Amino acid dipepetide frequency for Flavobacteriaceae bacterium 14752

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.378AlaAla: 3.378 ± 0.084	0.55AlaCys: 0.55 ± 0.03	3.23AlaAsp: 3.23 ± 0.066	4.069AlaGlu: 4.069 ± 0.077	3.49AlaPhe: 3.49 ± 0.056	3.565AlaGly: 3.565 ± 0.074	1.091AlaHis: 1.091 ± 0.042	4.835AlaIle: 4.835 ± 0.099	4.927AlaLys: 4.927 ± 0.084	5.949AlaLeu: 5.949 ± 0.091	1.362AlaMet: 1.362 ± 0.048	3.124AlaAsn: 3.124 ± 0.073	1.498AlaPro: 1.498 ± 0.043	2.813AlaGln: 2.813 ± 0.059	1.765AlaArg: 1.765 ± 0.046	3.656AlaSer: 3.656 ± 0.07	2.81AlaThr: 2.81 ± 0.058	3.692AlaVal: 3.692 ± 0.075	0.609AlaTrp: 0.609 ± 0.026	2.495AlaTyr: 2.495 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.388CysAla: 0.388 ± 0.024	0.091CysCys: 0.091 ± 0.01	0.417CysAsp: 0.417 ± 0.025	0.451CysGlu: 0.451 ± 0.026	0.468CysPhe: 0.468 ± 0.025	0.599CysGly: 0.599 ± 0.031	0.19CysHis: 0.19 ± 0.015	0.554CysIle: 0.554 ± 0.026	0.5CysLys: 0.5 ± 0.026	0.675CysLeu: 0.675 ± 0.031	0.133CysMet: 0.133 ± 0.013	0.342CysAsn: 0.342 ± 0.019	0.318CysPro: 0.318 ± 0.023	0.354CysGln: 0.354 ± 0.023	0.182CysArg: 0.182 ± 0.017	0.529CysSer: 0.529 ± 0.029	0.315CysThr: 0.315 ± 0.018	0.472CysVal: 0.472 ± 0.024	0.075CysTrp: 0.075 ± 0.011	0.286CysTyr: 0.286 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.351AspAla: 3.351 ± 0.067	0.432AspCys: 0.432 ± 0.03	3.528AspAsp: 3.528 ± 0.069	4.435AspGlu: 4.435 ± 0.083	4.156AspPhe: 4.156 ± 0.083	3.455AspGly: 3.455 ± 0.087	0.919AspHis: 0.919 ± 0.035	5.358AspIle: 5.358 ± 0.084	4.974AspLys: 4.974 ± 0.083	5.714AspLeu: 5.714 ± 0.085	1.14AspMet: 1.14 ± 0.04	3.588AspAsn: 3.588 ± 0.066	1.592AspPro: 1.592 ± 0.053	2.073AspGln: 2.073 ± 0.048	1.822AspArg: 1.822 ± 0.048	3.256AspSer: 3.256 ± 0.077	2.712AspThr: 2.712 ± 0.056	3.703AspVal: 3.703 ± 0.078	0.77AspTrp: 0.77 ± 0.032	2.914AspTyr: 2.914 ± 0.068	0.0AspXaa: 0.0 ± 0.0
Glu	4.133GluAla: 4.133 ± 0.077	0.33GluCys: 0.33 ± 0.021	4.052GluAsp: 4.052 ± 0.075	4.396GluGlu: 4.396 ± 0.109	3.216GluPhe: 3.216 ± 0.063	3.153GluGly: 3.153 ± 0.069	1.268GluHis: 1.268 ± 0.042	5.536GluIle: 5.536 ± 0.083	5.457GluLys: 5.457 ± 0.095	5.841GluLeu: 5.841 ± 0.086	1.431GluMet: 1.431 ± 0.043	4.996GluAsn: 4.996 ± 0.087	1.626GluPro: 1.626 ± 0.044	2.533GluGln: 2.533 ± 0.058	2.255GluArg: 2.255 ± 0.062	3.536GluSer: 3.536 ± 0.072	3.633GluThr: 3.633 ± 0.069	4.372GluVal: 4.372 ± 0.067	0.642GluTrp: 0.642 ± 0.03	2.288GluTyr: 2.288 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	2.839PheAla: 2.839 ± 0.067	0.465PheCys: 0.465 ± 0.027	3.993PheAsp: 3.993 ± 0.081	3.975PheGlu: 3.975 ± 0.073	2.847PhePhe: 2.847 ± 0.075	3.77PheGly: 3.77 ± 0.074	0.836PheHis: 0.836 ± 0.035	4.157PheIle: 4.157 ± 0.089	4.633PheLys: 4.633 ± 0.09	4.766PheLeu: 4.766 ± 0.087	1.135PheMet: 1.135 ± 0.041	3.498PheAsn: 3.498 ± 0.066	1.669PhePro: 1.669 ± 0.045	1.801PheGln: 1.801 ± 0.051	1.631PheArg: 1.631 ± 0.05	4.138PheSer: 4.138 ± 0.082	2.863PheThr: 2.863 ± 0.069	3.142PheVal: 3.142 ± 0.062	0.649PheTrp: 0.649 ± 0.03	2.345PheTyr: 2.345 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	3.488GlyAla: 3.488 ± 0.072	0.519GlyCys: 0.519 ± 0.033	3.293GlyAsp: 3.293 ± 0.079	3.495GlyGlu: 3.495 ± 0.077	3.734GlyPhe: 3.734 ± 0.075	4.048GlyGly: 4.048 ± 0.102	1.147GlyHis: 1.147 ± 0.033	4.883GlyIle: 4.883 ± 0.089	4.266GlyLys: 4.266 ± 0.081	5.878GlyLeu: 5.878 ± 0.086	1.396GlyMet: 1.396 ± 0.044	3.195GlyAsn: 3.195 ± 0.08	1.257GlyPro: 1.257 ± 0.045	2.527GlyGln: 2.527 ± 0.062	1.984GlyArg: 1.984 ± 0.067	3.563GlySer: 3.563 ± 0.085	3.064GlyThr: 3.064 ± 0.09	4.024GlyVal: 4.024 ± 0.069	0.612GlyTrp: 0.612 ± 0.025	2.377GlyTyr: 2.377 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	0.923HisAla: 0.923 ± 0.036	0.174HisCys: 0.174 ± 0.012	0.896HisAsp: 0.896 ± 0.034	0.988HisGlu: 0.988 ± 0.034	1.23HisPhe: 1.23 ± 0.04	1.014HisGly: 1.014 ± 0.037	0.573HisHis: 0.573 ± 0.027	1.717HisIle: 1.717 ± 0.047	1.499HisLys: 1.499 ± 0.05	2.032HisLeu: 2.032 ± 0.052	0.294HisMet: 0.294 ± 0.019	1.017HisAsn: 1.017 ± 0.036	0.932HisPro: 0.932 ± 0.038	1.093HisGln: 1.093 ± 0.037	0.656HisArg: 0.656 ± 0.029	1.035HisSer: 1.035 ± 0.04	0.846HisThr: 0.846 ± 0.033	0.866HisVal: 0.866 ± 0.035	0.222HisTrp: 0.222 ± 0.017	0.871HisTyr: 0.871 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.001IleAla: 5.001 ± 0.091	0.622IleCys: 0.622 ± 0.029	5.459IleAsp: 5.459 ± 0.095	5.63IleGlu: 5.63 ± 0.09	3.843IlePhe: 3.843 ± 0.083	4.841IleGly: 4.841 ± 0.093	1.351IleHis: 1.351 ± 0.039	6.051IleIle: 6.051 ± 0.11	6.747IleLys: 6.747 ± 0.104	7.342IleLeu: 7.342 ± 0.116	1.283IleMet: 1.283 ± 0.042	5.102IleAsn: 5.102 ± 0.085	3.125IlePro: 3.125 ± 0.071	3.023IleGln: 3.023 ± 0.057	2.359IleArg: 2.359 ± 0.052	5.791IleSer: 5.791 ± 0.085	4.123IleThr: 4.123 ± 0.082	4.534IleVal: 4.534 ± 0.086	0.731IleTrp: 0.731 ± 0.033	2.973IleTyr: 2.973 ± 0.067	0.0IleXaa: 0.0 ± 0.0
Lys	5.657LysAla: 5.657 ± 0.102	0.378LysCys: 0.378 ± 0.018	5.024LysAsp: 5.024 ± 0.089	5.017LysGlu: 5.017 ± 0.1	3.3LysPhe: 3.3 ± 0.075	4.095LysGly: 4.095 ± 0.088	1.966LysHis: 1.966 ± 0.053	6.469LysIle: 6.469 ± 0.093	6.434LysLys: 6.434 ± 0.107	7.241LysLeu: 7.241 ± 0.111	1.827LysMet: 1.827 ± 0.045	5.652LysAsn: 5.652 ± 0.098	3.086LysPro: 3.086 ± 0.063	3.387LysGln: 3.387 ± 0.071	3.09LysArg: 3.09 ± 0.063	5.712LysSer: 5.712 ± 0.092	5.651LysThr: 5.651 ± 0.092	4.69LysVal: 4.69 ± 0.09	0.669LysTrp: 0.669 ± 0.03	3.048LysTyr: 3.048 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	5.315LeuAla: 5.315 ± 0.084	0.712LeuCys: 0.712 ± 0.027	5.526LeuAsp: 5.526 ± 0.077	5.904LeuGlu: 5.904 ± 0.092	4.792LeuPhe: 4.792 ± 0.091	5.504LeuGly: 5.504 ± 0.094	1.538LeuHis: 1.538 ± 0.043	7.536LeuIle: 7.536 ± 0.128	9.531LeuLys: 9.531 ± 0.123	8.025LeuLeu: 8.025 ± 0.148	2.074LeuMet: 2.074 ± 0.054	6.533LeuAsn: 6.533 ± 0.121	3.483LeuPro: 3.483 ± 0.059	3.281LeuGln: 3.281 ± 0.063	2.996LeuArg: 2.996 ± 0.064	7.382LeuSer: 7.382 ± 0.11	4.647LeuThr: 4.647 ± 0.084	5.3LeuVal: 5.3 ± 0.09	0.881LeuTrp: 0.881 ± 0.036	3.102LeuTyr: 3.102 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	1.408MetAla: 1.408 ± 0.039	0.134MetCys: 0.134 ± 0.014	0.964MetAsp: 0.964 ± 0.036	0.996MetGlu: 0.996 ± 0.035	0.867MetPhe: 0.867 ± 0.031	1.265MetGly: 1.265 ± 0.04	0.405MetHis: 0.405 ± 0.021	1.472MetIle: 1.472 ± 0.039	2.079MetLys: 2.079 ± 0.045	1.905MetLeu: 1.905 ± 0.043	0.565MetMet: 0.565 ± 0.025	1.221MetAsn: 1.221 ± 0.032	0.877MetPro: 0.877 ± 0.032	0.866MetGln: 0.866 ± 0.032	0.814MetArg: 0.814 ± 0.032	1.556MetSer: 1.556 ± 0.047	1.171MetThr: 1.171 ± 0.038	1.117MetVal: 1.117 ± 0.04	0.137MetTrp: 0.137 ± 0.013	0.556MetTyr: 0.556 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.822AsnAla: 3.822 ± 0.073	0.434AsnCys: 0.434 ± 0.022	3.371AsnAsp: 3.371 ± 0.077	3.581AsnGlu: 3.581 ± 0.071	3.58AsnPhe: 3.58 ± 0.08	3.496AsnGly: 3.496 ± 0.1	1.215AsnHis: 1.215 ± 0.041	5.173AsnIle: 5.173 ± 0.088	4.447AsnLys: 4.447 ± 0.088	6.292AsnLeu: 6.292 ± 0.096	1.23AsnMet: 1.23 ± 0.043	3.891AsnAsn: 3.891 ± 0.091	2.993AsnPro: 2.993 ± 0.07	3.235AsnGln: 3.235 ± 0.079	2.277AsnArg: 2.277 ± 0.06	3.927AsnSer: 3.927 ± 0.081	3.652AsnThr: 3.652 ± 0.071	3.383AsnVal: 3.383 ± 0.066	0.756AsnTrp: 0.756 ± 0.032	2.724AsnTyr: 2.724 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	1.604ProAla: 1.604 ± 0.05	0.23ProCys: 0.23 ± 0.021	2.212ProAsp: 2.212 ± 0.053	2.856ProGlu: 2.856 ± 0.059	1.843ProPhe: 1.843 ± 0.05	1.765ProGly: 1.765 ± 0.046	0.619ProHis: 0.619 ± 0.027	2.713ProIle: 2.713 ± 0.059	3.009ProLys: 3.009 ± 0.064	2.847ProLeu: 2.847 ± 0.06	0.648ProMet: 0.648 ± 0.031	2.406ProAsn: 2.406 ± 0.061	0.837ProPro: 0.837 ± 0.037	1.463ProGln: 1.463 ± 0.045	0.932ProArg: 0.932 ± 0.031	2.0ProSer: 2.0 ± 0.047	1.827ProThr: 1.827 ± 0.06	2.182ProVal: 2.182 ± 0.056	0.332ProTrp: 0.332 ± 0.022	1.365ProTyr: 1.365 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.414GlnAla: 2.414 ± 0.06	0.208GlnCys: 0.208 ± 0.016	2.52GlnAsp: 2.52 ± 0.053	2.213GlnGlu: 2.213 ± 0.052	2.096GlnPhe: 2.096 ± 0.063	1.937GlnGly: 1.937 ± 0.047	0.84GlnHis: 0.84 ± 0.033	3.258GlnIle: 3.258 ± 0.061	3.594GlnLys: 3.594 ± 0.086	3.88GlnLeu: 3.88 ± 0.084	0.881GlnMet: 0.881 ± 0.038	3.424GlnAsn: 3.424 ± 0.078	1.443GlnPro: 1.443 ± 0.049	1.961GlnGln: 1.961 ± 0.064	1.395GlnArg: 1.395 ± 0.043	2.577GlnSer: 2.577 ± 0.065	2.393GlnThr: 2.393 ± 0.057	2.359GlnVal: 2.359 ± 0.049	0.442GlnTrp: 0.442 ± 0.022	1.489GlnTyr: 1.489 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	1.845ArgAla: 1.845 ± 0.056	0.179ArgCys: 0.179 ± 0.014	1.807ArgAsp: 1.807 ± 0.05	2.056ArgGlu: 2.056 ± 0.05	2.03ArgPhe: 2.03 ± 0.051	1.815ArgGly: 1.815 ± 0.044	0.629ArgHis: 0.629 ± 0.027	2.605ArgIle: 2.605 ± 0.058	2.582ArgLys: 2.582 ± 0.067	3.483ArgLeu: 3.483 ± 0.072	0.786ArgMet: 0.786 ± 0.026	1.889ArgAsn: 1.889 ± 0.049	1.101ArgPro: 1.101 ± 0.036	1.523ArgGln: 1.523 ± 0.043	1.339ArgArg: 1.339 ± 0.049	1.881ArgSer: 1.881 ± 0.055	1.538ArgThr: 1.538 ± 0.049	1.859ArgVal: 1.859 ± 0.048	0.356ArgTrp: 0.356 ± 0.02	1.51ArgTyr: 1.51 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.641SerAla: 3.641 ± 0.067	0.593SerCys: 0.593 ± 0.027	3.705SerAsp: 3.705 ± 0.07	4.2SerGlu: 4.2 ± 0.063	3.949SerPhe: 3.949 ± 0.082	4.366SerGly: 4.366 ± 0.093	1.177SerHis: 1.177 ± 0.036	5.44SerIle: 5.44 ± 0.086	5.289SerLys: 5.289 ± 0.084	6.295SerLeu: 6.295 ± 0.088	1.21SerMet: 1.21 ± 0.035	3.798SerAsn: 3.798 ± 0.079	2.157SerPro: 2.157 ± 0.048	2.858SerGln: 2.858 ± 0.071	2.092SerArg: 2.092 ± 0.048	4.351SerSer: 4.351 ± 0.096	3.421SerThr: 3.421 ± 0.073	3.85SerVal: 3.85 ± 0.069	0.679SerTrp: 0.679 ± 0.03	2.71SerTyr: 2.71 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	3.253ThrAla: 3.253 ± 0.065	0.357ThrCys: 0.357 ± 0.021	3.085ThrAsp: 3.085 ± 0.076	3.389ThrGlu: 3.389 ± 0.064	2.898ThrPhe: 2.898 ± 0.069	3.561ThrGly: 3.561 ± 0.084	1.053ThrHis: 1.053 ± 0.04	3.944ThrIle: 3.944 ± 0.082	3.768ThrLys: 3.768 ± 0.086	5.236ThrLeu: 5.236 ± 0.085	0.766ThrMet: 0.766 ± 0.032	3.005ThrAsn: 3.005 ± 0.07	2.2ThrPro: 2.2 ± 0.06	2.37ThrGln: 2.37 ± 0.057	1.53ThrArg: 1.53 ± 0.042	3.685ThrSer: 3.685 ± 0.071	3.08ThrThr: 3.08 ± 0.073	3.104ThrVal: 3.104 ± 0.074	0.47ThrTrp: 0.47 ± 0.022	2.328ThrTyr: 2.328 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	3.552ValAla: 3.552 ± 0.069	0.536ValCys: 0.536 ± 0.029	3.81ValAsp: 3.81 ± 0.077	4.074ValGlu: 4.074 ± 0.073	3.603ValPhe: 3.603 ± 0.075	3.62ValGly: 3.62 ± 0.072	0.894ValHis: 0.894 ± 0.035	4.724ValIle: 4.724 ± 0.081	4.612ValLys: 4.612 ± 0.085	5.861ValLeu: 5.861 ± 0.109	1.228ValMet: 1.228 ± 0.042	3.693ValAsn: 3.693 ± 0.059	1.782ValPro: 1.782 ± 0.047	1.761ValGln: 1.761 ± 0.046	1.781ValArg: 1.781 ± 0.047	4.229ValSer: 4.229 ± 0.075	2.804ValThr: 2.804 ± 0.068	4.08ValVal: 4.08 ± 0.072	0.58ValTrp: 0.58 ± 0.028	2.293ValTyr: 2.293 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.566TrpAla: 0.566 ± 0.026	0.092TrpCys: 0.092 ± 0.011	0.585TrpAsp: 0.585 ± 0.026	0.589TrpGlu: 0.589 ± 0.028	0.692TrpPhe: 0.692 ± 0.029	0.574TrpGly: 0.574 ± 0.026	0.251TrpHis: 0.251 ± 0.019	0.719TrpIle: 0.719 ± 0.033	0.685TrpLys: 0.685 ± 0.034	1.032TrpLeu: 1.032 ± 0.043	0.313TrpMet: 0.313 ± 0.019	0.579TrpAsn: 0.579 ± 0.027	0.273TrpPro: 0.273 ± 0.019	0.504TrpGln: 0.504 ± 0.024	0.417TrpArg: 0.417 ± 0.024	0.681TrpSer: 0.681 ± 0.031	0.497TrpThr: 0.497 ± 0.024	0.623TrpVal: 0.623 ± 0.029	0.144TrpTrp: 0.144 ± 0.015	0.382TrpTyr: 0.382 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.33TyrAla: 2.33 ± 0.055	0.3TyrCys: 0.3 ± 0.017	2.413TyrAsp: 2.413 ± 0.061	2.381TyrGlu: 2.381 ± 0.054	2.517TyrPhe: 2.517 ± 0.054	2.308TyrGly: 2.308 ± 0.059	0.916TyrHis: 0.916 ± 0.036	2.785TyrIle: 2.785 ± 0.056	3.358TyrLys: 3.358 ± 0.064	3.768TyrLeu: 3.768 ± 0.077	0.67TyrMet: 0.67 ± 0.028	2.528TyrAsn: 2.528 ± 0.058	1.438TyrPro: 1.438 ± 0.044	1.9TyrGln: 1.9 ± 0.057	1.496TyrArg: 1.496 ± 0.045	2.298TyrSer: 2.298 ± 0.056	2.036TyrThr: 2.036 ± 0.052	2.168TyrVal: 2.168 ± 0.05	0.442TyrTrp: 0.442 ± 0.024	1.688TyrTyr: 1.688 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2559 proteins (856683 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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