Amino acid dipepetide frequency for Exophiala sideris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.704AlaAla: 8.704 ± 0.052	1.049AlaCys: 1.049 ± 0.017	4.444AlaAsp: 4.444 ± 0.031	5.182AlaGlu: 5.182 ± 0.04	3.118AlaPhe: 3.118 ± 0.027	5.855AlaGly: 5.855 ± 0.04	1.798AlaHis: 1.798 ± 0.02	4.204AlaIle: 4.204 ± 0.029	4.158AlaLys: 4.158 ± 0.033	7.628AlaLeu: 7.628 ± 0.044	2.046AlaMet: 2.046 ± 0.021	3.029AlaAsn: 3.029 ± 0.023	4.57AlaPro: 4.57 ± 0.044	3.672AlaGln: 3.672 ± 0.03	5.045AlaArg: 5.045 ± 0.033	7.165AlaSer: 7.165 ± 0.056	5.495AlaThr: 5.495 ± 0.034	5.327AlaVal: 5.327 ± 0.035	1.149AlaTrp: 1.149 ± 0.015	2.205AlaTyr: 2.205 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.936CysAla: 0.936 ± 0.016	0.229CysCys: 0.229 ± 0.008	0.637CysAsp: 0.637 ± 0.012	0.574CysGlu: 0.574 ± 0.01	0.529CysPhe: 0.529 ± 0.009	0.872CysGly: 0.872 ± 0.016	0.323CysHis: 0.323 ± 0.009	0.682CysIle: 0.682 ± 0.012	0.496CysLys: 0.496 ± 0.01	1.24CysLeu: 1.24 ± 0.017	0.273CysMet: 0.273 ± 0.008	0.4CysAsn: 0.4 ± 0.009	0.608CysPro: 0.608 ± 0.011	0.453CysGln: 0.453 ± 0.009	0.758CysArg: 0.758 ± 0.015	0.858CysSer: 0.858 ± 0.014	0.662CysThr: 0.662 ± 0.01	0.767CysVal: 0.767 ± 0.013	0.197CysTrp: 0.197 ± 0.006	0.34CysTyr: 0.34 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.765AspAla: 4.765 ± 0.034	0.598AspCys: 0.598 ± 0.013	4.404AspAsp: 4.404 ± 0.046	4.629AspGlu: 4.629 ± 0.042	2.344AspPhe: 2.344 ± 0.023	3.949AspGly: 3.949 ± 0.034	1.33AspHis: 1.33 ± 0.017	3.03AspIle: 3.03 ± 0.028	2.499AspLys: 2.499 ± 0.024	5.225AspLeu: 5.225 ± 0.033	1.327AspMet: 1.327 ± 0.015	1.934AspAsn: 1.934 ± 0.019	3.349AspPro: 3.349 ± 0.028	2.047AspGln: 2.047 ± 0.021	3.101AspArg: 3.101 ± 0.034	4.062AspSer: 4.062 ± 0.031	3.139AspThr: 3.139 ± 0.023	3.854AspVal: 3.854 ± 0.028	0.898AspTrp: 0.898 ± 0.014	1.608AspTyr: 1.608 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.326GluAla: 5.326 ± 0.038	0.608GluCys: 0.608 ± 0.013	4.357GluAsp: 4.357 ± 0.046	5.263GluGlu: 5.263 ± 0.054	1.825GluPhe: 1.825 ± 0.021	3.62GluGly: 3.62 ± 0.028	1.508GluHis: 1.508 ± 0.017	2.989GluIle: 2.989 ± 0.026	3.673GluLys: 3.673 ± 0.036	5.006GluLeu: 5.006 ± 0.042	1.474GluMet: 1.474 ± 0.018	2.197GluAsn: 2.197 ± 0.02	2.773GluPro: 2.773 ± 0.029	2.697GluGln: 2.697 ± 0.023	3.897GluArg: 3.897 ± 0.034	4.266GluSer: 4.266 ± 0.034	3.527GluThr: 3.527 ± 0.031	3.706GluVal: 3.706 ± 0.029	0.855GluTrp: 0.855 ± 0.013	1.643GluTyr: 1.643 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.044PheAla: 3.044 ± 0.027	0.556PheCys: 0.556 ± 0.011	2.352PheAsp: 2.352 ± 0.018	2.211PheGlu: 2.211 ± 0.022	1.565PhePhe: 1.565 ± 0.018	2.842PheGly: 2.842 ± 0.03	0.884PheHis: 0.884 ± 0.013	1.685PheIle: 1.685 ± 0.023	1.448PheLys: 1.448 ± 0.019	3.386PheLeu: 3.386 ± 0.034	0.793PheMet: 0.793 ± 0.011	1.392PheAsn: 1.392 ± 0.017	1.878PhePro: 1.878 ± 0.018	1.42PheGln: 1.42 ± 0.016	1.932PheArg: 1.932 ± 0.019	2.897PheSer: 2.897 ± 0.028	2.098PheThr: 2.098 ± 0.019	2.356PheVal: 2.356 ± 0.022	0.619PheTrp: 0.619 ± 0.012	1.063PheTyr: 1.063 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.168GlyAla: 5.168 ± 0.037	0.778GlyCys: 0.778 ± 0.014	3.53GlyAsp: 3.53 ± 0.03	3.494GlyGlu: 3.494 ± 0.027	2.747GlyPhe: 2.747 ± 0.024	5.518GlyGly: 5.518 ± 0.053	1.747GlyHis: 1.747 ± 0.02	3.432GlyIle: 3.432 ± 0.03	3.43GlyLys: 3.43 ± 0.029	6.063GlyLeu: 6.063 ± 0.041	1.673GlyMet: 1.673 ± 0.019	2.42GlyAsn: 2.42 ± 0.021	3.307GlyPro: 3.307 ± 0.03	2.796GlyGln: 2.796 ± 0.031	4.108GlyArg: 4.108 ± 0.031	5.47GlySer: 5.47 ± 0.035	4.07GlyThr: 4.07 ± 0.031	4.288GlyVal: 4.288 ± 0.035	1.104GlyTrp: 1.104 ± 0.015	2.142GlyTyr: 2.142 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.917HisAla: 1.917 ± 0.021	0.322HisCys: 0.322 ± 0.008	1.483HisAsp: 1.483 ± 0.017	1.44HisGlu: 1.44 ± 0.019	0.951HisPhe: 0.951 ± 0.015	1.765HisGly: 1.765 ± 0.02	0.866HisHis: 0.866 ± 0.014	1.223HisIle: 1.223 ± 0.016	0.988HisLys: 0.988 ± 0.014	2.256HisLeu: 2.256 ± 0.021	0.524HisMet: 0.524 ± 0.01	0.895HisAsn: 0.895 ± 0.012	1.632HisPro: 1.632 ± 0.018	1.037HisGln: 1.037 ± 0.015	1.487HisArg: 1.487 ± 0.018	1.811HisSer: 1.811 ± 0.019	1.318HisThr: 1.318 ± 0.017	1.504HisVal: 1.504 ± 0.017	0.348HisTrp: 0.348 ± 0.008	0.702HisTyr: 0.702 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.183IleAla: 4.183 ± 0.031	0.726IleCys: 0.726 ± 0.012	2.887IleAsp: 2.887 ± 0.024	2.863IleGlu: 2.863 ± 0.025	1.914IlePhe: 1.914 ± 0.023	3.166IleGly: 3.166 ± 0.029	1.188IleHis: 1.188 ± 0.016	2.389IleIle: 2.389 ± 0.027	2.143IleLys: 2.143 ± 0.023	4.531IleLeu: 4.531 ± 0.036	1.009IleMet: 1.009 ± 0.014	1.784IleAsn: 1.784 ± 0.018	3.01IlePro: 3.01 ± 0.025	1.876IleGln: 1.876 ± 0.019	2.705IleArg: 2.705 ± 0.018	3.832IleSer: 3.832 ± 0.027	2.832IleThr: 2.832 ± 0.027	3.151IleVal: 3.151 ± 0.025	0.71IleTrp: 0.71 ± 0.012	1.386IleTyr: 1.386 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.378LysAla: 4.378 ± 0.035	0.514LysCys: 0.514 ± 0.01	2.964LysAsp: 2.964 ± 0.027	3.377LysGlu: 3.377 ± 0.038	1.45LysPhe: 1.45 ± 0.017	2.934LysGly: 2.934 ± 0.026	1.221LysHis: 1.221 ± 0.015	2.263LysIle: 2.263 ± 0.019	3.267LysLys: 3.267 ± 0.053	3.995LysLeu: 3.995 ± 0.029	1.058LysMet: 1.058 ± 0.016	1.696LysAsn: 1.696 ± 0.018	2.779LysPro: 2.779 ± 0.029	1.988LysGln: 1.988 ± 0.021	3.415LysArg: 3.415 ± 0.032	3.706LysSer: 3.706 ± 0.035	2.91LysThr: 2.91 ± 0.026	2.962LysVal: 2.962 ± 0.026	0.674LysTrp: 0.674 ± 0.012	1.4LysTyr: 1.4 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.699LeuAla: 7.699 ± 0.044	1.204LeuCys: 1.204 ± 0.015	5.257LeuAsp: 5.257 ± 0.033	5.413LeuGlu: 5.413 ± 0.045	3.231LeuPhe: 3.231 ± 0.027	5.761LeuGly: 5.761 ± 0.036	2.221LeuHis: 2.221 ± 0.021	3.875LeuIle: 3.875 ± 0.034	4.264LeuLys: 4.264 ± 0.035	8.203LeuLeu: 8.203 ± 0.056	1.794LeuMet: 1.794 ± 0.018	3.183LeuAsn: 3.183 ± 0.028	5.427LeuPro: 5.427 ± 0.035	3.945LeuGln: 3.945 ± 0.032	5.643LeuArg: 5.643 ± 0.038	7.221LeuSer: 7.221 ± 0.045	4.934LeuThr: 4.934 ± 0.033	5.281LeuVal: 5.281 ± 0.038	1.175LeuTrp: 1.175 ± 0.017	2.312LeuTyr: 2.312 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.279MetAla: 2.279 ± 0.021	0.237MetCys: 0.237 ± 0.008	1.273MetAsp: 1.273 ± 0.014	1.206MetGlu: 1.206 ± 0.016	0.769MetPhe: 0.769 ± 0.013	1.479MetGly: 1.479 ± 0.019	0.53MetHis: 0.53 ± 0.011	1.021MetIle: 1.021 ± 0.011	0.999MetLys: 0.999 ± 0.014	1.944MetLeu: 1.944 ± 0.019	0.566MetMet: 0.566 ± 0.011	0.827MetAsn: 0.827 ± 0.014	1.384MetPro: 1.384 ± 0.017	0.944MetGln: 0.944 ± 0.015	1.227MetArg: 1.227 ± 0.015	2.051MetSer: 2.051 ± 0.017	1.405MetThr: 1.405 ± 0.017	1.318MetVal: 1.318 ± 0.017	0.255MetTrp: 0.255 ± 0.008	0.549MetTyr: 0.549 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.215AsnAla: 3.215 ± 0.027	0.401AsnCys: 0.401 ± 0.008	2.071AsnAsp: 2.071 ± 0.019	2.046AsnGlu: 2.046 ± 0.022	1.347AsnPhe: 1.347 ± 0.018	3.035AsnGly: 3.035 ± 0.031	0.887AsnHis: 0.887 ± 0.013	2.014AsnIle: 2.014 ± 0.022	1.594AsnLys: 1.594 ± 0.019	3.234AsnLeu: 3.234 ± 0.024	0.857AsnMet: 0.857 ± 0.013	1.475AsnAsn: 1.475 ± 0.018	2.367AsnPro: 2.367 ± 0.023	1.377AsnGln: 1.377 ± 0.018	1.81AsnArg: 1.81 ± 0.018	2.648AsnSer: 2.648 ± 0.027	2.247AsnThr: 2.247 ± 0.022	2.47AsnVal: 2.47 ± 0.021	0.513AsnTrp: 0.513 ± 0.011	1.046AsnTyr: 1.046 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.177ProAla: 5.177 ± 0.038	0.485ProCys: 0.485 ± 0.009	3.257ProAsp: 3.257 ± 0.027	3.802ProGlu: 3.802 ± 0.029	1.983ProPhe: 1.983 ± 0.022	3.869ProGly: 3.869 ± 0.03	1.323ProHis: 1.323 ± 0.015	2.488ProIle: 2.488 ± 0.021	2.669ProLys: 2.669 ± 0.027	4.627ProLeu: 4.627 ± 0.032	1.131ProMet: 1.131 ± 0.016	2.208ProAsn: 2.208 ± 0.022	4.981ProPro: 4.981 ± 0.063	2.681ProGln: 2.681 ± 0.03	3.374ProArg: 3.374 ± 0.032	5.912ProSer: 5.912 ± 0.048	4.115ProThr: 4.115 ± 0.033	3.574ProVal: 3.574 ± 0.03	0.738ProTrp: 0.738 ± 0.012	1.519ProTyr: 1.519 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.731GlnAla: 3.731 ± 0.028	0.454GlnCys: 0.454 ± 0.011	2.28GlnAsp: 2.28 ± 0.02	2.582GlnGlu: 2.582 ± 0.025	1.313GlnPhe: 1.313 ± 0.017	2.557GlnGly: 2.557 ± 0.027	1.183GlnHis: 1.183 ± 0.017	2.008GlnIle: 2.008 ± 0.02	2.118GlnLys: 2.118 ± 0.022	3.429GlnLeu: 3.429 ± 0.023	0.932GlnMet: 0.932 ± 0.017	1.668GlnAsn: 1.668 ± 0.021	2.716GlnPro: 2.716 ± 0.034	2.601GlnGln: 2.601 ± 0.039	2.747GlnArg: 2.747 ± 0.022	3.455GlnSer: 3.455 ± 0.031	2.516GlnThr: 2.516 ± 0.022	2.239GlnVal: 2.239 ± 0.022	0.569GlnTrp: 0.569 ± 0.011	1.25GlnTyr: 1.25 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.627ArgAla: 4.627 ± 0.031	0.7ArgCys: 0.7 ± 0.013	3.351ArgAsp: 3.351 ± 0.034	3.675ArgGlu: 3.675 ± 0.036	2.009ArgPhe: 2.009 ± 0.016	3.574ArgGly: 3.574 ± 0.03	1.605ArgHis: 1.605 ± 0.017	2.793ArgIle: 2.793 ± 0.025	3.634ArgLys: 3.634 ± 0.029	5.429ArgLeu: 5.429 ± 0.035	1.31ArgMet: 1.31 ± 0.016	2.238ArgAsn: 2.238 ± 0.023	3.691ArgPro: 3.691 ± 0.029	2.745ArgGln: 2.745 ± 0.023	5.113ArgArg: 5.113 ± 0.044	4.899ArgSer: 4.899 ± 0.038	3.462ArgThr: 3.462 ± 0.028	3.21ArgVal: 3.21 ± 0.027	0.871ArgTrp: 0.871 ± 0.015	1.674ArgTyr: 1.674 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.747SerAla: 6.747 ± 0.048	0.842SerCys: 0.842 ± 0.015	4.227SerAsp: 4.227 ± 0.03	4.134SerGlu: 4.134 ± 0.034	2.939SerPhe: 2.939 ± 0.023	5.445SerGly: 5.445 ± 0.037	1.95SerHis: 1.95 ± 0.021	3.988SerIle: 3.988 ± 0.031	3.849SerLys: 3.849 ± 0.034	7.056SerLeu: 7.056 ± 0.044	1.827SerMet: 1.827 ± 0.023	3.011SerAsn: 3.011 ± 0.023	5.402SerPro: 5.402 ± 0.051	3.47SerGln: 3.47 ± 0.03	5.112SerArg: 5.112 ± 0.04	8.771SerSer: 8.771 ± 0.086	6.175SerThr: 6.175 ± 0.067	4.535SerVal: 4.535 ± 0.031	1.101SerTrp: 1.101 ± 0.015	2.047SerTyr: 2.047 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.377ThrAla: 5.377 ± 0.04	0.744ThrCys: 0.744 ± 0.012	2.958ThrAsp: 2.958 ± 0.025	3.152ThrGlu: 3.152 ± 0.022	2.33ThrPhe: 2.33 ± 0.02	4.204ThrGly: 4.204 ± 0.035	1.31ThrHis: 1.31 ± 0.017	3.206ThrIle: 3.206 ± 0.028	2.82ThrLys: 2.82 ± 0.028	5.245ThrLeu: 5.245 ± 0.034	1.321ThrMet: 1.321 ± 0.015	2.328ThrAsn: 2.328 ± 0.02	4.357ThrPro: 4.357 ± 0.034	2.324ThrGln: 2.324 ± 0.025	3.188ThrArg: 3.188 ± 0.027	5.955ThrSer: 5.955 ± 0.059	5.197ThrThr: 5.197 ± 0.103	3.785ThrVal: 3.785 ± 0.03	0.859ThrTrp: 0.859 ± 0.013	1.624ThrTyr: 1.624 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.252ValAla: 5.252 ± 0.033	0.799ValCys: 0.799 ± 0.013	3.804ValAsp: 3.804 ± 0.029	3.857ValGlu: 3.857 ± 0.028	2.348ValPhe: 2.348 ± 0.019	3.901ValGly: 3.901 ± 0.035	1.45ValHis: 1.45 ± 0.016	2.902ValIle: 2.902 ± 0.032	2.994ValLys: 2.994 ± 0.026	5.588ValLeu: 5.588 ± 0.037	1.34ValMet: 1.34 ± 0.017	2.256ValAsn: 2.256 ± 0.023	3.609ValPro: 3.609 ± 0.024	2.507ValGln: 2.507 ± 0.022	3.457ValArg: 3.457 ± 0.026	4.584ValSer: 4.584 ± 0.029	3.592ValThr: 3.592 ± 0.033	4.319ValVal: 4.319 ± 0.043	0.865ValTrp: 0.865 ± 0.014	1.692ValTyr: 1.692 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.089TrpAla: 1.089 ± 0.018	0.179TrpCys: 0.179 ± 0.006	0.852TrpAsp: 0.852 ± 0.015	0.774TrpGlu: 0.774 ± 0.012	0.531TrpPhe: 0.531 ± 0.01	0.855TrpGly: 0.855 ± 0.016	0.389TrpHis: 0.389 ± 0.009	0.744TrpIle: 0.744 ± 0.011	0.773TrpLys: 0.773 ± 0.012	1.34TrpLeu: 1.34 ± 0.016	0.375TrpMet: 0.375 ± 0.009	0.593TrpAsn: 0.593 ± 0.009	0.599TrpPro: 0.599 ± 0.011	0.614TrpGln: 0.614 ± 0.011	0.933TrpArg: 0.933 ± 0.014	1.078TrpSer: 1.078 ± 0.016	0.951TrpThr: 0.951 ± 0.014	0.82TrpVal: 0.82 ± 0.014	0.275TrpTrp: 0.275 ± 0.009	0.441TrpTyr: 0.441 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.227TyrAla: 2.227 ± 0.021	0.41TyrCys: 0.41 ± 0.01	1.704TyrAsp: 1.704 ± 0.017	1.538TyrGlu: 1.538 ± 0.016	1.177TyrPhe: 1.177 ± 0.017	2.081TyrGly: 2.081 ± 0.026	0.756TyrHis: 0.756 ± 0.011	1.348TyrIle: 1.348 ± 0.017	1.133TyrLys: 1.133 ± 0.015	2.617TyrLeu: 2.617 ± 0.023	0.635TyrMet: 0.635 ± 0.011	1.119TyrAsn: 1.119 ± 0.016	1.473TyrPro: 1.473 ± 0.019	1.156TyrGln: 1.156 ± 0.015	1.558TyrArg: 1.558 ± 0.016	1.989TyrSer: 1.989 ± 0.02	1.642TyrThr: 1.642 ± 0.017	1.649TyrVal: 1.649 ± 0.02	0.431TyrTrp: 0.431 ± 0.011	0.909TyrTyr: 0.909 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10841 proteins (5408673 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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