Amino acid dipepetide frequency for Prevotella pleuritidis F0068

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.851AlaAla: 5.851 ± 0.123
0.916AlaCys: 0.916 ± 0.036
4.718AlaAsp: 4.718 ± 0.08
4.65AlaGlu: 4.65 ± 0.084
3.282AlaPhe: 3.282 ± 0.071
4.872AlaGly: 4.872 ± 0.085
1.465AlaHis: 1.465 ± 0.04
4.66AlaIle: 4.66 ± 0.09
4.218AlaLys: 4.218 ± 0.089
6.941AlaLeu: 6.941 ± 0.111
1.968AlaMet: 1.968 ± 0.053
3.151AlaAsn: 3.151 ± 0.065
2.315AlaPro: 2.315 ± 0.059
2.965AlaGln: 2.965 ± 0.062
3.79AlaArg: 3.79 ± 0.075
3.985AlaSer: 3.985 ± 0.08
4.003AlaThr: 4.003 ± 0.079
5.183AlaVal: 5.183 ± 0.088
0.713AlaTrp: 0.713 ± 0.029
3.124AlaTyr: 3.124 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.875CysAla: 0.875 ± 0.033
0.178CysCys: 0.178 ± 0.015
0.703CysAsp: 0.703 ± 0.029
0.693CysGlu: 0.693 ± 0.032
0.566CysPhe: 0.566 ± 0.029
1.074CysGly: 1.074 ± 0.037
0.344CysHis: 0.344 ± 0.021
0.894CysIle: 0.894 ± 0.037
0.656CysLys: 0.656 ± 0.031
1.082CysLeu: 1.082 ± 0.044
0.255CysMet: 0.255 ± 0.018
0.673CysAsn: 0.673 ± 0.029
0.52CysPro: 0.52 ± 0.032
0.338CysGln: 0.338 ± 0.021
0.767CysArg: 0.767 ± 0.033
0.707CysSer: 0.707 ± 0.029
0.719CysThr: 0.719 ± 0.034
0.782CysVal: 0.782 ± 0.033
0.159CysTrp: 0.159 ± 0.015
0.547CysTyr: 0.547 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
4.17AspAla: 4.17 ± 0.079
0.73AspCys: 0.73 ± 0.032
3.045AspAsp: 3.045 ± 0.072
3.971AspGlu: 3.971 ± 0.083
3.061AspPhe: 3.061 ± 0.071
4.077AspGly: 4.077 ± 0.087
1.048AspHis: 1.048 ± 0.042
4.433AspIle: 4.433 ± 0.082
3.867AspLys: 3.867 ± 0.091
4.751AspLeu: 4.751 ± 0.074
1.378AspMet: 1.378 ± 0.043
2.9AspAsn: 2.9 ± 0.063
1.91AspPro: 1.91 ± 0.048
1.326AspGln: 1.326 ± 0.046
3.26AspArg: 3.26 ± 0.064
3.176AspSer: 3.176 ± 0.07
2.995AspThr: 2.995 ± 0.071
3.692AspVal: 3.692 ± 0.074
0.8AspTrp: 0.8 ± 0.036
2.914AspTyr: 2.914 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
4.451GluAla: 4.451 ± 0.09
0.64GluCys: 0.64 ± 0.028
2.953GluAsp: 2.953 ± 0.064
3.889GluGlu: 3.889 ± 0.093
2.177GluPhe: 2.177 ± 0.048
3.386GluGly: 3.386 ± 0.073
1.315GluHis: 1.315 ± 0.045
4.348GluIle: 4.348 ± 0.089
4.405GluLys: 4.405 ± 0.1
5.535GluLeu: 5.535 ± 0.097
2.055GluMet: 2.055 ± 0.053
3.086GluAsn: 3.086 ± 0.058
1.561GluPro: 1.561 ± 0.042
2.759GluGln: 2.759 ± 0.063
3.604GluArg: 3.604 ± 0.083
3.08GluSer: 3.08 ± 0.067
3.339GluThr: 3.339 ± 0.066
3.698GluVal: 3.698 ± 0.076
0.698GluTrp: 0.698 ± 0.029
2.28GluTyr: 2.28 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.091PheAla: 3.091 ± 0.062
0.761PheCys: 0.761 ± 0.033
2.891PheAsp: 2.891 ± 0.058
2.387PheGlu: 2.387 ± 0.061
2.112PhePhe: 2.112 ± 0.064
3.394PheGly: 3.394 ± 0.082
0.95PheHis: 0.95 ± 0.036
3.181PheIle: 3.181 ± 0.074
2.488PheLys: 2.488 ± 0.057
3.841PheLeu: 3.841 ± 0.079
1.022PheMet: 1.022 ± 0.043
2.431PheAsn: 2.431 ± 0.067
1.562PhePro: 1.562 ± 0.045
1.206PheGln: 1.206 ± 0.041
2.401PheArg: 2.401 ± 0.053
3.162PheSer: 3.162 ± 0.067
2.901PheThr: 2.901 ± 0.069
2.967PheVal: 2.967 ± 0.066
0.48PheTrp: 0.48 ± 0.028
1.824PheTyr: 1.824 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
4.377GlyAla: 4.377 ± 0.087
0.861GlyCys: 0.861 ± 0.035
3.438GlyAsp: 3.438 ± 0.069
3.824GlyGlu: 3.824 ± 0.076
3.209GlyPhe: 3.209 ± 0.06
4.756GlyGly: 4.756 ± 0.089
1.432GlyHis: 1.432 ± 0.048
5.273GlyIle: 5.273 ± 0.094
5.061GlyLys: 5.061 ± 0.085
5.86GlyLeu: 5.86 ± 0.093
1.837GlyMet: 1.837 ± 0.06
3.419GlyAsn: 3.419 ± 0.066
1.289GlyPro: 1.289 ± 0.051
2.261GlyGln: 2.261 ± 0.062
3.688GlyArg: 3.688 ± 0.076
3.961GlySer: 3.961 ± 0.082
4.254GlyThr: 4.254 ± 0.082
4.59GlyVal: 4.59 ± 0.097
0.901GlyTrp: 0.901 ± 0.041
3.061GlyTyr: 3.061 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
1.001HisAla: 1.001 ± 0.036
0.352HisCys: 0.352 ± 0.024
1.009HisAsp: 1.009 ± 0.038
0.87HisGlu: 0.87 ± 0.033
1.159HisPhe: 1.159 ± 0.035
1.285HisGly: 1.285 ± 0.044
0.608HisHis: 0.608 ± 0.027
1.684HisIle: 1.684 ± 0.046
1.143HisLys: 1.143 ± 0.041
2.185HisLeu: 2.185 ± 0.057
0.28HisMet: 0.28 ± 0.016
1.085HisAsn: 1.085 ± 0.04
1.189HisPro: 1.189 ± 0.041
0.805HisGln: 0.805 ± 0.03
1.376HisArg: 1.376 ± 0.044
1.274HisSer: 1.274 ± 0.045
1.271HisThr: 1.271 ± 0.039
1.009HisVal: 1.009 ± 0.035
0.288HisTrp: 0.288 ± 0.018
1.066HisTyr: 1.066 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.51IleAla: 5.51 ± 0.098
0.968IleCys: 0.968 ± 0.032
4.823IleAsp: 4.823 ± 0.09
4.34IleGlu: 4.34 ± 0.087
2.622IlePhe: 2.622 ± 0.07
4.844IleGly: 4.844 ± 0.088
1.305IleHis: 1.305 ± 0.044
4.692IleIle: 4.692 ± 0.098
4.03IleLys: 4.03 ± 0.077
5.558IleLeu: 5.558 ± 0.102
1.34IleMet: 1.34 ± 0.041
3.538IleAsn: 3.538 ± 0.082
3.072IlePro: 3.072 ± 0.065
2.125IleGln: 2.125 ± 0.053
3.869IleArg: 3.869 ± 0.08
4.412IleSer: 4.412 ± 0.082
4.245IleThr: 4.245 ± 0.077
4.631IleVal: 4.631 ± 0.077
0.618IleTrp: 0.618 ± 0.032
2.659IleTyr: 2.659 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
4.859LysAla: 4.859 ± 0.096
0.538LysCys: 0.538 ± 0.03
3.823LysAsp: 3.823 ± 0.095
4.57LysGlu: 4.57 ± 0.092
2.149LysPhe: 2.149 ± 0.059
4.157LysGly: 4.157 ± 0.07
1.2LysHis: 1.2 ± 0.042
3.97LysIle: 3.97 ± 0.086
4.288LysLys: 4.288 ± 0.096
5.044LysLeu: 5.044 ± 0.095
2.112LysMet: 2.112 ± 0.055
3.154LysAsn: 3.154 ± 0.075
2.17LysPro: 2.17 ± 0.061
2.672LysGln: 2.672 ± 0.059
3.489LysArg: 3.489 ± 0.074
3.496LysSer: 3.496 ± 0.07
3.984LysThr: 3.984 ± 0.076
3.961LysVal: 3.961 ± 0.072
0.725LysTrp: 0.725 ± 0.029
2.649LysTyr: 2.649 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
6.442LeuAla: 6.442 ± 0.105
1.432LeuCys: 1.432 ± 0.045
4.714LeuAsp: 4.714 ± 0.08
4.17LeuGlu: 4.17 ± 0.08
4.321LeuPhe: 4.321 ± 0.098
5.571LeuGly: 5.571 ± 0.102
2.075LeuHis: 2.075 ± 0.052
5.752LeuIle: 5.752 ± 0.094
5.651LeuLys: 5.651 ± 0.095
8.718LeuLeu: 8.718 ± 0.148
2.558LeuMet: 2.558 ± 0.059
4.647LeuAsn: 4.647 ± 0.075
3.947LeuPro: 3.947 ± 0.078
3.474LeuGln: 3.474 ± 0.066
5.277LeuArg: 5.277 ± 0.088
6.705LeuSer: 6.705 ± 0.104
5.744LeuThr: 5.744 ± 0.094
5.018LeuVal: 5.018 ± 0.087
1.046LeuTrp: 1.046 ± 0.038
3.497LeuTyr: 3.497 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.15MetAla: 2.15 ± 0.054
0.255MetCys: 0.255 ± 0.019
1.432MetAsp: 1.432 ± 0.044
1.605MetGlu: 1.605 ± 0.05
1.037MetPhe: 1.037 ± 0.043
1.745MetGly: 1.745 ± 0.045
0.478MetHis: 0.478 ± 0.025
1.584MetIle: 1.584 ± 0.048
2.254MetLys: 2.254 ± 0.052
2.522MetLeu: 2.522 ± 0.056
0.945MetMet: 0.945 ± 0.036
1.519MetAsn: 1.519 ± 0.037
1.121MetPro: 1.121 ± 0.036
1.129MetGln: 1.129 ± 0.036
1.511MetArg: 1.511 ± 0.051
1.628MetSer: 1.628 ± 0.049
1.587MetThr: 1.587 ± 0.044
1.463MetVal: 1.463 ± 0.044
0.215MetTrp: 0.215 ± 0.017
0.738MetTyr: 0.738 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.758AsnAla: 3.758 ± 0.08
0.53AsnCys: 0.53 ± 0.026
2.906AsnAsp: 2.906 ± 0.073
3.042AsnGlu: 3.042 ± 0.058
2.051AsnPhe: 2.051 ± 0.047
3.889AsnGly: 3.889 ± 0.083
0.968AsnHis: 0.968 ± 0.041
3.654AsnIle: 3.654 ± 0.074
3.082AsnLys: 3.082 ± 0.077
4.014AsnLeu: 4.014 ± 0.07
1.126AsnMet: 1.126 ± 0.037
2.525AsnAsn: 2.525 ± 0.073
2.316AsnPro: 2.316 ± 0.054
1.591AsnGln: 1.591 ± 0.045
2.884AsnArg: 2.884 ± 0.068
2.525AsnSer: 2.525 ± 0.063
2.64AsnThr: 2.64 ± 0.066
3.358AsnVal: 3.358 ± 0.067
0.581AsnTrp: 0.581 ± 0.027
2.164AsnTyr: 2.164 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.55ProAla: 2.55 ± 0.065
0.369ProCys: 0.369 ± 0.024
2.395ProAsp: 2.395 ± 0.05
2.608ProGlu: 2.608 ± 0.057
1.836ProPhe: 1.836 ± 0.043
2.177ProGly: 2.177 ± 0.055
0.799ProHis: 0.799 ± 0.031
2.456ProIle: 2.456 ± 0.06
2.152ProLys: 2.152 ± 0.055
3.28ProLeu: 3.28 ± 0.072
1.004ProMet: 1.004 ± 0.036
1.707ProAsn: 1.707 ± 0.048
0.768ProPro: 0.768 ± 0.039
1.535ProGln: 1.535 ± 0.049
1.519ProArg: 1.519 ± 0.04
2.054ProSer: 2.054 ± 0.044
2.25ProThr: 2.25 ± 0.054
2.675ProVal: 2.675 ± 0.062
0.422ProTrp: 0.422 ± 0.022
1.671ProTyr: 1.671 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.651GlnAla: 2.651 ± 0.051
0.352GlnCys: 0.352 ± 0.022
1.654GlnAsp: 1.654 ± 0.049
2.145GlnGlu: 2.145 ± 0.049
1.389GlnPhe: 1.389 ± 0.045
2.241GlnGly: 2.241 ± 0.06
0.753GlnHis: 0.753 ± 0.032
2.587GlnIle: 2.587 ± 0.059
2.389GlnLys: 2.389 ± 0.059
3.715GlnLeu: 3.715 ± 0.072
1.248GlnMet: 1.248 ± 0.045
1.767GlnAsn: 1.767 ± 0.043
1.311GlnPro: 1.311 ± 0.039
1.781GlnGln: 1.781 ± 0.061
2.139GlnArg: 2.139 ± 0.049
2.041GlnSer: 2.041 ± 0.056
2.275GlnThr: 2.275 ± 0.058
2.185GlnVal: 2.185 ± 0.055
0.516GlnTrp: 0.516 ± 0.025
1.423GlnTyr: 1.423 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
3.385ArgAla: 3.385 ± 0.073
0.612ArgCys: 0.612 ± 0.028
2.668ArgAsp: 2.668 ± 0.058
3.472ArgGlu: 3.472 ± 0.092
2.701ArgPhe: 2.701 ± 0.051
3.028ArgGly: 3.028 ± 0.069
1.32ArgHis: 1.32 ± 0.042
4.028ArgIle: 4.028 ± 0.071
3.772ArgLys: 3.772 ± 0.077
5.623ArgLeu: 5.623 ± 0.099
1.814ArgMet: 1.814 ± 0.046
2.854ArgAsn: 2.854 ± 0.066
1.929ArgPro: 1.929 ± 0.053
2.363ArgGln: 2.363 ± 0.054
3.39ArgArg: 3.39 ± 0.078
2.949ArgSer: 2.949 ± 0.067
2.921ArgThr: 2.921 ± 0.064
3.176ArgVal: 3.176 ± 0.063
0.752ArgTrp: 0.752 ± 0.033
2.596ArgTyr: 2.596 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
4.447SerAla: 4.447 ± 0.083
0.771SerCys: 0.771 ± 0.032
3.419SerAsp: 3.419 ± 0.07
3.213SerGlu: 3.213 ± 0.069
3.026SerPhe: 3.026 ± 0.054
4.375SerGly: 4.375 ± 0.085
1.248SerHis: 1.248 ± 0.045
4.111SerIle: 4.111 ± 0.079
3.323SerLys: 3.323 ± 0.071
5.772SerLeu: 5.772 ± 0.089
1.468SerMet: 1.468 ± 0.052
2.66SerAsn: 2.66 ± 0.058
2.187SerPro: 2.187 ± 0.056
2.003SerGln: 2.003 ± 0.049
3.003SerArg: 3.003 ± 0.058
3.661SerSer: 3.661 ± 0.08
3.27SerThr: 3.27 ± 0.062
4.328SerVal: 4.328 ± 0.081
0.729SerTrp: 0.729 ± 0.029
2.584SerTyr: 2.584 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
4.836ThrAla: 4.836 ± 0.081
0.601ThrCys: 0.601 ± 0.03
3.919ThrAsp: 3.919 ± 0.072
3.361ThrGlu: 3.361 ± 0.07
2.877ThrPhe: 2.877 ± 0.055
4.328ThrGly: 4.328 ± 0.083
1.148ThrHis: 1.148 ± 0.039
4.084ThrIle: 4.084 ± 0.083
2.901ThrLys: 2.901 ± 0.062
5.529ThrLeu: 5.529 ± 0.088
1.375ThrMet: 1.375 ± 0.043
2.398ThrAsn: 2.398 ± 0.059
2.688ThrPro: 2.688 ± 0.065
1.942ThrGln: 1.942 ± 0.049
2.613ThrArg: 2.613 ± 0.061
3.235ThrSer: 3.235 ± 0.062
3.349ThrThr: 3.349 ± 0.073
4.278ThrVal: 4.278 ± 0.079
0.571ThrTrp: 0.571 ± 0.033
2.517ThrTyr: 2.517 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
4.579ValAla: 4.579 ± 0.084
1.006ValCys: 1.006 ± 0.038
3.67ValAsp: 3.67 ± 0.072
3.687ValGlu: 3.687 ± 0.072
2.852ValPhe: 2.852 ± 0.067
4.33ValGly: 4.33 ± 0.083
1.242ValHis: 1.242 ± 0.043
4.317ValIle: 4.317 ± 0.102
4.219ValLys: 4.219 ± 0.08
5.753ValLeu: 5.753 ± 0.083
1.738ValMet: 1.738 ± 0.051
3.115ValAsn: 3.115 ± 0.069
2.447ValPro: 2.447 ± 0.059
2.134ValGln: 2.134 ± 0.058
3.582ValArg: 3.582 ± 0.077
4.481ValSer: 4.481 ± 0.077
3.635ValThr: 3.635 ± 0.066
4.496ValVal: 4.496 ± 0.081
0.753ValTrp: 0.753 ± 0.032
2.6ValTyr: 2.6 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.747TrpAla: 0.747 ± 0.031
0.157TrpCys: 0.157 ± 0.012
0.676TrpAsp: 0.676 ± 0.034
0.606TrpGlu: 0.606 ± 0.026
0.571TrpPhe: 0.571 ± 0.027
0.822TrpGly: 0.822 ± 0.032
0.283TrpHis: 0.283 ± 0.021
0.752TrpIle: 0.752 ± 0.032
0.78TrpLys: 0.78 ± 0.035
1.229TrpLeu: 1.229 ± 0.043
0.414TrpMet: 0.414 ± 0.025
0.682TrpAsn: 0.682 ± 0.035
0.288TrpPro: 0.288 ± 0.019
0.58TrpGln: 0.58 ± 0.023
0.642TrpArg: 0.642 ± 0.031
0.596TrpSer: 0.596 ± 0.028
0.643TrpThr: 0.643 ± 0.031
0.633TrpVal: 0.633 ± 0.032
0.182TrpTrp: 0.182 ± 0.016
0.437TrpTyr: 0.437 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.036TyrAla: 3.036 ± 0.065
0.503TyrCys: 0.503 ± 0.026
2.647TyrAsp: 2.647 ± 0.062
2.157TyrGlu: 2.157 ± 0.054
2.055TyrPhe: 2.055 ± 0.046
3.004TyrGly: 3.004 ± 0.068
0.959TyrHis: 0.959 ± 0.037
2.738TyrIle: 2.738 ± 0.061
2.331TyrLys: 2.331 ± 0.06
3.807TyrLeu: 3.807 ± 0.075
0.978TyrMet: 0.978 ± 0.034
2.297TyrAsn: 2.297 ± 0.071
1.64TyrPro: 1.64 ± 0.049
1.573TyrGln: 1.573 ± 0.048
2.548TyrArg: 2.548 ± 0.053
2.47TyrSer: 2.47 ± 0.053
2.522TyrThr: 2.522 ± 0.06
2.515TyrVal: 2.515 ± 0.06
0.571TyrTrp: 0.571 ± 0.029
2.1TyrTyr: 2.1 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2257 proteins (784947 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski