Amino acid dipepetide frequency for Legionella shakespearei DSM 23087

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.796AlaAla: 6.796 ± 0.097	1.054AlaCys: 1.054 ± 0.036	3.894AlaAsp: 3.894 ± 0.07	4.801AlaGlu: 4.801 ± 0.081	3.179AlaPhe: 3.179 ± 0.062	5.219AlaGly: 5.219 ± 0.095	1.865AlaHis: 1.865 ± 0.048	5.631AlaIle: 5.631 ± 0.072	4.628AlaLys: 4.628 ± 0.072	9.73AlaLeu: 9.73 ± 0.13	2.237AlaMet: 2.237 ± 0.047	3.478AlaAsn: 3.478 ± 0.068	2.682AlaPro: 2.682 ± 0.057	3.782AlaGln: 3.782 ± 0.073	3.49AlaArg: 3.49 ± 0.059	4.85AlaSer: 4.85 ± 0.07	4.103AlaThr: 4.103 ± 0.078	5.199AlaVal: 5.199 ± 0.082	0.778AlaTrp: 0.778 ± 0.031	2.606AlaTyr: 2.606 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.812CysAla: 0.812 ± 0.034	0.185CysCys: 0.185 ± 0.015	0.65CysAsp: 0.65 ± 0.024	0.568CysGlu: 0.568 ± 0.024	0.673CysPhe: 0.673 ± 0.027	0.788CysGly: 0.788 ± 0.028	0.359CysHis: 0.359 ± 0.021	0.79CysIle: 0.79 ± 0.033	0.552CysLys: 0.552 ± 0.025	1.198CysLeu: 1.198 ± 0.035	0.284CysMet: 0.284 ± 0.018	0.47CysAsn: 0.47 ± 0.023	0.482CysPro: 0.482 ± 0.026	0.5CysGln: 0.5 ± 0.023	0.501CysArg: 0.501 ± 0.025	0.835CysSer: 0.835 ± 0.029	0.609CysThr: 0.609 ± 0.027	0.685CysVal: 0.685 ± 0.029	0.131CysTrp: 0.131 ± 0.011	0.449CysTyr: 0.449 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.038AspAla: 4.038 ± 0.075	0.559AspCys: 0.559 ± 0.025	2.677AspAsp: 2.677 ± 0.058	3.898AspGlu: 3.898 ± 0.062	2.594AspPhe: 2.594 ± 0.06	2.978AspGly: 2.978 ± 0.064	1.071AspHis: 1.071 ± 0.03	3.502AspIle: 3.502 ± 0.058	3.525AspLys: 3.525 ± 0.062	5.455AspLeu: 5.455 ± 0.085	1.143AspMet: 1.143 ± 0.033	2.408AspAsn: 2.408 ± 0.05	2.071AspPro: 2.071 ± 0.049	1.7AspGln: 1.7 ± 0.042	2.006AspArg: 2.006 ± 0.053	3.222AspSer: 3.222 ± 0.059	2.545AspThr: 2.545 ± 0.073	3.281AspVal: 3.281 ± 0.062	0.688AspTrp: 0.688 ± 0.026	2.084AspTyr: 2.084 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	4.513GluAla: 4.513 ± 0.068	0.604GluCys: 0.604 ± 0.024	2.7GluAsp: 2.7 ± 0.055	4.116GluGlu: 4.116 ± 0.083	2.454GluPhe: 2.454 ± 0.054	3.049GluGly: 3.049 ± 0.057	1.914GluHis: 1.914 ± 0.053	3.996GluIle: 3.996 ± 0.073	4.04GluLys: 4.04 ± 0.073	7.11GluLeu: 7.11 ± 0.105	1.522GluMet: 1.522 ± 0.037	2.614GluAsn: 2.614 ± 0.053	2.182GluPro: 2.182 ± 0.094	3.905GluGln: 3.905 ± 0.079	2.985GluArg: 2.985 ± 0.056	3.527GluSer: 3.527 ± 0.055	2.959GluThr: 2.959 ± 0.055	3.459GluVal: 3.459 ± 0.066	0.662GluTrp: 0.662 ± 0.028	1.901GluTyr: 1.901 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.533PheAla: 3.533 ± 0.065	0.644PheCys: 0.644 ± 0.028	2.503PheAsp: 2.503 ± 0.051	2.172PheGlu: 2.172 ± 0.047	2.255PhePhe: 2.255 ± 0.072	2.644PheGly: 2.644 ± 0.057	0.997PheHis: 0.997 ± 0.027	3.447PheIle: 3.447 ± 0.072	2.492PheLys: 2.492 ± 0.052	4.406PheLeu: 4.406 ± 0.073	1.02PheMet: 1.02 ± 0.035	2.36PheAsn: 2.36 ± 0.051	1.656PhePro: 1.656 ± 0.044	1.402PheGln: 1.402 ± 0.037	1.518PheArg: 1.518 ± 0.04	3.543PheSer: 3.543 ± 0.065	2.447PheThr: 2.447 ± 0.05	2.443PheVal: 2.443 ± 0.046	0.554PheTrp: 0.554 ± 0.028	1.706PheTyr: 1.706 ± 0.043	0.001PheXaa: 0.001 ± 0.001
Gly	4.378GlyAla: 4.378 ± 0.077	0.774GlyCys: 0.774 ± 0.031	2.916GlyAsp: 2.916 ± 0.073	3.264GlyGlu: 3.264 ± 0.082	3.191GlyPhe: 3.191 ± 0.058	4.012GlyGly: 4.012 ± 0.083	1.58GlyHis: 1.58 ± 0.041	4.742GlyIle: 4.742 ± 0.073	3.845GlyLys: 3.845 ± 0.069	6.549GlyLeu: 6.549 ± 0.068	1.827GlyMet: 1.827 ± 0.046	2.564GlyAsn: 2.564 ± 0.065	1.588GlyPro: 1.588 ± 0.04	2.476GlyGln: 2.476 ± 0.056	2.585GlyArg: 2.585 ± 0.057	3.938GlySer: 3.938 ± 0.098	3.405GlyThr: 3.405 ± 0.089	4.204GlyVal: 4.204 ± 0.083	0.837GlyTrp: 0.837 ± 0.026	2.448GlyTyr: 2.448 ± 0.047	0.001GlyXaa: 0.001 ± 0.001
His	1.927HisAla: 1.927 ± 0.046	0.386HisCys: 0.386 ± 0.019	1.195HisAsp: 1.195 ± 0.036	1.332HisGlu: 1.332 ± 0.037	1.346HisPhe: 1.346 ± 0.04	1.621HisGly: 1.621 ± 0.044	0.897HisHis: 0.897 ± 0.031	1.582HisIle: 1.582 ± 0.04	1.154HisLys: 1.154 ± 0.04	2.867HisLeu: 2.867 ± 0.057	0.56HisMet: 0.56 ± 0.028	0.998HisAsn: 0.998 ± 0.029	1.396HisPro: 1.396 ± 0.044	1.325HisGln: 1.325 ± 0.041	1.098HisArg: 1.098 ± 0.034	1.674HisSer: 1.674 ± 0.039	1.147HisThr: 1.147 ± 0.03	1.382HisVal: 1.382 ± 0.041	0.378HisTrp: 0.378 ± 0.021	1.267HisTyr: 1.267 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.131IleAla: 6.131 ± 0.089	0.699IleCys: 0.699 ± 0.026	4.124IleAsp: 4.124 ± 0.071	4.379IleGlu: 4.379 ± 0.071	2.369IlePhe: 2.369 ± 0.061	4.22IleGly: 4.22 ± 0.087	1.757IleHis: 1.757 ± 0.044	4.81IleIle: 4.81 ± 0.075	4.592IleLys: 4.592 ± 0.074	6.443IleLeu: 6.443 ± 0.09	1.413IleMet: 1.413 ± 0.038	3.963IleAsn: 3.963 ± 0.075	3.327IlePro: 3.327 ± 0.062	2.668IleGln: 2.668 ± 0.053	2.901IleArg: 2.901 ± 0.054	4.862IleSer: 4.862 ± 0.078	3.905IleThr: 3.905 ± 0.078	3.809IleVal: 3.809 ± 0.074	0.588IleTrp: 0.588 ± 0.026	2.025IleTyr: 2.025 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	5.083LysAla: 5.083 ± 0.082	0.424LysCys: 0.424 ± 0.022	3.094LysAsp: 3.094 ± 0.068	4.313LysGlu: 4.313 ± 0.075	1.53LysPhe: 1.53 ± 0.045	3.28LysGly: 3.28 ± 0.065	1.402LysHis: 1.402 ± 0.038	4.041LysIle: 4.041 ± 0.069	4.378LysLys: 4.378 ± 0.079	5.529LysLeu: 5.529 ± 0.087	1.529LysMet: 1.529 ± 0.04	3.194LysAsn: 3.194 ± 0.064	2.77LysPro: 2.77 ± 0.053	3.023LysGln: 3.023 ± 0.063	2.929LysArg: 2.929 ± 0.067	3.795LysSer: 3.795 ± 0.065	3.466LysThr: 3.466 ± 0.06	3.304LysVal: 3.304 ± 0.071	0.468LysTrp: 0.468 ± 0.024	1.557LysTyr: 1.557 ± 0.039	0.001LysXaa: 0.001 ± 0.001
Leu	9.287LeuAla: 9.287 ± 0.108	1.37LeuCys: 1.37 ± 0.047	5.441LeuAsp: 5.441 ± 0.079	5.711LeuGlu: 5.711 ± 0.077	5.083LeuPhe: 5.083 ± 0.104	6.51LeuGly: 6.51 ± 0.108	2.698LeuHis: 2.698 ± 0.061	7.852LeuIle: 7.852 ± 0.101	6.585LeuLys: 6.585 ± 0.1	11.719LeuLeu: 11.719 ± 0.131	2.647LeuMet: 2.647 ± 0.052	5.749LeuAsn: 5.749 ± 0.09	4.99LeuPro: 4.99 ± 0.083	4.392LeuGln: 4.392 ± 0.071	4.456LeuArg: 4.456 ± 0.085	8.547LeuSer: 8.547 ± 0.086	5.974LeuThr: 5.974 ± 0.08	6.161LeuVal: 6.161 ± 0.093	1.05LeuTrp: 1.05 ± 0.037	3.173LeuTyr: 3.173 ± 0.062	0.001LeuXaa: 0.001 ± 0.001
Met	2.117MetAla: 2.117 ± 0.056	0.175MetCys: 0.175 ± 0.015	1.344MetAsp: 1.344 ± 0.038	1.286MetGlu: 1.286 ± 0.038	0.806MetPhe: 0.806 ± 0.031	1.577MetGly: 1.577 ± 0.048	0.581MetHis: 0.581 ± 0.027	1.576MetIle: 1.576 ± 0.042	1.57MetLys: 1.57 ± 0.039	2.551MetLeu: 2.551 ± 0.051	0.747MetMet: 0.747 ± 0.029	1.42MetAsn: 1.42 ± 0.038	1.108MetPro: 1.108 ± 0.03	1.176MetGln: 1.176 ± 0.035	1.115MetArg: 1.115 ± 0.033	1.816MetSer: 1.816 ± 0.039	1.477MetThr: 1.477 ± 0.038	1.533MetVal: 1.533 ± 0.037	0.179MetTrp: 0.179 ± 0.013	0.598MetTyr: 0.598 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.53AsnAla: 3.53 ± 0.061	0.544AsnCys: 0.544 ± 0.024	2.436AsnAsp: 2.436 ± 0.061	3.021AsnGlu: 3.021 ± 0.056	1.703AsnPhe: 1.703 ± 0.04	2.744AsnGly: 2.744 ± 0.092	1.326AsnHis: 1.326 ± 0.034	2.989AsnIle: 2.989 ± 0.062	3.068AsnLys: 3.068 ± 0.057	4.602AsnLeu: 4.602 ± 0.072	0.927AsnMet: 0.927 ± 0.03	2.504AsnAsn: 2.504 ± 0.059	2.716AsnPro: 2.716 ± 0.059	2.57AsnGln: 2.57 ± 0.06	2.067AsnArg: 2.067 ± 0.051	3.169AsnSer: 3.169 ± 0.055	2.617AsnThr: 2.617 ± 0.057	2.308AsnVal: 2.308 ± 0.056	0.601AsnTrp: 0.601 ± 0.026	1.816AsnTyr: 1.816 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	3.234ProAla: 3.234 ± 0.062	0.43ProCys: 0.43 ± 0.019	2.582ProAsp: 2.582 ± 0.051	3.56ProGlu: 3.56 ± 0.07	1.903ProPhe: 1.903 ± 0.043	2.742ProGly: 2.742 ± 0.052	0.952ProHis: 0.952 ± 0.035	2.346ProIle: 2.346 ± 0.052	2.055ProLys: 2.055 ± 0.049	4.579ProLeu: 4.579 ± 0.085	0.967ProMet: 0.967 ± 0.037	1.644ProAsn: 1.644 ± 0.045	1.511ProPro: 1.511 ± 0.051	1.919ProGln: 1.919 ± 0.05	1.477ProArg: 1.477 ± 0.047	2.461ProSer: 2.461 ± 0.052	1.862ProThr: 1.862 ± 0.044	3.694ProVal: 3.694 ± 0.064	0.491ProTrp: 0.491 ± 0.022	1.404ProTyr: 1.404 ± 0.036	0.003ProXaa: 0.003 ± 0.002
Gln	3.774GlnAla: 3.774 ± 0.07	0.522GlnCys: 0.522 ± 0.022	2.001GlnAsp: 2.001 ± 0.041	2.79GlnGlu: 2.79 ± 0.058	2.12GlnPhe: 2.12 ± 0.047	2.72GlnGly: 2.72 ± 0.049	1.226GlnHis: 1.226 ± 0.041	3.083GlnIle: 3.083 ± 0.057	2.658GlnLys: 2.658 ± 0.053	5.305GlnLeu: 5.305 ± 0.094	1.137GlnMet: 1.137 ± 0.036	2.095GlnAsn: 2.095 ± 0.053	1.586GlnPro: 1.586 ± 0.041	2.821GlnGln: 2.821 ± 0.077	2.03GlnArg: 2.03 ± 0.051	2.987GlnSer: 2.987 ± 0.059	2.271GlnThr: 2.271 ± 0.054	2.7GlnVal: 2.7 ± 0.053	0.606GlnTrp: 0.606 ± 0.026	1.554GlnTyr: 1.554 ± 0.042	0.001GlnXaa: 0.001 ± 0.001
Arg	3.056ArgAla: 3.056 ± 0.064	0.479ArgCys: 0.479 ± 0.025	2.169ArgAsp: 2.169 ± 0.05	2.751ArgGlu: 2.751 ± 0.061	2.194ArgPhe: 2.194 ± 0.058	2.302ArgGly: 2.302 ± 0.05	1.21ArgHis: 1.21 ± 0.039	3.185ArgIle: 3.185 ± 0.057	2.482ArgLys: 2.482 ± 0.059	4.924ArgLeu: 4.924 ± 0.076	1.165ArgMet: 1.165 ± 0.038	1.933ArgAsn: 1.933 ± 0.042	1.458ArgPro: 1.458 ± 0.041	2.052ArgGln: 2.052 ± 0.044	1.97ArgArg: 1.97 ± 0.061	2.386ArgSer: 2.386 ± 0.049	2.185ArgThr: 2.185 ± 0.048	2.724ArgVal: 2.724 ± 0.051	0.532ArgTrp: 0.532 ± 0.022	1.709ArgTyr: 1.709 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.051SerAla: 5.051 ± 0.08	0.795SerCys: 0.795 ± 0.03	3.414SerAsp: 3.414 ± 0.069	3.747SerGlu: 3.747 ± 0.071	3.19SerPhe: 3.19 ± 0.057	4.703SerGly: 4.703 ± 0.081	1.683SerHis: 1.683 ± 0.041	4.511SerIle: 4.511 ± 0.068	3.34SerLys: 3.34 ± 0.068	7.752SerLeu: 7.752 ± 0.098	1.774SerMet: 1.774 ± 0.044	2.748SerAsn: 2.748 ± 0.058	3.023SerPro: 3.023 ± 0.058	2.99SerGln: 2.99 ± 0.052	2.932SerArg: 2.932 ± 0.057	4.882SerSer: 4.882 ± 0.094	3.251SerThr: 3.251 ± 0.059	4.036SerVal: 4.036 ± 0.073	0.781SerTrp: 0.781 ± 0.025	2.358SerTyr: 2.358 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.504ThrAla: 4.504 ± 0.076	0.53ThrCys: 0.53 ± 0.024	2.658ThrAsp: 2.658 ± 0.06	2.956ThrGlu: 2.956 ± 0.062	2.04ThrPhe: 2.04 ± 0.04	3.715ThrGly: 3.715 ± 0.071	1.365ThrHis: 1.365 ± 0.04	3.587ThrIle: 3.587 ± 0.078	2.403ThrLys: 2.403 ± 0.052	6.319ThrLeu: 6.319 ± 0.085	1.195ThrMet: 1.195 ± 0.032	2.107ThrAsn: 2.107 ± 0.049	2.862ThrPro: 2.862 ± 0.064	2.329ThrGln: 2.329 ± 0.045	2.241ThrArg: 2.241 ± 0.046	3.159ThrSer: 3.159 ± 0.066	2.895ThrThr: 2.895 ± 0.063	3.789ThrVal: 3.789 ± 0.1	0.525ThrTrp: 0.525 ± 0.026	1.619ThrTyr: 1.619 ± 0.05	0.001ThrXaa: 0.001 ± 0.001
Val	5.077ValAla: 5.077 ± 0.08	0.689ValCys: 0.689 ± 0.027	3.32ValAsp: 3.32 ± 0.061	3.293ValGlu: 3.293 ± 0.058	2.82ValPhe: 2.82 ± 0.053	3.503ValGly: 3.503 ± 0.07	1.411ValHis: 1.411 ± 0.039	4.617ValIle: 4.617 ± 0.079	3.449ValLys: 3.449 ± 0.07	6.809ValLeu: 6.809 ± 0.079	1.62ValMet: 1.62 ± 0.04	3.036ValAsn: 3.036 ± 0.067	2.444ValPro: 2.444 ± 0.052	2.175ValGln: 2.175 ± 0.046	2.441ValArg: 2.441 ± 0.055	4.368ValSer: 4.368 ± 0.076	3.581ValThr: 3.581 ± 0.091	4.179ValVal: 4.179 ± 0.082	0.613ValTrp: 0.613 ± 0.029	1.926ValTyr: 1.926 ± 0.045	0.001ValXaa: 0.001 ± 0.001
Trp	0.685TrpAla: 0.685 ± 0.026	0.152TrpCys: 0.152 ± 0.013	0.562TrpAsp: 0.562 ± 0.025	0.486TrpGlu: 0.486 ± 0.024	0.561TrpPhe: 0.561 ± 0.025	0.719TrpGly: 0.719 ± 0.03	0.331TrpHis: 0.331 ± 0.017	0.812TrpIle: 0.812 ± 0.028	0.509TrpLys: 0.509 ± 0.02	1.445TrpLeu: 1.445 ± 0.04	0.311TrpMet: 0.311 ± 0.017	0.526TrpAsn: 0.526 ± 0.022	0.422TrpPro: 0.422 ± 0.021	0.718TrpGln: 0.718 ± 0.031	0.538TrpArg: 0.538 ± 0.023	0.671TrpSer: 0.671 ± 0.03	0.461TrpThr: 0.461 ± 0.021	0.67TrpVal: 0.67 ± 0.027	0.164TrpTrp: 0.164 ± 0.014	0.396TrpTyr: 0.396 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.477TyrAla: 2.477 ± 0.053	0.503TyrCys: 0.503 ± 0.022	1.765TyrAsp: 1.765 ± 0.066	1.763TyrGlu: 1.763 ± 0.045	1.73TyrPhe: 1.73 ± 0.044	2.076TyrGly: 2.076 ± 0.05	0.906TyrHis: 0.906 ± 0.034	1.89TyrIle: 1.89 ± 0.044	1.785TyrLys: 1.785 ± 0.053	4.101TyrLeu: 4.101 ± 0.058	0.724TyrMet: 0.724 ± 0.026	1.448TyrAsn: 1.448 ± 0.042	1.538TyrPro: 1.538 ± 0.044	2.067TyrGln: 2.067 ± 0.047	1.589TyrArg: 1.589 ± 0.041	2.268TyrSer: 2.268 ± 0.047	1.64TyrThr: 1.64 ± 0.045	1.811TyrVal: 1.811 ± 0.048	0.513TyrTrp: 0.513 ± 0.023	1.354TyrTyr: 1.354 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.002XaaMet: 0.002 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.027XaaXaa: 0.027 ± 0.009

Statistics based on 2916 proteins (998065 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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