Amino acid dipepetide frequency for Torque teno midi virus 7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.061AlaAla: 6.061 ± 4.342
0.0AlaCys: 0.0 ± 0.0
6.818AlaAsp: 6.818 ± 4.527
3.788AlaGlu: 3.788 ± 0.683
0.758AlaPhe: 0.758 ± 0.882
4.545AlaGly: 4.545 ± 1.939
3.788AlaHis: 3.788 ± 1.725
0.758AlaIle: 0.758 ± 0.476
3.788AlaLys: 3.788 ± 2.281
3.03AlaLeu: 3.03 ± 1.005
0.0AlaMet: 0.0 ± 0.0
4.545AlaAsn: 4.545 ± 0.492
1.515AlaPro: 1.515 ± 0.634
2.273AlaGln: 2.273 ± 0.676
3.03AlaArg: 3.03 ± 1.07
2.273AlaSer: 2.273 ± 1.429
5.303AlaThr: 5.303 ± 0.687
1.515AlaVal: 1.515 ± 0.647
1.515AlaTrp: 1.515 ± 0.634
0.758AlaTyr: 0.758 ± 0.476
0.0AlaXaa: 0.0 ± 0.0
Cys
1.515CysAla: 1.515 ± 0.647
0.0CysCys: 0.0 ± 0.0
0.758CysAsp: 0.758 ± 0.476
0.758CysGlu: 0.758 ± 0.476
3.788CysPhe: 3.788 ± 0.683
0.0CysGly: 0.0 ± 0.0
3.03CysHis: 3.03 ± 1.07
0.758CysIle: 0.758 ± 0.476
0.758CysLys: 0.758 ± 0.476
0.758CysLeu: 0.758 ± 0.476
0.0CysMet: 0.0 ± 0.0
5.303CysAsn: 5.303 ± 2.572
0.758CysPro: 0.758 ± 0.727
0.0CysGln: 0.0 ± 0.0
0.758CysArg: 0.758 ± 0.476
0.758CysSer: 0.758 ± 0.476
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
1.515CysTyr: 1.515 ± 0.647
0.0CysXaa: 0.0 ± 0.0
Asp
4.545AspAla: 4.545 ± 3.018
0.758AspCys: 0.758 ± 0.476
0.758AspAsp: 0.758 ± 0.476
1.515AspGlu: 1.515 ± 0.953
2.273AspPhe: 2.273 ± 0.872
3.03AspGly: 3.03 ± 1.07
0.0AspHis: 0.0 ± 0.0
0.0AspIle: 0.0 ± 0.0
0.758AspLys: 0.758 ± 0.476
10.606AspLeu: 10.606 ± 3.029
0.758AspMet: 0.758 ± 0.859
5.303AspAsn: 5.303 ± 2.572
1.515AspPro: 1.515 ± 0.634
0.0AspGln: 0.0 ± 0.0
2.273AspArg: 2.273 ± 1.509
3.03AspSer: 3.03 ± 1.07
4.545AspThr: 4.545 ± 0.492
0.758AspVal: 0.758 ± 0.476
0.0AspTrp: 0.0 ± 0.0
2.273AspTyr: 2.273 ± 1.429
0.0AspXaa: 0.0 ± 0.0
Glu
1.515GluAla: 1.515 ± 0.634
0.758GluCys: 0.758 ± 0.727
6.061GluAsp: 6.061 ± 3.179
11.364GluGlu: 11.364 ± 2.049
1.515GluPhe: 1.515 ± 0.953
3.788GluGly: 3.788 ± 0.683
0.0GluHis: 0.0 ± 0.0
2.273GluIle: 2.273 ± 0.692
2.273GluLys: 2.273 ± 1.429
3.788GluLeu: 3.788 ± 0.683
0.758GluMet: 0.758 ± 0.476
3.03GluAsn: 3.03 ± 2.171
1.515GluPro: 1.515 ± 0.953
2.273GluGln: 2.273 ± 0.872
3.03GluArg: 3.03 ± 2.171
1.515GluSer: 1.515 ± 0.953
5.303GluThr: 5.303 ± 2.309
2.273GluVal: 2.273 ± 0.692
0.0GluTrp: 0.0 ± 0.0
0.758GluTyr: 0.758 ± 0.476
0.0GluXaa: 0.0 ± 0.0
Phe
2.273PheAla: 2.273 ± 1.509
0.0PheCys: 0.0 ± 0.0
0.0PheAsp: 0.0 ± 0.0
1.515PheGlu: 1.515 ± 1.082
2.273PhePhe: 2.273 ± 1.509
1.515PheGly: 1.515 ± 0.953
0.758PheHis: 0.758 ± 0.882
2.273PheIle: 2.273 ± 1.429
3.03PheLys: 3.03 ± 1.267
0.758PheLeu: 0.758 ± 0.476
1.515PheMet: 1.515 ± 0.608
3.03PheAsn: 3.03 ± 1.88
3.788PhePro: 3.788 ± 1.437
0.758PheGln: 0.758 ± 0.476
3.03PheArg: 3.03 ± 1.07
3.03PheSer: 3.03 ± 1.005
3.03PheThr: 3.03 ± 1.005
1.515PheVal: 1.515 ± 0.953
0.758PheTrp: 0.758 ± 0.476
2.273PheTyr: 2.273 ± 0.692
0.0PheXaa: 0.0 ± 0.0
Gly
3.788GlyAla: 3.788 ± 1.437
0.0GlyCys: 0.0 ± 0.0
3.03GlyAsp: 3.03 ± 1.88
2.273GlyGlu: 2.273 ± 1.509
1.515GlyPhe: 1.515 ± 0.634
8.333GlyGly: 8.333 ± 1.883
2.273GlyHis: 2.273 ± 1.509
0.0GlyIle: 0.0 ± 0.0
6.061GlyLys: 6.061 ± 0.702
3.03GlyLeu: 3.03 ± 1.906
0.758GlyMet: 0.758 ± 0.476
1.515GlyAsn: 1.515 ± 0.634
4.545GlyPro: 4.545 ± 0.492
0.758GlyGln: 0.758 ± 0.882
2.273GlyArg: 2.273 ± 2.156
2.273GlySer: 2.273 ± 0.872
3.03GlyThr: 3.03 ± 1.88
0.758GlyVal: 0.758 ± 0.476
0.758GlyTrp: 0.758 ± 0.476
3.03GlyTyr: 3.03 ± 1.906
0.0GlyXaa: 0.0 ± 0.0
His
1.515HisAla: 1.515 ± 0.953
0.0HisCys: 0.0 ± 0.0
2.273HisAsp: 2.273 ± 1.509
1.515HisGlu: 1.515 ± 0.953
2.273HisPhe: 2.273 ± 1.509
0.758HisGly: 0.758 ± 0.882
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
3.788HisLys: 3.788 ± 1.437
3.03HisLeu: 3.03 ± 2.171
0.0HisMet: 0.0 ± 0.0
0.758HisAsn: 0.758 ± 0.476
2.273HisPro: 2.273 ± 0.872
3.03HisGln: 3.03 ± 0.443
1.515HisArg: 1.515 ± 0.634
2.273HisSer: 2.273 ± 1.509
0.0HisThr: 0.0 ± 0.0
0.758HisVal: 0.758 ± 0.476
0.0HisTrp: 0.0 ± 0.0
2.273HisTyr: 2.273 ± 1.509
0.0HisXaa: 0.0 ± 0.0
Ile
3.03IleAla: 3.03 ± 1.07
3.03IleCys: 3.03 ± 1.07
3.03IleAsp: 3.03 ± 1.906
4.545IleGlu: 4.545 ± 1.302
2.273IlePhe: 2.273 ± 1.509
2.273IleGly: 2.273 ± 1.429
0.758IleHis: 0.758 ± 0.476
3.03IleIle: 3.03 ± 1.906
4.545IleLys: 4.545 ± 2.859
3.788IleLeu: 3.788 ± 0.683
0.0IleMet: 0.0 ± 0.0
3.788IleAsn: 3.788 ± 1.437
0.758IlePro: 0.758 ± 0.476
6.818IleGln: 6.818 ± 2.491
0.758IleArg: 0.758 ± 0.476
6.061IleSer: 6.061 ± 1.075
0.758IleThr: 0.758 ± 0.476
1.515IleVal: 1.515 ± 0.953
3.03IleTrp: 3.03 ± 1.07
0.758IleTyr: 0.758 ± 0.476
0.0IleXaa: 0.0 ± 0.0
Lys
3.03LysAla: 3.03 ± 1.267
2.273LysCys: 2.273 ± 0.872
3.788LysAsp: 3.788 ± 0.683
4.545LysGlu: 4.545 ± 0.881
1.515LysPhe: 1.515 ± 0.634
0.0LysGly: 0.0 ± 0.0
3.03LysHis: 3.03 ± 1.88
3.788LysIle: 3.788 ± 2.382
9.091LysLys: 9.091 ± 4.184
7.576LysLeu: 7.576 ± 1.897
0.758LysMet: 0.758 ± 0.882
3.788LysAsn: 3.788 ± 1.676
4.545LysPro: 4.545 ± 1.018
10.606LysGln: 10.606 ± 2.183
6.061LysArg: 6.061 ± 2.496
4.545LysSer: 4.545 ± 2.582
6.061LysThr: 6.061 ± 2.011
2.273LysVal: 2.273 ± 0.676
1.515LysTrp: 1.515 ± 0.953
6.061LysTyr: 6.061 ± 2.771
0.0LysXaa: 0.0 ± 0.0
Leu
5.303LeuAla: 5.303 ± 3.633
1.515LeuCys: 1.515 ± 0.953
0.758LeuAsp: 0.758 ± 0.476
0.758LeuGlu: 0.758 ± 0.476
4.545LeuPhe: 4.545 ± 1.018
1.515LeuGly: 1.515 ± 0.953
0.0LeuHis: 0.0 ± 0.0
8.333LeuIle: 8.333 ± 1.666
5.303LeuLys: 5.303 ± 2.1
9.848LeuLeu: 9.848 ± 1.932
0.0LeuMet: 0.0 ± 0.0
4.545LeuAsn: 4.545 ± 1.302
4.545LeuPro: 4.545 ± 1.384
7.576LeuGln: 7.576 ± 1.161
1.515LeuArg: 1.515 ± 0.634
7.576LeuSer: 7.576 ± 1.971
3.788LeuThr: 3.788 ± 1.089
2.273LeuVal: 2.273 ± 0.692
1.515LeuTrp: 1.515 ± 0.953
3.788LeuTyr: 3.788 ± 1.676
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
1.515MetCys: 1.515 ± 0.647
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.758MetIle: 0.758 ± 0.476
1.515MetLys: 1.515 ± 0.953
2.273MetLeu: 2.273 ± 1.429
0.758MetMet: 0.758 ± 0.727
1.515MetAsn: 1.515 ± 0.647
1.515MetPro: 1.515 ± 0.953
4.545MetGln: 4.545 ± 3.018
0.0MetArg: 0.0 ± 0.0
1.515MetSer: 1.515 ± 0.634
0.0MetThr: 0.0 ± 0.0
0.758MetVal: 0.758 ± 0.476
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
0.0AsnAla: 0.0 ± 0.0
2.273AsnCys: 2.273 ± 1.509
0.0AsnAsp: 0.0 ± 0.0
0.0AsnGlu: 0.0 ± 0.0
6.061AsnPhe: 6.061 ± 2.188
0.758AsnGly: 0.758 ± 0.476
0.0AsnHis: 0.0 ± 0.0
9.848AsnIle: 9.848 ± 2.795
2.273AsnLys: 2.273 ± 0.692
2.273AsnLeu: 2.273 ± 1.429
1.515AsnMet: 1.515 ± 0.953
2.273AsnAsn: 2.273 ± 0.692
4.545AsnPro: 4.545 ± 2.859
10.606AsnGln: 10.606 ± 3.842
2.273AsnArg: 2.273 ± 0.692
4.545AsnSer: 4.545 ± 1.939
7.576AsnThr: 7.576 ± 4.065
0.758AsnVal: 0.758 ± 0.727
1.515AsnTrp: 1.515 ± 0.953
1.515AsnTyr: 1.515 ± 0.634
0.0AsnXaa: 0.0 ± 0.0
Pro
6.061ProAla: 6.061 ± 0.702
2.273ProCys: 2.273 ± 1.509
1.515ProAsp: 1.515 ± 0.953
8.333ProGlu: 8.333 ± 2.435
3.03ProPhe: 3.03 ± 1.267
3.03ProGly: 3.03 ± 1.88
2.273ProHis: 2.273 ± 0.692
0.758ProIle: 0.758 ± 0.727
4.545ProLys: 4.545 ± 0.881
3.788ProLeu: 3.788 ± 1.089
0.758ProMet: 0.758 ± 0.727
2.273ProAsn: 2.273 ± 1.429
7.576ProPro: 7.576 ± 2.573
2.273ProGln: 2.273 ± 0.692
5.303ProArg: 5.303 ± 2.799
2.273ProSer: 2.273 ± 1.429
6.061ProThr: 6.061 ± 2.321
0.758ProVal: 0.758 ± 0.476
2.273ProTrp: 2.273 ± 0.692
3.03ProTyr: 3.03 ± 1.906
0.0ProXaa: 0.0 ± 0.0
Gln
5.303GlnAla: 5.303 ± 1.659
0.0GlnCys: 0.0 ± 0.0
3.788GlnAsp: 3.788 ± 1.437
3.788GlnGlu: 3.788 ± 0.683
0.0GlnPhe: 0.0 ± 0.0
0.758GlnGly: 0.758 ± 0.882
1.515GlnHis: 1.515 ± 1.082
11.364GlnIle: 11.364 ± 3.518
10.606GlnLys: 10.606 ± 4.05
5.303GlnLeu: 5.303 ± 2.083
2.273GlnMet: 2.273 ± 0.872
4.545GlnAsn: 4.545 ± 1.024
5.303GlnPro: 5.303 ± 0.931
9.848GlnGln: 9.848 ± 1.096
0.758GlnArg: 0.758 ± 0.476
2.273GlnSer: 2.273 ± 0.872
3.03GlnThr: 3.03 ± 1.293
2.273GlnVal: 2.273 ± 1.509
0.758GlnTrp: 0.758 ± 0.476
0.758GlnTyr: 0.758 ± 0.727
0.0GlnXaa: 0.0 ± 0.0
Arg
0.758ArgAla: 0.758 ± 0.476
0.0ArgCys: 0.0 ± 0.0
4.545ArgAsp: 4.545 ± 3.018
0.758ArgGlu: 0.758 ± 0.882
0.0ArgPhe: 0.0 ± 0.0
2.273ArgGly: 2.273 ± 1.46
2.273ArgHis: 2.273 ± 1.429
0.758ArgIle: 0.758 ± 0.476
6.818ArgLys: 6.818 ± 1.765
3.03ArgLeu: 3.03 ± 1.267
1.515ArgMet: 1.515 ± 0.861
1.515ArgAsn: 1.515 ± 1.764
7.576ArgPro: 7.576 ± 3.451
0.758ArgGln: 0.758 ± 0.476
15.152ArgArg: 15.152 ± 6.535
3.03ArgSer: 3.03 ± 1.253
3.788ArgThr: 3.788 ± 1.725
0.0ArgVal: 0.0 ± 0.0
0.758ArgTrp: 0.758 ± 0.476
2.273ArgTyr: 2.273 ± 1.429
0.0ArgXaa: 0.0 ± 0.0
Ser
3.788SerAla: 3.788 ± 1.437
3.788SerCys: 3.788 ± 0.683
1.515SerAsp: 1.515 ± 0.953
1.515SerGlu: 1.515 ± 0.953
1.515SerPhe: 1.515 ± 0.953
6.061SerGly: 6.061 ± 0.614
3.788SerHis: 3.788 ± 1.437
4.545SerIle: 4.545 ± 1.024
5.303SerLys: 5.303 ± 2.54
3.788SerLeu: 3.788 ± 2.382
0.758SerMet: 0.758 ± 0.623
4.545SerAsn: 4.545 ± 1.018
3.03SerPro: 3.03 ± 1.267
3.788SerGln: 3.788 ± 0.985
2.273SerArg: 2.273 ± 0.676
11.364SerSer: 11.364 ± 8.426
3.788SerThr: 3.788 ± 1.413
0.758SerVal: 0.758 ± 0.476
1.515SerTrp: 1.515 ± 0.953
1.515SerTyr: 1.515 ± 0.953
0.0SerXaa: 0.0 ± 0.0
Thr
3.788ThrAla: 3.788 ± 0.624
0.0ThrCys: 0.0 ± 0.0
3.03ThrAsp: 3.03 ± 1.906
4.545ThrGlu: 4.545 ± 2.523
1.515ThrPhe: 1.515 ± 0.953
8.333ThrGly: 8.333 ± 3.639
3.788ThrHis: 3.788 ± 0.683
1.515ThrIle: 1.515 ± 0.953
4.545ThrLys: 4.545 ± 1.939
3.788ThrLeu: 3.788 ± 2.382
0.758ThrMet: 0.758 ± 0.476
4.545ThrAsn: 4.545 ± 1.302
5.303ThrPro: 5.303 ± 2.058
3.03ThrGln: 3.03 ± 1.293
4.545ThrArg: 4.545 ± 1.302
4.545ThrSer: 4.545 ± 0.909
4.545ThrThr: 4.545 ± 1.351
2.273ThrVal: 2.273 ± 1.429
0.758ThrTrp: 0.758 ± 0.727
3.03ThrTyr: 3.03 ± 1.906
0.0ThrXaa: 0.0 ± 0.0
Val
1.515ValAla: 1.515 ± 0.634
0.758ValCys: 0.758 ± 0.476
0.0ValAsp: 0.0 ± 0.0
0.758ValGlu: 0.758 ± 0.476
0.758ValPhe: 0.758 ± 0.476
0.758ValGly: 0.758 ± 0.476
0.0ValHis: 0.0 ± 0.0
0.758ValIle: 0.758 ± 0.476
4.545ValLys: 4.545 ± 2.859
0.758ValLeu: 0.758 ± 0.476
0.0ValMet: 0.0 ± 0.0
1.515ValAsn: 1.515 ± 0.634
3.788ValPro: 3.788 ± 1.46
2.273ValGln: 2.273 ± 1.429
0.758ValArg: 0.758 ± 0.476
2.273ValSer: 2.273 ± 0.676
2.273ValThr: 2.273 ± 1.509
1.515ValVal: 1.515 ± 0.953
0.0ValTrp: 0.0 ± 0.0
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
2.273TrpAla: 2.273 ± 0.692
0.0TrpCys: 0.0 ± 0.0
0.758TrpAsp: 0.758 ± 0.476
0.758TrpGlu: 0.758 ± 0.476
0.758TrpPhe: 0.758 ± 0.476
2.273TrpGly: 2.273 ± 1.429
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
2.273TrpLeu: 2.273 ± 0.692
2.273TrpMet: 2.273 ± 1.509
0.758TrpAsn: 0.758 ± 0.476
0.758TrpPro: 0.758 ± 0.476
1.515TrpGln: 1.515 ± 0.953
0.0TrpArg: 0.0 ± 0.0
0.758TrpSer: 0.758 ± 0.727
0.758TrpThr: 0.758 ± 0.476
0.0TrpVal: 0.0 ± 0.0
1.515TrpTrp: 1.515 ± 0.953
0.758TrpTyr: 0.758 ± 0.476
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
2.273TyrCys: 2.273 ± 1.429
3.03TyrAsp: 3.03 ± 1.906
0.758TyrGlu: 0.758 ± 0.476
0.758TyrPhe: 0.758 ± 0.476
0.0TyrGly: 0.0 ± 0.0
0.758TyrHis: 0.758 ± 0.476
3.03TyrIle: 3.03 ± 1.07
5.303TyrLys: 5.303 ± 1.462
1.515TyrLeu: 1.515 ± 0.634
0.758TyrMet: 0.758 ± 0.476
1.515TyrAsn: 1.515 ± 0.953
3.03TyrPro: 3.03 ± 0.443
1.515TyrGln: 1.515 ± 0.953
2.273TyrArg: 2.273 ± 1.429
3.03TyrSer: 3.03 ± 1.906
4.545TyrThr: 4.545 ± 2.125
2.273TyrVal: 2.273 ± 1.429
0.0TyrTrp: 0.0 ± 0.0
0.758TyrTyr: 0.758 ± 0.476
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1321 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski