Amino acid dipepetide frequency for Inhella crocodyli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.665AlaAla: 19.665 ± 0.208	1.422AlaCys: 1.422 ± 0.042	6.731AlaAsp: 6.731 ± 0.073	7.588AlaGlu: 7.588 ± 0.113	4.225AlaPhe: 4.225 ± 0.062	10.645AlaGly: 10.645 ± 0.099	3.12AlaHis: 3.12 ± 0.05	4.177AlaIle: 4.177 ± 0.071	4.003AlaLys: 4.003 ± 0.078	18.727AlaLeu: 18.727 ± 0.24	3.519AlaMet: 3.519 ± 0.055	2.702AlaAsn: 2.702 ± 0.06	7.907AlaPro: 7.907 ± 0.116	7.673AlaGln: 7.673 ± 0.124	9.615AlaArg: 9.615 ± 0.116	6.608AlaSer: 6.608 ± 0.084	6.195AlaThr: 6.195 ± 0.089	9.711AlaVal: 9.711 ± 0.108	2.964AlaTrp: 2.964 ± 0.061	2.498AlaTyr: 2.498 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.153CysAla: 1.153 ± 0.034	0.097CysCys: 0.097 ± 0.01	0.442CysAsp: 0.442 ± 0.02	0.485CysGlu: 0.485 ± 0.021	0.289CysPhe: 0.289 ± 0.016	0.875CysGly: 0.875 ± 0.027	0.278CysHis: 0.278 ± 0.015	0.296CysIle: 0.296 ± 0.016	0.193CysLys: 0.193 ± 0.014	0.858CysLeu: 0.858 ± 0.027	0.157CysMet: 0.157 ± 0.011	0.216CysAsn: 0.216 ± 0.013	0.528CysPro: 0.528 ± 0.022	0.322CysGln: 0.322 ± 0.017	0.541CysArg: 0.541 ± 0.024	0.429CysSer: 0.429 ± 0.019	0.477CysThr: 0.477 ± 0.019	0.614CysVal: 0.614 ± 0.024	0.155CysTrp: 0.155 ± 0.012	0.153CysTyr: 0.153 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.93AspAla: 7.93 ± 0.084	0.447AspCys: 0.447 ± 0.023	2.889AspAsp: 2.889 ± 0.06	3.332AspGlu: 3.332 ± 0.067	1.94AspPhe: 1.94 ± 0.042	4.934AspGly: 4.934 ± 0.082	1.038AspHis: 1.038 ± 0.029	1.722AspIle: 1.722 ± 0.04	1.363AspLys: 1.363 ± 0.04	5.841AspLeu: 5.841 ± 0.081	0.87AspMet: 0.87 ± 0.026	1.022AspAsn: 1.022 ± 0.031	3.422AspPro: 3.422 ± 0.065	1.694AspGln: 1.694 ± 0.06	3.62AspArg: 3.62 ± 0.057	2.025AspSer: 2.025 ± 0.044	2.423AspThr: 2.423 ± 0.041	3.597AspVal: 3.597 ± 0.061	1.182AspTrp: 1.182 ± 0.033	1.117AspTyr: 1.117 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	8.295GluAla: 8.295 ± 0.121	0.328GluCys: 0.328 ± 0.017	1.946GluAsp: 1.946 ± 0.041	1.952GluGlu: 1.952 ± 0.052	1.51GluPhe: 1.51 ± 0.046	4.32GluGly: 4.32 ± 0.061	1.28GluHis: 1.28 ± 0.037	1.975GluIle: 1.975 ± 0.047	1.339GluLys: 1.339 ± 0.05	6.029GluLeu: 6.029 ± 0.085	1.052GluMet: 1.052 ± 0.035	0.883GluAsn: 0.883 ± 0.03	2.74GluPro: 2.74 ± 0.05	2.467GluGln: 2.467 ± 0.055	5.259GluArg: 5.259 ± 0.09	2.07GluSer: 2.07 ± 0.043	2.039GluThr: 2.039 ± 0.037	4.06GluVal: 4.06 ± 0.06	0.779GluTrp: 0.779 ± 0.024	0.734GluTyr: 0.734 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.075PheAla: 4.075 ± 0.074	0.313PheCys: 0.313 ± 0.018	2.461PheAsp: 2.461 ± 0.048	2.042PheGlu: 2.042 ± 0.045	1.182PhePhe: 1.182 ± 0.036	3.05PheGly: 3.05 ± 0.055	0.75PheHis: 0.75 ± 0.025	1.122PheIle: 1.122 ± 0.032	1.077PheLys: 1.077 ± 0.037	2.665PheLeu: 2.665 ± 0.058	0.621PheMet: 0.621 ± 0.023	0.99PheAsn: 0.99 ± 0.03	1.301PhePro: 1.301 ± 0.033	1.135PheGln: 1.135 ± 0.034	1.722PheArg: 1.722 ± 0.04	1.775PheSer: 1.775 ± 0.045	1.725PheThr: 1.725 ± 0.04	2.713PheVal: 2.713 ± 0.048	0.505PheTrp: 0.505 ± 0.022	0.688PheTyr: 0.688 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.92GlyAla: 9.92 ± 0.103	0.877GlyCys: 0.877 ± 0.027	4.264GlyAsp: 4.264 ± 0.071	4.427GlyGlu: 4.427 ± 0.07	3.156GlyPhe: 3.156 ± 0.052	7.082GlyGly: 7.082 ± 0.093	2.113GlyHis: 2.113 ± 0.05	2.928GlyIle: 2.928 ± 0.058	2.708GlyLys: 2.708 ± 0.068	10.596GlyLeu: 10.596 ± 0.114	1.899GlyMet: 1.899 ± 0.043	1.869GlyAsn: 1.869 ± 0.044	3.766GlyPro: 3.766 ± 0.068	3.945GlyGln: 3.945 ± 0.064	6.196GlyArg: 6.196 ± 0.078	4.333GlySer: 4.333 ± 0.075	4.21GlyThr: 4.21 ± 0.079	6.61GlyVal: 6.61 ± 0.086	1.841GlyTrp: 1.841 ± 0.039	1.881GlyTyr: 1.881 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	3.279HisAla: 3.279 ± 0.06	0.284HisCys: 0.284 ± 0.017	1.182HisAsp: 1.182 ± 0.03	1.203HisGlu: 1.203 ± 0.033	0.879HisPhe: 0.879 ± 0.028	2.269HisGly: 2.269 ± 0.053	0.661HisHis: 0.661 ± 0.026	0.716HisIle: 0.716 ± 0.026	0.505HisLys: 0.505 ± 0.021	2.677HisLeu: 2.677 ± 0.056	0.34HisMet: 0.34 ± 0.015	0.446HisAsn: 0.446 ± 0.018	1.703HisPro: 1.703 ± 0.043	0.887HisGln: 0.887 ± 0.028	1.868HisArg: 1.868 ± 0.042	1.005HisSer: 1.005 ± 0.028	1.084HisThr: 1.084 ± 0.031	1.51HisVal: 1.51 ± 0.037	0.534HisTrp: 0.534 ± 0.024	0.543HisTyr: 0.543 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.701IleAla: 4.701 ± 0.071	0.234IleCys: 0.234 ± 0.016	2.602IleAsp: 2.602 ± 0.046	2.353IleGlu: 2.353 ± 0.052	0.721IlePhe: 0.721 ± 0.031	3.209IleGly: 3.209 ± 0.06	0.673IleHis: 0.673 ± 0.024	0.704IleIle: 0.704 ± 0.03	1.189IleLys: 1.189 ± 0.036	2.344IleLeu: 2.344 ± 0.057	0.448IleMet: 0.448 ± 0.028	1.001IleAsn: 1.001 ± 0.029	1.481IlePro: 1.481 ± 0.036	1.242IleGln: 1.242 ± 0.034	1.94IleArg: 1.94 ± 0.045	1.567IleSer: 1.567 ± 0.042	1.806IleThr: 1.806 ± 0.04	2.759IleVal: 2.759 ± 0.05	0.354IleTrp: 0.354 ± 0.018	0.589IleTyr: 0.589 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.098LysAla: 4.098 ± 0.085	0.129LysCys: 0.129 ± 0.011	1.49LysAsp: 1.49 ± 0.043	1.187LysGlu: 1.187 ± 0.04	0.767LysPhe: 0.767 ± 0.028	2.284LysGly: 2.284 ± 0.052	0.612LysHis: 0.612 ± 0.026	0.992LysIle: 0.992 ± 0.039	1.158LysLys: 1.158 ± 0.05	3.084LysLeu: 3.084 ± 0.066	0.598LysMet: 0.598 ± 0.024	0.732LysAsn: 0.732 ± 0.028	1.989LysPro: 1.989 ± 0.044	1.007LysGln: 1.007 ± 0.031	2.069LysArg: 2.069 ± 0.047	1.406LysSer: 1.406 ± 0.038	1.548LysThr: 1.548 ± 0.039	2.25LysVal: 2.25 ± 0.061	0.279LysTrp: 0.279 ± 0.015	0.461LysTyr: 0.461 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	17.327LeuAla: 17.327 ± 0.152	0.932LeuCys: 0.932 ± 0.03	6.33LeuAsp: 6.33 ± 0.073	4.851LeuGlu: 4.851 ± 0.082	3.145LeuPhe: 3.145 ± 0.06	9.925LeuGly: 9.925 ± 0.127	2.735LeuHis: 2.735 ± 0.055	3.544LeuIle: 3.544 ± 0.061	3.539LeuLys: 3.539 ± 0.069	12.67LeuLeu: 12.67 ± 0.168	2.712LeuMet: 2.712 ± 0.049	2.8LeuAsn: 2.8 ± 0.061	7.163LeuPro: 7.163 ± 0.086	5.391LeuGln: 5.391 ± 0.077	9.554LeuArg: 9.554 ± 0.108	6.381LeuSer: 6.381 ± 0.089	5.547LeuThr: 5.547 ± 0.104	8.613LeuVal: 8.613 ± 0.098	1.761LeuTrp: 1.761 ± 0.053	1.865LeuTyr: 1.865 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.114MetAla: 3.114 ± 0.058	0.113MetCys: 0.113 ± 0.009	1.079MetAsp: 1.079 ± 0.031	0.824MetGlu: 0.824 ± 0.032	0.508MetPhe: 0.508 ± 0.023	1.891MetGly: 1.891 ± 0.042	0.482MetHis: 0.482 ± 0.021	0.563MetIle: 0.563 ± 0.022	0.848MetLys: 0.848 ± 0.026	2.2MetLeu: 2.2 ± 0.051	0.4MetMet: 0.4 ± 0.017	0.754MetAsn: 0.754 ± 0.026	1.449MetPro: 1.449 ± 0.035	0.923MetGln: 0.923 ± 0.029	1.605MetArg: 1.605 ± 0.041	1.348MetSer: 1.348 ± 0.032	1.226MetThr: 1.226 ± 0.035	1.573MetVal: 1.573 ± 0.038	0.201MetTrp: 0.201 ± 0.013	0.259MetTyr: 0.259 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.287AsnAla: 3.287 ± 0.06	0.22AsnCys: 0.22 ± 0.013	1.207AsnAsp: 1.207 ± 0.037	1.124AsnGlu: 1.124 ± 0.033	0.769AsnPhe: 0.769 ± 0.03	1.973AsnGly: 1.973 ± 0.053	0.501AsnHis: 0.501 ± 0.022	0.74AsnIle: 0.74 ± 0.03	0.603AsnLys: 0.603 ± 0.025	2.591AsnLeu: 2.591 ± 0.055	0.412AsnMet: 0.412 ± 0.018	0.584AsnAsn: 0.584 ± 0.025	1.686AsnPro: 1.686 ± 0.043	0.821AsnGln: 0.821 ± 0.032	1.521AsnArg: 1.521 ± 0.035	0.889AsnSer: 0.889 ± 0.031	1.202AsnThr: 1.202 ± 0.037	1.622AsnVal: 1.622 ± 0.035	0.377AsnTrp: 0.377 ± 0.017	0.505AsnTyr: 0.505 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	8.235ProAla: 8.235 ± 0.114	0.406ProCys: 0.406 ± 0.023	3.252ProAsp: 3.252 ± 0.06	3.765ProGlu: 3.765 ± 0.065	1.77ProPhe: 1.77 ± 0.039	4.961ProGly: 4.961 ± 0.072	1.212ProHis: 1.212 ± 0.035	1.654ProIle: 1.654 ± 0.04	1.676ProLys: 1.676 ± 0.046	6.179ProLeu: 6.179 ± 0.078	1.385ProMet: 1.385 ± 0.032	1.345ProAsn: 1.345 ± 0.034	3.382ProPro: 3.382 ± 0.072	2.384ProGln: 2.384 ± 0.053	3.505ProArg: 3.505 ± 0.06	3.068ProSer: 3.068 ± 0.051	2.966ProThr: 2.966 ± 0.063	4.442ProVal: 4.442 ± 0.072	1.093ProTrp: 1.093 ± 0.033	1.003ProTyr: 1.003 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	7.868GlnAla: 7.868 ± 0.123	0.279GlnCys: 0.279 ± 0.016	1.74GlnAsp: 1.74 ± 0.038	1.582GlnGlu: 1.582 ± 0.042	1.264GlnPhe: 1.264 ± 0.043	4.132GlnGly: 4.132 ± 0.068	1.254GlnHis: 1.254 ± 0.034	1.325GlnIle: 1.325 ± 0.049	0.822GlnLys: 0.822 ± 0.027	4.957GlnLeu: 4.957 ± 0.081	0.832GlnMet: 0.832 ± 0.029	0.68GlnAsn: 0.68 ± 0.025	2.583GlnPro: 2.583 ± 0.048	2.215GlnGln: 2.215 ± 0.054	4.544GlnArg: 4.544 ± 0.079	1.906GlnSer: 1.906 ± 0.04	1.829GlnThr: 1.829 ± 0.04	3.584GlnVal: 3.584 ± 0.076	0.842GlnTrp: 0.842 ± 0.027	0.627GlnTyr: 0.627 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.306ArgAla: 9.306 ± 0.104	0.693ArgCys: 0.693 ± 0.024	3.882ArgAsp: 3.882 ± 0.062	4.371ArgGlu: 4.371 ± 0.077	2.918ArgPhe: 2.918 ± 0.053	4.992ArgGly: 4.992 ± 0.077	2.088ArgHis: 2.088 ± 0.043	2.703ArgIle: 2.703 ± 0.048	1.638ArgLys: 1.638 ± 0.042	9.516ArgLeu: 9.516 ± 0.118	1.707ArgMet: 1.707 ± 0.039	1.498ArgAsn: 1.498 ± 0.038	3.883ArgPro: 3.883 ± 0.075	3.56ArgGln: 3.56 ± 0.061	5.808ArgArg: 5.808 ± 0.09	3.384ArgSer: 3.384 ± 0.055	3.229ArgThr: 3.229 ± 0.053	5.795ArgVal: 5.795 ± 0.074	1.923ArgTrp: 1.923 ± 0.051	1.702ArgTyr: 1.702 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.609SerAla: 6.609 ± 0.095	0.35SerCys: 0.35 ± 0.02	2.487SerAsp: 2.487 ± 0.051	2.255SerGlu: 2.255 ± 0.047	1.728SerPhe: 1.728 ± 0.044	4.594SerGly: 4.594 ± 0.064	1.052SerHis: 1.052 ± 0.027	1.604SerIle: 1.604 ± 0.042	1.257SerLys: 1.257 ± 0.038	5.755SerLeu: 5.755 ± 0.087	1.007SerMet: 1.007 ± 0.032	1.198SerAsn: 1.198 ± 0.037	3.022SerPro: 3.022 ± 0.056	1.824SerGln: 1.824 ± 0.036	3.166SerArg: 3.166 ± 0.054	2.587SerSer: 2.587 ± 0.062	2.773SerThr: 2.773 ± 0.094	3.595SerVal: 3.595 ± 0.064	0.739SerTrp: 0.739 ± 0.023	0.966SerTyr: 0.966 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.96ThrAla: 5.96 ± 0.101	0.359ThrCys: 0.359 ± 0.018	2.493ThrAsp: 2.493 ± 0.11	2.426ThrGlu: 2.426 ± 0.052	1.369ThrPhe: 1.369 ± 0.037	4.412ThrGly: 4.412 ± 0.071	1.14ThrHis: 1.14 ± 0.027	1.453ThrIle: 1.453 ± 0.043	1.151ThrLys: 1.151 ± 0.038	6.386ThrLeu: 6.386 ± 0.091	0.873ThrMet: 0.873 ± 0.028	1.07ThrAsn: 1.07 ± 0.038	3.614ThrPro: 3.614 ± 0.056	2.143ThrGln: 2.143 ± 0.042	3.189ThrArg: 3.189 ± 0.049	2.105ThrSer: 2.105 ± 0.055	2.471ThrThr: 2.471 ± 0.098	4.166ThrVal: 4.166 ± 0.066	0.839ThrTrp: 0.839 ± 0.028	0.883ThrTyr: 0.883 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	10.24ValAla: 10.24 ± 0.102	0.714ValCys: 0.714 ± 0.027	4.231ValAsp: 4.231 ± 0.066	3.803ValGlu: 3.803 ± 0.066	2.487ValPhe: 2.487 ± 0.045	6.036ValGly: 6.036 ± 0.086	1.758ValHis: 1.758 ± 0.042	2.582ValIle: 2.582 ± 0.05	2.187ValLys: 2.187 ± 0.057	9.106ValLeu: 9.106 ± 0.101	1.767ValMet: 1.767 ± 0.038	1.992ValAsn: 1.992 ± 0.042	4.107ValPro: 4.107 ± 0.062	3.416ValGln: 3.416 ± 0.063	5.393ValArg: 5.393 ± 0.075	3.861ValSer: 3.861 ± 0.061	3.832ValThr: 3.832 ± 0.068	6.236ValVal: 6.236 ± 0.095	1.193ValTrp: 1.193 ± 0.034	1.368ValTyr: 1.368 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	2.309TrpAla: 2.309 ± 0.048	0.168TrpCys: 0.168 ± 0.013	0.787TrpAsp: 0.787 ± 0.026	0.566TrpGlu: 0.566 ± 0.022	0.54TrpPhe: 0.54 ± 0.025	1.361TrpGly: 1.361 ± 0.035	0.463TrpHis: 0.463 ± 0.018	0.558TrpIle: 0.558 ± 0.026	0.377TrpLys: 0.377 ± 0.02	2.475TrpLeu: 2.475 ± 0.056	0.452TrpMet: 0.452 ± 0.02	0.374TrpAsn: 0.374 ± 0.02	0.986TrpPro: 0.986 ± 0.031	1.052TrpGln: 1.052 ± 0.038	1.895TrpArg: 1.895 ± 0.049	0.88TrpSer: 0.88 ± 0.028	0.911TrpThr: 0.911 ± 0.027	1.513TrpVal: 1.513 ± 0.045	0.413TrpTrp: 0.413 ± 0.021	0.232TrpTyr: 0.232 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.323TyrAla: 2.323 ± 0.045	0.193TyrCys: 0.193 ± 0.014	0.914TyrAsp: 0.914 ± 0.028	0.926TyrGlu: 0.926 ± 0.03	0.745TyrPhe: 0.745 ± 0.025	1.674TyrGly: 1.674 ± 0.037	0.363TyrHis: 0.363 ± 0.017	0.558TyrIle: 0.558 ± 0.024	0.506TyrLys: 0.506 ± 0.022	2.13TyrLeu: 2.13 ± 0.047	0.308TyrMet: 0.308 ± 0.018	0.48TyrAsn: 0.48 ± 0.02	0.974TyrPro: 0.974 ± 0.028	0.763TyrGln: 0.763 ± 0.028	1.589TyrArg: 1.589 ± 0.038	0.937TyrSer: 0.937 ± 0.03	1.011TyrThr: 1.011 ± 0.034	1.346TyrVal: 1.346 ± 0.033	0.334TyrTrp: 0.334 ± 0.018	0.426TyrTyr: 0.426 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3430 proteins (1173898 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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