Amino acid dipepetide frequency for Dishui Lake virophage 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.163AlaAla: 7.163 ± 1.678
1.228AlaCys: 1.228 ± 0.43
3.07AlaAsp: 3.07 ± 0.565
4.503AlaGlu: 4.503 ± 1.24
2.251AlaPhe: 2.251 ± 0.538
4.707AlaGly: 4.707 ± 1.435
0.409AlaHis: 0.409 ± 0.243
5.321AlaIle: 5.321 ± 0.726
5.321AlaLys: 5.321 ± 1.106
5.526AlaLeu: 5.526 ± 1.044
1.228AlaMet: 1.228 ± 0.445
5.117AlaAsn: 5.117 ± 1.192
3.479AlaPro: 3.479 ± 0.947
2.251AlaGln: 2.251 ± 0.804
4.707AlaArg: 4.707 ± 1.291
5.321AlaSer: 5.321 ± 1.439
7.163AlaThr: 7.163 ± 2.674
3.684AlaVal: 3.684 ± 0.439
0.614AlaTrp: 0.614 ± 0.305
1.637AlaTyr: 1.637 ± 0.6
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.205CysCys: 0.205 ± 0.229
0.819CysAsp: 0.819 ± 0.319
1.023CysGlu: 1.023 ± 0.307
0.205CysPhe: 0.205 ± 0.18
0.819CysGly: 0.819 ± 0.36
0.205CysHis: 0.205 ± 0.188
0.819CysIle: 0.819 ± 0.443
1.228CysLys: 1.228 ± 0.468
1.023CysLeu: 1.023 ± 0.603
0.205CysMet: 0.205 ± 0.188
0.819CysAsn: 0.819 ± 0.425
0.819CysPro: 0.819 ± 0.461
0.0CysGln: 0.0 ± 0.0
0.614CysArg: 0.614 ± 0.396
0.614CysSer: 0.614 ± 0.274
0.0CysThr: 0.0 ± 0.0
0.819CysVal: 0.819 ± 0.468
0.819CysTrp: 0.819 ± 0.468
0.614CysTyr: 0.614 ± 0.347
0.0CysXaa: 0.0 ± 0.0
Asp
3.275AspAla: 3.275 ± 0.892
0.614AspCys: 0.614 ± 0.28
3.684AspAsp: 3.684 ± 0.977
4.707AspGlu: 4.707 ± 1.266
3.684AspPhe: 3.684 ± 1.011
3.684AspGly: 3.684 ± 1.281
0.409AspHis: 0.409 ± 0.212
4.093AspIle: 4.093 ± 1.094
4.093AspLys: 4.093 ± 1.023
4.912AspLeu: 4.912 ± 0.813
2.456AspMet: 2.456 ± 0.662
2.047AspAsn: 2.047 ± 0.737
2.456AspPro: 2.456 ± 0.522
0.819AspGln: 0.819 ± 0.392
2.047AspArg: 2.047 ± 0.526
1.842AspSer: 1.842 ± 0.376
2.456AspThr: 2.456 ± 0.647
4.093AspVal: 4.093 ± 0.784
0.409AspTrp: 0.409 ± 0.259
2.865AspTyr: 2.865 ± 0.613
0.0AspXaa: 0.0 ± 0.0
Glu
4.912GluAla: 4.912 ± 1.13
1.023GluCys: 1.023 ± 0.608
4.707GluAsp: 4.707 ± 1.113
3.479GluGlu: 3.479 ± 1.567
2.456GluPhe: 2.456 ± 0.944
3.684GluGly: 3.684 ± 0.94
1.023GluHis: 1.023 ± 0.312
4.707GluIle: 4.707 ± 1.162
5.526GluLys: 5.526 ± 1.493
5.731GluLeu: 5.731 ± 1.529
2.251GluMet: 2.251 ± 0.569
1.433GluAsn: 1.433 ± 0.452
2.661GluPro: 2.661 ± 0.733
1.842GluGln: 1.842 ± 0.71
3.684GluArg: 3.684 ± 0.824
1.842GluSer: 1.842 ± 0.814
4.298GluThr: 4.298 ± 0.855
4.912GluVal: 4.912 ± 1.298
1.023GluTrp: 1.023 ± 0.419
2.661GluTyr: 2.661 ± 0.67
0.0GluXaa: 0.0 ± 0.0
Phe
2.251PheAla: 2.251 ± 0.352
0.205PheCys: 0.205 ± 0.199
2.251PheAsp: 2.251 ± 0.685
1.228PheGlu: 1.228 ± 0.363
1.023PhePhe: 1.023 ± 0.487
1.842PheGly: 1.842 ± 0.638
0.614PheHis: 0.614 ± 0.378
2.661PheIle: 2.661 ± 0.742
4.298PheLys: 4.298 ± 1.11
2.251PheLeu: 2.251 ± 0.758
0.205PheMet: 0.205 ± 0.201
2.865PheAsn: 2.865 ± 0.975
1.433PhePro: 1.433 ± 0.473
1.637PheGln: 1.637 ± 0.643
1.637PheArg: 1.637 ± 0.486
2.456PheSer: 2.456 ± 0.685
2.456PheThr: 2.456 ± 0.472
2.251PheVal: 2.251 ± 0.744
0.409PheTrp: 0.409 ± 0.212
0.614PheTyr: 0.614 ± 0.264
0.0PheXaa: 0.0 ± 0.0
Gly
6.14GlyAla: 6.14 ± 1.527
1.023GlyCys: 1.023 ± 0.452
4.707GlyAsp: 4.707 ± 1.021
3.684GlyGlu: 3.684 ± 0.87
2.456GlyPhe: 2.456 ± 0.57
5.935GlyGly: 5.935 ± 1.663
1.228GlyHis: 1.228 ± 0.473
5.526GlyIle: 5.526 ± 0.593
5.117GlyLys: 5.117 ± 0.747
4.298GlyLeu: 4.298 ± 0.927
1.228GlyMet: 1.228 ± 0.611
3.684GlyAsn: 3.684 ± 0.732
0.0GlyPro: 0.0 ± 0.0
2.661GlyGln: 2.661 ± 0.931
3.684GlyArg: 3.684 ± 0.778
5.526GlySer: 5.526 ± 1.807
3.07GlyThr: 3.07 ± 1.55
5.321GlyVal: 5.321 ± 1.226
1.023GlyTrp: 1.023 ± 0.491
1.842GlyTyr: 1.842 ± 0.571
0.0GlyXaa: 0.0 ± 0.0
His
0.819HisAla: 0.819 ± 0.353
0.0HisCys: 0.0 ± 0.0
0.409HisAsp: 0.409 ± 0.303
0.409HisGlu: 0.409 ± 0.284
0.409HisPhe: 0.409 ± 0.458
0.819HisGly: 0.819 ± 0.405
0.205HisHis: 0.205 ± 0.191
2.047HisIle: 2.047 ± 0.668
1.023HisLys: 1.023 ± 0.607
1.433HisLeu: 1.433 ± 0.517
0.0HisMet: 0.0 ± 0.0
0.409HisAsn: 0.409 ± 0.302
0.409HisPro: 0.409 ± 0.295
0.409HisGln: 0.409 ± 0.239
0.819HisArg: 0.819 ± 0.55
1.637HisSer: 1.637 ± 0.598
0.409HisThr: 0.409 ± 0.285
0.409HisVal: 0.409 ± 0.285
0.205HisTrp: 0.205 ± 0.228
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
4.298IleAla: 4.298 ± 0.828
1.637IleCys: 1.637 ± 0.479
3.889IleAsp: 3.889 ± 0.894
4.912IleGlu: 4.912 ± 0.804
2.251IlePhe: 2.251 ± 0.589
3.479IleGly: 3.479 ± 0.734
0.614IleHis: 0.614 ± 0.294
2.456IleIle: 2.456 ± 0.631
3.684IleLys: 3.684 ± 1.249
5.117IleLeu: 5.117 ± 0.865
1.433IleMet: 1.433 ± 0.646
3.275IleAsn: 3.275 ± 0.692
3.275IlePro: 3.275 ± 0.683
3.07IleGln: 3.07 ± 0.696
3.275IleArg: 3.275 ± 0.623
5.321IleSer: 5.321 ± 1.198
4.707IleThr: 4.707 ± 0.802
4.503IleVal: 4.503 ± 1.187
0.819IleTrp: 0.819 ± 0.503
3.275IleTyr: 3.275 ± 0.823
0.0IleXaa: 0.0 ± 0.0
Lys
4.093LysAla: 4.093 ± 1.058
1.228LysCys: 1.228 ± 0.644
3.889LysAsp: 3.889 ± 0.89
6.345LysGlu: 6.345 ± 2.033
1.842LysPhe: 1.842 ± 0.544
5.321LysGly: 5.321 ± 1.408
0.819LysHis: 0.819 ± 0.461
5.731LysIle: 5.731 ± 1.389
7.368LysLys: 7.368 ± 2.226
4.707LysLeu: 4.707 ± 1.008
2.047LysMet: 2.047 ± 0.675
3.684LysAsn: 3.684 ± 0.995
4.707LysPro: 4.707 ± 1.271
2.865LysGln: 2.865 ± 0.938
3.889LysArg: 3.889 ± 0.972
4.093LysSer: 4.093 ± 1.081
3.07LysThr: 3.07 ± 0.95
3.07LysVal: 3.07 ± 0.897
0.819LysTrp: 0.819 ± 0.464
3.275LysTyr: 3.275 ± 0.578
0.0LysXaa: 0.0 ± 0.0
Leu
6.549LeuAla: 6.549 ± 0.862
0.614LeuCys: 0.614 ± 0.297
4.093LeuAsp: 4.093 ± 0.981
4.912LeuGlu: 4.912 ± 1.463
2.661LeuPhe: 2.661 ± 0.913
5.935LeuGly: 5.935 ± 0.805
0.819LeuHis: 0.819 ± 0.443
4.093LeuIle: 4.093 ± 0.802
8.596LeuLys: 8.596 ± 1.847
6.549LeuLeu: 6.549 ± 1.098
1.842LeuMet: 1.842 ± 0.543
6.959LeuAsn: 6.959 ± 1.501
3.889LeuPro: 3.889 ± 0.964
3.479LeuGln: 3.479 ± 0.674
3.889LeuArg: 3.889 ± 1.042
5.321LeuSer: 5.321 ± 0.67
5.935LeuThr: 5.935 ± 0.953
4.707LeuVal: 4.707 ± 0.741
1.637LeuTrp: 1.637 ± 0.629
3.684LeuTyr: 3.684 ± 0.815
0.0LeuXaa: 0.0 ± 0.0
Met
2.251MetAla: 2.251 ± 0.62
0.205MetCys: 0.205 ± 0.156
2.047MetAsp: 2.047 ± 0.617
2.047MetGlu: 2.047 ± 0.617
0.614MetPhe: 0.614 ± 0.269
1.023MetGly: 1.023 ± 0.455
0.0MetHis: 0.0 ± 0.0
0.819MetIle: 0.819 ± 0.373
1.228MetLys: 1.228 ± 0.512
1.842MetLeu: 1.842 ± 0.579
1.637MetMet: 1.637 ± 0.74
2.047MetAsn: 2.047 ± 0.531
2.047MetPro: 2.047 ± 0.542
0.0MetGln: 0.0 ± 0.0
1.023MetArg: 1.023 ± 0.404
1.433MetSer: 1.433 ± 0.303
1.228MetThr: 1.228 ± 0.423
1.637MetVal: 1.637 ± 0.425
0.409MetTrp: 0.409 ± 0.301
0.614MetTyr: 0.614 ± 0.402
0.0MetXaa: 0.0 ± 0.0
Asn
4.707AsnAla: 4.707 ± 0.978
0.205AsnCys: 0.205 ± 0.201
3.684AsnAsp: 3.684 ± 0.513
2.456AsnGlu: 2.456 ± 0.707
2.251AsnPhe: 2.251 ± 0.673
5.321AsnGly: 5.321 ± 1.37
1.228AsnHis: 1.228 ± 0.392
5.321AsnIle: 5.321 ± 1.171
2.251AsnLys: 2.251 ± 0.74
6.345AsnLeu: 6.345 ± 1.019
1.023AsnMet: 1.023 ± 0.643
5.117AsnAsn: 5.117 ± 1.505
4.298AsnPro: 4.298 ± 1.073
2.251AsnGln: 2.251 ± 0.762
2.251AsnArg: 2.251 ± 0.596
4.707AsnSer: 4.707 ± 1.143
5.731AsnThr: 5.731 ± 1.69
2.661AsnVal: 2.661 ± 0.486
0.614AsnTrp: 0.614 ± 0.272
1.433AsnTyr: 1.433 ± 0.497
0.0AsnXaa: 0.0 ± 0.0
Pro
3.479ProAla: 3.479 ± 1.027
0.205ProCys: 0.205 ± 0.156
1.228ProAsp: 1.228 ± 0.554
2.661ProGlu: 2.661 ± 0.897
1.228ProPhe: 1.228 ± 0.611
0.0ProGly: 0.0 ± 0.0
1.023ProHis: 1.023 ± 0.369
3.684ProIle: 3.684 ± 0.76
4.093ProLys: 4.093 ± 1.022
5.526ProLeu: 5.526 ± 1.083
1.842ProMet: 1.842 ± 0.76
3.684ProAsn: 3.684 ± 0.829
3.479ProPro: 3.479 ± 0.914
2.661ProGln: 2.661 ± 1.204
1.842ProArg: 1.842 ± 0.525
2.865ProSer: 2.865 ± 1.126
3.889ProThr: 3.889 ± 1.159
2.456ProVal: 2.456 ± 0.68
0.0ProTrp: 0.0 ± 0.0
3.479ProTyr: 3.479 ± 1.015
0.0ProXaa: 0.0 ± 0.0
Gln
1.842GlnAla: 1.842 ± 0.691
0.0GlnCys: 0.0 ± 0.0
1.637GlnAsp: 1.637 ± 0.394
1.842GlnGlu: 1.842 ± 0.52
1.023GlnPhe: 1.023 ± 0.503
1.433GlnGly: 1.433 ± 0.48
0.0GlnHis: 0.0 ± 0.0
2.865GlnIle: 2.865 ± 0.893
2.661GlnLys: 2.661 ± 0.489
3.684GlnLeu: 3.684 ± 0.6
1.023GlnMet: 1.023 ± 0.482
1.637GlnAsn: 1.637 ± 0.462
2.251GlnPro: 2.251 ± 0.721
2.251GlnGln: 2.251 ± 0.855
1.433GlnArg: 1.433 ± 0.667
2.865GlnSer: 2.865 ± 0.646
1.637GlnThr: 1.637 ± 0.502
2.456GlnVal: 2.456 ± 0.799
0.0GlnTrp: 0.0 ± 0.0
1.433GlnTyr: 1.433 ± 0.589
0.0GlnXaa: 0.0 ± 0.0
Arg
2.456ArgAla: 2.456 ± 0.73
0.409ArgCys: 0.409 ± 0.245
2.251ArgAsp: 2.251 ± 0.919
2.456ArgGlu: 2.456 ± 0.661
1.637ArgPhe: 1.637 ± 0.441
3.889ArgGly: 3.889 ± 1.116
1.637ArgHis: 1.637 ± 0.64
2.251ArgIle: 2.251 ± 0.516
3.07ArgLys: 3.07 ± 0.562
5.526ArgLeu: 5.526 ± 1.108
0.819ArgMet: 0.819 ± 0.552
3.889ArgAsn: 3.889 ± 0.964
2.865ArgPro: 2.865 ± 1.175
1.433ArgGln: 1.433 ± 0.549
3.479ArgArg: 3.479 ± 1.278
2.251ArgSer: 2.251 ± 0.863
2.047ArgThr: 2.047 ± 0.514
2.661ArgVal: 2.661 ± 0.508
1.023ArgTrp: 1.023 ± 0.459
2.661ArgTyr: 2.661 ± 0.784
0.0ArgXaa: 0.0 ± 0.0
Ser
9.415SerAla: 9.415 ± 2.04
0.205SerCys: 0.205 ± 0.229
3.07SerAsp: 3.07 ± 0.847
2.456SerGlu: 2.456 ± 0.581
2.047SerPhe: 2.047 ± 0.623
6.959SerGly: 6.959 ± 1.782
1.228SerHis: 1.228 ± 0.449
3.889SerIle: 3.889 ± 0.487
2.456SerLys: 2.456 ± 0.942
6.14SerLeu: 6.14 ± 1.221
1.433SerMet: 1.433 ± 0.571
4.093SerAsn: 4.093 ± 1.263
2.251SerPro: 2.251 ± 0.553
1.842SerGln: 1.842 ± 0.555
1.433SerArg: 1.433 ± 0.406
6.14SerSer: 6.14 ± 1.344
4.093SerThr: 4.093 ± 0.971
4.093SerVal: 4.093 ± 1.237
1.023SerTrp: 1.023 ± 0.271
2.251SerTyr: 2.251 ± 0.635
0.0SerXaa: 0.0 ± 0.0
Thr
4.093ThrAla: 4.093 ± 0.803
1.228ThrCys: 1.228 ± 0.727
4.298ThrAsp: 4.298 ± 0.968
5.117ThrGlu: 5.117 ± 1.063
1.842ThrPhe: 1.842 ± 0.63
5.321ThrGly: 5.321 ± 1.886
0.0ThrHis: 0.0 ± 0.0
4.298ThrIle: 4.298 ± 0.943
3.889ThrLys: 3.889 ± 0.576
4.707ThrLeu: 4.707 ± 1.036
1.023ThrMet: 1.023 ± 0.312
4.503ThrAsn: 4.503 ± 1.414
3.275ThrPro: 3.275 ± 0.768
2.047ThrGln: 2.047 ± 1.065
2.456ThrArg: 2.456 ± 0.884
3.275ThrSer: 3.275 ± 1.144
5.526ThrThr: 5.526 ± 2.172
1.228ThrVal: 1.228 ± 0.553
0.205ThrTrp: 0.205 ± 0.156
2.456ThrTyr: 2.456 ± 0.781
0.0ThrXaa: 0.0 ± 0.0
Val
4.093ValAla: 4.093 ± 0.722
0.614ValCys: 0.614 ± 0.231
2.251ValAsp: 2.251 ± 0.822
4.912ValGlu: 4.912 ± 0.937
2.661ValPhe: 2.661 ± 0.486
5.526ValGly: 5.526 ± 1.177
0.0ValHis: 0.0 ± 0.0
3.889ValIle: 3.889 ± 0.927
3.07ValLys: 3.07 ± 0.484
5.731ValLeu: 5.731 ± 0.986
1.023ValMet: 1.023 ± 0.491
3.07ValAsn: 3.07 ± 1.387
3.275ValPro: 3.275 ± 0.997
1.637ValGln: 1.637 ± 0.723
3.889ValArg: 3.889 ± 1.34
5.321ValSer: 5.321 ± 0.768
0.0ValThr: 0.0 ± 0.0
4.298ValVal: 4.298 ± 0.968
0.205ValTrp: 0.205 ± 0.228
2.251ValTyr: 2.251 ± 0.524
0.0ValXaa: 0.0 ± 0.0
Trp
0.614TrpAla: 0.614 ± 0.356
0.614TrpCys: 0.614 ± 0.28
0.409TrpAsp: 0.409 ± 0.301
2.456TrpGlu: 2.456 ± 0.765
0.409TrpPhe: 0.409 ± 0.289
0.819TrpGly: 0.819 ± 0.425
0.0TrpHis: 0.0 ± 0.0
0.205TrpIle: 0.205 ± 0.228
0.819TrpLys: 0.819 ± 0.488
0.819TrpLeu: 0.819 ± 0.406
0.409TrpMet: 0.409 ± 0.31
1.228TrpAsn: 1.228 ± 0.411
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.023TrpArg: 1.023 ± 0.467
0.819TrpSer: 0.819 ± 0.269
0.205TrpThr: 0.205 ± 0.228
0.614TrpVal: 0.614 ± 0.29
0.205TrpTrp: 0.205 ± 0.199
0.205TrpTyr: 0.205 ± 0.156
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.251TyrAla: 2.251 ± 0.679
0.205TyrCys: 0.205 ± 0.229
2.251TyrAsp: 2.251 ± 0.538
2.251TyrGlu: 2.251 ± 0.639
1.637TyrPhe: 1.637 ± 0.488
1.842TyrGly: 1.842 ± 0.362
0.819TyrHis: 0.819 ± 0.308
0.614TyrIle: 0.614 ± 0.304
3.07TyrLys: 3.07 ± 0.688
4.298TyrLeu: 4.298 ± 1.534
0.819TyrMet: 0.819 ± 0.328
4.298TyrAsn: 4.298 ± 0.623
2.456TyrPro: 2.456 ± 0.662
0.819TyrGln: 0.819 ± 0.445
1.637TyrArg: 1.637 ± 0.398
2.865TyrSer: 2.865 ± 0.747
2.865TyrThr: 2.865 ± 0.85
1.842TyrVal: 1.842 ± 0.649
0.409TyrTrp: 0.409 ± 0.262
1.637TyrTyr: 1.637 ± 0.512
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (4887 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski