Amino acid dipepetide frequency for Roseivirga ehrenbergii (strain DSM 102268 / JCM 13514 / KCTC 12282 / NCIMB 14502 / KMM 6017)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.738AlaAla: 4.738 ± 0.077
0.561AlaCys: 0.561 ± 0.023
3.68AlaAsp: 3.68 ± 0.072
4.615AlaGlu: 4.615 ± 0.061
3.681AlaPhe: 3.681 ± 0.06
4.712AlaGly: 4.712 ± 0.083
1.139AlaHis: 1.139 ± 0.033
5.391AlaIle: 5.391 ± 0.073
4.692AlaLys: 4.692 ± 0.078
6.805AlaLeu: 6.805 ± 0.094
1.79AlaMet: 1.79 ± 0.039
3.527AlaAsn: 3.527 ± 0.065
2.123AlaPro: 2.123 ± 0.047
2.705AlaGln: 2.705 ± 0.049
2.255AlaArg: 2.255 ± 0.046
4.469AlaSer: 4.469 ± 0.059
3.634AlaThr: 3.634 ± 0.098
4.193AlaVal: 4.193 ± 0.073
0.701AlaTrp: 0.701 ± 0.025
2.605AlaTyr: 2.605 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.425CysAla: 0.425 ± 0.021
0.087CysCys: 0.087 ± 0.009
0.346CysAsp: 0.346 ± 0.018
0.41CysGlu: 0.41 ± 0.022
0.376CysPhe: 0.376 ± 0.023
0.53CysGly: 0.53 ± 0.022
0.156CysHis: 0.156 ± 0.012
0.48CysIle: 0.48 ± 0.02
0.349CysLys: 0.349 ± 0.019
0.638CysLeu: 0.638 ± 0.023
0.131CysMet: 0.131 ± 0.011
0.307CysAsn: 0.307 ± 0.018
0.276CysPro: 0.276 ± 0.019
0.202CysGln: 0.202 ± 0.014
0.21CysArg: 0.21 ± 0.014
0.465CysSer: 0.465 ± 0.023
0.347CysThr: 0.347 ± 0.016
0.371CysVal: 0.371 ± 0.018
0.067CysTrp: 0.067 ± 0.007
0.245CysTyr: 0.245 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.555AspAla: 3.555 ± 0.074
0.368AspCys: 0.368 ± 0.021
2.978AspAsp: 2.978 ± 0.084
3.884AspGlu: 3.884 ± 0.057
3.654AspPhe: 3.654 ± 0.06
3.966AspGly: 3.966 ± 0.123
0.989AspHis: 0.989 ± 0.034
4.117AspIle: 4.117 ± 0.07
3.677AspLys: 3.677 ± 0.068
5.605AspLeu: 5.605 ± 0.07
1.218AspMet: 1.218 ± 0.035
2.902AspAsn: 2.902 ± 0.07
2.065AspPro: 2.065 ± 0.044
2.111AspGln: 2.111 ± 0.045
2.254AspArg: 2.254 ± 0.041
3.263AspSer: 3.263 ± 0.06
2.457AspThr: 2.457 ± 0.064
3.361AspVal: 3.361 ± 0.065
0.773AspTrp: 0.773 ± 0.029
2.565AspTyr: 2.565 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
5.024GluAla: 5.024 ± 0.081
0.304GluCys: 0.304 ± 0.018
3.523GluAsp: 3.523 ± 0.061
5.219GluGlu: 5.219 ± 0.093
3.147GluPhe: 3.147 ± 0.055
4.502GluGly: 4.502 ± 0.065
1.158GluHis: 1.158 ± 0.035
5.436GluIle: 5.436 ± 0.075
5.583GluLys: 5.583 ± 0.096
6.596GluLeu: 6.596 ± 0.086
1.913GluMet: 1.913 ± 0.041
4.196GluAsn: 4.196 ± 0.057
1.772GluPro: 1.772 ± 0.043
2.362GluGln: 2.362 ± 0.049
2.929GluArg: 2.929 ± 0.05
3.959GluSer: 3.959 ± 0.057
3.368GluThr: 3.368 ± 0.052
5.023GluVal: 5.023 ± 0.06
0.728GluTrp: 0.728 ± 0.024
2.431GluTyr: 2.431 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.037PheAla: 3.037 ± 0.057
0.373PheCys: 0.373 ± 0.018
3.432PheAsp: 3.432 ± 0.056
3.604PheGlu: 3.604 ± 0.061
2.705PhePhe: 2.705 ± 0.066
3.793PheGly: 3.793 ± 0.06
0.851PheHis: 0.851 ± 0.026
3.615PheIle: 3.615 ± 0.06
3.415PheLys: 3.415 ± 0.059
4.612PheLeu: 4.612 ± 0.073
1.171PheMet: 1.171 ± 0.027
3.022PheAsn: 3.022 ± 0.055
1.691PhePro: 1.691 ± 0.041
1.774PheGln: 1.774 ± 0.037
1.893PheArg: 1.893 ± 0.046
4.133PheSer: 4.133 ± 0.069
3.008PheThr: 3.008 ± 0.063
3.102PheVal: 3.102 ± 0.057
0.565PheTrp: 0.565 ± 0.021
2.047PheTyr: 2.047 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
4.689GlyAla: 4.689 ± 0.081
0.555GlyCys: 0.555 ± 0.038
3.585GlyAsp: 3.585 ± 0.068
4.199GlyGlu: 4.199 ± 0.063
3.744GlyPhe: 3.744 ± 0.061
5.017GlyGly: 5.017 ± 0.11
1.194GlyHis: 1.194 ± 0.032
5.286GlyIle: 5.286 ± 0.084
4.834GlyLys: 4.834 ± 0.07
6.446GlyLeu: 6.446 ± 0.072
1.778GlyMet: 1.778 ± 0.041
3.686GlyAsn: 3.686 ± 0.084
1.56GlyPro: 1.56 ± 0.043
2.31GlyGln: 2.31 ± 0.042
2.584GlyArg: 2.584 ± 0.051
4.274GlySer: 4.274 ± 0.074
4.155GlyThr: 4.155 ± 0.114
4.66GlyVal: 4.66 ± 0.073
0.815GlyTrp: 0.815 ± 0.029
2.718GlyTyr: 2.718 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
0.961HisAla: 0.961 ± 0.032
0.146HisCys: 0.146 ± 0.011
0.853HisAsp: 0.853 ± 0.027
1.07HisGlu: 1.07 ± 0.032
1.116HisPhe: 1.116 ± 0.035
1.082HisGly: 1.082 ± 0.031
0.461HisHis: 0.461 ± 0.022
1.26HisIle: 1.26 ± 0.034
1.033HisLys: 1.033 ± 0.028
1.821HisLeu: 1.821 ± 0.046
0.4HisMet: 0.4 ± 0.016
0.819HisAsn: 0.819 ± 0.026
0.882HisPro: 0.882 ± 0.03
0.686HisGln: 0.686 ± 0.027
0.673HisArg: 0.673 ± 0.024
1.099HisSer: 1.099 ± 0.033
0.877HisThr: 0.877 ± 0.026
0.911HisVal: 0.911 ± 0.025
0.239HisTrp: 0.239 ± 0.015
0.739HisTyr: 0.739 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.31IleAla: 5.31 ± 0.065
0.519IleCys: 0.519 ± 0.019
4.767IleAsp: 4.767 ± 0.063
5.468IleGlu: 5.468 ± 0.066
3.326IlePhe: 3.326 ± 0.061
5.148IleGly: 5.148 ± 0.077
1.332IleHis: 1.332 ± 0.036
5.076IleIle: 5.076 ± 0.087
5.035IleLys: 5.035 ± 0.081
6.472IleLeu: 6.472 ± 0.082
1.49IleMet: 1.49 ± 0.04
3.982IleAsn: 3.982 ± 0.063
2.97IlePro: 2.97 ± 0.051
2.678IleGln: 2.678 ± 0.046
2.763IleArg: 2.763 ± 0.045
5.532IleSer: 5.532 ± 0.064
4.518IleThr: 4.518 ± 0.096
4.407IleVal: 4.407 ± 0.058
0.69IleTrp: 0.69 ± 0.026
2.536IleTyr: 2.536 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
5.111LysAla: 5.111 ± 0.08
0.283LysCys: 0.283 ± 0.015
3.763LysAsp: 3.763 ± 0.057
5.658LysGlu: 5.658 ± 0.074
2.605LysPhe: 2.605 ± 0.05
4.485LysGly: 4.485 ± 0.073
1.195LysHis: 1.195 ± 0.038
4.876LysIle: 4.876 ± 0.071
5.436LysLys: 5.436 ± 0.101
6.24LysLeu: 6.24 ± 0.082
1.909LysMet: 1.909 ± 0.043
3.982LysAsn: 3.982 ± 0.058
2.522LysPro: 2.522 ± 0.052
2.317LysGln: 2.317 ± 0.049
2.934LysArg: 2.934 ± 0.049
4.483LysSer: 4.483 ± 0.074
3.99LysThr: 3.99 ± 0.066
4.906LysVal: 4.906 ± 0.077
0.767LysTrp: 0.767 ± 0.029
2.635LysTyr: 2.635 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
6.662LeuAla: 6.662 ± 0.101
0.623LeuCys: 0.623 ± 0.027
5.194LeuAsp: 5.194 ± 0.082
6.302LeuGlu: 6.302 ± 0.086
4.711LeuPhe: 4.711 ± 0.079
6.245LeuGly: 6.245 ± 0.08
1.383LeuHis: 1.383 ± 0.041
7.061LeuIle: 7.061 ± 0.086
7.379LeuLys: 7.379 ± 0.096
8.804LeuLeu: 8.804 ± 0.139
2.351LeuMet: 2.351 ± 0.047
5.555LeuAsn: 5.555 ± 0.075
3.596LeuPro: 3.596 ± 0.057
2.93LeuGln: 2.93 ± 0.053
3.551LeuArg: 3.551 ± 0.059
7.221LeuSer: 7.221 ± 0.085
5.436LeuThr: 5.436 ± 0.084
5.911LeuVal: 5.911 ± 0.075
0.853LeuTrp: 0.853 ± 0.033
3.06LeuTyr: 3.06 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
2.075MetAla: 2.075 ± 0.049
0.122MetCys: 0.122 ± 0.011
1.343MetAsp: 1.343 ± 0.031
1.525MetGlu: 1.525 ± 0.036
0.904MetPhe: 0.904 ± 0.027
1.699MetGly: 1.699 ± 0.04
0.394MetHis: 0.394 ± 0.017
1.76MetIle: 1.76 ± 0.044
2.166MetLys: 2.166 ± 0.045
2.164MetLeu: 2.164 ± 0.042
0.68MetMet: 0.68 ± 0.025
1.344MetAsn: 1.344 ± 0.031
0.962MetPro: 0.962 ± 0.034
0.792MetGln: 0.792 ± 0.025
1.023MetArg: 1.023 ± 0.028
1.573MetSer: 1.573 ± 0.039
1.231MetThr: 1.231 ± 0.032
1.558MetVal: 1.558 ± 0.035
0.192MetTrp: 0.192 ± 0.013
0.616MetTyr: 0.616 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.586AsnAla: 3.586 ± 0.06
0.342AsnCys: 0.342 ± 0.017
2.948AsnAsp: 2.948 ± 0.067
3.698AsnGlu: 3.698 ± 0.057
2.769AsnPhe: 2.769 ± 0.055
4.095AsnGly: 4.095 ± 0.091
1.004AsnHis: 1.004 ± 0.031
4.005AsnIle: 4.005 ± 0.065
3.281AsnLys: 3.281 ± 0.052
5.117AsnLeu: 5.117 ± 0.077
1.209AsnMet: 1.209 ± 0.032
2.898AsnAsn: 2.898 ± 0.074
2.619AsnPro: 2.619 ± 0.044
2.205AsnGln: 2.205 ± 0.045
2.352AsnArg: 2.352 ± 0.046
3.643AsnSer: 3.643 ± 0.063
3.115AsnThr: 3.115 ± 0.06
3.252AsnVal: 3.252 ± 0.059
0.743AsnTrp: 0.743 ± 0.024
2.355AsnTyr: 2.355 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
2.2ProAla: 2.2 ± 0.047
0.187ProCys: 0.187 ± 0.013
2.168ProAsp: 2.168 ± 0.049
3.126ProGlu: 3.126 ± 0.06
1.934ProPhe: 1.934 ± 0.042
1.969ProGly: 1.969 ± 0.043
0.612ProHis: 0.612 ± 0.021
2.568ProIle: 2.568 ± 0.044
2.395ProLys: 2.395 ± 0.049
3.078ProLeu: 3.078 ± 0.061
0.782ProMet: 0.782 ± 0.025
2.171ProAsn: 2.171 ± 0.046
0.924ProPro: 0.924 ± 0.03
1.17ProGln: 1.17 ± 0.034
1.035ProArg: 1.035 ± 0.03
2.412ProSer: 2.412 ± 0.046
2.015ProThr: 2.015 ± 0.046
2.493ProVal: 2.493 ± 0.05
0.374ProTrp: 0.374 ± 0.019
1.403ProTyr: 1.403 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
2.408GlnAla: 2.408 ± 0.044
0.141GlnCys: 0.141 ± 0.01
1.619GlnAsp: 1.619 ± 0.041
2.317GlnGlu: 2.317 ± 0.05
1.841GlnPhe: 1.841 ± 0.037
2.028GlnGly: 2.028 ± 0.039
0.621GlnHis: 0.621 ± 0.025
2.597GlnIle: 2.597 ± 0.04
2.605GlnLys: 2.605 ± 0.054
3.644GlnLeu: 3.644 ± 0.071
0.985GlnMet: 0.985 ± 0.024
1.958GlnAsn: 1.958 ± 0.046
1.219GlnPro: 1.219 ± 0.03
1.343GlnGln: 1.343 ± 0.039
1.519GlnArg: 1.519 ± 0.034
2.279GlnSer: 2.279 ± 0.049
1.92GlnThr: 1.92 ± 0.047
2.345GlnVal: 2.345 ± 0.045
0.41GlnTrp: 0.41 ± 0.02
1.294GlnTyr: 1.294 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.381ArgAla: 2.381 ± 0.047
0.182ArgCys: 0.182 ± 0.014
1.933ArgAsp: 1.933 ± 0.042
2.59ArgGlu: 2.59 ± 0.05
2.107ArgPhe: 2.107 ± 0.04
2.219ArgGly: 2.219 ± 0.04
0.614ArgHis: 0.614 ± 0.023
3.098ArgIle: 3.098 ± 0.047
3.069ArgLys: 3.069 ± 0.058
3.829ArgLeu: 3.829 ± 0.057
1.159ArgMet: 1.159 ± 0.034
2.185ArgAsn: 2.185 ± 0.042
1.296ArgPro: 1.296 ± 0.034
1.26ArgGln: 1.26 ± 0.033
1.56ArgArg: 1.56 ± 0.04
2.393ArgSer: 2.393 ± 0.048
2.034ArgThr: 2.034 ± 0.043
2.586ArgVal: 2.586 ± 0.044
0.406ArgTrp: 0.406 ± 0.018
1.569ArgTyr: 1.569 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
4.298SerAla: 4.298 ± 0.063
0.475SerCys: 0.475 ± 0.02
3.64SerAsp: 3.64 ± 0.068
4.514SerGlu: 4.514 ± 0.065
4.055SerPhe: 4.055 ± 0.065
4.98SerGly: 4.98 ± 0.095
1.032SerHis: 1.032 ± 0.031
5.275SerIle: 5.275 ± 0.074
4.45SerLys: 4.45 ± 0.072
6.544SerLeu: 6.544 ± 0.086
1.474SerMet: 1.474 ± 0.034
3.564SerAsn: 3.564 ± 0.073
2.385SerPro: 2.385 ± 0.042
2.351SerGln: 2.351 ± 0.046
2.442SerArg: 2.442 ± 0.05
4.554SerSer: 4.554 ± 0.09
3.778SerThr: 3.778 ± 0.063
4.301SerVal: 4.301 ± 0.069
0.664SerTrp: 0.664 ± 0.024
2.593SerTyr: 2.593 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
4.036ThrAla: 4.036 ± 0.113
0.326ThrCys: 0.326 ± 0.019
3.299ThrAsp: 3.299 ± 0.078
3.706ThrGlu: 3.706 ± 0.052
2.879ThrPhe: 2.879 ± 0.058
4.129ThrGly: 4.129 ± 0.089
0.982ThrHis: 0.982 ± 0.026
4.196ThrIle: 4.196 ± 0.094
3.123ThrLys: 3.123 ± 0.046
5.313ThrLeu: 5.313 ± 0.088
0.973ThrMet: 0.973 ± 0.028
2.867ThrAsn: 2.867 ± 0.062
2.261ThrPro: 2.261 ± 0.047
1.911ThrGln: 1.911 ± 0.04
1.831ThrArg: 1.831 ± 0.037
3.766ThrSer: 3.766 ± 0.071
3.252ThrThr: 3.252 ± 0.078
3.964ThrVal: 3.964 ± 0.106
0.624ThrTrp: 0.624 ± 0.026
2.266ThrTyr: 2.266 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
4.431ValAla: 4.431 ± 0.08
0.465ValCys: 0.465 ± 0.019
3.75ValAsp: 3.75 ± 0.063
4.245ValGlu: 4.245 ± 0.065
3.478ValPhe: 3.478 ± 0.057
4.143ValGly: 4.143 ± 0.062
1.044ValHis: 1.044 ± 0.028
4.959ValIle: 4.959 ± 0.068
4.459ValLys: 4.459 ± 0.075
6.265ValLeu: 6.265 ± 0.082
1.567ValMet: 1.567 ± 0.037
3.577ValAsn: 3.577 ± 0.06
2.138ValPro: 2.138 ± 0.042
2.012ValGln: 2.012 ± 0.041
2.452ValArg: 2.452 ± 0.048
4.523ValSer: 4.523 ± 0.083
3.761ValThr: 3.761 ± 0.101
4.331ValVal: 4.331 ± 0.068
0.665ValTrp: 0.665 ± 0.023
2.339ValTyr: 2.339 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.708TrpAla: 0.708 ± 0.026
0.085TrpCys: 0.085 ± 0.009
0.637TrpAsp: 0.637 ± 0.025
0.673TrpGlu: 0.673 ± 0.027
0.593TrpPhe: 0.593 ± 0.022
0.692TrpGly: 0.692 ± 0.024
0.199TrpHis: 0.199 ± 0.013
0.683TrpIle: 0.683 ± 0.027
0.754TrpLys: 0.754 ± 0.025
1.09TrpLeu: 1.09 ± 0.03
0.349TrpMet: 0.349 ± 0.016
0.624TrpAsn: 0.624 ± 0.024
0.324TrpPro: 0.324 ± 0.016
0.426TrpGln: 0.426 ± 0.02
0.488TrpArg: 0.488 ± 0.021
0.653TrpSer: 0.653 ± 0.03
0.561TrpThr: 0.561 ± 0.021
0.808TrpVal: 0.808 ± 0.028
0.16TrpTrp: 0.16 ± 0.015
0.396TrpTyr: 0.396 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.381TyrAla: 2.381 ± 0.046
0.276TyrCys: 0.276 ± 0.014
2.305TyrAsp: 2.305 ± 0.056
2.348TyrGlu: 2.348 ± 0.047
2.218TyrPhe: 2.218 ± 0.051
2.655TyrGly: 2.655 ± 0.046
0.769TyrHis: 0.769 ± 0.028
2.281TyrIle: 2.281 ± 0.051
2.361TyrLys: 2.361 ± 0.045
3.745TyrLeu: 3.745 ± 0.067
0.792TyrMet: 0.792 ± 0.03
2.071TyrAsn: 2.071 ± 0.051
1.433TyrPro: 1.433 ± 0.035
1.548TyrGln: 1.548 ± 0.035
1.722TyrArg: 1.722 ± 0.037
2.674TyrSer: 2.674 ± 0.053
2.246TyrThr: 2.246 ± 0.059
2.119TyrVal: 2.119 ± 0.049
0.469TyrTrp: 0.469 ± 0.021
1.679TyrTyr: 1.679 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3632 proteins (1259309 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski