe: 0.758 ± 0.022
1.448CysGly: 1.448 ± 0.031
0.357CysHis: 0.357 ± 0.014
1.143CysIle: 1.143 ± 0.024
0.944CysLys: 0.944 ± 0.024
1.302CysLeu: 1.302 ± 0.028
0.441CysMet: 0.441 ± 0.012
0.603CysAsn: 0.603 ± 0.018
0.665CysPro: 0.665 ± 0.021
0.526CysGln: 0.526 ± 0.017
0.726CysArg: 0.726 ± 0.023
0.976CysSer: 0.976 ± 0.024
0.763CysThr: 0.763 ± 0.018
0.89CysVal: 0.89 ± 0.022
0.133CysTrp: 0.133 ± 0.008
0.543CysTyr: 0.543 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.48AspAla: 3.48 ± 0.051
0.8AspCys: 0.8 ± 0.023
2.172AspAsp: 2.172 ± 0.041
3.752AspGlu: 3.752 ± 0.049
2.704AspPhe: 2.704 ± 0.043
3.921AspGly: 3.921 ± 0.049
0.791AspHis: 0.791 ± 0.02
4.268AspIle: 4.268 ± 0.055
3.322AspLys: 3.322 ± 0.045
4.571AspLeu: 4.571 ± 0.054
1.679AspMet: 1.679 ± 0.029
2.01AspAsn: 2.01 ± 0.032
1.841AspPro: 1.841 ± 0.029
1.364AspGln: 1.364 ± 0.023
2.39AspArg: 2.39 ± 0.042
2.997AspSer: 2.997 ± 0.045
2.709AspThr: 2.709 ± 0.037
3.146AspVal: 3.146 ± 0.045
0.577AspTrp: 0.577 ± 0.017
2.547AspTyr: 2.547 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
5.419GluAla: 5.419 ± 0.056
0.765GluCys: 0.765 ± 0.021
3.812GluAsp: 3.812 ± 0.051
7.94GluGlu: 7.94 ± 0.097
2.494GluPhe: 2.494 ± 0.036
4.915GluGly: 4.915 ± 0.059
1.238GluHis: 1.238 ± 0.03
6.092GluIle: 6.092 ± 0.064
7.508GluLys: 7.508 ± 0.075
6.561GluLeu: 6.561 ± 0.058
2.43GluMet: 2.43 ± 0.037
4.215GluAsn: 4.215 ± 0.048
2.072GluPro: 2.072 ± 0.039
3.177GluGln: 3.177 ± 0.046
3.92GluArg: 3.92 ± 0.048
3.37GluSer: 3.37 ± 0.038
3.663GluThr: 3.663 ± 0.039
4.025GluVal: 4.025 ± 0.058
0.698GluTrp: 0.698 ± 0.016
2.976GluTyr: 2.976 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
2.902PheAla: 2.902 ± 0.041
0.884PheCys: 0.884 ± 0.023
2.373PheAsp: 2.373 ± 0.033
2.545PheGlu: 2.545 ± 0.037
2.306PhePhe: 2.306 ± 0.039
3.018PheGly: 3.018 ± 0.042
1.054PheHis: 1.054 ± 0.024
3.055PheIle: 3.055 ± 0.046
1.847PheLys: 1.847 ± 0.031
4.853PheLeu: 4.853 ± 0.067
1.168PheMet: 1.168 ± 0.026
1.416PheAsn: 1.416 ± 0.026
1.689PhePro: 1.689 ± 0.033
1.837PheGln: 1.837 ± 0.032
1.731PheArg: 1.731 ± 0.025
3.372PheSer: 3.372 ± 0.048
2.34PheThr: 2.34 ± 0.038
2.736PheVal: 2.736 ± 0.037
0.461PheTrp: 0.461 ± 0.017
1.956PheTyr: 1.956 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
4.989GlyAla: 4.989 ± 0.065
1.239GlyCys: 1.239 ± 0.029
3.453GlyAsp: 3.453 ± 0.049
5.177GlyGlu: 5.177 ± 0.053
3.11GlyPhe: 3.11 ± 0.037
5.065GlyGly: 5.065 ± 0.06
1.253GlyHis: 1.253 ± 0.027
6.286GlyIle: 6.286 ± 0.062
5.732GlyLys: 5.732 ± 0.053
5.921GlyLeu: 5.921 ± 0.06
2.501GlyMet: 2.501 ± 0.039
3.217GlyAsn: 3.217 ± 0.044
1.454GlyPro: 1.454 ± 0.039
2.34GlyGln: 2.34 ± 0.035
3.39GlyArg: 3.39 ± 0.049
3.973GlySer: 3.973 ± 0.051
3.935GlyThr: 3.935 ± 0.047
4.616GlyVal: 4.616 ± 0.055
0.712GlyTrp: 0.712 ± 0.02
3.064GlyTyr: 3.064 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
1.024HisAla: 1.024 ± 0.023
0.332HisCys: 0.332 ± 0.015
0.768HisAsp: 0.768 ± 0.019
1.037HisGlu: 1.037 ± 0.023
0.961HisPhe: 0.961 ± 0.021
1.288HisGly: 1.288 ± 0.031
0.459HisHis: 0.459 ± 0.016
1.608HisIle: 1.608 ± 0.03
1.038HisLys: 1.038 ± 0.026
1.708HisLeu: 1.708 ± 0.03
0.572HisMet: 0.572 ± 0.016
0.717HisAsn: 0.717 ± 0.019
0.934HisPro: 0.934 ± 0.019
0.612HisGln: 0.612 ± 0.018
0.8HisArg: 0.8 ± 0.021
1.104HisSer: 1.104 ± 0.025
0.982HisThr: 0.982 ± 0.023
1.044HisVal: 1.044 ± 0.026
0.212HisTrp: 0.212 ± 0.011
0.85HisTyr: 0.85 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.419IleAla: 5.419 ± 0.059
1.348IleCys: 1.348 ± 0.027
3.934IleAsp: 3.934 ± 0.05
5.198IleGlu: 5.198 ± 0.057
3.261IlePhe: 3.261 ± 0.051
5.38IleGly: 5.38 ± 0.06
1.567IleHis: 1.567 ± 0.032
5.136IleIle: 5.136 ± 0.056
4.25IleLys: 4.25 ± 0.06
7.544IleLeu: 7.544 ± 0.076
1.898IleMet: 1.898 ± 0.033
2.66IleAsn: 2.66 ± 0.035
3.405IlePro: 3.405 ± 0.046
2.958IleGln: 2.958 ± 0.04
3.527IleArg: 3.527 ± 0.047
5.07IleSer: 5.07 ± 0.055
4.024IleThr: 4.024 ± 0.048
4.755IleVal: 4.755 ± 0.05
0.677IleTrp: 0.677 ± 0.018
2.838IleTyr: 2.838 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.897LysAla: 4.897 ± 0.06
0.729LysCys: 0.729 ± 0.023
3.792LysAsp: 3.792 ± 0.047
7.712LysGlu: 7.712 ± 0.083
1.895LysPhe: 1.895 ± 0.033
4.844LysGly: 4.844 ± 0.054
0.965LysHis: 0.965 ± 0.021
5.247LysIle: 5.247 ± 0.05
6.484LysLys: 6.484 ± 0.081
5.361LysLeu: 5.361 ± 0.052
2.21LysMet: 2.21 ± 0.033
3.678LysAsn: 3.678 ± 0.045
2.119LysPro: 2.119 ± 0.035
2.339LysGln: 2.339 ± 0.037
3.516LysArg: 3.516 ± 0.044
3.413LysSer: 3.413 ± 0.044
3.617LysThr: 3.617 ± 0.045
4.025LysVal: 4.025 ± 0.051
0.643LysTrp: 0.643 ± 0.018
2.705LysTyr: 2.705 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
6.851LeuAla: 6.851 ± 0.063
1.753LeuCys: 1.753 ± 0.032
4.9LeuAsp: 4.9 ± 0.055
7.224LeuGlu: 7.224 ± 0.074
4.445LeuPhe: 4.445 ± 0.061
6.026LeuGly: 6.026 ± 0.06
1.693LeuHis: 1.693 ± 0.028
5.854LeuIle: 5.854 ± 0.059
6.208LeuLys: 6.208 ± 0.057
9.71LeuLeu: 9.71 ± 0.097
2.531LeuMet: 2.531 ± 0.04
3.675LeuAsn: 3.675 ± 0.05
3.838LeuPro: 3.838 ± 0.051
3.17LeuGln: 3.17 ± 0.043
4.17LeuArg: 4.17 ± 0.054
6.918LeuSer: 6.918 ± 0.075
4.955LeuThr: 4.955 ± 0.05
4.969LeuVal: 4.969 ± 0.052
0.94LeuTrp: 0.94 ± 0.023
3.547LeuTyr: 3.547 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.498MetAla: 2.498 ± 0.037
0.335MetCys: 0.335 ± 0.012
1.885MetAsp: 1.885 ± 0.03
2.91MetGlu: 2.91 ± 0.041
0.939MetPhe: 0.939 ± 0.022
2.263MetGly: 2.263 ± 0.039
0.355MetHis: 0.355 ± 0.014
2.096MetIle: 2.096 ± 0.031
2.41MetLys: 2.41 ± 0.04
2.603MetLeu: 2.603 ± 0.039
0.872MetMet: 0.872 ± 0.024
1.461MetAsn: 1.461 ± 0.028
1.16MetPro: 1.16 ± 0.024
0.934MetGln: 0.934 ± 0.024
1.313MetArg: 1.313 ± 0.026
1.58MetSer: 1.58 ± 0.031
1.586MetThr: 1.586 ± 0.033
1.769MetVal: 1.769 ± 0.03
0.217MetTrp: 0.217 ± 0.011
0.848MetTyr: 0.848 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.931AsnAla: 2.931 ± 0.042
0.58AsnCys: 0.58 ± 0.02
1.817AsnAsp: 1.817 ± 0.035
2.65AsnGlu: 2.65 ± 0.044
1.67AsnPhe: 1.67 ± 0.032
3.403AsnGly: 3.403 ± 0.044
0.879AsnHis: 0.879 ± 0.023
3.613AsnIle: 3.613 ± 0.04
2.653AsnLys: 2.653 ± 0.036
3.815AsnLeu: 3.815 ± 0.046
1.367AsnMet: 1.367 ± 0.028
1.836AsnAsn: 1.836 ± 0.037
2.106AsnPro: 2.106 ± 0.033
1.541AsnGln: 1.541 ± 0.027
2.099AsnArg: 2.099 ± 0.034
2.253AsnSer: 2.253 ± 0.035
2.258AsnThr: 2.258 ± 0.035
2.522AsnVal: 2.522 ± 0.035
0.408AsnTrp: 0.408 ± 0.016
1.754AsnTyr: 1.754 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
2.663ProAla: 2.663 ± 0.046
0.489ProCys: 0.489 ± 0.017
2.234ProAsp: 2.234 ± 0.035
3.312ProGlu: 3.312 ± 0.052
1.831ProPhe: 1.831 ± 0.031
2.32ProGly: 2.32 ± 0.038
0.653ProHis: 0.653 ± 0.019
2.393ProIle: 2.393 ± 0.037
2.271ProLys: 2.271 ± 0.034
3.277ProLeu: 3.277 ± 0.043
0.964ProMet: 0.964 ± 0.02
1.34ProAsn: 1.34 ± 0.025
1.246ProPro: 1.246 ± 0.032
1.323ProGln: 1.323 ± 0.035
1.156ProArg: 1.156 ± 0.032
2.205ProSer: 2.205 ± 0.037
1.531ProThr: 1.531 ± 0.029
2.924ProVal: 2.924 ± 0.045
0.342ProTrp: 0.342 ± 0.014
1.585ProTyr: 1.585 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
2.822GlnAla: 2.822 ± 0.044
0.422GlnCys: 0.422 ± 0.015
1.659GlnAsp: 1.659 ± 0.033
3.066GlnGlu: 3.066 ± 0.043
1.357GlnPhe: 1.357 ± 0.026
2.506GlnGly: 2.506 ± 0.039
0.521GlnHis: 0.521 ± 0.016
2.824GlnIle: 2.824 ± 0.041
2.915GlnLys: 2.915 ± 0.04
3.051GlnLeu: 3.051 ± 0.042
1.194GlnMet: 1.194 ± 0.028
1.686GlnAsn: 1.686 ± 0.026
1.116GlnPro: 1.116 ± 0.025
1.435GlnGln: 1.435 ± 0.033
1.753GlnArg: 1.753 ± 0.032
1.841GlnSer: 1.841 ± 0.032
1.712GlnThr: 1.712 ± 0.028
2.223GlnVal: 2.223 ± 0.034
0.45GlnTrp: 0.45 ± 0.018
1.582GlnTyr: 1.582 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
2.782ArgAla: 2.782 ± 0.039
0.66ArgCys: 0.66 ± 0.019
2.256ArgAsp: 2.256 ± 0.036
4.138ArgGlu: 4.138 ± 0.055
1.965ArgPhe: 1.965 ± 0.033
2.81ArgGly: 2.81 ± 0.038
0.838ArgHis: 0.838 ± 0.022
3.545ArgIle: 3.545 ± 0.042
3.682ArgLys: 3.682 ± 0.047
4.433ArgLeu: 4.433 ± 0.05
1.485ArgMet: 1.485 ± 0.03
2.097ArgAsn: 2.097 ± 0.037
1.427ArgPro: 1.427 ± 0.029
1.983ArgGln: 1.983 ± 0.036
2.55ArgArg: 2.55 ± 0.043
2.236ArgSer: 2.236 ± 0.031
2.139ArgThr: 2.139 ± 0.033
2.528ArgVal: 2.528 ± 0.039
0.441ArgTrp: 0.441 ± 0.016
1.79ArgTyr: 1.79 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
4.11SerAla: 4.11 ± 0.051
0.872SerCys: 0.872 ± 0.024
2.777SerAsp: 2.777 ± 0.039
3.488SerGlu: 3.488 ± 0.038
3.054SerPhe: 3.054 ± 0.042
4.735SerGly: 4.735 ± 0.053
1.21SerHis: 1.21 ± 0.028
4.745SerIle: 4.745 ± 0.055
3.59SerLys: 3.59 ± 0.05
5.852SerLeu: 5.852 ± 0.064
1.887SerMet: 1.887 ± 0.03
2.292SerAsn: 2.292 ± 0.036
2.218SerPro: 2.218 ± 0.038
2.338SerGln: 2.338 ± 0.036
2.636SerArg: 2.636 ± 0.039
4.065SerSer: 4.065 ± 0.078
2.701SerThr: 2.701 ± 0.04
3.954SerVal: 3.954 ± 0.047
0.527SerTrp: 0.527 ± 0.017
2.471SerTyr: 2.471 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
4.241ThrAla: 4.241 ± 0.053
0.562ThrCys: 0.562 ± 0.019
2.695ThrAsp: 2.695 ± 0.042
3.51ThrGlu: 3.51 ± 0.046
2.212ThrPhe: 2.212 ± 0.033
4.273ThrGly: 4.273 ± 0.055
0.833ThrHis: 0.833 ± 0.019
3.793ThrIle: 3.793 ± 0.05
3.095ThrLys: 3.095 ± 0.042
4.753ThrLeu: 4.753 ± 0.052
1.413ThrMet: 1.413 ± 0.031
1.947ThrAsn: 1.947 ± 0.03
2.184ThrPro: 2.184 ± 0.036
1.505ThrGln: 1.505 ± 0.029
1.92ThrArg: 1.92 ± 0.031
2.821ThrSer: 2.821 ± 0.04
2.379ThrThr: 2.379 ± 0.037
3.879ThrVal: 3.879 ± 0.042
0.426ThrTrp: 0.426 ± 0.015
1.916ThrTyr: 1.916 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
4.078ValAla: 4.078 ± 0.05
1.119ValCys: 1.119 ± 0.024
3.321ValAsp: 3.321 ± 0.046
4.429ValGlu: 4.429 ± 0.053
2.929ValPhe: 2.929 ± 0.042
3.901ValGly: 3.901 ± 0.054
1.129ValHis: 1.129 ± 0.026
4.643ValIle: 4.643 ± 0.057
4.171ValLys: 4.171 ± 0.05
6.101ValLeu: 6.101 ± 0.058
1.788ValMet: 1.788 ± 0.029
2.603ValAsn: 2.603 ± 0.039
2.458ValPro: 2.458 ± 0.035
2.071ValGln: 2.071 ± 0.039
2.786ValArg: 2.786 ± 0.043
4.371ValSer: 4.371 ± 0.053
3.631ValThr: 3.631 ± 0.045
4.022ValVal: 4.022 ± 0.052
0.595ValTrp: 0.595 ± 0.021
2.473ValTyr: 2.473 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.554TrpAla: 0.554 ± 0.017
0.138TrpCys: 0.138 ± 0.009
0.551TrpAsp: 0.551 ± 0.017
0.834TrpGlu: 0.834 ± 0.023
0.413TrpPhe: 0.413 ± 0.015
0.705TrpGly: 0.705 ± 0.02
0.189TrpHis: 0.189 ± 0.011
0.752TrpIle: 0.752 ± 0.019
0.817TrpLys: 0.817 ± 0.021
0.902TrpLeu: 0.902 ± 0.023
0.309TrpMet: 0.309 ± 0.013
0.568TrpAsn: 0.568 ± 0.017
0.222TrpPro: 0.222 ± 0.011
0.367TrpGln: 0.367 ± 0.013
0.43TrpArg: 0.43 ± 0.013
0.467TrpSer: 0.467 ± 0.017
0.431TrpThr: 0.431 ± 0.015
0.475TrpVal: 0.475 ± 0.017
0.106TrpTrp: 0.106 ± 0.006
0.348TrpTyr: 0.348 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.522TyrAla: 2.522 ± 0.035
0.683TyrCys: 0.683 ± 0.02
2.257TyrAsp: 2.257 ± 0.037
3.026TyrGlu: 3.026 ± 0.043
2.015TyrPhe: 2.015 ± 0.038
3.012TyrGly: 3.012 ± 0.043
0.927TyrHis: 0.927 ± 0.026
2.916TyrIle: 2.916 ± 0.037
2.389TyrLys: 2.389 ± 0.043
3.725TyrLeu: 3.725 ± 0.05
1.031TyrMet: 1.031 ± 0.023
1.709TyrAsn: 1.709 ± 0.036
1.534TyrPro: 1.534 ± 0.029
1.557TyrGln: 1.557 ± 0.033
1.958TyrArg: 1.958 ± 0.037
2.346TyrSer: 2.346 ± 0.037
2.205TyrThr: 2.205 ± 0.038
2.283TyrVal: 2.283 ± 0.036
0.4TyrTrp: 0.4 ± 0.013
1.899TyrTyr: 1.899 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7100 proteins (1928657 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski