Amino acid dipepetide frequency for Antarctobacter heliothermus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.927AlaAla: 15.927 ± 0.156	1.17AlaCys: 1.17 ± 0.031	7.056AlaAsp: 7.056 ± 0.079	7.87AlaGlu: 7.87 ± 0.083	4.201AlaPhe: 4.201 ± 0.064	10.282AlaGly: 10.282 ± 0.103	2.389AlaHis: 2.389 ± 0.039	5.579AlaIle: 5.579 ± 0.073	3.629AlaLys: 3.629 ± 0.056	14.044AlaLeu: 14.044 ± 0.131	3.656AlaMet: 3.656 ± 0.05	2.55AlaAsn: 2.55 ± 0.042	5.894AlaPro: 5.894 ± 0.085	4.604AlaGln: 4.604 ± 0.06	8.849AlaArg: 8.849 ± 0.098	5.38AlaSer: 5.38 ± 0.075	5.98AlaThr: 5.98 ± 0.073	8.508AlaVal: 8.508 ± 0.094	1.421AlaTrp: 1.421 ± 0.034	2.473AlaTyr: 2.473 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.143CysAla: 1.143 ± 0.028	0.118CysCys: 0.118 ± 0.01	0.706CysAsp: 0.706 ± 0.022	0.433CysGlu: 0.433 ± 0.017	0.373CysPhe: 0.373 ± 0.015	1.0CysGly: 1.0 ± 0.027	0.292CysHis: 0.292 ± 0.015	0.435CysIle: 0.435 ± 0.015	0.218CysLys: 0.218 ± 0.012	0.949CysLeu: 0.949 ± 0.028	0.193CysMet: 0.193 ± 0.012	0.236CysAsn: 0.236 ± 0.012	0.538CysPro: 0.538 ± 0.02	0.248CysGln: 0.248 ± 0.012	0.588CysArg: 0.588 ± 0.019	0.453CysSer: 0.453 ± 0.018	0.476CysThr: 0.476 ± 0.018	0.683CysVal: 0.683 ± 0.024	0.128CysTrp: 0.128 ± 0.008	0.227CysTyr: 0.227 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.474AspAla: 7.474 ± 0.084	0.567AspCys: 0.567 ± 0.021	3.61AspAsp: 3.61 ± 0.074	3.344AspGlu: 3.344 ± 0.055	2.312AspPhe: 2.312 ± 0.041	6.113AspGly: 6.113 ± 0.139	1.413AspHis: 1.413 ± 0.037	3.056AspIle: 3.056 ± 0.047	1.81AspLys: 1.81 ± 0.039	6.822AspLeu: 6.822 ± 0.082	1.809AspMet: 1.809 ± 0.036	1.395AspAsn: 1.395 ± 0.033	3.929AspPro: 3.929 ± 0.072	1.82AspGln: 1.82 ± 0.038	4.513AspArg: 4.513 ± 0.059	2.533AspSer: 2.533 ± 0.05	3.475AspThr: 3.475 ± 0.07	4.499AspVal: 4.499 ± 0.061	1.268AspTrp: 1.268 ± 0.031	1.586AspTyr: 1.586 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.659GluAla: 7.659 ± 0.087	0.355GluCys: 0.355 ± 0.017	3.379GluAsp: 3.379 ± 0.068	3.162GluGlu: 3.162 ± 0.055	1.806GluPhe: 1.806 ± 0.036	4.691GluGly: 4.691 ± 0.063	1.099GluHis: 1.099 ± 0.029	3.5GluIle: 3.5 ± 0.053	1.915GluLys: 1.915 ± 0.038	4.716GluLeu: 4.716 ± 0.057	1.803GluMet: 1.803 ± 0.038	1.601GluAsn: 1.601 ± 0.029	2.417GluPro: 2.417 ± 0.039	1.925GluGln: 1.925 ± 0.038	3.929GluArg: 3.929 ± 0.055	2.12GluSer: 2.12 ± 0.039	3.836GluThr: 3.836 ± 0.054	4.302GluVal: 4.302 ± 0.057	0.675GluTrp: 0.675 ± 0.021	1.018GluTyr: 1.018 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.416PheAla: 4.416 ± 0.062	0.472PheCys: 0.472 ± 0.019	2.938PheAsp: 2.938 ± 0.048	2.161PheGlu: 2.161 ± 0.044	1.44PhePhe: 1.44 ± 0.038	3.68PheGly: 3.68 ± 0.056	0.715PheHis: 0.715 ± 0.022	1.533PheIle: 1.533 ± 0.036	0.843PheLys: 0.843 ± 0.026	3.399PheLeu: 3.399 ± 0.053	0.843PheMet: 0.843 ± 0.025	1.022PheAsn: 1.022 ± 0.029	1.569PhePro: 1.569 ± 0.032	1.055PheGln: 1.055 ± 0.027	2.204PheArg: 2.204 ± 0.032	2.092PheSer: 2.092 ± 0.035	2.043PheThr: 2.043 ± 0.045	2.844PheVal: 2.844 ± 0.045	0.576PheTrp: 0.576 ± 0.021	0.909PheTyr: 0.909 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.975GlyAla: 9.975 ± 0.107	0.906GlyCys: 0.906 ± 0.026	5.034GlyAsp: 5.034 ± 0.093	4.427GlyGlu: 4.427 ± 0.089	3.702GlyPhe: 3.702 ± 0.058	7.648GlyGly: 7.648 ± 0.107	1.975GlyHis: 1.975 ± 0.042	4.53GlyIle: 4.53 ± 0.06	2.994GlyLys: 2.994 ± 0.053	9.442GlyLeu: 9.442 ± 0.124	2.676GlyMet: 2.676 ± 0.041	2.217GlyAsn: 2.217 ± 0.055	3.918GlyPro: 3.918 ± 0.052	3.192GlyGln: 3.192 ± 0.046	5.651GlyArg: 5.651 ± 0.059	4.195GlySer: 4.195 ± 0.053	5.201GlyThr: 5.201 ± 0.08	6.496GlyVal: 6.496 ± 0.082	1.475GlyTrp: 1.475 ± 0.034	2.384GlyTyr: 2.384 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.33HisAla: 2.33 ± 0.041	0.286HisCys: 0.286 ± 0.016	1.313HisAsp: 1.313 ± 0.036	1.031HisGlu: 1.031 ± 0.026	0.819HisPhe: 0.819 ± 0.023	1.961HisGly: 1.961 ± 0.036	0.579HisHis: 0.579 ± 0.02	0.968HisIle: 0.968 ± 0.026	0.551HisLys: 0.551 ± 0.022	2.229HisLeu: 2.229 ± 0.041	0.543HisMet: 0.543 ± 0.019	0.462HisAsn: 0.462 ± 0.018	1.391HisPro: 1.391 ± 0.034	0.597HisGln: 0.597 ± 0.023	1.382HisArg: 1.382 ± 0.031	0.969HisSer: 0.969 ± 0.023	0.865HisThr: 0.865 ± 0.028	1.652HisVal: 1.652 ± 0.034	0.364HisTrp: 0.364 ± 0.013	0.512HisTyr: 0.512 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.778IleAla: 6.778 ± 0.068	0.611IleCys: 0.611 ± 0.02	3.599IleAsp: 3.599 ± 0.051	3.307IleGlu: 3.307 ± 0.052	1.739IlePhe: 1.739 ± 0.039	4.716IleGly: 4.716 ± 0.06	0.941IleHis: 0.941 ± 0.023	2.077IleIle: 2.077 ± 0.048	1.364IleLys: 1.364 ± 0.038	4.76IleLeu: 4.76 ± 0.057	1.074IleMet: 1.074 ± 0.028	1.358IleAsn: 1.358 ± 0.028	2.336IlePro: 2.336 ± 0.045	1.214IleGln: 1.214 ± 0.032	3.102IleArg: 3.102 ± 0.05	2.837IleSer: 2.837 ± 0.045	2.858IleThr: 2.858 ± 0.045	3.84IleVal: 3.84 ± 0.058	0.707IleTrp: 0.707 ± 0.022	1.121IleTyr: 1.121 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.794LysAla: 3.794 ± 0.064	0.172LysCys: 0.172 ± 0.009	1.714LysAsp: 1.714 ± 0.037	1.437LysGlu: 1.437 ± 0.039	0.854LysPhe: 0.854 ± 0.027	2.618LysGly: 2.618 ± 0.049	0.574LysHis: 0.574 ± 0.02	1.503LysIle: 1.503 ± 0.036	1.067LysLys: 1.067 ± 0.036	2.81LysLeu: 2.81 ± 0.048	0.85LysMet: 0.85 ± 0.026	0.752LysAsn: 0.752 ± 0.026	1.818LysPro: 1.818 ± 0.042	0.856LysGln: 0.856 ± 0.027	2.152LysArg: 2.152 ± 0.037	1.721LysSer: 1.721 ± 0.038	1.92LysThr: 1.92 ± 0.039	2.188LysVal: 2.188 ± 0.042	0.404LysTrp: 0.404 ± 0.015	0.601LysTyr: 0.601 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	12.469LeuAla: 12.469 ± 0.136	1.053LeuCys: 1.053 ± 0.024	6.442LeuAsp: 6.442 ± 0.094	5.156LeuGlu: 5.156 ± 0.061	3.545LeuPhe: 3.545 ± 0.065	8.539LeuGly: 8.539 ± 0.092	1.965LeuHis: 1.965 ± 0.038	5.168LeuIle: 5.168 ± 0.069	3.038LeuLys: 3.038 ± 0.048	9.076LeuLeu: 9.076 ± 0.106	2.803LeuMet: 2.803 ± 0.048	2.789LeuAsn: 2.789 ± 0.042	5.795LeuPro: 5.795 ± 0.07	2.757LeuGln: 2.757 ± 0.038	7.234LeuArg: 7.234 ± 0.078	6.67LeuSer: 6.67 ± 0.086	6.44LeuThr: 6.44 ± 0.083	6.968LeuVal: 6.968 ± 0.085	1.367LeuTrp: 1.367 ± 0.035	2.003LeuTyr: 2.003 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.477MetAla: 3.477 ± 0.048	0.18MetCys: 0.18 ± 0.01	1.549MetAsp: 1.549 ± 0.034	1.272MetGlu: 1.272 ± 0.036	0.819MetPhe: 0.819 ± 0.026	2.289MetGly: 2.289 ± 0.053	0.453MetHis: 0.453 ± 0.018	1.564MetIle: 1.564 ± 0.032	1.015MetLys: 1.015 ± 0.025	2.603MetLeu: 2.603 ± 0.043	0.823MetMet: 0.823 ± 0.026	0.806MetAsn: 0.806 ± 0.025	1.571MetPro: 1.571 ± 0.035	0.98MetGln: 0.98 ± 0.027	1.914MetArg: 1.914 ± 0.04	1.806MetSer: 1.806 ± 0.033	2.223MetThr: 2.223 ± 0.037	1.969MetVal: 1.969 ± 0.04	0.236MetTrp: 0.236 ± 0.012	0.357MetTyr: 0.357 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.198AsnAla: 3.198 ± 0.047	0.261AsnCys: 0.261 ± 0.013	1.49AsnAsp: 1.49 ± 0.047	1.122AsnGlu: 1.122 ± 0.028	0.905AsnPhe: 0.905 ± 0.025	2.495AsnGly: 2.495 ± 0.044	0.538AsnHis: 0.538 ± 0.02	1.294AsnIle: 1.294 ± 0.028	0.631AsnLys: 0.631 ± 0.022	2.479AsnLeu: 2.479 ± 0.036	0.732AsnMet: 0.732 ± 0.022	0.689AsnAsn: 0.689 ± 0.021	1.763AsnPro: 1.763 ± 0.034	0.676AsnGln: 0.676 ± 0.021	1.711AsnArg: 1.711 ± 0.032	1.203AsnSer: 1.203 ± 0.033	1.385AsnThr: 1.385 ± 0.033	1.846AsnVal: 1.846 ± 0.033	0.455AsnTrp: 0.455 ± 0.022	0.628AsnTyr: 0.628 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	5.665ProAla: 5.665 ± 0.084	0.392ProCys: 0.392 ± 0.017	4.353ProAsp: 4.353 ± 0.067	4.067ProGlu: 4.067 ± 0.062	1.933ProPhe: 1.933 ± 0.034	4.669ProGly: 4.669 ± 0.057	1.083ProHis: 1.083 ± 0.028	2.285ProIle: 2.285 ± 0.036	1.66ProLys: 1.66 ± 0.033	4.755ProLeu: 4.755 ± 0.061	1.352ProMet: 1.352 ± 0.028	1.302ProAsn: 1.302 ± 0.032	2.409ProPro: 2.409 ± 0.052	1.819ProGln: 1.819 ± 0.036	2.983ProArg: 2.983 ± 0.049	2.472ProSer: 2.472 ± 0.047	2.582ProThr: 2.582 ± 0.054	4.407ProVal: 4.407 ± 0.06	0.683ProTrp: 0.683 ± 0.024	1.145ProTyr: 1.145 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.011GlnAla: 4.011 ± 0.066	0.231GlnCys: 0.231 ± 0.013	1.884GlnAsp: 1.884 ± 0.033	1.597GlnGlu: 1.597 ± 0.033	1.102GlnPhe: 1.102 ± 0.028	2.7GlnGly: 2.7 ± 0.042	0.59GlnHis: 0.59 ± 0.021	2.054GlnIle: 2.054 ± 0.038	0.977GlnLys: 0.977 ± 0.023	2.82GlnLeu: 2.82 ± 0.051	1.075GlnMet: 1.075 ± 0.025	0.876GlnAsn: 0.876 ± 0.022	1.586GlnPro: 1.586 ± 0.033	1.09GlnGln: 1.09 ± 0.026	2.181GlnArg: 2.181 ± 0.037	1.791GlnSer: 1.791 ± 0.032	1.924GlnThr: 1.924 ± 0.038	2.502GlnVal: 2.502 ± 0.041	0.38GlnTrp: 0.38 ± 0.016	0.583GlnTyr: 0.583 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	8.21ArgAla: 8.21 ± 0.083	0.533ArgCys: 0.533 ± 0.018	4.453ArgAsp: 4.453 ± 0.059	3.63ArgGlu: 3.63 ± 0.052	2.735ArgPhe: 2.735 ± 0.045	4.638ArgGly: 4.638 ± 0.058	1.604ArgHis: 1.604 ± 0.037	3.729ArgIle: 3.729 ± 0.053	2.208ArgLys: 2.208 ± 0.046	7.437ArgLeu: 7.437 ± 0.077	1.962ArgMet: 1.962 ± 0.037	1.778ArgAsn: 1.778 ± 0.036	3.315ArgPro: 3.315 ± 0.045	2.338ArgGln: 2.338 ± 0.043	4.895ArgArg: 4.895 ± 0.067	3.267ArgSer: 3.267 ± 0.047	3.151ArgThr: 3.151 ± 0.042	4.836ArgVal: 4.836 ± 0.061	0.948ArgTrp: 0.948 ± 0.027	1.554ArgTyr: 1.554 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.75SerAla: 5.75 ± 0.066	0.48SerCys: 0.48 ± 0.02	3.457SerAsp: 3.457 ± 0.052	2.726SerGlu: 2.726 ± 0.044	2.182SerPhe: 2.182 ± 0.043	5.535SerGly: 5.535 ± 0.069	1.094SerHis: 1.094 ± 0.028	2.461SerIle: 2.461 ± 0.048	1.462SerLys: 1.462 ± 0.031	5.005SerLeu: 5.005 ± 0.061	1.335SerMet: 1.335 ± 0.029	1.304SerAsn: 1.304 ± 0.03	2.586SerPro: 2.586 ± 0.046	1.498SerGln: 1.498 ± 0.032	3.21SerArg: 3.21 ± 0.05	2.494SerSer: 2.494 ± 0.041	2.591SerThr: 2.591 ± 0.046	3.894SerVal: 3.894 ± 0.058	0.696SerTrp: 0.696 ± 0.022	1.329SerTyr: 1.329 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.507ThrAla: 6.507 ± 0.075	0.559ThrCys: 0.559 ± 0.023	3.532ThrAsp: 3.532 ± 0.099	3.005ThrGlu: 3.005 ± 0.044	1.958ThrPhe: 1.958 ± 0.041	5.73ThrGly: 5.73 ± 0.077	1.167ThrHis: 1.167 ± 0.03	2.703ThrIle: 2.703 ± 0.052	1.403ThrLys: 1.403 ± 0.037	6.282ThrLeu: 6.282 ± 0.078	1.311ThrMet: 1.311 ± 0.029	1.329ThrAsn: 1.329 ± 0.03	3.624ThrPro: 3.624 ± 0.055	1.707ThrGln: 1.707 ± 0.03	3.777ThrArg: 3.777 ± 0.054	2.856ThrSer: 2.856 ± 0.05	2.902ThrThr: 2.902 ± 0.052	4.483ThrVal: 4.483 ± 0.077	0.708ThrTrp: 0.708 ± 0.022	1.293ThrTyr: 1.293 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.781ValAla: 8.781 ± 0.087	0.694ValCys: 0.694 ± 0.02	4.416ValAsp: 4.416 ± 0.076	4.302ValGlu: 4.302 ± 0.058	2.892ValPhe: 2.892 ± 0.045	5.555ValGly: 5.555 ± 0.079	1.391ValHis: 1.391 ± 0.029	4.237ValIle: 4.237 ± 0.045	2.024ValLys: 2.024 ± 0.045	7.792ValLeu: 7.792 ± 0.096	2.142ValMet: 2.142 ± 0.042	2.021ValAsn: 2.021 ± 0.038	3.762ValPro: 3.762 ± 0.061	2.251ValGln: 2.251 ± 0.043	4.329ValArg: 4.329 ± 0.057	4.27ValSer: 4.27 ± 0.053	5.002ValThr: 5.002 ± 0.072	5.815ValVal: 5.815 ± 0.088	1.021ValTrp: 1.021 ± 0.029	1.481ValTyr: 1.481 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.381TrpAla: 1.381 ± 0.036	0.153TrpCys: 0.153 ± 0.009	0.808TrpAsp: 0.808 ± 0.022	0.662TrpGlu: 0.662 ± 0.021	0.539TrpPhe: 0.539 ± 0.019	1.018TrpGly: 1.018 ± 0.028	0.379TrpHis: 0.379 ± 0.015	0.74TrpIle: 0.74 ± 0.023	0.424TrpLys: 0.424 ± 0.018	1.616TrpLeu: 1.616 ± 0.039	0.431TrpMet: 0.431 ± 0.018	0.409TrpAsn: 0.409 ± 0.016	0.727TrpPro: 0.727 ± 0.023	0.656TrpGln: 0.656 ± 0.023	1.132TrpArg: 1.132 ± 0.032	0.791TrpSer: 0.791 ± 0.025	0.838TrpThr: 0.838 ± 0.022	0.89TrpVal: 0.89 ± 0.027	0.211TrpTrp: 0.211 ± 0.012	0.285TrpTyr: 0.285 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.517TyrAla: 2.517 ± 0.038	0.245TyrCys: 0.245 ± 0.013	1.617TyrAsp: 1.617 ± 0.032	1.196TyrGlu: 1.196 ± 0.032	0.901TyrPhe: 0.901 ± 0.023	2.161TyrGly: 2.161 ± 0.036	0.565TyrHis: 0.565 ± 0.02	0.923TyrIle: 0.923 ± 0.025	0.573TyrLys: 0.573 ± 0.02	2.241TyrLeu: 2.241 ± 0.037	0.491TyrMet: 0.491 ± 0.017	0.603TyrAsn: 0.603 ± 0.019	1.068TyrPro: 1.068 ± 0.025	0.671TyrGln: 0.671 ± 0.02	1.487TyrArg: 1.487 ± 0.032	1.169TyrSer: 1.169 ± 0.031	1.143TyrThr: 1.143 ± 0.033	1.552TyrVal: 1.552 ± 0.034	0.369TyrTrp: 0.369 ± 0.016	0.556TyrTyr: 0.556 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4962 proteins (1553299 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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