Amino acid dipepetide frequency for Rubripirellula amarantea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.037AlaAla: 10.037 ± 0.095	0.992AlaCys: 0.992 ± 0.029	6.219AlaAsp: 6.219 ± 0.063	5.617AlaGlu: 5.617 ± 0.063	3.299AlaPhe: 3.299 ± 0.043	7.471AlaGly: 7.471 ± 0.096	1.455AlaHis: 1.455 ± 0.031	6.391AlaIle: 6.391 ± 0.07	4.212AlaLys: 4.212 ± 0.071	7.351AlaLeu: 7.351 ± 0.067	2.851AlaMet: 2.851 ± 0.052	3.456AlaAsn: 3.456 ± 0.046	3.447AlaPro: 3.447 ± 0.06	2.901AlaGln: 2.901 ± 0.043	4.822AlaArg: 4.822 ± 0.061	7.333AlaSer: 7.333 ± 0.079	5.992AlaThr: 5.992 ± 0.069	6.653AlaVal: 6.653 ± 0.066	1.253AlaTrp: 1.253 ± 0.03	2.01AlaTyr: 2.01 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.665CysAla: 0.665 ± 0.019	0.21CysCys: 0.21 ± 0.014	0.777CysAsp: 0.777 ± 0.024	0.69CysGlu: 0.69 ± 0.028	0.414CysPhe: 0.414 ± 0.016	1.031CysGly: 1.031 ± 0.032	0.403CysHis: 0.403 ± 0.019	0.454CysIle: 0.454 ± 0.015	0.317CysLys: 0.317 ± 0.013	1.05CysLeu: 1.05 ± 0.029	0.189CysMet: 0.189 ± 0.01	0.308CysAsn: 0.308 ± 0.014	0.491CysPro: 0.491 ± 0.018	0.422CysGln: 0.422 ± 0.016	0.716CysArg: 0.716 ± 0.026	0.638CysSer: 0.638 ± 0.021	0.477CysThr: 0.477 ± 0.016	0.849CysVal: 0.849 ± 0.022	0.153CysTrp: 0.153 ± 0.009	0.289CysTyr: 0.289 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.574AspAla: 6.574 ± 0.068	0.596AspCys: 0.596 ± 0.019	4.95AspAsp: 4.95 ± 0.088	4.533AspGlu: 4.533 ± 0.06	2.576AspPhe: 2.576 ± 0.042	5.908AspGly: 5.908 ± 0.136	1.544AspHis: 1.544 ± 0.035	2.804AspIle: 2.804 ± 0.055	1.782AspLys: 1.782 ± 0.036	6.075AspLeu: 6.075 ± 0.088	1.074AspMet: 1.074 ± 0.026	1.997AspAsn: 1.997 ± 0.045	3.659AspPro: 3.659 ± 0.053	3.006AspGln: 3.006 ± 0.044	4.439AspArg: 4.439 ± 0.052	4.483AspSer: 4.483 ± 0.067	3.027AspThr: 3.027 ± 0.064	4.821AspVal: 4.821 ± 0.069	1.039AspTrp: 1.039 ± 0.026	1.718AspTyr: 1.718 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	5.471GluAla: 5.471 ± 0.066	0.491GluCys: 0.491 ± 0.017	3.047GluAsp: 3.047 ± 0.044	2.996GluGlu: 2.996 ± 0.058	2.215GluPhe: 2.215 ± 0.036	3.71GluGly: 3.71 ± 0.05	1.269GluHis: 1.269 ± 0.033	3.534GluIle: 3.534 ± 0.044	2.32GluLys: 2.32 ± 0.051	6.52GluLeu: 6.52 ± 0.065	1.562GluMet: 1.562 ± 0.032	2.115GluAsn: 2.115 ± 0.034	2.781GluPro: 2.781 ± 0.046	2.621GluGln: 2.621 ± 0.044	3.68GluArg: 3.68 ± 0.06	4.802GluSer: 4.802 ± 0.057	3.77GluThr: 3.77 ± 0.046	4.425GluVal: 4.425 ± 0.046	0.606GluTrp: 0.606 ± 0.02	1.309GluTyr: 1.309 ± 0.028	0.001GluXaa: 0.001 ± 0.001
Phe	3.952PheAla: 3.952 ± 0.052	0.466PheCys: 0.466 ± 0.017	3.227PheAsp: 3.227 ± 0.063	2.311PheGlu: 2.311 ± 0.04	1.487PhePhe: 1.487 ± 0.038	3.383PheGly: 3.383 ± 0.057	0.773PheHis: 0.773 ± 0.022	1.478PheIle: 1.478 ± 0.029	1.031PheLys: 1.031 ± 0.025	3.192PheLeu: 3.192 ± 0.049	0.682PheMet: 0.682 ± 0.02	1.233PheAsn: 1.233 ± 0.028	1.559PhePro: 1.559 ± 0.032	1.27PheGln: 1.27 ± 0.027	2.229PheArg: 2.229 ± 0.038	2.479PheSer: 2.479 ± 0.046	2.151PheThr: 2.151 ± 0.052	2.958PheVal: 2.958 ± 0.043	0.509PheTrp: 0.509 ± 0.019	0.903PheTyr: 0.903 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	5.503GlyAla: 5.503 ± 0.08	1.005GlyCys: 1.005 ± 0.033	5.323GlyAsp: 5.323 ± 0.116	4.628GlyGlu: 4.628 ± 0.054	3.036GlyPhe: 3.036 ± 0.043	6.781GlyGly: 6.781 ± 0.163	1.616GlyHis: 1.616 ± 0.036	4.125GlyIle: 4.125 ± 0.058	3.405GlyLys: 3.405 ± 0.052	6.817GlyLeu: 6.817 ± 0.073	1.923GlyMet: 1.923 ± 0.04	3.132GlyAsn: 3.132 ± 0.093	3.006GlyPro: 3.006 ± 0.04	2.967GlyGln: 2.967 ± 0.052	4.613GlyArg: 4.613 ± 0.06	5.644GlySer: 5.644 ± 0.109	4.924GlyThr: 4.924 ± 0.138	5.416GlyVal: 5.416 ± 0.064	1.22GlyTrp: 1.22 ± 0.032	2.14GlyTyr: 2.14 ± 0.036	0.001GlyXaa: 0.001 ± 0.001
His	1.947HisAla: 1.947 ± 0.046	0.319HisCys: 0.319 ± 0.016	1.373HisAsp: 1.373 ± 0.026	1.245HisGlu: 1.245 ± 0.031	0.917HisPhe: 0.917 ± 0.024	1.706HisGly: 1.706 ± 0.037	0.706HisHis: 0.706 ± 0.023	0.804HisIle: 0.804 ± 0.024	0.5HisLys: 0.5 ± 0.016	2.067HisLeu: 2.067 ± 0.042	0.36HisMet: 0.36 ± 0.012	0.634HisAsn: 0.634 ± 0.021	1.319HisPro: 1.319 ± 0.029	0.964HisGln: 0.964 ± 0.023	1.602HisArg: 1.602 ± 0.035	1.379HisSer: 1.379 ± 0.026	0.911HisThr: 0.911 ± 0.023	1.511HisVal: 1.511 ± 0.033	0.429HisTrp: 0.429 ± 0.015	0.623HisTyr: 0.623 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.585IleAla: 6.585 ± 0.062	0.577IleCys: 0.577 ± 0.021	4.425IleAsp: 4.425 ± 0.064	4.323IleGlu: 4.323 ± 0.053	1.493IlePhe: 1.493 ± 0.031	4.544IleGly: 4.544 ± 0.053	1.117IleHis: 1.117 ± 0.026	2.11IleIle: 2.11 ± 0.042	1.609IleLys: 1.609 ± 0.033	3.832IleLeu: 3.832 ± 0.05	0.751IleMet: 0.751 ± 0.021	1.852IleAsn: 1.852 ± 0.039	2.469IlePro: 2.469 ± 0.041	1.775IleGln: 1.775 ± 0.033	3.427IleArg: 3.427 ± 0.045	3.5IleSer: 3.5 ± 0.042	2.991IleThr: 2.991 ± 0.057	4.3IleVal: 4.3 ± 0.056	0.58IleTrp: 0.58 ± 0.017	1.234IleTyr: 1.234 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.063LysAla: 3.063 ± 0.052	0.299LysCys: 0.299 ± 0.013	1.801LysAsp: 1.801 ± 0.032	1.772LysGlu: 1.772 ± 0.041	1.299LysPhe: 1.299 ± 0.027	1.878LysGly: 1.878 ± 0.035	0.824LysHis: 0.824 ± 0.022	1.945LysIle: 1.945 ± 0.038	1.633LysLys: 1.633 ± 0.044	3.877LysLeu: 3.877 ± 0.052	0.909LysMet: 0.909 ± 0.026	1.196LysAsn: 1.196 ± 0.027	2.11LysPro: 2.11 ± 0.042	1.534LysGln: 1.534 ± 0.033	2.566LysArg: 2.566 ± 0.047	2.58LysSer: 2.58 ± 0.046	2.173LysThr: 2.173 ± 0.039	2.541LysVal: 2.541 ± 0.046	0.498LysTrp: 0.498 ± 0.018	0.841LysTyr: 0.841 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	10.033LeuAla: 10.033 ± 0.09	1.033LeuCys: 1.033 ± 0.029	6.206LeuAsp: 6.206 ± 0.073	5.143LeuGlu: 5.143 ± 0.059	3.259LeuPhe: 3.259 ± 0.05	6.96LeuGly: 6.96 ± 0.078	1.894LeuHis: 1.894 ± 0.035	5.0LeuIle: 5.0 ± 0.058	3.327LeuLys: 3.327 ± 0.051	8.749LeuLeu: 8.749 ± 0.104	2.099LeuMet: 2.099 ± 0.041	2.958LeuAsn: 2.958 ± 0.042	4.974LeuPro: 4.974 ± 0.061	3.376LeuGln: 3.376 ± 0.041	5.999LeuArg: 5.999 ± 0.063	6.989LeuSer: 6.989 ± 0.061	5.523LeuThr: 5.523 ± 0.064	7.091LeuVal: 7.091 ± 0.056	1.146LeuTrp: 1.146 ± 0.034	1.939LeuTyr: 1.939 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.104MetAla: 2.104 ± 0.04	0.209MetCys: 0.209 ± 0.011	1.09MetAsp: 1.09 ± 0.024	1.071MetGlu: 1.071 ± 0.026	0.793MetPhe: 0.793 ± 0.022	1.504MetGly: 1.504 ± 0.035	0.482MetHis: 0.482 ± 0.015	1.401MetIle: 1.401 ± 0.024	1.062MetLys: 1.062 ± 0.027	2.47MetLeu: 2.47 ± 0.048	0.689MetMet: 0.689 ± 0.024	0.98MetAsn: 0.98 ± 0.025	1.379MetPro: 1.379 ± 0.03	0.982MetGln: 0.982 ± 0.021	1.428MetArg: 1.428 ± 0.031	1.739MetSer: 1.739 ± 0.036	1.618MetThr: 1.618 ± 0.03	1.648MetVal: 1.648 ± 0.033	0.236MetTrp: 0.236 ± 0.012	0.383MetTyr: 0.383 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.234AsnAla: 3.234 ± 0.054	0.313AsnCys: 0.313 ± 0.014	2.556AsnAsp: 2.556 ± 0.064	2.242AsnGlu: 2.242 ± 0.033	1.229AsnPhe: 1.229 ± 0.029	2.924AsnGly: 2.924 ± 0.072	0.82AsnHis: 0.82 ± 0.024	1.394AsnIle: 1.394 ± 0.03	0.846AsnLys: 0.846 ± 0.02	3.115AsnLeu: 3.115 ± 0.046	0.57AsnMet: 0.57 ± 0.019	1.214AsnAsn: 1.214 ± 0.04	2.07AsnPro: 2.07 ± 0.038	1.64AsnGln: 1.64 ± 0.03	2.394AsnArg: 2.394 ± 0.032	2.268AsnSer: 2.268 ± 0.043	1.652AsnThr: 1.652 ± 0.043	2.762AsnVal: 2.762 ± 0.052	0.498AsnTrp: 0.498 ± 0.018	0.867AsnTyr: 0.867 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.394ProAla: 4.394 ± 0.054	0.342ProCys: 0.342 ± 0.015	3.291ProAsp: 3.291 ± 0.044	3.355ProGlu: 3.355 ± 0.056	1.687ProPhe: 1.687 ± 0.03	3.58ProGly: 3.58 ± 0.057	1.001ProHis: 1.001 ± 0.027	2.802ProIle: 2.802 ± 0.041	1.783ProLys: 1.783 ± 0.038	4.231ProLeu: 4.231 ± 0.049	1.29ProMet: 1.29 ± 0.028	1.933ProAsn: 1.933 ± 0.037	2.381ProPro: 2.381 ± 0.045	1.733ProGln: 1.733 ± 0.032	2.48ProArg: 2.48 ± 0.043	3.887ProSer: 3.887 ± 0.054	3.226ProThr: 3.226 ± 0.049	3.611ProVal: 3.611 ± 0.05	0.648ProTrp: 0.648 ± 0.02	1.113ProTyr: 1.113 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.555GlnAla: 3.555 ± 0.047	0.418GlnCys: 0.418 ± 0.015	1.819GlnAsp: 1.819 ± 0.031	1.724GlnGlu: 1.724 ± 0.036	1.531GlnPhe: 1.531 ± 0.026	2.326GlnGly: 2.326 ± 0.037	0.889GlnHis: 0.889 ± 0.025	2.256GlnIle: 2.256 ± 0.037	1.225GlnLys: 1.225 ± 0.034	4.052GlnLeu: 4.052 ± 0.04	0.95GlnMet: 0.95 ± 0.025	1.25GlnAsn: 1.25 ± 0.027	2.111GlnPro: 2.111 ± 0.034	1.838GlnGln: 1.838 ± 0.041	2.769GlnArg: 2.769 ± 0.047	3.232GlnSer: 3.232 ± 0.04	2.59GlnThr: 2.59 ± 0.037	2.74GlnVal: 2.74 ± 0.039	0.703GlnTrp: 0.703 ± 0.02	0.954GlnTyr: 0.954 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	4.405ArgAla: 4.405 ± 0.058	0.686ArgCys: 0.686 ± 0.02	4.024ArgAsp: 4.024 ± 0.053	3.776ArgGlu: 3.776 ± 0.059	2.768ArgPhe: 2.768 ± 0.038	4.079ArgGly: 4.079 ± 0.058	1.346ArgHis: 1.346 ± 0.034	3.631ArgIle: 3.631 ± 0.047	2.3ArgLys: 2.3 ± 0.043	6.553ArgLeu: 6.553 ± 0.071	1.79ArgMet: 1.79 ± 0.033	2.047ArgAsn: 2.047 ± 0.035	2.833ArgPro: 2.833 ± 0.043	2.545ArgGln: 2.545 ± 0.039	4.636ArgArg: 4.636 ± 0.077	4.42ArgSer: 4.42 ± 0.057	3.226ArgThr: 3.226 ± 0.048	4.506ArgVal: 4.506 ± 0.051	1.141ArgTrp: 1.141 ± 0.031	1.762ArgTyr: 1.762 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.938SerAla: 5.938 ± 0.06	0.661SerCys: 0.661 ± 0.022	5.156SerAsp: 5.156 ± 0.068	4.287SerGlu: 4.287 ± 0.05	2.708SerPhe: 2.708 ± 0.043	6.394SerGly: 6.394 ± 0.104	1.525SerHis: 1.525 ± 0.032	3.885SerIle: 3.885 ± 0.055	2.468SerLys: 2.468 ± 0.042	7.31SerLeu: 7.31 ± 0.064	1.707SerMet: 1.707 ± 0.038	2.525SerAsn: 2.525 ± 0.055	3.718SerPro: 3.718 ± 0.049	2.9SerGln: 2.9 ± 0.039	4.164SerArg: 4.164 ± 0.052	5.514SerSer: 5.514 ± 0.081	4.079SerThr: 4.079 ± 0.063	5.458SerVal: 5.458 ± 0.065	0.9SerTrp: 0.9 ± 0.022	1.536SerTyr: 1.536 ± 0.03	0.001SerXaa: 0.001 ± 0.001
Thr	5.439ThrAla: 5.439 ± 0.064	0.549ThrCys: 0.549 ± 0.02	3.734ThrAsp: 3.734 ± 0.071	3.031ThrGlu: 3.031 ± 0.051	2.294ThrPhe: 2.294 ± 0.055	4.668ThrGly: 4.668 ± 0.088	1.185ThrHis: 1.185 ± 0.025	3.721ThrIle: 3.721 ± 0.075	1.978ThrLys: 1.978 ± 0.039	5.925ThrLeu: 5.925 ± 0.079	1.29ThrMet: 1.29 ± 0.031	2.019ThrAsn: 2.019 ± 0.047	3.202ThrPro: 3.202 ± 0.05	2.102ThrGln: 2.102 ± 0.034	3.181ThrArg: 3.181 ± 0.054	4.22ThrSer: 4.22 ± 0.072	3.54ThrThr: 3.54 ± 0.078	4.379ThrVal: 4.379 ± 0.078	0.759ThrTrp: 0.759 ± 0.021	1.405ThrTyr: 1.405 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.748ValAla: 7.748 ± 0.065	0.899ValCys: 0.899 ± 0.025	5.262ValAsp: 5.262 ± 0.065	4.407ValGlu: 4.407 ± 0.055	2.624ValPhe: 2.624 ± 0.038	5.561ValGly: 5.561 ± 0.073	1.476ValHis: 1.476 ± 0.031	4.083ValIle: 4.083 ± 0.055	2.313ValLys: 2.313 ± 0.042	6.612ValLeu: 6.612 ± 0.067	1.793ValMet: 1.793 ± 0.036	2.482ValAsn: 2.482 ± 0.046	3.494ValPro: 3.494 ± 0.046	2.49ValGln: 2.49 ± 0.035	4.488ValArg: 4.488 ± 0.055	5.299ValSer: 5.299 ± 0.07	4.681ValThr: 4.681 ± 0.09	6.099ValVal: 6.099 ± 0.07	0.942ValTrp: 0.942 ± 0.026	1.643ValTyr: 1.643 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	0.972TrpAla: 0.972 ± 0.027	0.188TrpCys: 0.188 ± 0.01	0.737TrpAsp: 0.737 ± 0.019	0.587TrpGlu: 0.587 ± 0.019	0.565TrpPhe: 0.565 ± 0.015	0.887TrpGly: 0.887 ± 0.026	0.386TrpHis: 0.386 ± 0.015	0.878TrpIle: 0.878 ± 0.02	0.648TrpLys: 0.648 ± 0.022	1.595TrpLeu: 1.595 ± 0.04	0.421TrpMet: 0.421 ± 0.015	0.582TrpAsn: 0.582 ± 0.018	0.616TrpPro: 0.616 ± 0.021	0.698TrpGln: 0.698 ± 0.022	0.861TrpArg: 0.861 ± 0.023	0.922TrpSer: 0.922 ± 0.025	0.876TrpThr: 0.876 ± 0.025	0.913TrpVal: 0.913 ± 0.024	0.249TrpTrp: 0.249 ± 0.012	0.323TrpTyr: 0.323 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.144TyrAla: 2.144 ± 0.036	0.289TyrCys: 0.289 ± 0.011	1.586TyrAsp: 1.586 ± 0.03	1.507TyrGlu: 1.507 ± 0.028	1.078TyrPhe: 1.078 ± 0.023	1.928TyrGly: 1.928 ± 0.036	0.606TyrHis: 0.606 ± 0.021	0.798TyrIle: 0.798 ± 0.019	0.584TyrLys: 0.584 ± 0.018	2.303TyrLeu: 2.303 ± 0.035	0.366TyrMet: 0.366 ± 0.014	0.694TyrAsn: 0.694 ± 0.022	1.15TyrPro: 1.15 ± 0.029	1.164TyrGln: 1.164 ± 0.028	1.98TyrArg: 1.98 ± 0.035	1.506TyrSer: 1.506 ± 0.027	1.196TyrThr: 1.196 ± 0.037	1.717TyrVal: 1.717 ± 0.033	0.393TyrTrp: 0.393 ± 0.017	0.691TyrTyr: 0.691 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 5179 proteins (2058698 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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