Amino acid dipepetide frequency for Dolosigranulum pigrum ATCC 51524

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.131AlaAla: 5.131 ± 0.121	0.46AlaCys: 0.46 ± 0.03	4.671AlaAsp: 4.671 ± 0.106	5.836AlaGlu: 5.836 ± 0.124	2.775AlaPhe: 2.775 ± 0.071	5.293AlaGly: 5.293 ± 0.136	1.532AlaHis: 1.532 ± 0.061	5.97AlaIle: 5.97 ± 0.099	4.111AlaLys: 4.111 ± 0.107	7.362AlaLeu: 7.362 ± 0.136	1.881AlaMet: 1.881 ± 0.067	2.983AlaAsn: 2.983 ± 0.08	2.129AlaPro: 2.129 ± 0.072	3.314AlaGln: 3.314 ± 0.087	2.946AlaArg: 2.946 ± 0.099	4.241AlaSer: 4.241 ± 0.079	4.377AlaThr: 4.377 ± 0.086	5.144AlaVal: 5.144 ± 0.098	0.54AlaTrp: 0.54 ± 0.034	2.536AlaTyr: 2.536 ± 0.082	0.0AlaXaa: 0.0 ± 0.0
Cys	0.309CysAla: 0.309 ± 0.026	0.076CysCys: 0.076 ± 0.014	0.296CysAsp: 0.296 ± 0.027	0.298CysGlu: 0.298 ± 0.026	0.199CysPhe: 0.199 ± 0.018	0.543CysGly: 0.543 ± 0.034	0.16CysHis: 0.16 ± 0.018	0.303CysIle: 0.303 ± 0.025	0.216CysLys: 0.216 ± 0.021	0.471CysLeu: 0.471 ± 0.031	0.119CysMet: 0.119 ± 0.013	0.195CysAsn: 0.195 ± 0.022	0.251CysPro: 0.251 ± 0.023	0.259CysGln: 0.259 ± 0.023	0.225CysArg: 0.225 ± 0.021	0.329CysSer: 0.329 ± 0.025	0.246CysThr: 0.246 ± 0.022	0.301CysVal: 0.301 ± 0.024	0.048CysTrp: 0.048 ± 0.011	0.192CysTyr: 0.192 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.919AspAla: 3.919 ± 0.1	0.29AspCys: 0.29 ± 0.026	3.497AspAsp: 3.497 ± 0.106	5.529AspGlu: 5.529 ± 0.119	2.544AspPhe: 2.544 ± 0.07	4.035AspGly: 4.035 ± 0.132	1.478AspHis: 1.478 ± 0.056	4.915AspIle: 4.915 ± 0.103	3.714AspLys: 3.714 ± 0.098	5.348AspLeu: 5.348 ± 0.111	1.664AspMet: 1.664 ± 0.053	2.447AspAsn: 2.447 ± 0.073	1.988AspPro: 1.988 ± 0.063	2.991AspGln: 2.991 ± 0.079	2.561AspArg: 2.561 ± 0.073	3.005AspSer: 3.005 ± 0.079	2.996AspThr: 2.996 ± 0.077	4.518AspVal: 4.518 ± 0.098	0.59AspTrp: 0.59 ± 0.038	2.864AspTyr: 2.864 ± 0.091	0.0AspXaa: 0.0 ± 0.0
Glu	6.921GluAla: 6.921 ± 0.134	0.285GluCys: 0.285 ± 0.028	4.416GluAsp: 4.416 ± 0.1	6.792GluGlu: 6.792 ± 0.155	2.598GluPhe: 2.598 ± 0.083	4.094GluGly: 4.094 ± 0.113	1.669GluHis: 1.669 ± 0.057	4.989GluIle: 4.989 ± 0.108	4.838GluLys: 4.838 ± 0.136	7.956GluLeu: 7.956 ± 0.141	2.207GluMet: 2.207 ± 0.071	3.143GluAsn: 3.143 ± 0.083	2.215GluPro: 2.215 ± 0.063	4.379GluGln: 4.379 ± 0.113	3.856GluArg: 3.856 ± 0.088	3.86GluSer: 3.86 ± 0.095	4.349GluThr: 4.349 ± 0.112	5.473GluVal: 5.473 ± 0.107	0.677GluTrp: 0.677 ± 0.037	2.311GluTyr: 2.311 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	2.613PheAla: 2.613 ± 0.07	0.212PheCys: 0.212 ± 0.022	2.717PheAsp: 2.717 ± 0.071	2.605PheGlu: 2.605 ± 0.066	1.982PhePhe: 1.982 ± 0.08	3.046PheGly: 3.046 ± 0.09	0.668PheHis: 0.668 ± 0.037	3.402PheIle: 3.402 ± 0.102	2.419PheLys: 2.419 ± 0.086	3.761PheLeu: 3.761 ± 0.088	1.044PheMet: 1.044 ± 0.047	2.168PheAsn: 2.168 ± 0.07	1.433PhePro: 1.433 ± 0.051	1.446PheGln: 1.446 ± 0.051	1.463PheArg: 1.463 ± 0.057	3.104PheSer: 3.104 ± 0.084	2.337PheThr: 2.337 ± 0.063	2.89PheVal: 2.89 ± 0.076	0.367PheTrp: 0.367 ± 0.031	1.632PheTyr: 1.632 ± 0.062	0.0PheXaa: 0.0 ± 0.0
Gly	4.853GlyAla: 4.853 ± 0.124	0.38GlyCys: 0.38 ± 0.027	3.607GlyAsp: 3.607 ± 0.099	4.742GlyGlu: 4.742 ± 0.118	2.951GlyPhe: 2.951 ± 0.074	4.693GlyGly: 4.693 ± 0.129	1.468GlyHis: 1.468 ± 0.057	5.44GlyIle: 5.44 ± 0.132	3.953GlyLys: 3.953 ± 0.11	6.541GlyLeu: 6.541 ± 0.139	1.935GlyMet: 1.935 ± 0.067	2.423GlyAsn: 2.423 ± 0.082	1.556GlyPro: 1.556 ± 0.055	3.158GlyGln: 3.158 ± 0.08	2.747GlyArg: 2.747 ± 0.084	3.638GlySer: 3.638 ± 0.078	4.066GlyThr: 4.066 ± 0.096	5.051GlyVal: 5.051 ± 0.123	0.569GlyTrp: 0.569 ± 0.038	2.635GlyTyr: 2.635 ± 0.075	0.0GlyXaa: 0.0 ± 0.0
His	1.353HisAla: 1.353 ± 0.054	0.127HisCys: 0.127 ± 0.014	1.28HisAsp: 1.28 ± 0.049	1.5HisGlu: 1.5 ± 0.044	0.914HisPhe: 0.914 ± 0.04	1.383HisGly: 1.383 ± 0.047	0.683HisHis: 0.683 ± 0.037	1.716HisIle: 1.716 ± 0.064	1.027HisLys: 1.027 ± 0.044	2.188HisLeu: 2.188 ± 0.074	0.542HisMet: 0.542 ± 0.036	0.912HisAsn: 0.912 ± 0.042	1.107HisPro: 1.107 ± 0.046	1.04HisGln: 1.04 ± 0.051	0.895HisArg: 0.895 ± 0.047	1.176HisSer: 1.176 ± 0.051	1.118HisThr: 1.118 ± 0.053	1.491HisVal: 1.491 ± 0.05	0.207HisTrp: 0.207 ± 0.021	1.053HisTyr: 1.053 ± 0.042	0.0HisXaa: 0.0 ± 0.0
Ile	6.02IleAla: 6.02 ± 0.103	0.475IleCys: 0.475 ± 0.036	5.268IleAsp: 5.268 ± 0.112	5.97IleGlu: 5.97 ± 0.102	3.216IlePhe: 3.216 ± 0.095	5.492IleGly: 5.492 ± 0.138	1.465IleHis: 1.465 ± 0.053	6.19IleIle: 6.19 ± 0.159	3.966IleLys: 3.966 ± 0.089	6.882IleLeu: 6.882 ± 0.157	1.766IleMet: 1.766 ± 0.064	3.461IleAsn: 3.461 ± 0.094	2.894IlePro: 2.894 ± 0.08	3.184IleGln: 3.184 ± 0.072	2.879IleArg: 2.879 ± 0.071	4.639IleSer: 4.639 ± 0.102	4.23IleThr: 4.23 ± 0.111	5.428IleVal: 5.428 ± 0.101	0.556IleTrp: 0.556 ± 0.035	2.68IleTyr: 2.68 ± 0.075	0.0IleXaa: 0.0 ± 0.0
Lys	4.062LysAla: 4.062 ± 0.101	0.175LysCys: 0.175 ± 0.021	3.313LysAsp: 3.313 ± 0.103	5.222LysGlu: 5.222 ± 0.134	1.835LysPhe: 1.835 ± 0.062	3.136LysGly: 3.136 ± 0.09	1.273LysHis: 1.273 ± 0.053	3.742LysIle: 3.742 ± 0.09	4.293LysLys: 4.293 ± 0.115	5.103LysLeu: 5.103 ± 0.096	1.602LysMet: 1.602 ± 0.056	2.667LysAsn: 2.667 ± 0.098	1.937LysPro: 1.937 ± 0.085	3.478LysGln: 3.478 ± 0.094	3.004LysArg: 3.004 ± 0.084	3.059LysSer: 3.059 ± 0.09	3.18LysThr: 3.18 ± 0.076	3.688LysVal: 3.688 ± 0.088	0.512LysTrp: 0.512 ± 0.033	1.893LysTyr: 1.893 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	7.87LeuAla: 7.87 ± 0.152	0.488LeuCys: 0.488 ± 0.031	5.977LeuAsp: 5.977 ± 0.099	6.792LeuGlu: 6.792 ± 0.113	4.323LeuPhe: 4.323 ± 0.118	6.257LeuGly: 6.257 ± 0.135	1.785LeuHis: 1.785 ± 0.061	7.444LeuIle: 7.444 ± 0.157	5.553LeuLys: 5.553 ± 0.105	9.323LeuLeu: 9.323 ± 0.187	2.641LeuMet: 2.641 ± 0.079	4.466LeuAsn: 4.466 ± 0.097	3.674LeuPro: 3.674 ± 0.094	3.573LeuGln: 3.573 ± 0.086	3.58LeuArg: 3.58 ± 0.084	6.949LeuSer: 6.949 ± 0.136	6.316LeuThr: 6.316 ± 0.122	6.1LeuVal: 6.1 ± 0.107	0.69LeuTrp: 0.69 ± 0.032	3.177LeuTyr: 3.177 ± 0.092	0.0LeuXaa: 0.0 ± 0.0
Met	1.79MetAla: 1.79 ± 0.064	0.1MetCys: 0.1 ± 0.014	1.472MetAsp: 1.472 ± 0.058	1.515MetGlu: 1.515 ± 0.05	0.849MetPhe: 0.849 ± 0.038	1.846MetGly: 1.846 ± 0.072	0.478MetHis: 0.478 ± 0.029	2.226MetIle: 2.226 ± 0.069	1.917MetLys: 1.917 ± 0.056	2.326MetLeu: 2.326 ± 0.077	0.891MetMet: 0.891 ± 0.043	1.513MetAsn: 1.513 ± 0.058	0.88MetPro: 0.88 ± 0.04	0.951MetGln: 0.951 ± 0.043	1.068MetArg: 1.068 ± 0.044	1.874MetSer: 1.874 ± 0.06	1.906MetThr: 1.906 ± 0.062	1.623MetVal: 1.623 ± 0.062	0.182MetTrp: 0.182 ± 0.02	0.722MetTyr: 0.722 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	2.622AsnAla: 2.622 ± 0.075	0.268AsnCys: 0.268 ± 0.026	2.408AsnAsp: 2.408 ± 0.067	3.143AsnGlu: 3.143 ± 0.087	1.706AsnPhe: 1.706 ± 0.062	2.858AsnGly: 2.858 ± 0.086	1.109AsnHis: 1.109 ± 0.046	3.789AsnIle: 3.789 ± 0.098	2.689AsnLys: 2.689 ± 0.098	3.927AsnLeu: 3.927 ± 0.084	1.152AsnMet: 1.152 ± 0.049	2.194AsnAsn: 2.194 ± 0.08	1.907AsnPro: 1.907 ± 0.066	2.326AsnGln: 2.326 ± 0.073	2.06AsnArg: 2.06 ± 0.083	2.129AsnSer: 2.129 ± 0.064	2.192AsnThr: 2.192 ± 0.063	2.741AsnVal: 2.741 ± 0.073	0.484AsnTrp: 0.484 ± 0.029	1.785AsnTyr: 1.785 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	2.561ProAla: 2.561 ± 0.078	0.128ProCys: 0.128 ± 0.015	2.376ProAsp: 2.376 ± 0.073	3.227ProGlu: 3.227 ± 0.103	1.608ProPhe: 1.608 ± 0.063	2.192ProGly: 2.192 ± 0.084	0.806ProHis: 0.806 ± 0.037	2.648ProIle: 2.648 ± 0.072	1.822ProLys: 1.822 ± 0.064	3.069ProLeu: 3.069 ± 0.08	0.683ProMet: 0.683 ± 0.036	1.692ProAsn: 1.692 ± 0.066	0.748ProPro: 0.748 ± 0.034	1.288ProGln: 1.288 ± 0.053	1.057ProArg: 1.057 ± 0.05	2.03ProSer: 2.03 ± 0.061	2.389ProThr: 2.389 ± 0.064	2.501ProVal: 2.501 ± 0.073	0.29ProTrp: 0.29 ± 0.024	1.373ProTyr: 1.373 ± 0.061	0.0ProXaa: 0.0 ± 0.0
Gln	4.332GlnAla: 4.332 ± 0.108	0.166GlnCys: 0.166 ± 0.018	2.216GlnAsp: 2.216 ± 0.067	3.443GlnGlu: 3.443 ± 0.09	1.863GlnPhe: 1.863 ± 0.068	2.358GlnGly: 2.358 ± 0.07	1.018GlnHis: 1.018 ± 0.043	2.603GlnIle: 2.603 ± 0.063	2.458GlnLys: 2.458 ± 0.085	5.564GlnLeu: 5.564 ± 0.127	1.176GlnMet: 1.176 ± 0.042	1.593GlnAsn: 1.593 ± 0.054	1.755GlnPro: 1.755 ± 0.081	2.695GlnGln: 2.695 ± 0.099	1.785GlnArg: 1.785 ± 0.062	2.844GlnSer: 2.844 ± 0.086	2.663GlnThr: 2.663 ± 0.079	3.179GlnVal: 3.179 ± 0.086	0.419GlnTrp: 0.419 ± 0.032	1.747GlnTyr: 1.747 ± 0.064	0.0GlnXaa: 0.0 ± 0.0
Arg	2.659ArgAla: 2.659 ± 0.075	0.218ArgCys: 0.218 ± 0.021	2.389ArgAsp: 2.389 ± 0.075	3.603ArgGlu: 3.603 ± 0.099	1.747ArgPhe: 1.747 ± 0.059	2.522ArgGly: 2.522 ± 0.072	0.906ArgHis: 0.906 ± 0.043	3.035ArgIle: 3.035 ± 0.084	2.449ArgLys: 2.449 ± 0.08	4.156ArgLeu: 4.156 ± 0.088	1.126ArgMet: 1.126 ± 0.043	1.573ArgAsn: 1.573 ± 0.056	1.347ArgPro: 1.347 ± 0.046	2.434ArgGln: 2.434 ± 0.065	2.012ArgArg: 2.012 ± 0.064	2.241ArgSer: 2.241 ± 0.075	2.097ArgThr: 2.097 ± 0.068	2.842ArgVal: 2.842 ± 0.078	0.346ArgTrp: 0.346 ± 0.026	1.621ArgTyr: 1.621 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	3.923SerAla: 3.923 ± 0.088	0.259SerCys: 0.259 ± 0.025	3.683SerAsp: 3.683 ± 0.104	4.356SerGlu: 4.356 ± 0.092	2.68SerPhe: 2.68 ± 0.081	4.688SerGly: 4.688 ± 0.097	1.314SerHis: 1.314 ± 0.05	4.533SerIle: 4.533 ± 0.111	2.951SerLys: 2.951 ± 0.074	5.78SerLeu: 5.78 ± 0.107	1.409SerMet: 1.409 ± 0.048	2.563SerAsn: 2.563 ± 0.069	1.978SerPro: 1.978 ± 0.061	2.425SerGln: 2.425 ± 0.057	2.451SerArg: 2.451 ± 0.069	3.61SerSer: 3.61 ± 0.084	3.435SerThr: 3.435 ± 0.081	4.09SerVal: 4.09 ± 0.088	0.534SerTrp: 0.534 ± 0.034	2.248SerTyr: 2.248 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	4.129ThrAla: 4.129 ± 0.098	0.275ThrCys: 0.275 ± 0.024	3.811ThrAsp: 3.811 ± 0.092	4.17ThrGlu: 4.17 ± 0.095	2.518ThrPhe: 2.518 ± 0.068	4.005ThrGly: 4.005 ± 0.091	1.364ThrHis: 1.364 ± 0.052	4.963ThrIle: 4.963 ± 0.097	2.769ThrLys: 2.769 ± 0.071	5.892ThrLeu: 5.892 ± 0.117	1.29ThrMet: 1.29 ± 0.052	2.339ThrAsn: 2.339 ± 0.074	2.594ThrPro: 2.594 ± 0.091	2.071ThrGln: 2.071 ± 0.068	1.902ThrArg: 1.902 ± 0.066	3.29ThrSer: 3.29 ± 0.077	3.607ThrThr: 3.607 ± 0.1	4.617ThrVal: 4.617 ± 0.106	0.441ThrTrp: 0.441 ± 0.033	2.213ThrTyr: 2.213 ± 0.064	0.0ThrXaa: 0.0 ± 0.0
Val	5.32ValAla: 5.32 ± 0.099	0.337ValCys: 0.337 ± 0.027	4.693ValAsp: 4.693 ± 0.102	5.08ValGlu: 5.08 ± 0.12	2.795ValPhe: 2.795 ± 0.079	5.012ValGly: 5.012 ± 0.114	1.347ValHis: 1.347 ± 0.056	5.404ValIle: 5.404 ± 0.131	3.713ValLys: 3.713 ± 0.086	6.482ValLeu: 6.482 ± 0.135	1.9ValMet: 1.9 ± 0.059	2.998ValAsn: 2.998 ± 0.081	2.492ValPro: 2.492 ± 0.071	2.592ValGln: 2.592 ± 0.072	2.713ValArg: 2.713 ± 0.08	4.381ValSer: 4.381 ± 0.095	4.303ValThr: 4.303 ± 0.099	5.162ValVal: 5.162 ± 0.11	0.584ValTrp: 0.584 ± 0.04	2.369ValTyr: 2.369 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.497TrpAla: 0.497 ± 0.033	0.056TrpCys: 0.056 ± 0.01	0.43TrpAsp: 0.43 ± 0.026	0.581TrpGlu: 0.581 ± 0.035	0.404TrpPhe: 0.404 ± 0.027	0.553TrpGly: 0.553 ± 0.035	0.203TrpHis: 0.203 ± 0.019	0.625TrpIle: 0.625 ± 0.035	0.439TrpLys: 0.439 ± 0.027	1.105TrpLeu: 1.105 ± 0.044	0.242TrpMet: 0.242 ± 0.024	0.381TrpAsn: 0.381 ± 0.028	0.223TrpPro: 0.223 ± 0.02	0.478TrpGln: 0.478 ± 0.033	0.376TrpArg: 0.376 ± 0.028	0.489TrpSer: 0.489 ± 0.028	0.462TrpThr: 0.462 ± 0.031	0.515TrpVal: 0.515 ± 0.033	0.119TrpTrp: 0.119 ± 0.014	0.296TrpTyr: 0.296 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.345TyrAla: 2.345 ± 0.076	0.264TyrCys: 0.264 ± 0.024	2.371TyrAsp: 2.371 ± 0.072	2.624TyrGlu: 2.624 ± 0.075	1.805TyrPhe: 1.805 ± 0.058	2.402TyrGly: 2.402 ± 0.076	0.986TyrHis: 0.986 ± 0.043	2.723TyrIle: 2.723 ± 0.082	1.876TyrLys: 1.876 ± 0.062	3.742TyrLeu: 3.742 ± 0.097	0.858TyrMet: 0.858 ± 0.041	1.779TyrAsn: 1.779 ± 0.061	1.381TyrPro: 1.381 ± 0.051	1.794TyrGln: 1.794 ± 0.066	1.744TyrArg: 1.744 ± 0.06	2.021TyrSer: 2.021 ± 0.068	1.991TyrThr: 1.991 ± 0.065	2.322TyrVal: 2.322 ± 0.066	0.318TyrTrp: 0.318 ± 0.023	1.591TyrTyr: 1.591 ± 0.062	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1691 proteins (537359 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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