Amino acid dipepetide frequency for Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.783AlaAla: 3.783 ± 0.19
0.715AlaCys: 0.715 ± 0.078
3.019AlaAsp: 3.019 ± 0.137
2.582AlaGlu: 2.582 ± 0.141
2.68AlaPhe: 2.68 ± 0.13
3.706AlaGly: 3.706 ± 0.177
1.463AlaHis: 1.463 ± 0.087
5.42AlaIle: 5.42 ± 0.2
3.996AlaLys: 3.996 ± 0.165
6.305AlaLeu: 6.305 ± 0.191
1.703AlaMet: 1.703 ± 0.101
3.09AlaAsn: 3.09 ± 0.144
2.14AlaPro: 2.14 ± 0.12
2.5AlaGln: 2.5 ± 0.16
1.872AlaArg: 1.872 ± 0.106
4.345AlaSer: 4.345 ± 0.193
3.504AlaThr: 3.504 ± 0.171
3.461AlaVal: 3.461 ± 0.16
0.415AlaTrp: 0.415 ± 0.056
1.965AlaTyr: 1.965 ± 0.115
0.0AlaXaa: 0.0 ± 0.0
Cys
0.611CysAla: 0.611 ± 0.065
0.207CysCys: 0.207 ± 0.039
0.688CysAsp: 0.688 ± 0.056
0.606CysGlu: 0.606 ± 0.055
0.508CysPhe: 0.508 ± 0.054
0.742CysGly: 0.742 ± 0.066
0.366CysHis: 0.366 ± 0.057
0.879CysIle: 0.879 ± 0.089
0.524CysLys: 0.524 ± 0.052
1.185CysLeu: 1.185 ± 0.077
0.257CysMet: 0.257 ± 0.038
0.6CysAsn: 0.6 ± 0.058
0.508CysPro: 0.508 ± 0.064
0.497CysGln: 0.497 ± 0.058
0.338CysArg: 0.338 ± 0.04
0.786CysSer: 0.786 ± 0.071
0.551CysThr: 0.551 ± 0.052
0.562CysVal: 0.562 ± 0.06
0.147CysTrp: 0.147 ± 0.028
0.393CysTyr: 0.393 ± 0.056
0.0CysXaa: 0.0 ± 0.0
Asp
4.127AspAla: 4.127 ± 0.155
0.557AspCys: 0.557 ± 0.066
4.056AspAsp: 4.056 ± 0.199
3.652AspGlu: 3.652 ± 0.159
2.304AspPhe: 2.304 ± 0.124
3.761AspGly: 3.761 ± 0.222
1.649AspHis: 1.649 ± 0.1
5.491AspIle: 5.491 ± 0.207
2.92AspLys: 2.92 ± 0.132
5.388AspLeu: 5.388 ± 0.18
1.365AspMet: 1.365 ± 0.084
2.713AspAsn: 2.713 ± 0.148
2.478AspPro: 2.478 ± 0.13
2.959AspGln: 2.959 ± 0.143
2.254AspArg: 2.254 ± 0.124
3.936AspSer: 3.936 ± 0.182
3.09AspThr: 3.09 ± 0.152
4.383AspVal: 4.383 ± 0.2
0.611AspTrp: 0.611 ± 0.068
2.271AspTyr: 2.271 ± 0.125
0.0AspXaa: 0.0 ± 0.0
Glu
3.292GluAla: 3.292 ± 0.156
0.562GluCys: 0.562 ± 0.057
2.718GluAsp: 2.718 ± 0.164
3.188GluGlu: 3.188 ± 0.207
2.626GluPhe: 2.626 ± 0.113
3.019GluGly: 3.019 ± 0.158
1.299GluHis: 1.299 ± 0.092
4.318GluIle: 4.318 ± 0.185
4.602GluLys: 4.602 ± 0.201
6.343GluLeu: 6.343 ± 0.249
1.381GluMet: 1.381 ± 0.095
2.986GluAsn: 2.986 ± 0.156
1.528GluPro: 1.528 ± 0.109
1.987GluGln: 1.987 ± 0.134
2.265GluArg: 2.265 ± 0.109
4.241GluSer: 4.241 ± 0.145
3.242GluThr: 3.242 ± 0.177
3.079GluVal: 3.079 ± 0.153
0.715GluTrp: 0.715 ± 0.064
1.643GluTyr: 1.643 ± 0.092
0.0GluXaa: 0.0 ± 0.0
Phe
1.965PheAla: 1.965 ± 0.125
0.535PheCys: 0.535 ± 0.052
3.232PheAsp: 3.232 ± 0.126
2.653PheGlu: 2.653 ± 0.117
2.227PhePhe: 2.227 ± 0.131
2.909PheGly: 2.909 ± 0.121
1.054PheHis: 1.054 ± 0.08
3.745PheIle: 3.745 ± 0.165
3.172PheLys: 3.172 ± 0.119
4.291PheLeu: 4.291 ± 0.173
0.961PheMet: 0.961 ± 0.07
3.515PheAsn: 3.515 ± 0.14
1.621PhePro: 1.621 ± 0.13
1.845PheGln: 1.845 ± 0.094
1.463PheArg: 1.463 ± 0.091
4.192PheSer: 4.192 ± 0.178
2.342PheThr: 2.342 ± 0.118
2.336PheVal: 2.336 ± 0.13
0.371PheTrp: 0.371 ± 0.048
1.539PheTyr: 1.539 ± 0.107
0.0PheXaa: 0.0 ± 0.0
Gly
4.291GlyAla: 4.291 ± 0.194
0.884GlyCys: 0.884 ± 0.088
3.728GlyAsp: 3.728 ± 0.214
3.035GlyGlu: 3.035 ± 0.136
3.079GlyPhe: 3.079 ± 0.146
4.411GlyGly: 4.411 ± 0.224
1.703GlyHis: 1.703 ± 0.116
5.502GlyIle: 5.502 ± 0.21
3.423GlyLys: 3.423 ± 0.141
5.781GlyLeu: 5.781 ± 0.193
1.528GlyMet: 1.528 ± 0.1
2.604GlyAsn: 2.604 ± 0.149
1.632GlyPro: 1.632 ± 0.106
2.44GlyGln: 2.44 ± 0.141
2.222GlyArg: 2.222 ± 0.145
3.827GlySer: 3.827 ± 0.203
3.657GlyThr: 3.657 ± 0.214
4.902GlyVal: 4.902 ± 0.215
0.715GlyTrp: 0.715 ± 0.073
2.211GlyTyr: 2.211 ± 0.116
0.0GlyXaa: 0.0 ± 0.0
His
1.545HisAla: 1.545 ± 0.118
0.366HisCys: 0.366 ± 0.051
1.408HisAsp: 1.408 ± 0.109
1.021HisGlu: 1.021 ± 0.083
1.255HisPhe: 1.255 ± 0.08
1.578HisGly: 1.578 ± 0.103
1.081HisHis: 1.081 ± 0.106
1.932HisIle: 1.932 ± 0.101
1.277HisLys: 1.277 ± 0.076
2.577HisLeu: 2.577 ± 0.114
0.606HisMet: 0.606 ± 0.054
1.07HisAsn: 1.07 ± 0.089
1.359HisPro: 1.359 ± 0.1
1.463HisGln: 1.463 ± 0.099
0.977HisArg: 0.977 ± 0.079
1.769HisSer: 1.769 ± 0.116
1.25HisThr: 1.25 ± 0.09
1.758HisVal: 1.758 ± 0.098
0.355HisTrp: 0.355 ± 0.049
0.933HisTyr: 0.933 ± 0.076
0.0HisXaa: 0.0 ± 0.0
Ile
4.574IleAla: 4.574 ± 0.197
1.021IleCys: 1.021 ± 0.085
5.3IleAsp: 5.3 ± 0.166
5.257IleGlu: 5.257 ± 0.18
3.101IlePhe: 3.101 ± 0.16
5.579IleGly: 5.579 ± 0.228
2.123IleHis: 2.123 ± 0.11
6.812IleIle: 6.812 ± 0.367
5.546IleLys: 5.546 ± 0.214
7.064IleLeu: 7.064 ± 0.257
1.719IleMet: 1.719 ± 0.101
4.88IleAsn: 4.88 ± 0.191
3.384IlePro: 3.384 ± 0.148
4.422IleGln: 4.422 ± 0.199
3.035IleArg: 3.035 ± 0.154
6.119IleSer: 6.119 ± 0.174
4.804IleThr: 4.804 ± 0.201
4.258IleVal: 4.258 ± 0.194
0.535IleTrp: 0.535 ± 0.057
2.418IleTyr: 2.418 ± 0.136
0.0IleXaa: 0.0 ± 0.0
Lys
3.854LysAla: 3.854 ± 0.204
0.497LysCys: 0.497 ± 0.044
3.919LysAsp: 3.919 ± 0.148
4.962LysGlu: 4.962 ± 0.221
2.052LysPhe: 2.052 ± 0.104
3.766LysGly: 3.766 ± 0.148
1.539LysHis: 1.539 ± 0.103
4.864LysIle: 4.864 ± 0.208
7.184LysLys: 7.184 ± 0.319
5.748LysLeu: 5.748 ± 0.253
1.692LysMet: 1.692 ± 0.098
4.323LysAsn: 4.323 ± 0.234
2.211LysPro: 2.211 ± 0.121
3.084LysGln: 3.084 ± 0.16
2.92LysArg: 2.92 ± 0.156
4.858LysSer: 4.858 ± 0.17
4.11LysThr: 4.11 ± 0.191
3.745LysVal: 3.745 ± 0.163
0.606LysTrp: 0.606 ± 0.055
2.156LysTyr: 2.156 ± 0.119
0.0LysXaa: 0.0 ± 0.0
Leu
5.366LeuAla: 5.366 ± 0.185
1.048LeuCys: 1.048 ± 0.067
6.163LeuAsp: 6.163 ± 0.17
4.842LeuGlu: 4.842 ± 0.165
5.044LeuPhe: 5.044 ± 0.202
5.486LeuGly: 5.486 ± 0.201
2.096LeuHis: 2.096 ± 0.105
7.544LeuIle: 7.544 ± 0.281
6.856LeuLys: 6.856 ± 0.25
9.214LeuLeu: 9.214 ± 0.309
2.729LeuMet: 2.729 ± 0.147
6.381LeuAsn: 6.381 ± 0.248
3.766LeuPro: 3.766 ± 0.175
3.155LeuGln: 3.155 ± 0.155
3.133LeuArg: 3.133 ± 0.128
8.723LeuSer: 8.723 ± 0.254
6.267LeuThr: 6.267 ± 0.176
5.508LeuVal: 5.508 ± 0.222
0.742LeuTrp: 0.742 ± 0.069
2.533LeuTyr: 2.533 ± 0.117
0.0LeuXaa: 0.0 ± 0.0
Met
1.943MetAla: 1.943 ± 0.123
0.273MetCys: 0.273 ± 0.039
1.605MetAsp: 1.605 ± 0.117
1.108MetGlu: 1.108 ± 0.083
0.868MetPhe: 0.868 ± 0.075
1.703MetGly: 1.703 ± 0.098
0.48MetHis: 0.48 ± 0.053
1.976MetIle: 1.976 ± 0.116
1.769MetLys: 1.769 ± 0.101
2.009MetLeu: 2.009 ± 0.111
0.71MetMet: 0.71 ± 0.056
1.419MetAsn: 1.419 ± 0.084
0.993MetPro: 0.993 ± 0.071
0.699MetGln: 0.699 ± 0.069
0.699MetArg: 0.699 ± 0.063
2.042MetSer: 2.042 ± 0.109
1.583MetThr: 1.583 ± 0.091
1.921MetVal: 1.921 ± 0.118
0.147MetTrp: 0.147 ± 0.029
0.666MetTyr: 0.666 ± 0.063
0.0MetXaa: 0.0 ± 0.0
Asn
3.417AsnAla: 3.417 ± 0.144
0.497AsnCys: 0.497 ± 0.05
3.772AsnAsp: 3.772 ± 0.149
3.575AsnGlu: 3.575 ± 0.173
1.987AsnPhe: 1.987 ± 0.122
3.461AsnGly: 3.461 ± 0.182
1.703AsnHis: 1.703 ± 0.112
4.825AsnIle: 4.825 ± 0.191
3.958AsnLys: 3.958 ± 0.179
4.203AsnLeu: 4.203 ± 0.144
1.255AsnMet: 1.255 ± 0.08
3.477AsnAsn: 3.477 ± 0.239
2.293AsnPro: 2.293 ± 0.101
3.292AsnGln: 3.292 ± 0.129
2.069AsnArg: 2.069 ± 0.106
3.586AsnSer: 3.586 ± 0.197
3.221AsnThr: 3.221 ± 0.201
3.45AsnVal: 3.45 ± 0.162
0.371AsnTrp: 0.371 ± 0.042
1.878AsnTyr: 1.878 ± 0.124
0.0AsnXaa: 0.0 ± 0.0
Pro
1.73ProAla: 1.73 ± 0.109
0.311ProCys: 0.311 ± 0.046
2.347ProAsp: 2.347 ± 0.143
2.451ProGlu: 2.451 ± 0.119
2.02ProPhe: 2.02 ± 0.101
2.14ProGly: 2.14 ± 0.107
0.862ProHis: 0.862 ± 0.079
3.193ProIle: 3.193 ± 0.151
2.708ProLys: 2.708 ± 0.125
3.668ProLeu: 3.668 ± 0.157
0.879ProMet: 0.879 ± 0.065
2.729ProAsn: 2.729 ± 0.123
1.305ProPro: 1.305 ± 0.098
1.447ProGln: 1.447 ± 0.091
1.064ProArg: 1.064 ± 0.088
3.161ProSer: 3.161 ± 0.192
2.495ProThr: 2.495 ± 0.141
2.385ProVal: 2.385 ± 0.147
0.246ProTrp: 0.246 ± 0.037
1.419ProTyr: 1.419 ± 0.095
0.0ProXaa: 0.0 ± 0.0
Gln
2.62GlnAla: 2.62 ± 0.19
0.524GlnCys: 0.524 ± 0.063
1.774GlnAsp: 1.774 ± 0.101
2.167GlnGlu: 2.167 ± 0.12
2.314GlnPhe: 2.314 ± 0.12
2.222GlnGly: 2.222 ± 0.129
1.174GlnHis: 1.174 ± 0.077
2.937GlnIle: 2.937 ± 0.148
3.051GlnLys: 3.051 ± 0.168
5.584GlnLeu: 5.584 ± 0.211
1.021GlnMet: 1.021 ± 0.071
1.905GlnAsn: 1.905 ± 0.125
1.85GlnPro: 1.85 ± 0.105
2.369GlnGln: 2.369 ± 0.192
1.512GlnArg: 1.512 ± 0.101
3.461GlnSer: 3.461 ± 0.146
2.718GlnThr: 2.718 ± 0.147
2.533GlnVal: 2.533 ± 0.153
0.464GlnTrp: 0.464 ± 0.054
1.414GlnTyr: 1.414 ± 0.102
0.0GlnXaa: 0.0 ± 0.0
Arg
2.014ArgAla: 2.014 ± 0.115
0.338ArgCys: 0.338 ± 0.047
1.676ArgAsp: 1.676 ± 0.1
1.878ArgGlu: 1.878 ± 0.137
1.976ArgPhe: 1.976 ± 0.117
1.834ArgGly: 1.834 ± 0.1
0.955ArgHis: 0.955 ± 0.07
2.773ArgIle: 2.773 ± 0.128
2.107ArgLys: 2.107 ± 0.13
4.154ArgLeu: 4.154 ± 0.176
0.819ArgMet: 0.819 ± 0.061
1.501ArgAsn: 1.501 ± 0.084
1.365ArgPro: 1.365 ± 0.082
1.725ArgGln: 1.725 ± 0.094
1.528ArgArg: 1.528 ± 0.106
2.642ArgSer: 2.642 ± 0.135
1.594ArgThr: 1.594 ± 0.09
2.211ArgVal: 2.211 ± 0.117
0.426ArgTrp: 0.426 ± 0.053
1.343ArgTyr: 1.343 ± 0.092
0.0ArgXaa: 0.0 ± 0.0
Ser
4.012SerAla: 4.012 ± 0.147
0.699SerCys: 0.699 ± 0.071
4.7SerAsp: 4.7 ± 0.228
3.696SerGlu: 3.696 ± 0.166
3.925SerPhe: 3.925 ± 0.166
4.989SerGly: 4.989 ± 0.19
1.812SerHis: 1.812 ± 0.125
6.665SerIle: 6.665 ± 0.221
5.06SerLys: 5.06 ± 0.192
7.391SerLeu: 7.391 ± 0.235
2.058SerMet: 2.058 ± 0.115
4.487SerAsn: 4.487 ± 0.213
3.253SerPro: 3.253 ± 0.18
3.062SerGln: 3.062 ± 0.138
2.304SerArg: 2.304 ± 0.106
6.25SerSer: 6.25 ± 0.315
4.536SerThr: 4.536 ± 0.177
4.82SerVal: 4.82 ± 0.202
0.535SerTrp: 0.535 ± 0.056
2.32SerTyr: 2.32 ± 0.11
0.0SerXaa: 0.0 ± 0.0
Thr
3.504ThrAla: 3.504 ± 0.176
0.6ThrCys: 0.6 ± 0.063
3.155ThrAsp: 3.155 ± 0.125
2.789ThrGlu: 2.789 ± 0.137
2.724ThrPhe: 2.724 ± 0.151
3.548ThrGly: 3.548 ± 0.142
1.687ThrHis: 1.687 ± 0.102
5.289ThrIle: 5.289 ± 0.196
3.892ThrLys: 3.892 ± 0.194
5.551ThrLeu: 5.551 ± 0.186
1.447ThrMet: 1.447 ± 0.088
3.237ThrAsn: 3.237 ± 0.16
2.871ThrPro: 2.871 ± 0.14
2.336ThrGln: 2.336 ± 0.115
1.665ThrArg: 1.665 ± 0.121
4.078ThrSer: 4.078 ± 0.19
3.674ThrThr: 3.674 ± 0.219
3.63ThrVal: 3.63 ± 0.163
0.508ThrTrp: 0.508 ± 0.061
2.151ThrTyr: 2.151 ± 0.131
0.0ThrXaa: 0.0 ± 0.0
Val
3.668ValAla: 3.668 ± 0.146
0.786ValCys: 0.786 ± 0.065
4.018ValAsp: 4.018 ± 0.152
3.242ValGlu: 3.242 ± 0.17
2.948ValPhe: 2.948 ± 0.126
4.001ValGly: 4.001 ± 0.23
1.452ValHis: 1.452 ± 0.086
4.995ValIle: 4.995 ± 0.201
3.597ValLys: 3.597 ± 0.146
5.759ValLeu: 5.759 ± 0.195
1.556ValMet: 1.556 ± 0.095
3.308ValAsn: 3.308 ± 0.144
2.32ValPro: 2.32 ± 0.148
2.358ValGln: 2.358 ± 0.118
1.78ValArg: 1.78 ± 0.127
5.584ValSer: 5.584 ± 0.213
3.75ValThr: 3.75 ± 0.167
4.039ValVal: 4.039 ± 0.21
0.486ValTrp: 0.486 ± 0.049
1.78ValTyr: 1.78 ± 0.098
0.0ValXaa: 0.0 ± 0.0
Trp
0.59TrpAla: 0.59 ± 0.058
0.109TrpCys: 0.109 ± 0.029
0.59TrpAsp: 0.59 ± 0.06
0.475TrpGlu: 0.475 ± 0.058
0.469TrpPhe: 0.469 ± 0.045
0.644TrpGly: 0.644 ± 0.064
0.251TrpHis: 0.251 ± 0.042
0.628TrpIle: 0.628 ± 0.057
0.459TrpLys: 0.459 ± 0.052
0.95TrpLeu: 0.95 ± 0.078
0.267TrpMet: 0.267 ± 0.037
0.388TrpAsn: 0.388 ± 0.042
0.311TrpPro: 0.311 ± 0.048
0.366TrpGln: 0.366 ± 0.039
0.393TrpArg: 0.393 ± 0.04
0.551TrpSer: 0.551 ± 0.047
0.404TrpThr: 0.404 ± 0.05
0.639TrpVal: 0.639 ± 0.067
0.136TrpTrp: 0.136 ± 0.026
0.262TrpTyr: 0.262 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.758TyrAla: 1.758 ± 0.107
0.426TyrCys: 0.426 ± 0.054
2.096TyrAsp: 2.096 ± 0.116
1.856TyrGlu: 1.856 ± 0.113
1.861TyrPhe: 1.861 ± 0.11
2.074TyrGly: 2.074 ± 0.109
0.83TyrHis: 0.83 ± 0.069
2.167TyrIle: 2.167 ± 0.133
1.992TyrLys: 1.992 ± 0.126
3.434TyrLeu: 3.434 ± 0.178
0.655TyrMet: 0.655 ± 0.065
1.676TyrAsn: 1.676 ± 0.105
1.37TyrPro: 1.37 ± 0.092
1.61TyrGln: 1.61 ± 0.094
1.365TyrArg: 1.365 ± 0.084
2.424TyrSer: 2.424 ± 0.157
1.545TyrThr: 1.545 ± 0.101
1.807TyrVal: 1.807 ± 0.103
0.349TyrTrp: 0.349 ± 0.047
1.168TyrTyr: 1.168 ± 0.096
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 504 proteins (183195 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski