Amino acid dipepetide frequency for Candidatus Syntrophosphaera thermopropionivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.451AlaAla: 4.451 ± 0.113
0.681AlaCys: 0.681 ± 0.037
3.336AlaAsp: 3.336 ± 0.077
4.495AlaGlu: 4.495 ± 0.116
2.683AlaPhe: 2.683 ± 0.071
4.295AlaGly: 4.295 ± 0.116
1.158AlaHis: 1.158 ± 0.048
5.678AlaIle: 5.678 ± 0.113
4.02AlaLys: 4.02 ± 0.097
7.055AlaLeu: 7.055 ± 0.134
1.636AlaMet: 1.636 ± 0.064
3.074AlaAsn: 3.074 ± 0.087
2.094AlaPro: 2.094 ± 0.07
2.739AlaGln: 2.739 ± 0.075
2.767AlaArg: 2.767 ± 0.081
3.727AlaSer: 3.727 ± 0.094
3.282AlaThr: 3.282 ± 0.108
3.807AlaVal: 3.807 ± 0.091
0.648AlaTrp: 0.648 ± 0.039
2.609AlaTyr: 2.609 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.729CysAla: 0.729 ± 0.037
0.153CysCys: 0.153 ± 0.019
0.553CysAsp: 0.553 ± 0.033
0.584CysGlu: 0.584 ± 0.037
0.538CysPhe: 0.538 ± 0.037
0.923CysGly: 0.923 ± 0.061
0.244CysHis: 0.244 ± 0.02
0.763CysIle: 0.763 ± 0.042
0.507CysLys: 0.507 ± 0.035
0.891CysLeu: 0.891 ± 0.037
0.168CysMet: 0.168 ± 0.02
0.57CysAsn: 0.57 ± 0.037
0.631CysPro: 0.631 ± 0.044
0.372CysGln: 0.372 ± 0.028
0.435CysArg: 0.435 ± 0.031
0.79CysSer: 0.79 ± 0.04
0.534CysThr: 0.534 ± 0.034
0.637CysVal: 0.637 ± 0.042
0.126CysTrp: 0.126 ± 0.016
0.507CysTyr: 0.507 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
3.118AspAla: 3.118 ± 0.08
0.53AspCys: 0.53 ± 0.032
2.468AspAsp: 2.468 ± 0.068
3.646AspGlu: 3.646 ± 0.088
3.036AspPhe: 3.036 ± 0.079
3.017AspGly: 3.017 ± 0.093
0.715AspHis: 0.715 ± 0.037
5.001AspIle: 5.001 ± 0.094
3.612AspLys: 3.612 ± 0.104
5.554AspLeu: 5.554 ± 0.112
1.093AspMet: 1.093 ± 0.048
3.082AspAsn: 3.082 ± 0.086
2.39AspPro: 2.39 ± 0.067
1.295AspGln: 1.295 ± 0.057
1.968AspArg: 1.968 ± 0.072
3.303AspSer: 3.303 ± 0.08
2.519AspThr: 2.519 ± 0.071
2.556AspVal: 2.556 ± 0.076
0.751AspTrp: 0.751 ± 0.039
3.071AspTyr: 3.071 ± 0.086
0.0AspXaa: 0.0 ± 0.0
Glu
4.48GluAla: 4.48 ± 0.122
0.483GluCys: 0.483 ± 0.033
3.479GluAsp: 3.479 ± 0.095
5.754GluGlu: 5.754 ± 0.167
2.716GluPhe: 2.716 ± 0.076
3.77GluGly: 3.77 ± 0.096
1.293GluHis: 1.293 ± 0.047
5.723GluIle: 5.723 ± 0.119
5.128GluLys: 5.128 ± 0.131
7.388GluLeu: 7.388 ± 0.132
1.695GluMet: 1.695 ± 0.06
3.873GluAsn: 3.873 ± 0.098
2.369GluPro: 2.369 ± 0.067
2.668GluGln: 2.668 ± 0.082
2.575GluArg: 2.575 ± 0.084
3.193GluSer: 3.193 ± 0.075
3.248GluThr: 3.248 ± 0.084
3.856GluVal: 3.856 ± 0.09
0.622GluTrp: 0.622 ± 0.036
2.685GluTyr: 2.685 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
2.878PheAla: 2.878 ± 0.078
0.618PheCys: 0.618 ± 0.036
2.367PheAsp: 2.367 ± 0.066
2.38PheGlu: 2.38 ± 0.062
2.062PhePhe: 2.062 ± 0.073
2.681PheGly: 2.681 ± 0.076
0.893PheHis: 0.893 ± 0.045
3.58PheIle: 3.58 ± 0.085
2.187PheLys: 2.187 ± 0.071
4.186PheLeu: 4.186 ± 0.097
0.936PheMet: 0.936 ± 0.042
2.68PheAsn: 2.68 ± 0.09
2.142PhePro: 2.142 ± 0.059
1.631PheGln: 1.631 ± 0.057
1.751PheArg: 1.751 ± 0.068
3.406PheSer: 3.406 ± 0.103
2.561PheThr: 2.561 ± 0.075
2.306PheVal: 2.306 ± 0.072
0.585PheTrp: 0.585 ± 0.031
2.094PheTyr: 2.094 ± 0.071
0.0PheXaa: 0.0 ± 0.0
Gly
3.658GlyAla: 3.658 ± 0.101
0.769GlyCys: 0.769 ± 0.041
3.055GlyAsp: 3.055 ± 0.093
3.513GlyGlu: 3.513 ± 0.09
2.741GlyPhe: 2.741 ± 0.07
3.877GlyGly: 3.877 ± 0.102
1.095GlyHis: 1.095 ± 0.054
5.819GlyIle: 5.819 ± 0.109
4.714GlyLys: 4.714 ± 0.115
5.506GlyLeu: 5.506 ± 0.125
1.625GlyMet: 1.625 ± 0.061
3.519GlyAsn: 3.519 ± 0.107
1.642GlyPro: 1.642 ± 0.057
1.816GlyGln: 1.816 ± 0.062
2.298GlyArg: 2.298 ± 0.065
3.706GlySer: 3.706 ± 0.102
4.137GlyThr: 4.137 ± 0.157
3.591GlyVal: 3.591 ± 0.094
0.868GlyTrp: 0.868 ± 0.046
3.013GlyTyr: 3.013 ± 0.083
0.0GlyXaa: 0.0 ± 0.0
His
0.532HisAla: 0.532 ± 0.037
0.338HisCys: 0.338 ± 0.028
0.513HisAsp: 0.513 ± 0.033
0.555HisGlu: 0.555 ± 0.04
1.057HisPhe: 1.057 ± 0.041
0.824HisGly: 0.824 ± 0.043
0.532HisHis: 0.532 ± 0.037
1.964HisIle: 1.964 ± 0.063
1.278HisLys: 1.278 ± 0.05
2.088HisLeu: 2.088 ± 0.065
0.294HisMet: 0.294 ± 0.024
1.308HisAsn: 1.308 ± 0.053
1.373HisPro: 1.373 ± 0.054
0.872HisGln: 0.872 ± 0.035
0.891HisArg: 0.891 ± 0.045
1.497HisSer: 1.497 ± 0.056
1.02HisThr: 1.02 ± 0.047
0.265HisVal: 0.265 ± 0.022
0.24HisTrp: 0.24 ± 0.023
0.999HisTyr: 0.999 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
5.88IleAla: 5.88 ± 0.133
1.02IleCys: 1.02 ± 0.045
4.859IleAsp: 4.859 ± 0.105
5.153IleGlu: 5.153 ± 0.116
3.702IlePhe: 3.702 ± 0.091
4.917IleGly: 4.917 ± 0.107
1.503IleHis: 1.503 ± 0.051
7.24IleIle: 7.24 ± 0.154
5.107IleLys: 5.107 ± 0.117
8.096IleLeu: 8.096 ± 0.131
1.612IleMet: 1.612 ± 0.059
4.587IleAsn: 4.587 ± 0.1
4.623IlePro: 4.623 ± 0.096
2.99IleGln: 2.99 ± 0.072
3.505IleArg: 3.505 ± 0.091
6.004IleSer: 6.004 ± 0.114
4.789IleThr: 4.789 ± 0.112
4.755IleVal: 4.755 ± 0.102
0.889IleTrp: 0.889 ± 0.043
3.801IleTyr: 3.801 ± 0.102
0.0IleXaa: 0.0 ± 0.0
Lys
4.19LysAla: 4.19 ± 0.106
0.456LysCys: 0.456 ± 0.033
3.62LysAsp: 3.62 ± 0.106
5.237LysGlu: 5.237 ± 0.128
2.056LysPhe: 2.056 ± 0.064
3.511LysGly: 3.511 ± 0.098
1.022LysHis: 1.022 ± 0.05
5.445LysIle: 5.445 ± 0.118
4.776LysLys: 4.776 ± 0.133
6.053LysLeu: 6.053 ± 0.134
1.875LysMet: 1.875 ± 0.062
3.599LysAsn: 3.599 ± 0.1
2.434LysPro: 2.434 ± 0.073
2.237LysGln: 2.237 ± 0.087
2.552LysArg: 2.552 ± 0.078
3.469LysSer: 3.469 ± 0.095
3.358LysThr: 3.358 ± 0.073
4.196LysVal: 4.196 ± 0.106
0.557LysTrp: 0.557 ± 0.033
2.742LysTyr: 2.742 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
7.259LeuAla: 7.259 ± 0.149
1.196LeuCys: 1.196 ± 0.058
5.266LeuAsp: 5.266 ± 0.12
6.557LeuGlu: 6.557 ± 0.127
3.978LeuPhe: 3.978 ± 0.123
5.674LeuGly: 5.674 ± 0.131
1.909LeuHis: 1.909 ± 0.066
8.218LeuIle: 8.218 ± 0.14
6.995LeuLys: 6.995 ± 0.133
9.854LeuLeu: 9.854 ± 0.176
2.38LeuMet: 2.38 ± 0.071
5.994LeuAsn: 5.994 ± 0.114
4.739LeuPro: 4.739 ± 0.095
4.11LeuGln: 4.11 ± 0.104
4.173LeuArg: 4.173 ± 0.099
7.272LeuSer: 7.272 ± 0.139
5.535LeuThr: 5.535 ± 0.123
5.168LeuVal: 5.168 ± 0.117
1.017LeuTrp: 1.017 ± 0.05
3.961LeuTyr: 3.961 ± 0.108
0.0LeuXaa: 0.0 ± 0.0
Met
1.537MetAla: 1.537 ± 0.057
0.168MetCys: 0.168 ± 0.019
1.255MetAsp: 1.255 ± 0.045
1.779MetGlu: 1.779 ± 0.061
0.685MetPhe: 0.685 ± 0.034
1.446MetGly: 1.446 ± 0.053
0.429MetHis: 0.429 ± 0.031
1.812MetIle: 1.812 ± 0.063
1.861MetLys: 1.861 ± 0.062
2.245MetLeu: 2.245 ± 0.075
0.614MetMet: 0.614 ± 0.041
1.285MetAsn: 1.285 ± 0.046
1.049MetPro: 1.049 ± 0.043
1.066MetGln: 1.066 ± 0.049
0.959MetArg: 0.959 ± 0.052
1.28MetSer: 1.28 ± 0.049
1.041MetThr: 1.041 ± 0.045
1.398MetVal: 1.398 ± 0.054
0.139MetTrp: 0.139 ± 0.017
0.595MetTyr: 0.595 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.389AsnAla: 3.389 ± 0.088
0.601AsnCys: 0.601 ± 0.035
2.388AsnAsp: 2.388 ± 0.075
3.008AsnGlu: 3.008 ± 0.091
2.455AsnPhe: 2.455 ± 0.077
3.336AsnGly: 3.336 ± 0.116
0.997AsnHis: 0.997 ± 0.044
4.966AsnIle: 4.966 ± 0.112
3.027AsnLys: 3.027 ± 0.089
6.471AsnLeu: 6.471 ± 0.114
1.068AsnMet: 1.068 ± 0.047
3.275AsnAsn: 3.275 ± 0.112
3.648AsnPro: 3.648 ± 0.104
2.35AsnGln: 2.35 ± 0.073
2.268AsnArg: 2.268 ± 0.067
3.36AsnSer: 3.36 ± 0.11
2.775AsnThr: 2.775 ± 0.097
2.948AsnVal: 2.948 ± 0.098
0.845AsnTrp: 0.845 ± 0.046
2.962AsnTyr: 2.962 ± 0.101
0.0AsnXaa: 0.0 ± 0.0
Pro
2.91ProAla: 2.91 ± 0.084
0.37ProCys: 0.37 ± 0.027
2.998ProAsp: 2.998 ± 0.069
4.505ProGlu: 4.505 ± 0.085
2.018ProPhe: 2.018 ± 0.067
2.729ProGly: 2.729 ± 0.075
0.847ProHis: 0.847 ± 0.037
3.189ProIle: 3.189 ± 0.072
1.997ProLys: 1.997 ± 0.075
4.154ProLeu: 4.154 ± 0.096
0.736ProMet: 0.736 ± 0.042
2.146ProAsn: 2.146 ± 0.073
1.823ProPro: 1.823 ± 0.066
1.964ProGln: 1.964 ± 0.066
1.386ProArg: 1.386 ± 0.046
2.847ProSer: 2.847 ± 0.079
2.207ProThr: 2.207 ± 0.083
3.244ProVal: 3.244 ± 0.09
0.532ProTrp: 0.532 ± 0.031
2.073ProTyr: 2.073 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
2.514GlnAla: 2.514 ± 0.068
0.341GlnCys: 0.341 ± 0.028
1.957GlnAsp: 1.957 ± 0.065
2.868GlnGlu: 2.868 ± 0.069
1.413GlnPhe: 1.413 ± 0.049
2.085GlnGly: 2.085 ± 0.07
0.671GlnHis: 0.671 ± 0.039
3.393GlnIle: 3.393 ± 0.087
2.912GlnLys: 2.912 ± 0.083
3.807GlnLeu: 3.807 ± 0.101
0.965GlnMet: 0.965 ± 0.048
2.321GlnAsn: 2.321 ± 0.07
1.457GlnPro: 1.457 ± 0.056
1.539GlnGln: 1.539 ± 0.071
1.602GlnArg: 1.602 ± 0.059
2.155GlnSer: 2.155 ± 0.067
1.995GlnThr: 1.995 ± 0.075
2.325GlnVal: 2.325 ± 0.067
0.408GlnTrp: 0.408 ± 0.03
1.724GlnTyr: 1.724 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
2.298ArgAla: 2.298 ± 0.069
0.425ArgCys: 0.425 ± 0.032
2.123ArgAsp: 2.123 ± 0.065
2.918ArgGlu: 2.918 ± 0.077
2.006ArgPhe: 2.006 ± 0.063
2.235ArgGly: 2.235 ± 0.067
0.668ArgHis: 0.668 ± 0.039
3.605ArgIle: 3.605 ± 0.075
2.948ArgLys: 2.948 ± 0.084
4.121ArgLeu: 4.121 ± 0.09
1.026ArgMet: 1.026 ± 0.043
2.191ArgAsn: 2.191 ± 0.076
1.339ArgPro: 1.339 ± 0.055
1.564ArgGln: 1.564 ± 0.053
1.743ArgArg: 1.743 ± 0.074
2.041ArgSer: 2.041 ± 0.066
1.978ArgThr: 1.978 ± 0.059
2.247ArgVal: 2.247 ± 0.069
0.513ArgTrp: 0.513 ± 0.035
1.97ArgTyr: 1.97 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
3.898SerAla: 3.898 ± 0.104
0.648SerCys: 0.648 ± 0.038
3.303SerAsp: 3.303 ± 0.085
3.976SerGlu: 3.976 ± 0.089
3.168SerPhe: 3.168 ± 0.081
4.709SerGly: 4.709 ± 0.125
1.171SerHis: 1.171 ± 0.048
4.947SerIle: 4.947 ± 0.11
3.069SerLys: 3.069 ± 0.076
6.828SerLeu: 6.828 ± 0.127
1.352SerMet: 1.352 ± 0.049
3.149SerAsn: 3.149 ± 0.102
2.794SerPro: 2.794 ± 0.075
2.348SerGln: 2.348 ± 0.068
2.371SerArg: 2.371 ± 0.068
4.449SerSer: 4.449 ± 0.105
3.456SerThr: 3.456 ± 0.099
3.605SerVal: 3.605 ± 0.094
0.891SerTrp: 0.891 ± 0.04
2.964SerTyr: 2.964 ± 0.086
0.0SerXaa: 0.0 ± 0.0
Thr
3.734ThrAla: 3.734 ± 0.1
0.561ThrCys: 0.561 ± 0.031
2.777ThrAsp: 2.777 ± 0.085
3.263ThrGlu: 3.263 ± 0.084
2.338ThrPhe: 2.338 ± 0.07
4.062ThrGly: 4.062 ± 0.111
1.043ThrHis: 1.043 ± 0.045
4.663ThrIle: 4.663 ± 0.132
2.559ThrLys: 2.559 ± 0.071
5.742ThrLeu: 5.742 ± 0.117
1.072ThrMet: 1.072 ± 0.044
2.722ThrAsn: 2.722 ± 0.102
2.807ThrPro: 2.807 ± 0.089
1.913ThrGln: 1.913 ± 0.068
1.957ThrArg: 1.957 ± 0.063
3.122ThrSer: 3.122 ± 0.098
3.191ThrThr: 3.191 ± 0.134
3.442ThrVal: 3.442 ± 0.092
0.654ThrTrp: 0.654 ± 0.045
2.178ThrTyr: 2.178 ± 0.086
0.0ThrXaa: 0.0 ± 0.0
Val
3.547ValAla: 3.547 ± 0.104
0.65ValCys: 0.65 ± 0.039
3.107ValAsp: 3.107 ± 0.093
3.347ValGlu: 3.347 ± 0.081
2.55ValPhe: 2.55 ± 0.063
3.406ValGly: 3.406 ± 0.1
0.95ValHis: 0.95 ± 0.045
4.766ValIle: 4.766 ± 0.091
3.431ValLys: 3.431 ± 0.079
5.412ValLeu: 5.412 ± 0.119
1.419ValMet: 1.419 ± 0.061
3.095ValAsn: 3.095 ± 0.094
2.619ValPro: 2.619 ± 0.073
2.197ValGln: 2.197 ± 0.072
2.315ValArg: 2.315 ± 0.071
3.877ValSer: 3.877 ± 0.101
3.114ValThr: 3.114 ± 0.1
3.507ValVal: 3.507 ± 0.096
0.627ValTrp: 0.627 ± 0.037
2.496ValTyr: 2.496 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.557TrpAla: 0.557 ± 0.039
0.113TrpCys: 0.113 ± 0.015
0.782TrpAsp: 0.782 ± 0.04
0.82TrpGlu: 0.82 ± 0.04
0.54TrpPhe: 0.54 ± 0.03
0.7TrpGly: 0.7 ± 0.035
0.282TrpHis: 0.282 ± 0.024
0.936TrpIle: 0.936 ± 0.042
0.795TrpLys: 0.795 ± 0.041
1.247TrpLeu: 1.247 ± 0.052
0.296TrpMet: 0.296 ± 0.026
0.852TrpAsn: 0.852 ± 0.048
0.187TrpPro: 0.187 ± 0.019
0.706TrpGln: 0.706 ± 0.038
0.425TrpArg: 0.425 ± 0.031
0.654TrpSer: 0.654 ± 0.039
0.584TrpThr: 0.584 ± 0.049
0.517TrpVal: 0.517 ± 0.032
0.151TrpTrp: 0.151 ± 0.021
0.496TrpTyr: 0.496 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.676TyrAla: 2.676 ± 0.08
0.534TyrCys: 0.534 ± 0.033
2.521TyrAsp: 2.521 ± 0.089
2.639TyrGlu: 2.639 ± 0.076
2.184TyrPhe: 2.184 ± 0.077
2.763TyrGly: 2.763 ± 0.08
1.018TyrHis: 1.018 ± 0.043
3.324TyrIle: 3.324 ± 0.084
2.458TyrLys: 2.458 ± 0.075
4.556TyrLeu: 4.556 ± 0.116
0.78TyrMet: 0.78 ± 0.041
2.813TyrAsn: 2.813 ± 0.091
2.516TyrPro: 2.516 ± 0.072
2.077TyrGln: 2.077 ± 0.077
2.018TyrArg: 2.018 ± 0.059
2.945TyrSer: 2.945 ± 0.08
2.477TyrThr: 2.477 ± 0.1
2.065TyrVal: 2.065 ± 0.068
0.576TyrTrp: 0.576 ± 0.037
2.622TyrTyr: 2.622 ± 0.095
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1369 proteins (524344 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski