Amino acid dipepetide frequency for Marinobacter sp. Z-F4-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.448AlaAla: 9.448 ± 0.149
0.988AlaCys: 0.988 ± 0.039
5.3AlaAsp: 5.3 ± 0.096
6.663AlaGlu: 6.663 ± 0.124
3.723AlaPhe: 3.723 ± 0.085
7.644AlaGly: 7.644 ± 0.124
1.823AlaHis: 1.823 ± 0.052
5.25AlaIle: 5.25 ± 0.113
3.628AlaLys: 3.628 ± 0.09
10.777AlaLeu: 10.777 ± 0.169
2.842AlaMet: 2.842 ± 0.067
3.149AlaAsn: 3.149 ± 0.067
3.609AlaPro: 3.609 ± 0.09
3.405AlaGln: 3.405 ± 0.078
6.103AlaArg: 6.103 ± 0.112
5.838AlaSer: 5.838 ± 0.105
4.59AlaThr: 4.59 ± 0.082
6.677AlaVal: 6.677 ± 0.122
1.373AlaTrp: 1.373 ± 0.044
2.356AlaTyr: 2.356 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.778CysAla: 0.778 ± 0.033
0.148CysCys: 0.148 ± 0.019
0.588CysAsp: 0.588 ± 0.032
0.581CysGlu: 0.581 ± 0.032
0.425CysPhe: 0.425 ± 0.025
0.854CysGly: 0.854 ± 0.039
0.294CysHis: 0.294 ± 0.023
0.472CysIle: 0.472 ± 0.028
0.344CysLys: 0.344 ± 0.023
0.965CysLeu: 0.965 ± 0.038
0.207CysMet: 0.207 ± 0.017
0.311CysAsn: 0.311 ± 0.023
0.503CysPro: 0.503 ± 0.033
0.377CysGln: 0.377 ± 0.023
0.633CysArg: 0.633 ± 0.029
0.59CysSer: 0.59 ± 0.034
0.431CysThr: 0.431 ± 0.027
0.654CysVal: 0.654 ± 0.032
0.173CysTrp: 0.173 ± 0.016
0.277CysTyr: 0.277 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
5.027AspAla: 5.027 ± 0.088
0.548AspCys: 0.548 ± 0.031
3.493AspAsp: 3.493 ± 0.09
4.274AspGlu: 4.274 ± 0.098
2.445AspPhe: 2.445 ± 0.071
4.378AspGly: 4.378 ± 0.112
1.318AspHis: 1.318 ± 0.051
3.256AspIle: 3.256 ± 0.073
2.223AspLys: 2.223 ± 0.069
5.846AspLeu: 5.846 ± 0.098
1.438AspMet: 1.438 ± 0.045
1.946AspAsn: 1.946 ± 0.056
2.666AspPro: 2.666 ± 0.066
2.422AspGln: 2.422 ± 0.072
3.824AspArg: 3.824 ± 0.076
3.184AspSer: 3.184 ± 0.072
2.693AspThr: 2.693 ± 0.071
3.838AspVal: 3.838 ± 0.091
1.005AspTrp: 1.005 ± 0.041
1.981AspTyr: 1.981 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
6.957GluAla: 6.957 ± 0.126
0.507GluCys: 0.507 ± 0.029
3.592GluAsp: 3.592 ± 0.085
4.501GluGlu: 4.501 ± 0.108
2.377GluPhe: 2.377 ± 0.063
4.335GluGly: 4.335 ± 0.093
1.628GluHis: 1.628 ± 0.051
3.631GluIle: 3.631 ± 0.08
3.418GluLys: 3.418 ± 0.091
7.318GluLeu: 7.318 ± 0.121
1.541GluMet: 1.541 ± 0.049
2.444GluAsn: 2.444 ± 0.068
2.929GluPro: 2.929 ± 0.082
3.675GluGln: 3.675 ± 0.093
4.861GluArg: 4.861 ± 0.089
3.854GluSer: 3.854 ± 0.08
3.555GluThr: 3.555 ± 0.078
4.598GluVal: 4.598 ± 0.096
0.988GluTrp: 0.988 ± 0.038
1.626GluTyr: 1.626 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.465PheAla: 3.465 ± 0.089
0.47PheCys: 0.47 ± 0.027
2.679PheAsp: 2.679 ± 0.072
2.588PheGlu: 2.588 ± 0.067
1.823PhePhe: 1.823 ± 0.062
3.167PheGly: 3.167 ± 0.086
0.803PheHis: 0.803 ± 0.032
2.062PheIle: 2.062 ± 0.055
1.438PheLys: 1.438 ± 0.041
3.784PheLeu: 3.784 ± 0.088
0.925PheMet: 0.925 ± 0.044
1.46PheAsn: 1.46 ± 0.055
1.605PhePro: 1.605 ± 0.046
1.219PheGln: 1.219 ± 0.043
2.574PheArg: 2.574 ± 0.065
2.853PheSer: 2.853 ± 0.077
2.054PheThr: 2.054 ± 0.059
2.727PheVal: 2.727 ± 0.072
0.601PheTrp: 0.601 ± 0.033
1.156PheTyr: 1.156 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
6.154GlyAla: 6.154 ± 0.101
0.83GlyCys: 0.83 ± 0.039
4.269GlyAsp: 4.269 ± 0.096
4.912GlyGlu: 4.912 ± 0.09
3.432GlyPhe: 3.432 ± 0.081
5.427GlyGly: 5.427 ± 0.132
1.916GlyHis: 1.916 ± 0.047
4.414GlyIle: 4.414 ± 0.092
3.477GlyLys: 3.477 ± 0.086
8.053GlyLeu: 8.053 ± 0.138
2.31GlyMet: 2.31 ± 0.07
2.487GlyAsn: 2.487 ± 0.075
2.377GlyPro: 2.377 ± 0.055
3.139GlyGln: 3.139 ± 0.072
4.553GlyArg: 4.553 ± 0.084
4.451GlySer: 4.451 ± 0.1
3.729GlyThr: 3.729 ± 0.082
5.552GlyVal: 5.552 ± 0.091
1.27GlyTrp: 1.27 ± 0.041
2.475GlyTyr: 2.475 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.798HisAla: 1.798 ± 0.054
0.316HisCys: 0.316 ± 0.022
1.183HisAsp: 1.183 ± 0.046
1.292HisGlu: 1.292 ± 0.044
0.948HisPhe: 0.948 ± 0.042
1.829HisGly: 1.829 ± 0.057
0.658HisHis: 0.658 ± 0.038
1.114HisIle: 1.114 ± 0.047
0.788HisLys: 0.788 ± 0.04
2.182HisLeu: 2.182 ± 0.055
0.448HisMet: 0.448 ± 0.026
0.654HisAsn: 0.654 ± 0.032
1.365HisPro: 1.365 ± 0.047
1.002HisGln: 1.002 ± 0.039
1.528HisArg: 1.528 ± 0.05
1.374HisSer: 1.374 ± 0.044
1.044HisThr: 1.044 ± 0.039
1.276HisVal: 1.276 ± 0.039
0.403HisTrp: 0.403 ± 0.028
0.767HisTyr: 0.767 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.367IleAla: 5.367 ± 0.1
0.526IleCys: 0.526 ± 0.03
3.518IleAsp: 3.518 ± 0.07
3.88IleGlu: 3.88 ± 0.087
1.704IlePhe: 1.704 ± 0.063
4.352IleGly: 4.352 ± 0.087
1.124IleHis: 1.124 ± 0.043
2.581IleIle: 2.581 ± 0.076
2.109IleLys: 2.109 ± 0.057
4.747IleLeu: 4.747 ± 0.098
1.057IleMet: 1.057 ± 0.048
2.056IleAsn: 2.056 ± 0.055
2.467IlePro: 2.467 ± 0.064
1.896IleGln: 1.896 ± 0.061
3.678IleArg: 3.678 ± 0.074
3.381IleSer: 3.381 ± 0.075
2.965IleThr: 2.965 ± 0.073
3.583IleVal: 3.583 ± 0.077
0.585IleTrp: 0.585 ± 0.034
1.402IleTyr: 1.402 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.479LysAla: 4.479 ± 0.104
0.261LysCys: 0.261 ± 0.017
2.223LysAsp: 2.223 ± 0.058
2.523LysGlu: 2.523 ± 0.079
1.118LysPhe: 1.118 ± 0.037
2.84LysGly: 2.84 ± 0.078
0.934LysHis: 0.934 ± 0.043
1.988LysIle: 1.988 ± 0.075
2.087LysLys: 2.087 ± 0.069
4.171LysLeu: 4.171 ± 0.088
0.876LysMet: 0.876 ± 0.038
1.416LysAsn: 1.416 ± 0.052
2.171LysPro: 2.171 ± 0.057
1.829LysGln: 1.829 ± 0.054
2.778LysArg: 2.778 ± 0.077
2.448LysSer: 2.448 ± 0.072
2.423LysThr: 2.423 ± 0.07
2.923LysVal: 2.923 ± 0.071
0.442LysTrp: 0.442 ± 0.029
0.889LysTyr: 0.889 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
11.247LeuAla: 11.247 ± 0.176
1.047LeuCys: 1.047 ± 0.035
6.056LeuAsp: 6.056 ± 0.108
7.315LeuGlu: 7.315 ± 0.114
4.062LeuPhe: 4.062 ± 0.108
7.721LeuGly: 7.721 ± 0.127
1.919LeuHis: 1.919 ± 0.057
5.429LeuIle: 5.429 ± 0.102
4.865LeuLys: 4.865 ± 0.094
10.554LeuLeu: 10.554 ± 0.168
2.585LeuMet: 2.585 ± 0.074
3.623LeuAsn: 3.623 ± 0.071
5.251LeuPro: 5.251 ± 0.091
3.751LeuGln: 3.751 ± 0.085
6.5LeuArg: 6.5 ± 0.107
7.097LeuSer: 7.097 ± 0.114
5.44LeuThr: 5.44 ± 0.106
7.455LeuVal: 7.455 ± 0.115
1.161LeuTrp: 1.161 ± 0.043
2.501LeuTyr: 2.501 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.741MetAla: 2.741 ± 0.066
0.176MetCys: 0.176 ± 0.017
1.278MetAsp: 1.278 ± 0.044
1.432MetGlu: 1.432 ± 0.046
0.828MetPhe: 0.828 ± 0.037
1.877MetGly: 1.877 ± 0.058
0.478MetHis: 0.478 ± 0.025
1.339MetIle: 1.339 ± 0.049
1.149MetLys: 1.149 ± 0.044
2.461MetLeu: 2.461 ± 0.059
0.713MetMet: 0.713 ± 0.042
1.007MetAsn: 1.007 ± 0.043
1.228MetPro: 1.228 ± 0.044
0.882MetGln: 0.882 ± 0.042
1.423MetArg: 1.423 ± 0.048
1.753MetSer: 1.753 ± 0.054
1.563MetThr: 1.563 ± 0.057
1.809MetVal: 1.809 ± 0.06
0.198MetTrp: 0.198 ± 0.02
0.423MetTyr: 0.423 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.09AsnAla: 3.09 ± 0.075
0.316AsnCys: 0.316 ± 0.023
1.762AsnAsp: 1.762 ± 0.049
2.061AsnGlu: 2.061 ± 0.054
1.206AsnPhe: 1.206 ± 0.046
2.713AsnGly: 2.713 ± 0.077
0.812AsnHis: 0.812 ± 0.032
1.79AsnIle: 1.79 ± 0.05
1.259AsnLys: 1.259 ± 0.05
3.749AsnLeu: 3.749 ± 0.077
0.758AsnMet: 0.758 ± 0.041
1.192AsnAsn: 1.192 ± 0.055
1.984AsnPro: 1.984 ± 0.053
1.471AsnGln: 1.471 ± 0.048
2.44AsnArg: 2.44 ± 0.058
1.952AsnSer: 1.952 ± 0.058
1.681AsnThr: 1.681 ± 0.052
2.149AsnVal: 2.149 ± 0.058
0.539AsnTrp: 0.539 ± 0.029
1.023AsnTyr: 1.023 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
4.229ProAla: 4.229 ± 0.09
0.322ProCys: 0.322 ± 0.023
3.476ProAsp: 3.476 ± 0.079
4.56ProGlu: 4.56 ± 0.105
1.787ProPhe: 1.787 ± 0.06
3.651ProGly: 3.651 ± 0.087
0.811ProHis: 0.811 ± 0.035
2.053ProIle: 2.053 ± 0.053
1.58ProLys: 1.58 ± 0.06
4.347ProLeu: 4.347 ± 0.094
1.047ProMet: 1.047 ± 0.041
1.405ProAsn: 1.405 ± 0.048
1.709ProPro: 1.709 ± 0.057
1.472ProGln: 1.472 ± 0.049
2.269ProArg: 2.269 ± 0.062
2.537ProSer: 2.537 ± 0.07
2.115ProThr: 2.115 ± 0.056
3.869ProVal: 3.869 ± 0.072
0.71ProTrp: 0.71 ± 0.034
1.156ProTyr: 1.156 ± 0.04
0.002ProXaa: 0.002 ± 0.002
Gln
4.392GlnAla: 4.392 ± 0.094
0.311GlnCys: 0.311 ± 0.023
1.824GlnAsp: 1.824 ± 0.045
2.454GlnGlu: 2.454 ± 0.069
1.365GlnPhe: 1.365 ± 0.047
2.831GlnGly: 2.831 ± 0.067
0.911GlnHis: 0.911 ± 0.041
2.005GlnIle: 2.005 ± 0.062
1.619GlnLys: 1.619 ± 0.056
4.423GlnLeu: 4.423 ± 0.097
0.999GlnMet: 0.999 ± 0.043
1.261GlnAsn: 1.261 ± 0.042
1.833GlnPro: 1.833 ± 0.063
2.145GlnGln: 2.145 ± 0.079
2.851GlnArg: 2.851 ± 0.075
2.44GlnSer: 2.44 ± 0.057
2.008GlnThr: 2.008 ± 0.06
2.772GlnVal: 2.772 ± 0.064
0.697GlnTrp: 0.697 ± 0.029
1.032GlnTyr: 1.032 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
5.356ArgAla: 5.356 ± 0.102
0.571ArgCys: 0.571 ± 0.032
3.623ArgAsp: 3.623 ± 0.09
4.805ArgGlu: 4.805 ± 0.093
2.965ArgPhe: 2.965 ± 0.074
3.684ArgGly: 3.684 ± 0.08
1.519ArgHis: 1.519 ± 0.052
3.678ArgIle: 3.678 ± 0.079
3.054ArgLys: 3.054 ± 0.064
7.415ArgLeu: 7.415 ± 0.128
1.634ArgMet: 1.634 ± 0.049
2.279ArgAsn: 2.279 ± 0.055
2.63ArgPro: 2.63 ± 0.066
3.088ArgGln: 3.088 ± 0.086
4.254ArgArg: 4.254 ± 0.092
3.709ArgSer: 3.709 ± 0.082
2.867ArgThr: 2.867 ± 0.057
4.431ArgVal: 4.431 ± 0.092
1.032ArgTrp: 1.032 ± 0.048
2.174ArgTyr: 2.174 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
5.574SerAla: 5.574 ± 0.108
0.542SerCys: 0.542 ± 0.028
3.791SerAsp: 3.791 ± 0.089
4.181SerGlu: 4.181 ± 0.088
2.454SerPhe: 2.454 ± 0.067
5.608SerGly: 5.608 ± 0.105
1.486SerHis: 1.486 ± 0.047
3.122SerIle: 3.122 ± 0.079
2.319SerLys: 2.319 ± 0.062
6.616SerLeu: 6.616 ± 0.117
1.488SerMet: 1.488 ± 0.054
1.936SerAsn: 1.936 ± 0.054
2.764SerPro: 2.764 ± 0.071
2.316SerGln: 2.316 ± 0.063
3.815SerArg: 3.815 ± 0.094
3.838SerSer: 3.838 ± 0.084
2.876SerThr: 2.876 ± 0.061
4.366SerVal: 4.366 ± 0.082
0.878SerTrp: 0.878 ± 0.04
1.591SerTyr: 1.591 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
4.749ThrAla: 4.749 ± 0.078
0.509ThrCys: 0.509 ± 0.029
2.836ThrAsp: 2.836 ± 0.067
3.158ThrGlu: 3.158 ± 0.072
1.947ThrPhe: 1.947 ± 0.058
4.551ThrGly: 4.551 ± 0.085
1.091ThrHis: 1.091 ± 0.045
2.59ThrIle: 2.59 ± 0.071
1.486ThrLys: 1.486 ± 0.056
5.96ThrLeu: 5.96 ± 0.12
1.08ThrMet: 1.08 ± 0.045
1.546ThrAsn: 1.546 ± 0.051
2.8ThrPro: 2.8 ± 0.07
1.659ThrGln: 1.659 ± 0.058
3.211ThrArg: 3.211 ± 0.072
3.029ThrSer: 3.029 ± 0.066
2.579ThrThr: 2.579 ± 0.068
3.908ThrVal: 3.908 ± 0.082
0.686ThrTrp: 0.686 ± 0.035
1.265ThrTyr: 1.265 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
7.024ValAla: 7.024 ± 0.117
0.747ValCys: 0.747 ± 0.034
4.054ValAsp: 4.054 ± 0.09
4.685ValGlu: 4.685 ± 0.083
2.996ValPhe: 2.996 ± 0.078
4.767ValGly: 4.767 ± 0.097
1.376ValHis: 1.376 ± 0.048
4.218ValIle: 4.218 ± 0.09
2.581ValLys: 2.581 ± 0.071
7.318ValLeu: 7.318 ± 0.124
1.894ValMet: 1.894 ± 0.058
2.437ValAsn: 2.437 ± 0.062
3.248ValPro: 3.248 ± 0.064
2.255ValGln: 2.255 ± 0.066
4.286ValArg: 4.286 ± 0.098
4.685ValSer: 4.685 ± 0.086
4.084ValThr: 4.084 ± 0.074
5.553ValVal: 5.553 ± 0.097
0.873ValTrp: 0.873 ± 0.037
1.731ValTyr: 1.731 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
1.099TrpAla: 1.099 ± 0.046
0.162TrpCys: 0.162 ± 0.015
0.674TrpAsp: 0.674 ± 0.035
0.758TrpGlu: 0.758 ± 0.033
0.691TrpPhe: 0.691 ± 0.033
0.802TrpGly: 0.802 ± 0.036
0.439TrpHis: 0.439 ± 0.029
0.736TrpIle: 0.736 ± 0.038
0.511TrpLys: 0.511 ± 0.027
1.978TrpLeu: 1.978 ± 0.058
0.42TrpMet: 0.42 ± 0.026
0.444TrpAsn: 0.444 ± 0.025
0.644TrpPro: 0.644 ± 0.035
0.868TrpGln: 0.868 ± 0.045
1.018TrpArg: 1.018 ± 0.043
0.856TrpSer: 0.856 ± 0.035
0.591TrpThr: 0.591 ± 0.034
1.002TrpVal: 1.002 ± 0.039
0.224TrpTrp: 0.224 ± 0.017
0.349TrpTyr: 0.349 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.213TyrAla: 2.213 ± 0.057
0.307TyrCys: 0.307 ± 0.021
1.588TyrAsp: 1.588 ± 0.054
1.712TyrGlu: 1.712 ± 0.052
1.156TyrPhe: 1.156 ± 0.05
2.195TyrGly: 2.195 ± 0.063
0.63TyrHis: 0.63 ± 0.034
1.25TyrIle: 1.25 ± 0.048
0.887TyrLys: 0.887 ± 0.042
2.917TyrLeu: 2.917 ± 0.069
0.49TyrMet: 0.49 ± 0.025
0.895TyrAsn: 0.895 ± 0.04
1.323TyrPro: 1.323 ± 0.045
1.303TyrGln: 1.303 ± 0.053
2.168TyrArg: 2.168 ± 0.059
1.692TyrSer: 1.692 ± 0.052
1.351TyrThr: 1.351 ± 0.052
1.672TyrVal: 1.672 ± 0.05
0.428TyrTrp: 0.428 ± 0.027
0.825TyrTyr: 0.825 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.002
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.003
Statistics based on 2568 proteins (642497 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski