Amino acid dipepetide frequency for Pandoravirus salinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.754AlaAla: 23.754 ± 0.307
3.779AlaCys: 3.779 ± 0.102
8.657AlaAsp: 8.657 ± 0.15
4.528AlaGlu: 4.528 ± 0.096
3.071AlaPhe: 3.071 ± 0.071
8.788AlaGly: 8.788 ± 0.166
4.271AlaHis: 4.271 ± 0.1
5.133AlaIle: 5.133 ± 0.103
2.634AlaLys: 2.634 ± 0.073
13.423AlaLeu: 13.423 ± 0.191
2.958AlaMet: 2.958 ± 0.081
2.559AlaAsn: 2.559 ± 0.091
8.258AlaPro: 8.258 ± 0.18
3.821AlaGln: 3.821 ± 0.096
13.472AlaArg: 13.472 ± 0.174
8.963AlaSer: 8.963 ± 0.142
8.234AlaThr: 8.234 ± 0.129
10.522AlaVal: 10.522 ± 0.159
2.748AlaTrp: 2.748 ± 0.084
2.934AlaTyr: 2.934 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
4.544CysAla: 4.544 ± 0.109
0.574CysCys: 0.574 ± 0.035
2.107CysAsp: 2.107 ± 0.067
1.051CysGlu: 1.051 ± 0.047
0.592CysPhe: 0.592 ± 0.037
2.051CysGly: 2.051 ± 0.075
0.596CysHis: 0.596 ± 0.035
0.729CysIle: 0.729 ± 0.038
0.537CysLys: 0.537 ± 0.032
2.421CysLeu: 2.421 ± 0.099
0.563CysMet: 0.563 ± 0.032
0.477CysAsn: 0.477 ± 0.027
2.269CysPro: 2.269 ± 0.11
0.586CysGln: 0.586 ± 0.028
2.617CysArg: 2.617 ± 0.071
1.231CysSer: 1.231 ± 0.062
1.544CysThr: 1.544 ± 0.063
2.065CysVal: 2.065 ± 0.065
0.364CysTrp: 0.364 ± 0.029
0.457CysTyr: 0.457 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
11.17AspAla: 11.17 ± 0.158
1.626AspCys: 1.626 ± 0.072
9.369AspAsp: 9.369 ± 0.223
3.382AspGlu: 3.382 ± 0.093
1.344AspPhe: 1.344 ± 0.053
7.375AspGly: 7.375 ± 0.172
2.009AspHis: 2.009 ± 0.06
2.297AspIle: 2.297 ± 0.067
1.328AspLys: 1.328 ± 0.063
5.333AspLeu: 5.333 ± 0.1
1.53AspMet: 1.53 ± 0.063
2.062AspAsn: 2.062 ± 0.072
4.448AspPro: 4.448 ± 0.108
1.677AspGln: 1.677 ± 0.056
6.154AspArg: 6.154 ± 0.113
3.643AspSer: 3.643 ± 0.096
3.462AspThr: 3.462 ± 0.082
5.728AspVal: 5.728 ± 0.115
1.224AspTrp: 1.224 ± 0.049
1.344AspTyr: 1.344 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
5.724GluAla: 5.724 ± 0.137
1.098GluCys: 1.098 ± 0.046
1.98GluAsp: 1.98 ± 0.071
1.379GluGlu: 1.379 ± 0.065
0.816GluPhe: 0.816 ± 0.037
2.634GluGly: 2.634 ± 0.093
1.177GluHis: 1.177 ± 0.049
1.734GluIle: 1.734 ± 0.062
1.04GluLys: 1.04 ± 0.04
1.361GluLeu: 1.361 ± 0.051
0.947GluMet: 0.947 ± 0.039
0.878GluAsn: 0.878 ± 0.048
2.406GluPro: 2.406 ± 0.064
1.013GluGln: 1.013 ± 0.046
4.262GluArg: 4.262 ± 0.101
2.632GluSer: 2.632 ± 0.068
2.581GluThr: 2.581 ± 0.078
2.116GluVal: 2.116 ± 0.061
1.218GluTrp: 1.218 ± 0.052
0.759GluTyr: 0.759 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.202PheAla: 3.202 ± 0.08
0.84PheCys: 0.84 ± 0.04
2.166PheAsp: 2.166 ± 0.064
0.994PheGlu: 0.994 ± 0.045
1.153PhePhe: 1.153 ± 0.057
2.249PheGly: 2.249 ± 0.073
0.39PheHis: 0.39 ± 0.024
0.579PheIle: 0.579 ± 0.029
0.384PheLys: 0.384 ± 0.026
2.069PheLeu: 2.069 ± 0.059
0.466PheMet: 0.466 ± 0.027
0.408PheAsn: 0.408 ± 0.029
0.843PhePro: 0.843 ± 0.045
0.319PheGln: 0.319 ± 0.022
1.257PheArg: 1.257 ± 0.048
1.348PheSer: 1.348 ± 0.052
0.843PheThr: 0.843 ± 0.046
2.393PheVal: 2.393 ± 0.073
0.499PheTrp: 0.499 ± 0.032
0.73PheTyr: 0.73 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
10.385GlyAla: 10.385 ± 0.171
2.661GlyCys: 2.661 ± 0.12
6.131GlyAsp: 6.131 ± 0.121
2.532GlyGlu: 2.532 ± 0.084
1.514GlyPhe: 1.514 ± 0.053
7.16GlyGly: 7.16 ± 0.225
3.901GlyHis: 3.901 ± 0.145
2.297GlyIle: 2.297 ± 0.066
1.701GlyLys: 1.701 ± 0.075
5.353GlyLeu: 5.353 ± 0.099
1.246GlyMet: 1.246 ± 0.051
1.756GlyAsn: 1.756 ± 0.059
4.828GlyPro: 4.828 ± 0.167
2.142GlyGln: 2.142 ± 0.072
7.549GlyArg: 7.549 ± 0.142
4.695GlySer: 4.695 ± 0.118
4.364GlyThr: 4.364 ± 0.123
5.236GlyVal: 5.236 ± 0.124
1.331GlyTrp: 1.331 ± 0.047
1.605GlyTyr: 1.605 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
3.95HisAla: 3.95 ± 0.084
0.667HisCys: 0.667 ± 0.037
2.007HisAsp: 2.007 ± 0.07
1.399HisGlu: 1.399 ± 0.058
0.687HisPhe: 0.687 ± 0.037
3.453HisGly: 3.453 ± 0.123
0.989HisHis: 0.989 ± 0.053
0.978HisIle: 0.978 ± 0.051
0.674HisLys: 0.674 ± 0.042
2.665HisLeu: 2.665 ± 0.097
0.688HisMet: 0.688 ± 0.039
0.681HisAsn: 0.681 ± 0.038
1.601HisPro: 1.601 ± 0.057
0.787HisGln: 0.787 ± 0.042
2.75HisArg: 2.75 ± 0.082
1.228HisSer: 1.228 ± 0.049
1.572HisThr: 1.572 ± 0.052
2.368HisVal: 2.368 ± 0.068
0.499HisTrp: 0.499 ± 0.025
0.658HisTyr: 0.658 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
4.544IleAla: 4.544 ± 0.1
0.596IleCys: 0.596 ± 0.035
3.712IleAsp: 3.712 ± 0.076
2.211IleGlu: 2.211 ± 0.068
0.616IlePhe: 0.616 ± 0.029
2.297IleGly: 2.297 ± 0.052
0.661IleHis: 0.661 ± 0.037
1.106IleIle: 1.106 ± 0.044
0.756IleLys: 0.756 ± 0.037
2.499IleLeu: 2.499 ± 0.068
0.583IleMet: 0.583 ± 0.033
0.887IleAsn: 0.887 ± 0.041
1.124IlePro: 1.124 ± 0.051
0.699IleGln: 0.699 ± 0.034
1.985IleArg: 1.985 ± 0.061
1.408IleSer: 1.408 ± 0.051
1.364IleThr: 1.364 ± 0.054
3.271IleVal: 3.271 ± 0.076
0.341IleTrp: 0.341 ± 0.026
0.814IleTyr: 0.814 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
2.512LysAla: 2.512 ± 0.079
0.532LysCys: 0.532 ± 0.034
1.313LysAsp: 1.313 ± 0.063
1.044LysGlu: 1.044 ± 0.053
0.324LysPhe: 0.324 ± 0.025
1.827LysGly: 1.827 ± 0.079
0.687LysHis: 0.687 ± 0.04
0.663LysIle: 0.663 ± 0.036
1.552LysLys: 1.552 ± 0.115
0.603LysLeu: 0.603 ± 0.033
0.413LysMet: 0.413 ± 0.028
0.596LysAsn: 0.596 ± 0.04
1.096LysPro: 1.096 ± 0.046
0.576LysGln: 0.576 ± 0.036
2.829LysArg: 2.829 ± 0.098
1.29LysSer: 1.29 ± 0.055
1.295LysThr: 1.295 ± 0.054
1.062LysVal: 1.062 ± 0.042
0.581LysTrp: 0.581 ± 0.042
0.384LysTyr: 0.384 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
12.815LeuAla: 12.815 ± 0.187
3.164LeuCys: 3.164 ± 0.09
6.999LeuAsp: 6.999 ± 0.142
2.231LeuGlu: 2.231 ± 0.07
2.524LeuPhe: 2.524 ± 0.072
5.622LeuGly: 5.622 ± 0.101
2.113LeuHis: 2.113 ± 0.067
2.044LeuIle: 2.044 ± 0.064
1.175LeuLys: 1.175 ± 0.058
7.336LeuLeu: 7.336 ± 0.148
1.293LeuMet: 1.293 ± 0.045
1.137LeuAsn: 1.137 ± 0.052
5.238LeuPro: 5.238 ± 0.12
1.776LeuGln: 1.776 ± 0.062
5.577LeuArg: 5.577 ± 0.102
4.792LeuSer: 4.792 ± 0.1
3.231LeuThr: 3.231 ± 0.078
7.406LeuVal: 7.406 ± 0.121
2.078LeuTrp: 2.078 ± 0.065
2.173LeuTyr: 2.173 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
3.135MetAla: 3.135 ± 0.073
0.561MetCys: 0.561 ± 0.036
1.493MetAsp: 1.493 ± 0.057
0.798MetGlu: 0.798 ± 0.032
0.317MetPhe: 0.317 ± 0.027
1.477MetGly: 1.477 ± 0.055
0.577MetHis: 0.577 ± 0.034
0.617MetIle: 0.617 ± 0.036
0.24MetLys: 0.24 ± 0.023
1.433MetLeu: 1.433 ± 0.055
0.33MetMet: 0.33 ± 0.026
0.339MetAsn: 0.339 ± 0.022
1.421MetPro: 1.421 ± 0.048
0.627MetGln: 0.627 ± 0.035
2.044MetArg: 2.044 ± 0.061
1.224MetSer: 1.224 ± 0.047
1.197MetThr: 1.197 ± 0.045
1.206MetVal: 1.206 ± 0.044
0.466MetTrp: 0.466 ± 0.029
0.279MetTyr: 0.279 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.49AsnAla: 2.49 ± 0.075
0.328AsnCys: 0.328 ± 0.024
1.716AsnAsp: 1.716 ± 0.056
0.765AsnGlu: 0.765 ± 0.039
0.341AsnPhe: 0.341 ± 0.028
3.042AsnGly: 3.042 ± 0.123
0.495AsnHis: 0.495 ± 0.03
0.636AsnIle: 0.636 ± 0.036
0.625AsnLys: 0.625 ± 0.039
1.271AsnLeu: 1.271 ± 0.045
0.392AsnMet: 0.392 ± 0.029
1.231AsnAsn: 1.231 ± 0.078
1.016AsnPro: 1.016 ± 0.042
0.475AsnGln: 0.475 ± 0.029
1.789AsnArg: 1.789 ± 0.061
0.958AsnSer: 0.958 ± 0.051
0.973AsnThr: 0.973 ± 0.048
1.497AsnVal: 1.497 ± 0.054
0.25AsnTrp: 0.25 ± 0.022
0.384AsnTyr: 0.384 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
7.114ProAla: 7.114 ± 0.157
1.639ProCys: 1.639 ± 0.054
4.182ProAsp: 4.182 ± 0.089
2.271ProGlu: 2.271 ± 0.067
1.694ProPhe: 1.694 ± 0.052
3.592ProGly: 3.592 ± 0.11
1.951ProHis: 1.951 ± 0.06
1.816ProIle: 1.816 ± 0.063
1.251ProLys: 1.251 ± 0.064
5.393ProLeu: 5.393 ± 0.12
1.359ProMet: 1.359 ± 0.047
1.144ProAsn: 1.144 ± 0.049
5.704ProPro: 5.704 ± 0.161
1.685ProGln: 1.685 ± 0.07
5.111ProArg: 5.111 ± 0.123
4.701ProSer: 4.701 ± 0.106
4.668ProThr: 4.668 ± 0.099
4.156ProVal: 4.156 ± 0.111
1.971ProTrp: 1.971 ± 0.089
1.284ProTyr: 1.284 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
2.932GlnAla: 2.932 ± 0.081
0.699GlnCys: 0.699 ± 0.038
1.361GlnAsp: 1.361 ± 0.049
1.084GlnGlu: 1.084 ± 0.049
0.546GlnPhe: 0.546 ± 0.036
1.96GlnGly: 1.96 ± 0.07
0.878GlnHis: 0.878 ± 0.042
0.687GlnIle: 0.687 ± 0.035
0.796GlnLys: 0.796 ± 0.04
1.381GlnLeu: 1.381 ± 0.05
0.525GlnMet: 0.525 ± 0.029
0.423GlnAsn: 0.423 ± 0.028
1.783GlnPro: 1.783 ± 0.072
1.714GlnGln: 1.714 ± 0.136
3.16GlnArg: 3.16 ± 0.089
1.566GlnSer: 1.566 ± 0.051
1.477GlnThr: 1.477 ± 0.051
1.388GlnVal: 1.388 ± 0.051
1.071GlnTrp: 1.071 ± 0.06
0.515GlnTyr: 0.515 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
12.072ArgAla: 12.072 ± 0.166
2.306ArgCys: 2.306 ± 0.069
5.626ArgAsp: 5.626 ± 0.106
3.036ArgGlu: 3.036 ± 0.08
2.202ArgPhe: 2.202 ± 0.062
7.025ArgGly: 7.025 ± 0.11
3.501ArgHis: 3.501 ± 0.096
2.752ArgIle: 2.752 ± 0.074
1.912ArgLys: 1.912 ± 0.065
8.079ArgLeu: 8.079 ± 0.124
1.696ArgMet: 1.696 ± 0.052
1.579ArgAsn: 1.579 ± 0.064
5.934ArgPro: 5.934 ± 0.123
3.051ArgGln: 3.051 ± 0.085
10.478ArgArg: 10.478 ± 0.179
4.819ArgSer: 4.819 ± 0.116
4.626ArgThr: 4.626 ± 0.1
5.763ArgVal: 5.763 ± 0.103
2.49ArgTrp: 2.49 ± 0.082
2.091ArgTyr: 2.091 ± 0.082
0.0ArgXaa: 0.0 ± 0.0
Ser
7.837SerAla: 7.837 ± 0.109
1.361SerCys: 1.361 ± 0.064
4.235SerAsp: 4.235 ± 0.107
1.645SerGlu: 1.645 ± 0.056
1.33SerPhe: 1.33 ± 0.052
4.923SerGly: 4.923 ± 0.118
1.492SerHis: 1.492 ± 0.048
1.952SerIle: 1.952 ± 0.06
1.12SerLys: 1.12 ± 0.046
4.927SerLeu: 4.927 ± 0.082
1.355SerMet: 1.355 ± 0.049
1.291SerAsn: 1.291 ± 0.052
4.082SerPro: 4.082 ± 0.1
1.113SerGln: 1.113 ± 0.043
4.806SerArg: 4.806 ± 0.105
4.517SerSer: 4.517 ± 0.263
4.083SerThr: 4.083 ± 0.096
4.464SerVal: 4.464 ± 0.089
1.062SerTrp: 1.062 ± 0.048
0.832SerTyr: 0.832 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
7.356ThrAla: 7.356 ± 0.143
1.601ThrCys: 1.601 ± 0.069
3.479ThrAsp: 3.479 ± 0.084
2.038ThrGlu: 2.038 ± 0.065
1.355ThrPhe: 1.355 ± 0.05
3.978ThrGly: 3.978 ± 0.081
1.512ThrHis: 1.512 ± 0.051
1.969ThrIle: 1.969 ± 0.06
1.35ThrLys: 1.35 ± 0.056
4.717ThrLeu: 4.717 ± 0.115
1.22ThrMet: 1.22 ± 0.047
1.208ThrAsn: 1.208 ± 0.05
3.832ThrPro: 3.832 ± 0.104
1.268ThrGln: 1.268 ± 0.052
4.526ThrArg: 4.526 ± 0.075
3.278ThrSer: 3.278 ± 0.086
4.859ThrThr: 4.859 ± 0.134
4.049ThrVal: 4.049 ± 0.093
1.056ThrTrp: 1.056 ± 0.042
1.237ThrTyr: 1.237 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
11.114ValAla: 11.114 ± 0.165
2.417ValCys: 2.417 ± 0.07
6.733ValAsp: 6.733 ± 0.121
3.349ValGlu: 3.349 ± 0.088
1.854ValPhe: 1.854 ± 0.052
5.661ValGly: 5.661 ± 0.115
1.887ValHis: 1.887 ± 0.062
2.224ValIle: 2.224 ± 0.067
1.164ValLys: 1.164 ± 0.053
6.309ValLeu: 6.309 ± 0.111
1.166ValMet: 1.166 ± 0.051
1.137ValAsn: 1.137 ± 0.05
4.435ValPro: 4.435 ± 0.105
1.643ValGln: 1.643 ± 0.057
6.371ValArg: 6.371 ± 0.108
3.752ValSer: 3.752 ± 0.072
3.118ValThr: 3.118 ± 0.082
6.455ValVal: 6.455 ± 0.135
1.266ValTrp: 1.266 ± 0.052
1.738ValTyr: 1.738 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
2.55TrpAla: 2.55 ± 0.085
0.492TrpCys: 0.492 ± 0.029
1.468TrpAsp: 1.468 ± 0.077
0.647TrpGlu: 0.647 ± 0.036
0.412TrpPhe: 0.412 ± 0.025
1.089TrpGly: 1.089 ± 0.05
0.767TrpHis: 0.767 ± 0.047
0.708TrpIle: 0.708 ± 0.031
0.428TrpLys: 0.428 ± 0.032
2.666TrpLeu: 2.666 ± 0.107
0.545TrpMet: 0.545 ± 0.033
0.461TrpAsn: 0.461 ± 0.031
1.328TrpPro: 1.328 ± 0.058
0.541TrpGln: 0.541 ± 0.031
2.49TrpArg: 2.49 ± 0.079
1.459TrpSer: 1.459 ± 0.057
1.41TrpThr: 1.41 ± 0.053
1.086TrpVal: 1.086 ± 0.042
0.448TrpTrp: 0.448 ± 0.032
0.342TrpTyr: 0.342 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.306TyrAla: 3.306 ± 0.098
0.437TyrCys: 0.437 ± 0.03
1.772TyrAsp: 1.772 ± 0.054
1.371TyrGlu: 1.371 ± 0.068
0.443TyrPhe: 0.443 ± 0.025
2.186TyrGly: 2.186 ± 0.084
0.448TyrHis: 0.448 ± 0.026
0.554TyrIle: 0.554 ± 0.025
0.51TyrLys: 0.51 ± 0.03
1.484TyrLeu: 1.484 ± 0.052
0.505TyrMet: 0.505 ± 0.029
0.421TyrAsn: 0.421 ± 0.03
1.04TyrPro: 1.04 ± 0.053
0.433TyrGln: 0.433 ± 0.031
1.81TyrArg: 1.81 ± 0.056
0.923TyrSer: 0.923 ± 0.037
0.985TyrThr: 0.985 ± 0.044
1.561TyrVal: 1.561 ± 0.062
0.372TyrTrp: 0.372 ± 0.025
0.546TyrTyr: 0.546 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1430 proteins (549050 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski