Amino acid dipepetide frequency for Corynebacterium sp. HMSC08D02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.421AlaAla: 14.421 ± 0.228	0.936AlaCys: 0.936 ± 0.041	6.649AlaAsp: 6.649 ± 0.107	7.566AlaGlu: 7.566 ± 0.14	3.729AlaPhe: 3.729 ± 0.079	9.427AlaGly: 9.427 ± 0.116	2.353AlaHis: 2.353 ± 0.072	5.262AlaIle: 5.262 ± 0.092	4.249AlaLys: 4.249 ± 0.102	11.717AlaLeu: 11.717 ± 0.162	2.754AlaMet: 2.754 ± 0.06	3.072AlaAsn: 3.072 ± 0.072	5.552AlaPro: 5.552 ± 0.106	4.626AlaGln: 4.626 ± 0.096	6.703AlaArg: 6.703 ± 0.108	6.392AlaSer: 6.392 ± 0.108	7.301AlaThr: 7.301 ± 0.111	9.686AlaVal: 9.686 ± 0.129	1.492AlaTrp: 1.492 ± 0.045	2.382AlaTyr: 2.382 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.921CysAla: 0.921 ± 0.038	0.082CysCys: 0.082 ± 0.013	0.408CysAsp: 0.408 ± 0.024	0.418CysGlu: 0.418 ± 0.023	0.244CysPhe: 0.244 ± 0.018	0.752CysGly: 0.752 ± 0.031	0.162CysHis: 0.162 ± 0.017	0.362CysIle: 0.362 ± 0.022	0.185CysLys: 0.185 ± 0.018	0.5CysLeu: 0.5 ± 0.032	0.153CysMet: 0.153 ± 0.017	0.189CysAsn: 0.189 ± 0.019	0.405CysPro: 0.405 ± 0.028	0.193CysGln: 0.193 ± 0.015	0.318CysArg: 0.318 ± 0.024	0.485CysSer: 0.485 ± 0.025	0.428CysThr: 0.428 ± 0.029	0.588CysVal: 0.588 ± 0.034	0.092CysTrp: 0.092 ± 0.011	0.128CysTyr: 0.128 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.979AspAla: 7.979 ± 0.135	0.385AspCys: 0.385 ± 0.024	3.528AspAsp: 3.528 ± 0.077	4.368AspGlu: 4.368 ± 0.091	2.049AspPhe: 2.049 ± 0.06	5.377AspGly: 5.377 ± 0.098	1.184AspHis: 1.184 ± 0.044	3.013AspIle: 3.013 ± 0.075	2.063AspLys: 2.063 ± 0.065	5.178AspLeu: 5.178 ± 0.089	1.212AspMet: 1.212 ± 0.049	1.656AspAsn: 1.656 ± 0.045	3.614AspPro: 3.614 ± 0.076	1.788AspGln: 1.788 ± 0.049	3.192AspArg: 3.192 ± 0.073	2.875AspSer: 2.875 ± 0.065	3.405AspThr: 3.405 ± 0.07	5.171AspVal: 5.171 ± 0.101	0.857AspTrp: 0.857 ± 0.04	1.496AspTyr: 1.496 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	7.586GluAla: 7.586 ± 0.132	0.368GluCys: 0.368 ± 0.022	3.597GluAsp: 3.597 ± 0.078	4.833GluGlu: 4.833 ± 0.116	2.238GluPhe: 2.238 ± 0.057	4.665GluGly: 4.665 ± 0.092	1.832GluHis: 1.832 ± 0.062	3.197GluIle: 3.197 ± 0.075	2.431GluLys: 2.431 ± 0.075	6.615GluLeu: 6.615 ± 0.118	1.458GluMet: 1.458 ± 0.046	1.853GluAsn: 1.853 ± 0.063	2.998GluPro: 2.998 ± 0.08	3.106GluGln: 3.106 ± 0.061	4.394GluArg: 4.394 ± 0.088	3.057GluSer: 3.057 ± 0.072	3.469GluThr: 3.469 ± 0.075	5.254GluVal: 5.254 ± 0.084	0.79GluTrp: 0.79 ± 0.039	1.528GluTyr: 1.528 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.904PheAla: 3.904 ± 0.087	0.236PheCys: 0.236 ± 0.019	2.498PheAsp: 2.498 ± 0.064	2.079PheGlu: 2.079 ± 0.056	1.215PhePhe: 1.215 ± 0.047	3.351PheGly: 3.351 ± 0.065	0.691PheHis: 0.691 ± 0.036	1.565PheIle: 1.565 ± 0.058	0.891PheLys: 0.891 ± 0.04	2.932PheLeu: 2.932 ± 0.068	0.698PheMet: 0.698 ± 0.032	1.036PheAsn: 1.036 ± 0.046	1.418PhePro: 1.418 ± 0.048	0.935PheGln: 0.935 ± 0.041	1.66PheArg: 1.66 ± 0.054	2.065PheSer: 2.065 ± 0.061	2.271PheThr: 2.271 ± 0.065	2.677PheVal: 2.677 ± 0.066	0.47PheTrp: 0.47 ± 0.028	0.833PheTyr: 0.833 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	8.631GlyAla: 8.631 ± 0.122	0.655GlyCys: 0.655 ± 0.036	4.581GlyAsp: 4.581 ± 0.098	5.193GlyGlu: 5.193 ± 0.098	3.03GlyPhe: 3.03 ± 0.063	6.433GlyGly: 6.433 ± 0.127	1.766GlyHis: 1.766 ± 0.054	4.525GlyIle: 4.525 ± 0.082	3.49GlyLys: 3.49 ± 0.096	7.53GlyLeu: 7.53 ± 0.11	2.005GlyMet: 2.005 ± 0.053	2.382GlyAsn: 2.382 ± 0.071	3.278GlyPro: 3.278 ± 0.075	2.795GlyGln: 2.795 ± 0.064	4.492GlyArg: 4.492 ± 0.098	4.648GlySer: 4.648 ± 0.08	5.315GlyThr: 5.315 ± 0.095	7.404GlyVal: 7.404 ± 0.101	1.324GlyTrp: 1.324 ± 0.044	2.119GlyTyr: 2.119 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.275HisAla: 2.275 ± 0.064	0.19HisCys: 0.19 ± 0.015	1.447HisAsp: 1.447 ± 0.05	1.307HisGlu: 1.307 ± 0.044	0.72HisPhe: 0.72 ± 0.039	1.911HisGly: 1.911 ± 0.051	0.573HisHis: 0.573 ± 0.031	0.993HisIle: 0.993 ± 0.037	0.57HisLys: 0.57 ± 0.031	1.974HisLeu: 1.974 ± 0.059	0.439HisMet: 0.439 ± 0.025	0.652HisAsn: 0.652 ± 0.032	1.403HisPro: 1.403 ± 0.046	0.708HisGln: 0.708 ± 0.032	1.303HisArg: 1.303 ± 0.045	1.152HisSer: 1.152 ± 0.044	1.245HisThr: 1.245 ± 0.044	1.754HisVal: 1.754 ± 0.06	0.257HisTrp: 0.257 ± 0.019	0.527HisTyr: 0.527 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.534IleAla: 6.534 ± 0.119	0.357IleCys: 0.357 ± 0.023	3.779IleAsp: 3.779 ± 0.08	3.233IleGlu: 3.233 ± 0.073	1.424IlePhe: 1.424 ± 0.053	4.374IleGly: 4.374 ± 0.092	0.855IleHis: 0.855 ± 0.036	2.517IleIle: 2.517 ± 0.072	1.349IleLys: 1.349 ± 0.053	3.752IleLeu: 3.752 ± 0.073	0.956IleMet: 0.956 ± 0.042	1.485IleAsn: 1.485 ± 0.049	2.613IlePro: 2.613 ± 0.06	1.417IleGln: 1.417 ± 0.043	2.549IleArg: 2.549 ± 0.054	2.659IleSer: 2.659 ± 0.068	3.199IleThr: 3.199 ± 0.075	4.391IleVal: 4.391 ± 0.089	0.5IleTrp: 0.5 ± 0.027	1.044IleTyr: 1.044 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.615LysAla: 3.615 ± 0.075	0.138LysCys: 0.138 ± 0.015	2.17LysAsp: 2.17 ± 0.076	2.186LysGlu: 2.186 ± 0.058	1.042LysPhe: 1.042 ± 0.041	2.369LysGly: 2.369 ± 0.073	0.82LysHis: 0.82 ± 0.038	1.658LysIle: 1.658 ± 0.067	1.732LysLys: 1.732 ± 0.07	3.251LysLeu: 3.251 ± 0.081	0.877LysMet: 0.877 ± 0.032	1.083LysAsn: 1.083 ± 0.043	1.972LysPro: 1.972 ± 0.072	1.499LysGln: 1.499 ± 0.055	2.35LysArg: 2.35 ± 0.071	1.725LysSer: 1.725 ± 0.057	2.072LysThr: 2.072 ± 0.064	2.811LysVal: 2.811 ± 0.084	0.409LysTrp: 0.409 ± 0.023	0.81LysTyr: 0.81 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	11.472LeuAla: 11.472 ± 0.148	0.676LeuCys: 0.676 ± 0.033	5.899LeuAsp: 5.899 ± 0.096	5.603LeuGlu: 5.603 ± 0.1	2.933LeuPhe: 2.933 ± 0.078	7.924LeuGly: 7.924 ± 0.115	2.026LeuHis: 2.026 ± 0.054	4.594LeuIle: 4.594 ± 0.083	2.747LeuLys: 2.747 ± 0.071	8.978LeuLeu: 8.978 ± 0.154	1.87LeuMet: 1.87 ± 0.059	2.599LeuAsn: 2.599 ± 0.062	5.137LeuPro: 5.137 ± 0.093	3.152LeuGln: 3.152 ± 0.078	6.263LeuArg: 6.263 ± 0.096	5.519LeuSer: 5.519 ± 0.096	5.625LeuThr: 5.625 ± 0.092	7.586LeuVal: 7.586 ± 0.129	1.067LeuTrp: 1.067 ± 0.042	1.823LeuTyr: 1.823 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.541MetAla: 2.541 ± 0.057	0.169MetCys: 0.169 ± 0.016	1.128MetAsp: 1.128 ± 0.045	1.114MetGlu: 1.114 ± 0.04	0.767MetPhe: 0.767 ± 0.034	1.694MetGly: 1.694 ± 0.053	0.465MetHis: 0.465 ± 0.028	1.15MetIle: 1.15 ± 0.048	0.786MetLys: 0.786 ± 0.035	2.228MetLeu: 2.228 ± 0.064	0.624MetMet: 0.624 ± 0.03	0.817MetAsn: 0.817 ± 0.04	1.167MetPro: 1.167 ± 0.039	0.828MetGln: 0.828 ± 0.039	1.513MetArg: 1.513 ± 0.054	1.583MetSer: 1.583 ± 0.049	1.513MetThr: 1.513 ± 0.043	1.744MetVal: 1.744 ± 0.054	0.291MetTrp: 0.291 ± 0.022	0.425MetTyr: 0.425 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.197AsnAla: 3.197 ± 0.072	0.18AsnCys: 0.18 ± 0.018	1.576AsnAsp: 1.576 ± 0.052	1.793AsnGlu: 1.793 ± 0.054	0.908AsnPhe: 0.908 ± 0.039	2.501AsnGly: 2.501 ± 0.07	0.566AsnHis: 0.566 ± 0.031	1.455AsnIle: 1.455 ± 0.047	0.999AsnLys: 0.999 ± 0.046	2.596AsnLeu: 2.596 ± 0.059	0.612AsnMet: 0.612 ± 0.033	1.027AsnAsn: 1.027 ± 0.054	2.153AsnPro: 2.153 ± 0.056	1.025AsnGln: 1.025 ± 0.039	1.633AsnArg: 1.633 ± 0.051	1.552AsnSer: 1.552 ± 0.053	1.742AsnThr: 1.742 ± 0.054	2.403AsnVal: 2.403 ± 0.057	0.431AsnTrp: 0.431 ± 0.024	0.753AsnTyr: 0.753 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	5.757ProAla: 5.757 ± 0.115	0.26ProCys: 0.26 ± 0.022	3.422ProAsp: 3.422 ± 0.068	4.461ProGlu: 4.461 ± 0.093	1.64ProPhe: 1.64 ± 0.053	4.361ProGly: 4.361 ± 0.088	1.091ProHis: 1.091 ± 0.041	2.07ProIle: 2.07 ± 0.062	1.924ProLys: 1.924 ± 0.064	4.357ProLeu: 4.357 ± 0.091	1.026ProMet: 1.026 ± 0.035	1.58ProAsn: 1.58 ± 0.053	1.845ProPro: 1.845 ± 0.07	1.856ProGln: 1.856 ± 0.057	2.68ProArg: 2.68 ± 0.064	2.967ProSer: 2.967 ± 0.065	3.43ProThr: 3.43 ± 0.072	4.499ProVal: 4.499 ± 0.081	0.679ProTrp: 0.679 ± 0.031	1.114ProTyr: 1.114 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.226GlnAla: 4.226 ± 0.092	0.18GlnCys: 0.18 ± 0.016	1.702GlnAsp: 1.702 ± 0.051	2.255GlnGlu: 2.255 ± 0.072	1.175GlnPhe: 1.175 ± 0.042	2.396GlnGly: 2.396 ± 0.053	0.863GlnHis: 0.863 ± 0.038	1.762GlnIle: 1.762 ± 0.045	1.103GlnLys: 1.103 ± 0.041	3.975GlnLeu: 3.975 ± 0.075	0.868GlnMet: 0.868 ± 0.037	0.828GlnAsn: 0.828 ± 0.031	1.978GlnPro: 1.978 ± 0.061	1.96GlnGln: 1.96 ± 0.074	2.976GlnArg: 2.976 ± 0.077	1.707GlnSer: 1.707 ± 0.046	1.727GlnThr: 1.727 ± 0.058	2.745GlnVal: 2.745 ± 0.066	0.57GlnTrp: 0.57 ± 0.031	0.809GlnTyr: 0.809 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	6.307ArgAla: 6.307 ± 0.1	0.399ArgCys: 0.399 ± 0.025	3.663ArgAsp: 3.663 ± 0.081	4.408ArgGlu: 4.408 ± 0.088	2.112ArgPhe: 2.112 ± 0.051	4.38ArgGly: 4.38 ± 0.092	1.341ArgHis: 1.341 ± 0.047	3.192ArgIle: 3.192 ± 0.061	2.252ArgLys: 2.252 ± 0.058	5.276ArgLeu: 5.276 ± 0.101	1.627ArgMet: 1.627 ± 0.053	1.818ArgAsn: 1.818 ± 0.056	2.764ArgPro: 2.764 ± 0.066	2.184ArgGln: 2.184 ± 0.056	4.623ArgArg: 4.623 ± 0.111	3.237ArgSer: 3.237 ± 0.08	3.715ArgThr: 3.715 ± 0.074	4.678ArgVal: 4.678 ± 0.08	0.874ArgTrp: 0.874 ± 0.036	1.687ArgTyr: 1.687 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	6.241SerAla: 6.241 ± 0.114	0.375SerCys: 0.375 ± 0.024	3.006SerAsp: 3.006 ± 0.07	3.29SerGlu: 3.29 ± 0.066	1.951SerPhe: 1.951 ± 0.053	4.927SerGly: 4.927 ± 0.093	1.144SerHis: 1.144 ± 0.042	2.637SerIle: 2.637 ± 0.062	2.024SerLys: 2.024 ± 0.051	5.076SerLeu: 5.076 ± 0.088	1.462SerMet: 1.462 ± 0.047	1.593SerAsn: 1.593 ± 0.04	2.663SerPro: 2.663 ± 0.068	1.894SerGln: 1.894 ± 0.052	3.212SerArg: 3.212 ± 0.076	3.553SerSer: 3.553 ± 0.096	3.85SerThr: 3.85 ± 0.094	4.432SerVal: 4.432 ± 0.085	0.914SerTrp: 0.914 ± 0.034	1.332SerTyr: 1.332 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	6.713ThrAla: 6.713 ± 0.099	0.415ThrCys: 0.415 ± 0.028	3.43ThrAsp: 3.43 ± 0.063	3.331ThrGlu: 3.331 ± 0.073	2.188ThrPhe: 2.188 ± 0.06	5.167ThrGly: 5.167 ± 0.104	1.296ThrHis: 1.296 ± 0.044	3.173ThrIle: 3.173 ± 0.074	2.099ThrLys: 2.099 ± 0.063	5.976ThrLeu: 5.976 ± 0.101	1.259ThrMet: 1.259 ± 0.036	1.874ThrAsn: 1.874 ± 0.056	4.014ThrPro: 4.014 ± 0.098	1.958ThrGln: 1.958 ± 0.054	3.29ThrArg: 3.29 ± 0.073	3.513ThrSer: 3.513 ± 0.079	4.36ThrThr: 4.36 ± 0.115	5.816ThrVal: 5.816 ± 0.108	0.875ThrTrp: 0.875 ± 0.044	1.457ThrTyr: 1.457 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	10.25ValAla: 10.25 ± 0.146	0.703ValCys: 0.703 ± 0.034	5.659ValAsp: 5.659 ± 0.113	5.531ValGlu: 5.531 ± 0.099	2.639ValPhe: 2.639 ± 0.067	6.642ValGly: 6.642 ± 0.113	1.637ValHis: 1.637 ± 0.055	4.24ValIle: 4.24 ± 0.086	2.483ValLys: 2.483 ± 0.075	8.025ValLeu: 8.025 ± 0.125	1.802ValMet: 1.802 ± 0.054	2.372ValAsn: 2.372 ± 0.072	4.216ValPro: 4.216 ± 0.084	2.44ValGln: 2.44 ± 0.07	4.985ValArg: 4.985 ± 0.098	4.731ValSer: 4.731 ± 0.08	5.386ValThr: 5.386 ± 0.093	7.839ValVal: 7.839 ± 0.12	1.064ValTrp: 1.064 ± 0.04	1.685ValTyr: 1.685 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	1.384TrpAla: 1.384 ± 0.04	0.128TrpCys: 0.128 ± 0.014	0.742TrpAsp: 0.742 ± 0.032	0.783TrpGlu: 0.783 ± 0.037	0.519TrpPhe: 0.519 ± 0.026	0.882TrpGly: 0.882 ± 0.038	0.291TrpHis: 0.291 ± 0.021	0.695TrpIle: 0.695 ± 0.036	0.486TrpLys: 0.486 ± 0.027	1.471TrpLeu: 1.471 ± 0.045	0.418TrpMet: 0.418 ± 0.025	0.466TrpAsn: 0.466 ± 0.026	0.611TrpPro: 0.611 ± 0.034	0.556TrpGln: 0.556 ± 0.027	0.904TrpArg: 0.904 ± 0.036	0.787TrpSer: 0.787 ± 0.036	0.767TrpThr: 0.767 ± 0.031	1.152TrpVal: 1.152 ± 0.04	0.308TrpTrp: 0.308 ± 0.024	0.279TrpTyr: 0.279 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.315TyrAla: 2.315 ± 0.05	0.179TyrCys: 0.179 ± 0.015	1.506TyrAsp: 1.506 ± 0.05	1.518TyrGlu: 1.518 ± 0.044	0.9TyrPhe: 0.9 ± 0.04	2.063TyrGly: 2.063 ± 0.059	0.445TyrHis: 0.445 ± 0.027	0.925TyrIle: 0.925 ± 0.034	0.728TyrLys: 0.728 ± 0.034	2.088TyrLeu: 2.088 ± 0.062	0.425TyrMet: 0.425 ± 0.022	0.72TyrAsn: 0.72 ± 0.038	1.218TyrPro: 1.218 ± 0.041	0.885TyrGln: 0.885 ± 0.04	1.498TyrArg: 1.498 ± 0.051	1.37TyrSer: 1.37 ± 0.038	1.387TyrThr: 1.387 ± 0.054	1.698TyrVal: 1.698 ± 0.049	0.362TyrTrp: 0.362 ± 0.022	0.587TyrTyr: 0.587 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2124 proteins (703705 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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