Amino acid dipepetide frequency for Weizmannia ginsengihum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.737AlaAla: 5.737 ± 0.106
0.68AlaCys: 0.68 ± 0.032
3.276AlaAsp: 3.276 ± 0.071
4.437AlaGlu: 4.437 ± 0.077
3.344AlaPhe: 3.344 ± 0.068
5.065AlaGly: 5.065 ± 0.108
1.352AlaHis: 1.352 ± 0.045
6.454AlaIle: 6.454 ± 0.1
5.178AlaLys: 5.178 ± 0.086
7.212AlaLeu: 7.212 ± 0.094
1.958AlaMet: 1.958 ± 0.05
3.087AlaAsn: 3.087 ± 0.066
1.972AlaPro: 1.972 ± 0.055
2.278AlaGln: 2.278 ± 0.053
2.567AlaArg: 2.567 ± 0.06
4.124AlaSer: 4.124 ± 0.076
3.481AlaThr: 3.481 ± 0.07
5.363AlaVal: 5.363 ± 0.093
0.581AlaTrp: 0.581 ± 0.027
2.273AlaTyr: 2.273 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.509CysAla: 0.509 ± 0.028
0.086CysCys: 0.086 ± 0.01
0.431CysAsp: 0.431 ± 0.026
0.524CysGlu: 0.524 ± 0.026
0.393CysPhe: 0.393 ± 0.02
0.752CysGly: 0.752 ± 0.031
0.223CysHis: 0.223 ± 0.018
0.622CysIle: 0.622 ± 0.025
0.447CysLys: 0.447 ± 0.021
0.801CysLeu: 0.801 ± 0.034
0.208CysMet: 0.208 ± 0.014
0.335CysAsn: 0.335 ± 0.022
0.384CysPro: 0.384 ± 0.021
0.244CysGln: 0.244 ± 0.018
0.315CysArg: 0.315 ± 0.021
0.534CysSer: 0.534 ± 0.026
0.457CysThr: 0.457 ± 0.023
0.45CysVal: 0.45 ± 0.026
0.095CysTrp: 0.095 ± 0.01
0.33CysTyr: 0.33 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.285AspAla: 3.285 ± 0.066
0.415AspCys: 0.415 ± 0.026
2.397AspAsp: 2.397 ± 0.065
3.997AspGlu: 3.997 ± 0.076
2.259AspPhe: 2.259 ± 0.055
3.197AspGly: 3.197 ± 0.059
1.436AspHis: 1.436 ± 0.044
4.335AspIle: 4.335 ± 0.073
2.842AspLys: 2.842 ± 0.06
4.848AspLeu: 4.848 ± 0.076
1.273AspMet: 1.273 ± 0.042
1.545AspAsn: 1.545 ± 0.046
1.918AspPro: 1.918 ± 0.052
2.18AspGln: 2.18 ± 0.05
2.18AspArg: 2.18 ± 0.053
2.38AspSer: 2.38 ± 0.067
2.382AspThr: 2.382 ± 0.056
3.735AspVal: 3.735 ± 0.08
0.587AspTrp: 0.587 ± 0.028
2.013AspTyr: 2.013 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
5.014GluAla: 5.014 ± 0.099
0.41GluCys: 0.41 ± 0.022
3.429GluAsp: 3.429 ± 0.071
6.143GluGlu: 6.143 ± 0.111
2.437GluPhe: 2.437 ± 0.068
3.834GluGly: 3.834 ± 0.079
1.806GluHis: 1.806 ± 0.05
5.816GluIle: 5.816 ± 0.106
6.505GluLys: 6.505 ± 0.105
6.581GluLeu: 6.581 ± 0.082
2.238GluMet: 2.238 ± 0.057
3.487GluAsn: 3.487 ± 0.071
1.739GluPro: 1.739 ± 0.044
3.417GluGln: 3.417 ± 0.076
3.335GluArg: 3.335 ± 0.07
3.062GluSer: 3.062 ± 0.064
3.706GluThr: 3.706 ± 0.07
4.688GluVal: 4.688 ± 0.076
0.726GluTrp: 0.726 ± 0.029
2.118GluTyr: 2.118 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.005PheAla: 3.005 ± 0.064
0.382PheCys: 0.382 ± 0.023
2.258PheAsp: 2.258 ± 0.046
2.565PheGlu: 2.565 ± 0.053
2.073PhePhe: 2.073 ± 0.067
3.354PheGly: 3.354 ± 0.071
1.128PheHis: 1.128 ± 0.041
4.081PheIle: 4.081 ± 0.086
2.49PheLys: 2.49 ± 0.054
4.397PheLeu: 4.397 ± 0.073
1.154PheMet: 1.154 ± 0.039
1.909PheAsn: 1.909 ± 0.047
1.707PhePro: 1.707 ± 0.049
1.728PheGln: 1.728 ± 0.05
1.514PheArg: 1.514 ± 0.043
3.118PheSer: 3.118 ± 0.065
2.443PheThr: 2.443 ± 0.065
3.002PheVal: 3.002 ± 0.061
0.436PheTrp: 0.436 ± 0.027
1.596PheTyr: 1.596 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
4.823GlyAla: 4.823 ± 0.101
0.683GlyCys: 0.683 ± 0.03
2.874GlyAsp: 2.874 ± 0.058
4.159GlyGlu: 4.159 ± 0.072
3.349GlyPhe: 3.349 ± 0.07
4.771GlyGly: 4.771 ± 0.101
1.475GlyHis: 1.475 ± 0.045
6.426GlyIle: 6.426 ± 0.096
5.318GlyLys: 5.318 ± 0.085
6.124GlyLeu: 6.124 ± 0.111
1.961GlyMet: 1.961 ± 0.055
2.841GlyAsn: 2.841 ± 0.069
1.757GlyPro: 1.757 ± 0.055
2.056GlyGln: 2.056 ± 0.058
2.606GlyArg: 2.606 ± 0.057
3.771GlySer: 3.771 ± 0.062
3.983GlyThr: 3.983 ± 0.075
4.959GlyVal: 4.959 ± 0.091
0.787GlyTrp: 0.787 ± 0.032
2.744GlyTyr: 2.744 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.474HisAla: 1.474 ± 0.04
0.227HisCys: 0.227 ± 0.019
1.179HisAsp: 1.179 ± 0.038
1.459HisGlu: 1.459 ± 0.045
1.288HisPhe: 1.288 ± 0.044
1.509HisGly: 1.509 ± 0.045
0.931HisHis: 0.931 ± 0.037
1.975HisIle: 1.975 ± 0.048
1.169HisLys: 1.169 ± 0.042
2.397HisLeu: 2.397 ± 0.06
0.59HisMet: 0.59 ± 0.024
0.808HisAsn: 0.808 ± 0.034
1.289HisPro: 1.289 ± 0.047
1.003HisGln: 1.003 ± 0.037
0.977HisArg: 0.977 ± 0.033
1.345HisSer: 1.345 ± 0.041
1.151HisThr: 1.151 ± 0.034
1.597HisVal: 1.597 ± 0.045
0.258HisTrp: 0.258 ± 0.019
0.984HisTyr: 0.984 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.825IleAla: 6.825 ± 0.109
0.861IleCys: 0.861 ± 0.035
4.548IleAsp: 4.548 ± 0.077
6.097IleGlu: 6.097 ± 0.103
3.47IlePhe: 3.47 ± 0.087
6.497IleGly: 6.497 ± 0.103
1.987IleHis: 1.987 ± 0.052
6.664IleIle: 6.664 ± 0.104
5.074IleLys: 5.074 ± 0.082
7.587IleLeu: 7.587 ± 0.1
1.918IleMet: 1.918 ± 0.047
3.453IleAsn: 3.453 ± 0.062
3.517IlePro: 3.517 ± 0.058
3.371IleGln: 3.371 ± 0.059
3.354IleArg: 3.354 ± 0.061
5.511IleSer: 5.511 ± 0.096
4.683IleThr: 4.683 ± 0.077
6.084IleVal: 6.084 ± 0.11
0.747IleTrp: 0.747 ± 0.034
2.58IleTyr: 2.58 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
4.92LysAla: 4.92 ± 0.08
0.358LysCys: 0.358 ± 0.022
3.852LysAsp: 3.852 ± 0.066
6.535LysGlu: 6.535 ± 0.098
1.946LysPhe: 1.946 ± 0.05
4.458LysGly: 4.458 ± 0.087
1.682LysHis: 1.682 ± 0.044
5.141LysIle: 5.141 ± 0.079
5.897LysLys: 5.897 ± 0.098
5.934LysLeu: 5.934 ± 0.092
2.387LysMet: 2.387 ± 0.054
3.433LysAsn: 3.433 ± 0.083
2.123LysPro: 2.123 ± 0.045
3.618LysGln: 3.618 ± 0.07
3.433LysArg: 3.433 ± 0.066
3.463LysSer: 3.463 ± 0.078
3.842LysThr: 3.842 ± 0.07
4.928LysVal: 4.928 ± 0.08
0.787LysTrp: 0.787 ± 0.031
2.341LysTyr: 2.341 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
7.053LeuAla: 7.053 ± 0.099
0.758LeuCys: 0.758 ± 0.031
4.709LeuAsp: 4.709 ± 0.094
6.276LeuGlu: 6.276 ± 0.112
4.639LeuPhe: 4.639 ± 0.086
6.286LeuGly: 6.286 ± 0.1
2.098LeuHis: 2.098 ± 0.059
7.466LeuIle: 7.466 ± 0.114
7.002LeuLys: 7.002 ± 0.098
9.696LeuLeu: 9.696 ± 0.122
2.404LeuMet: 2.404 ± 0.064
4.485LeuAsn: 4.485 ± 0.081
3.808LeuPro: 3.808 ± 0.076
3.998LeuGln: 3.998 ± 0.073
3.48LeuArg: 3.48 ± 0.08
6.613LeuSer: 6.613 ± 0.1
5.456LeuThr: 5.456 ± 0.074
5.98LeuVal: 5.98 ± 0.106
0.848LeuTrp: 0.848 ± 0.034
2.988LeuTyr: 2.988 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
1.966MetAla: 1.966 ± 0.05
0.162MetCys: 0.162 ± 0.013
1.301MetAsp: 1.301 ± 0.042
1.826MetGlu: 1.826 ± 0.048
1.115MetPhe: 1.115 ± 0.039
1.661MetGly: 1.661 ± 0.046
0.46MetHis: 0.46 ± 0.021
2.559MetIle: 2.559 ± 0.054
2.513MetLys: 2.513 ± 0.059
2.515MetLeu: 2.515 ± 0.063
0.916MetMet: 0.916 ± 0.037
1.591MetAsn: 1.591 ± 0.04
1.004MetPro: 1.004 ± 0.042
0.871MetGln: 0.871 ± 0.035
1.056MetArg: 1.056 ± 0.036
1.674MetSer: 1.674 ± 0.045
1.509MetThr: 1.509 ± 0.046
1.756MetVal: 1.756 ± 0.051
0.178MetTrp: 0.178 ± 0.015
0.772MetTyr: 0.772 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.786AsnAla: 2.786 ± 0.06
0.346AsnCys: 0.346 ± 0.019
2.363AsnAsp: 2.363 ± 0.063
3.409AsnGlu: 3.409 ± 0.071
1.558AsnPhe: 1.558 ± 0.044
3.504AsnGly: 3.504 ± 0.07
1.213AsnHis: 1.213 ± 0.042
4.16AsnIle: 4.16 ± 0.065
2.984AsnLys: 2.984 ± 0.059
3.712AsnLeu: 3.712 ± 0.076
1.284AsnMet: 1.284 ± 0.046
1.871AsnAsn: 1.871 ± 0.06
1.99AsnPro: 1.99 ± 0.047
2.087AsnGln: 2.087 ± 0.06
2.045AsnArg: 2.045 ± 0.05
2.231AsnSer: 2.231 ± 0.059
2.159AsnThr: 2.159 ± 0.05
3.152AsnVal: 3.152 ± 0.062
0.521AsnTrp: 0.521 ± 0.026
1.482AsnTyr: 1.482 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
2.176ProAla: 2.176 ± 0.053
0.233ProCys: 0.233 ± 0.017
1.844ProAsp: 1.844 ± 0.05
2.688ProGlu: 2.688 ± 0.058
1.911ProPhe: 1.911 ± 0.05
2.184ProGly: 2.184 ± 0.053
0.885ProHis: 0.885 ± 0.034
3.107ProIle: 3.107 ± 0.075
2.232ProLys: 2.232 ± 0.057
3.528ProLeu: 3.528 ± 0.061
0.786ProMet: 0.786 ± 0.031
1.871ProAsn: 1.871 ± 0.048
0.916ProPro: 0.916 ± 0.033
1.193ProGln: 1.193 ± 0.039
1.068ProArg: 1.068 ± 0.036
2.222ProSer: 2.222 ± 0.057
2.013ProThr: 2.013 ± 0.042
2.728ProVal: 2.728 ± 0.05
0.389ProTrp: 0.389 ± 0.024
1.464ProTyr: 1.464 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
2.9GlnAla: 2.9 ± 0.061
0.279GlnCys: 0.279 ± 0.021
1.635GlnAsp: 1.635 ± 0.052
2.718GlnGlu: 2.718 ± 0.065
1.861GlnPhe: 1.861 ± 0.051
2.066GlnGly: 2.066 ± 0.055
1.186GlnHis: 1.186 ± 0.044
2.855GlnIle: 2.855 ± 0.054
2.896GlnLys: 2.896 ± 0.062
4.524GlnLeu: 4.524 ± 0.085
1.242GlnMet: 1.242 ± 0.039
1.637GlnAsn: 1.637 ± 0.044
1.294GlnPro: 1.294 ± 0.042
2.237GlnGln: 2.237 ± 0.06
1.495GlnArg: 1.495 ± 0.043
2.314GlnSer: 2.314 ± 0.059
2.213GlnThr: 2.213 ± 0.06
2.393GlnVal: 2.393 ± 0.051
0.441GlnTrp: 0.441 ± 0.021
1.62GlnTyr: 1.62 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
2.424ArgAla: 2.424 ± 0.054
0.27ArgCys: 0.27 ± 0.018
1.936ArgAsp: 1.936 ± 0.055
3.112ArgGlu: 3.112 ± 0.081
1.873ArgPhe: 1.873 ± 0.05
2.376ArgGly: 2.376 ± 0.06
0.806ArgHis: 0.806 ± 0.035
3.199ArgIle: 3.199 ± 0.073
3.305ArgLys: 3.305 ± 0.066
3.937ArgLeu: 3.937 ± 0.069
1.211ArgMet: 1.211 ± 0.037
1.937ArgAsn: 1.937 ± 0.052
1.42ArgPro: 1.42 ± 0.047
1.476ArgGln: 1.476 ± 0.045
1.909ArgArg: 1.909 ± 0.052
2.23ArgSer: 2.23 ± 0.052
2.087ArgThr: 2.087 ± 0.052
2.496ArgVal: 2.496 ± 0.053
0.403ArgTrp: 0.403 ± 0.023
1.471ArgTyr: 1.471 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.861SerAla: 3.861 ± 0.073
0.43SerCys: 0.43 ± 0.021
2.707SerAsp: 2.707 ± 0.057
3.574SerGlu: 3.574 ± 0.077
3.199SerPhe: 3.199 ± 0.069
4.139SerGly: 4.139 ± 0.077
1.285SerHis: 1.285 ± 0.037
5.27SerIle: 5.27 ± 0.085
3.927SerLys: 3.927 ± 0.084
5.971SerLeu: 5.971 ± 0.095
1.661SerMet: 1.661 ± 0.047
2.673SerAsn: 2.673 ± 0.067
2.156SerPro: 2.156 ± 0.056
2.036SerGln: 2.036 ± 0.053
2.231SerArg: 2.231 ± 0.053
4.058SerSer: 4.058 ± 0.107
3.238SerThr: 3.238 ± 0.078
3.915SerVal: 3.915 ± 0.075
0.57SerTrp: 0.57 ± 0.03
2.2SerTyr: 2.2 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
3.932ThrAla: 3.932 ± 0.068
0.414ThrCys: 0.414 ± 0.022
2.521ThrAsp: 2.521 ± 0.049
3.238ThrGlu: 3.238 ± 0.074
2.642ThrPhe: 2.642 ± 0.054
4.054ThrGly: 4.054 ± 0.075
1.009ThrHis: 1.009 ± 0.037
5.08ThrIle: 5.08 ± 0.069
3.588ThrLys: 3.588 ± 0.059
5.101ThrLeu: 5.101 ± 0.078
1.301ThrMet: 1.301 ± 0.038
2.661ThrAsn: 2.661 ± 0.059
2.253ThrPro: 2.253 ± 0.055
1.388ThrGln: 1.388 ± 0.039
1.797ThrArg: 1.797 ± 0.049
3.308ThrSer: 3.308 ± 0.067
2.86ThrThr: 2.86 ± 0.068
4.246ThrVal: 4.246 ± 0.079
0.54ThrTrp: 0.54 ± 0.028
2.006ThrTyr: 2.006 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
5.1ValAla: 5.1 ± 0.078
0.652ValCys: 0.652 ± 0.03
3.558ValAsp: 3.558 ± 0.069
4.693ValGlu: 4.693 ± 0.087
2.725ValPhe: 2.725 ± 0.072
4.659ValGly: 4.659 ± 0.08
1.465ValHis: 1.465 ± 0.04
6.005ValIle: 6.005 ± 0.082
4.765ValLys: 4.765 ± 0.079
6.668ValLeu: 6.668 ± 0.095
1.734ValMet: 1.734 ± 0.053
3.202ValAsn: 3.202 ± 0.068
2.582ValPro: 2.582 ± 0.062
2.648ValGln: 2.648 ± 0.056
2.569ValArg: 2.569 ± 0.056
4.527ValSer: 4.527 ± 0.08
3.991ValThr: 3.991 ± 0.078
4.792ValVal: 4.792 ± 0.079
0.601ValTrp: 0.601 ± 0.029
2.161ValTyr: 2.161 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.587TrpAla: 0.587 ± 0.025
0.099TrpCys: 0.099 ± 0.01
0.478TrpAsp: 0.478 ± 0.027
0.56TrpGlu: 0.56 ± 0.027
0.554TrpPhe: 0.554 ± 0.024
0.682TrpGly: 0.682 ± 0.034
0.219TrpHis: 0.219 ± 0.015
0.879TrpIle: 0.879 ± 0.032
0.813TrpLys: 0.813 ± 0.035
1.104TrpLeu: 1.104 ± 0.046
0.307TrpMet: 0.307 ± 0.018
0.576TrpAsn: 0.576 ± 0.029
0.27TrpPro: 0.27 ± 0.02
0.364TrpGln: 0.364 ± 0.023
0.387TrpArg: 0.387 ± 0.027
0.597TrpSer: 0.597 ± 0.028
0.464TrpThr: 0.464 ± 0.024
0.592TrpVal: 0.592 ± 0.027
0.147TrpTrp: 0.147 ± 0.015
0.327TrpTyr: 0.327 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.04TyrAla: 2.04 ± 0.056
0.395TyrCys: 0.395 ± 0.023
1.91TyrAsp: 1.91 ± 0.05
2.481TyrGlu: 2.481 ± 0.059
1.704TyrPhe: 1.704 ± 0.049
2.419TyrGly: 2.419 ± 0.061
0.963TyrHis: 0.963 ± 0.033
2.735TyrIle: 2.735 ± 0.059
2.13TyrLys: 2.13 ± 0.05
3.408TyrLeu: 3.408 ± 0.069
0.872TyrMet: 0.872 ± 0.039
1.454TyrAsn: 1.454 ± 0.044
1.338TyrPro: 1.338 ± 0.037
1.612TyrGln: 1.612 ± 0.052
1.56TyrArg: 1.56 ± 0.044
2.019TyrSer: 2.019 ± 0.057
1.822TyrThr: 1.822 ± 0.049
2.242TyrVal: 2.242 ± 0.044
0.364TyrTrp: 0.364 ± 0.02
1.376TyrTyr: 1.376 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2914 proteins (806891 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski