Amino acid dipepetide frequency for Roseibacterium elongatum DSM 19469

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.356AlaAla: 18.356 ± 0.229	1.226AlaCys: 1.226 ± 0.038	7.702AlaAsp: 7.702 ± 0.096	9.164AlaGlu: 9.164 ± 0.103	4.368AlaPhe: 4.368 ± 0.069	11.405AlaGly: 11.405 ± 0.121	2.579AlaHis: 2.579 ± 0.059	6.031AlaIle: 6.031 ± 0.08	2.924AlaLys: 2.924 ± 0.078	14.417AlaLeu: 14.417 ± 0.16	4.148AlaMet: 4.148 ± 0.069	2.462AlaAsn: 2.462 ± 0.054	6.845AlaPro: 6.845 ± 0.113	4.606AlaGln: 4.606 ± 0.073	10.468AlaArg: 10.468 ± 0.133	5.201AlaSer: 5.201 ± 0.07	6.496AlaThr: 6.496 ± 0.083	8.511AlaVal: 8.511 ± 0.105	1.65AlaTrp: 1.65 ± 0.047	2.558AlaTyr: 2.558 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.172CysAla: 1.172 ± 0.037	0.103CysCys: 0.103 ± 0.009	0.641CysAsp: 0.641 ± 0.028	0.407CysGlu: 0.407 ± 0.021	0.32CysPhe: 0.32 ± 0.016	0.941CysGly: 0.941 ± 0.036	0.251CysHis: 0.251 ± 0.016	0.413CysIle: 0.413 ± 0.02	0.151CysLys: 0.151 ± 0.012	0.871CysLeu: 0.871 ± 0.029	0.163CysMet: 0.163 ± 0.014	0.207CysAsn: 0.207 ± 0.014	0.62CysPro: 0.62 ± 0.026	0.247CysGln: 0.247 ± 0.016	0.652CysArg: 0.652 ± 0.03	0.432CysSer: 0.432 ± 0.022	0.442CysThr: 0.442 ± 0.021	0.612CysVal: 0.612 ± 0.025	0.101CysTrp: 0.101 ± 0.01	0.212CysTyr: 0.212 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.058AspAla: 8.058 ± 0.091	0.512AspCys: 0.512 ± 0.023	3.778AspAsp: 3.778 ± 0.087	3.541AspGlu: 3.541 ± 0.062	2.217AspPhe: 2.217 ± 0.051	6.009AspGly: 6.009 ± 0.096	1.501AspHis: 1.501 ± 0.038	2.946AspIle: 2.946 ± 0.046	1.392AspLys: 1.392 ± 0.045	7.161AspLeu: 7.161 ± 0.091	1.826AspMet: 1.826 ± 0.045	1.086AspAsn: 1.086 ± 0.033	4.108AspPro: 4.108 ± 0.07	1.768AspGln: 1.768 ± 0.041	5.006AspArg: 5.006 ± 0.069	2.252AspSer: 2.252 ± 0.053	3.259AspThr: 3.259 ± 0.072	4.042AspVal: 4.042 ± 0.071	1.314AspTrp: 1.314 ± 0.032	1.488AspTyr: 1.488 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.892GluAla: 8.892 ± 0.109	0.304GluCys: 0.304 ± 0.017	3.566GluAsp: 3.566 ± 0.063	3.395GluGlu: 3.395 ± 0.08	1.655GluPhe: 1.655 ± 0.04	5.253GluGly: 5.253 ± 0.076	1.043GluHis: 1.043 ± 0.032	3.675GluIle: 3.675 ± 0.065	1.646GluLys: 1.646 ± 0.047	4.452GluLeu: 4.452 ± 0.065	1.924GluMet: 1.924 ± 0.05	1.548GluAsn: 1.548 ± 0.045	2.315GluPro: 2.315 ± 0.06	1.635GluGln: 1.635 ± 0.044	4.209GluArg: 4.209 ± 0.072	1.81GluSer: 1.81 ± 0.051	3.992GluThr: 3.992 ± 0.071	4.609GluVal: 4.609 ± 0.071	0.677GluTrp: 0.677 ± 0.029	0.931GluTyr: 0.931 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.522PheAla: 4.522 ± 0.075	0.429PheCys: 0.429 ± 0.019	2.983PheAsp: 2.983 ± 0.054	2.085PheGlu: 2.085 ± 0.053	1.39PhePhe: 1.39 ± 0.04	3.617PheGly: 3.617 ± 0.075	0.776PheHis: 0.776 ± 0.029	1.496PheIle: 1.496 ± 0.04	0.649PheLys: 0.649 ± 0.035	3.405PheLeu: 3.405 ± 0.069	0.839PheMet: 0.839 ± 0.03	0.938PheAsn: 0.938 ± 0.034	1.585PhePro: 1.585 ± 0.04	0.943PheGln: 0.943 ± 0.031	2.231PheArg: 2.231 ± 0.055	1.977PheSer: 1.977 ± 0.045	1.946PheThr: 1.946 ± 0.048	2.588PheVal: 2.588 ± 0.059	0.6PheTrp: 0.6 ± 0.025	0.845PheTyr: 0.845 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	11.116GlyAla: 11.116 ± 0.117	0.898GlyCys: 0.898 ± 0.031	5.307GlyAsp: 5.307 ± 0.104	4.561GlyGlu: 4.561 ± 0.081	3.641GlyPhe: 3.641 ± 0.063	8.13GlyGly: 8.13 ± 0.152	2.141GlyHis: 2.141 ± 0.051	4.414GlyIle: 4.414 ± 0.071	2.528GlyLys: 2.528 ± 0.058	9.68GlyLeu: 9.68 ± 0.105	2.611GlyMet: 2.611 ± 0.055	1.912GlyAsn: 1.912 ± 0.061	4.375GlyPro: 4.375 ± 0.063	3.221GlyGln: 3.221 ± 0.061	6.623GlyArg: 6.623 ± 0.079	3.963GlySer: 3.963 ± 0.073	4.943GlyThr: 4.943 ± 0.083	6.764GlyVal: 6.764 ± 0.085	1.579GlyTrp: 1.579 ± 0.042	2.233GlyTyr: 2.233 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.584HisAla: 2.584 ± 0.056	0.212HisCys: 0.212 ± 0.014	1.385HisAsp: 1.385 ± 0.038	1.055HisGlu: 1.055 ± 0.029	0.776HisPhe: 0.776 ± 0.028	2.063HisGly: 2.063 ± 0.049	0.626HisHis: 0.626 ± 0.028	0.915HisIle: 0.915 ± 0.034	0.455HisLys: 0.455 ± 0.024	2.28HisLeu: 2.28 ± 0.052	0.532HisMet: 0.532 ± 0.025	0.389HisAsn: 0.389 ± 0.02	1.505HisPro: 1.505 ± 0.046	0.555HisGln: 0.555 ± 0.023	1.569HisArg: 1.569 ± 0.046	0.829HisSer: 0.829 ± 0.032	0.82HisThr: 0.82 ± 0.031	1.665HisVal: 1.665 ± 0.043	0.361HisTrp: 0.361 ± 0.02	0.551HisTyr: 0.551 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.174IleAla: 7.174 ± 0.085	0.593IleCys: 0.593 ± 0.025	3.543IleAsp: 3.543 ± 0.07	3.453IleGlu: 3.453 ± 0.062	1.607IlePhe: 1.607 ± 0.047	4.816IleGly: 4.816 ± 0.072	0.949IleHis: 0.949 ± 0.028	1.879IleIle: 1.879 ± 0.055	1.022IleLys: 1.022 ± 0.035	4.87IleLeu: 4.87 ± 0.077	1.01IleMet: 1.01 ± 0.034	1.135IleAsn: 1.135 ± 0.035	2.363IlePro: 2.363 ± 0.048	1.078IleGln: 1.078 ± 0.032	3.15IleArg: 3.15 ± 0.063	2.512IleSer: 2.512 ± 0.052	2.74IleThr: 2.74 ± 0.055	3.712IleVal: 3.712 ± 0.068	0.764IleTrp: 0.764 ± 0.025	1.111IleTyr: 1.111 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.07LysAla: 3.07 ± 0.072	0.153LysCys: 0.153 ± 0.013	1.316LysAsp: 1.316 ± 0.047	1.119LysGlu: 1.119 ± 0.043	0.634LysPhe: 0.634 ± 0.029	2.234LysGly: 2.234 ± 0.058	0.459LysHis: 0.459 ± 0.025	1.204LysIle: 1.204 ± 0.044	0.94LysLys: 0.94 ± 0.043	2.42LysLeu: 2.42 ± 0.059	0.655LysMet: 0.655 ± 0.027	0.524LysAsn: 0.524 ± 0.026	1.469LysPro: 1.469 ± 0.037	0.674LysGln: 0.674 ± 0.032	1.933LysArg: 1.933 ± 0.045	1.398LysSer: 1.398 ± 0.038	1.555LysThr: 1.555 ± 0.042	1.654LysVal: 1.654 ± 0.047	0.291LysTrp: 0.291 ± 0.02	0.461LysTyr: 0.461 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.458LeuAla: 13.458 ± 0.149	0.946LeuCys: 0.946 ± 0.032	6.349LeuAsp: 6.349 ± 0.085	5.041LeuGlu: 5.041 ± 0.075	3.691LeuPhe: 3.691 ± 0.07	8.816LeuGly: 8.816 ± 0.12	1.92LeuHis: 1.92 ± 0.046	5.195LeuIle: 5.195 ± 0.086	2.466LeuLys: 2.466 ± 0.059	8.613LeuLeu: 8.613 ± 0.121	2.729LeuMet: 2.729 ± 0.051	2.403LeuAsn: 2.403 ± 0.048	5.792LeuPro: 5.792 ± 0.088	2.706LeuGln: 2.706 ± 0.051	7.646LeuArg: 7.646 ± 0.108	6.789LeuSer: 6.789 ± 0.084	5.999LeuThr: 5.999 ± 0.072	6.936LeuVal: 6.936 ± 0.089	1.32LeuTrp: 1.32 ± 0.04	1.881LeuTyr: 1.881 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.858MetAla: 3.858 ± 0.065	0.184MetCys: 0.184 ± 0.013	1.428MetAsp: 1.428 ± 0.033	1.366MetGlu: 1.366 ± 0.038	0.729MetPhe: 0.729 ± 0.023	2.473MetGly: 2.473 ± 0.049	0.478MetHis: 0.478 ± 0.021	1.537MetIle: 1.537 ± 0.036	0.821MetLys: 0.821 ± 0.027	2.585MetLeu: 2.585 ± 0.056	0.715MetMet: 0.715 ± 0.026	0.73MetAsn: 0.73 ± 0.025	1.692MetPro: 1.692 ± 0.047	0.983MetGln: 0.983 ± 0.029	2.068MetArg: 2.068 ± 0.045	1.645MetSer: 1.645 ± 0.041	2.209MetThr: 2.209 ± 0.045	1.816MetVal: 1.816 ± 0.044	0.262MetTrp: 0.262 ± 0.016	0.319MetTyr: 0.319 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.8AsnAla: 2.8 ± 0.052	0.199AsnCys: 0.199 ± 0.015	1.319AsnAsp: 1.319 ± 0.055	0.976AsnGlu: 0.976 ± 0.034	0.821AsnPhe: 0.821 ± 0.032	2.209AsnGly: 2.209 ± 0.062	0.438AsnHis: 0.438 ± 0.02	1.183AsnIle: 1.183 ± 0.031	0.434AsnLys: 0.434 ± 0.022	2.218AsnLeu: 2.218 ± 0.053	0.581AsnMet: 0.581 ± 0.03	0.516AsnAsn: 0.516 ± 0.024	1.776AsnPro: 1.776 ± 0.039	0.58AsnGln: 0.58 ± 0.027	1.646AsnArg: 1.646 ± 0.037	0.915AsnSer: 0.915 ± 0.03	1.167AsnThr: 1.167 ± 0.037	1.556AsnVal: 1.556 ± 0.043	0.35AsnTrp: 0.35 ± 0.018	0.547AsnTyr: 0.547 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.518ProAla: 6.518 ± 0.102	0.425ProCys: 0.425 ± 0.021	4.526ProAsp: 4.526 ± 0.083	4.499ProGlu: 4.499 ± 0.077	2.016ProPhe: 2.016 ± 0.05	5.016ProGly: 5.016 ± 0.076	1.179ProHis: 1.179 ± 0.034	2.323ProIle: 2.323 ± 0.051	1.348ProLys: 1.348 ± 0.035	4.761ProLeu: 4.761 ± 0.075	1.447ProMet: 1.447 ± 0.041	1.213ProAsn: 1.213 ± 0.039	2.827ProPro: 2.827 ± 0.066	1.737ProGln: 1.737 ± 0.048	3.585ProArg: 3.585 ± 0.062	2.49ProSer: 2.49 ± 0.051	2.528ProThr: 2.528 ± 0.048	4.504ProVal: 4.504 ± 0.076	0.735ProTrp: 0.735 ± 0.029	1.17ProTyr: 1.17 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.173GlnAla: 4.173 ± 0.07	0.21GlnCys: 0.21 ± 0.015	1.681GlnAsp: 1.681 ± 0.038	1.453GlnGlu: 1.453 ± 0.039	0.992GlnPhe: 0.992 ± 0.03	2.701GlnGly: 2.701 ± 0.061	0.594GlnHis: 0.594 ± 0.02	1.864GlnIle: 1.864 ± 0.043	0.802GlnLys: 0.802 ± 0.032	2.592GlnLeu: 2.592 ± 0.053	1.071GlnMet: 1.071 ± 0.034	0.719GlnAsn: 0.719 ± 0.027	1.738GlnPro: 1.738 ± 0.042	1.016GlnGln: 1.016 ± 0.034	2.13GlnArg: 2.13 ± 0.051	1.537GlnSer: 1.537 ± 0.04	1.78GlnThr: 1.78 ± 0.042	2.311GlnVal: 2.311 ± 0.049	0.396GlnTrp: 0.396 ± 0.018	0.551GlnTyr: 0.551 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.723ArgAla: 9.723 ± 0.137	0.581ArgCys: 0.581 ± 0.024	4.834ArgAsp: 4.834 ± 0.074	3.622ArgGlu: 3.622 ± 0.067	2.903ArgPhe: 2.903 ± 0.051	5.284ArgGly: 5.284 ± 0.079	1.838ArgHis: 1.838 ± 0.052	3.952ArgIle: 3.952 ± 0.07	1.932ArgLys: 1.932 ± 0.046	8.074ArgLeu: 8.074 ± 0.112	2.127ArgMet: 2.127 ± 0.044	1.626ArgAsn: 1.626 ± 0.041	4.102ArgPro: 4.102 ± 0.081	2.346ArgGln: 2.346 ± 0.056	5.953ArgArg: 5.953 ± 0.094	3.143ArgSer: 3.143 ± 0.06	3.084ArgThr: 3.084 ± 0.06	5.176ArgVal: 5.176 ± 0.079	0.981ArgTrp: 0.981 ± 0.035	1.629ArgTyr: 1.629 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.612SerAla: 5.612 ± 0.075	0.459SerCys: 0.459 ± 0.025	3.197SerAsp: 3.197 ± 0.06	2.507SerGlu: 2.507 ± 0.041	1.972SerPhe: 1.972 ± 0.05	5.153SerGly: 5.153 ± 0.078	1.01SerHis: 1.01 ± 0.034	2.169SerIle: 2.169 ± 0.048	1.059SerLys: 1.059 ± 0.035	4.715SerLeu: 4.715 ± 0.072	1.225SerMet: 1.225 ± 0.037	1.07SerAsn: 1.07 ± 0.036	2.459SerPro: 2.459 ± 0.05	1.429SerGln: 1.429 ± 0.039	3.134SerArg: 3.134 ± 0.063	2.025SerSer: 2.025 ± 0.048	2.181SerThr: 2.181 ± 0.046	3.483SerVal: 3.483 ± 0.059	0.633SerTrp: 0.633 ± 0.024	1.211SerTyr: 1.211 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.483ThrAla: 6.483 ± 0.093	0.484ThrCys: 0.484 ± 0.025	3.288ThrAsp: 3.288 ± 0.059	3.091ThrGlu: 3.091 ± 0.061	1.877ThrPhe: 1.877 ± 0.048	5.826ThrGly: 5.826 ± 0.098	1.145ThrHis: 1.145 ± 0.037	2.543ThrIle: 2.543 ± 0.053	1.087ThrLys: 1.087 ± 0.041	6.19ThrLeu: 6.19 ± 0.087	1.269ThrMet: 1.269 ± 0.035	1.091ThrAsn: 1.091 ± 0.033	3.731ThrPro: 3.731 ± 0.064	1.552ThrGln: 1.552 ± 0.04	3.838ThrArg: 3.838 ± 0.063	2.266ThrSer: 2.266 ± 0.049	2.751ThrThr: 2.751 ± 0.059	4.282ThrVal: 4.282 ± 0.071	0.749ThrTrp: 0.749 ± 0.026	1.186ThrTyr: 1.186 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.503ValAla: 9.503 ± 0.1	0.639ValCys: 0.639 ± 0.03	4.022ValAsp: 4.022 ± 0.065	4.462ValGlu: 4.462 ± 0.082	2.846ValPhe: 2.846 ± 0.056	5.505ValGly: 5.505 ± 0.081	1.316ValHis: 1.316 ± 0.036	4.169ValIle: 4.169 ± 0.061	1.752ValLys: 1.752 ± 0.06	7.534ValLeu: 7.534 ± 0.089	2.151ValMet: 2.151 ± 0.043	1.806ValAsn: 1.806 ± 0.047	3.704ValPro: 3.704 ± 0.064	1.99ValGln: 1.99 ± 0.047	4.177ValArg: 4.177 ± 0.065	3.745ValSer: 3.745 ± 0.062	4.921ValThr: 4.921 ± 0.073	5.465ValVal: 5.465 ± 0.1	0.943ValTrp: 0.943 ± 0.029	1.444ValTyr: 1.444 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.482TrpAla: 1.482 ± 0.045	0.169TrpCys: 0.169 ± 0.014	0.791TrpAsp: 0.791 ± 0.027	0.619TrpGlu: 0.619 ± 0.025	0.536TrpPhe: 0.536 ± 0.02	1.085TrpGly: 1.085 ± 0.036	0.376TrpHis: 0.376 ± 0.021	0.715TrpIle: 0.715 ± 0.027	0.326TrpLys: 0.326 ± 0.02	1.655TrpLeu: 1.655 ± 0.045	0.44TrpMet: 0.44 ± 0.021	0.358TrpAsn: 0.358 ± 0.018	0.806TrpPro: 0.806 ± 0.029	0.617TrpGln: 0.617 ± 0.023	1.291TrpArg: 1.291 ± 0.037	0.776TrpSer: 0.776 ± 0.026	0.781TrpThr: 0.781 ± 0.028	0.974TrpVal: 0.974 ± 0.028	0.264TrpTrp: 0.264 ± 0.015	0.27TrpTyr: 0.27 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.562TyrAla: 2.562 ± 0.05	0.231TyrCys: 0.231 ± 0.015	1.61TyrAsp: 1.61 ± 0.043	1.113TyrGlu: 1.113 ± 0.036	0.852TyrPhe: 0.852 ± 0.028	2.105TyrGly: 2.105 ± 0.053	0.509TyrHis: 0.509 ± 0.023	0.859TyrIle: 0.859 ± 0.028	0.428TyrLys: 0.428 ± 0.022	2.203TyrLeu: 2.203 ± 0.045	0.435TyrMet: 0.435 ± 0.023	0.499TyrAsn: 0.499 ± 0.024	1.033TyrPro: 1.033 ± 0.032	0.627TyrGln: 0.627 ± 0.026	1.602TyrArg: 1.602 ± 0.037	0.998TyrSer: 0.998 ± 0.037	1.138TyrThr: 1.138 ± 0.034	1.433TyrVal: 1.433 ± 0.04	0.359TyrTrp: 0.359 ± 0.02	0.534TyrTyr: 0.534 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3433 proteins (1011806 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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