Amino acid dipepetide frequency for Oscillibacter sp. KLE 1745

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.392AlaAla: 13.392 ± 0.169
1.634AlaCys: 1.634 ± 0.041
5.888AlaAsp: 5.888 ± 0.085
7.401AlaGlu: 7.401 ± 0.112
3.535AlaPhe: 3.535 ± 0.064
8.332AlaGly: 8.332 ± 0.119
1.488AlaHis: 1.488 ± 0.037
4.953AlaIle: 4.953 ± 0.088
4.043AlaLys: 4.043 ± 0.083
10.164AlaLeu: 10.164 ± 0.136
2.842AlaMet: 2.842 ± 0.052
2.353AlaAsn: 2.353 ± 0.05
3.635AlaPro: 3.635 ± 0.07
3.385AlaGln: 3.385 ± 0.061
4.973AlaArg: 4.973 ± 0.073
4.553AlaSer: 4.553 ± 0.075
3.815AlaThr: 3.815 ± 0.074
8.465AlaVal: 8.465 ± 0.098
1.08AlaTrp: 1.08 ± 0.035
2.927AlaTyr: 2.927 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
1.585CysAla: 1.585 ± 0.049
0.395CysCys: 0.395 ± 0.02
0.885CysAsp: 0.885 ± 0.028
0.818CysGlu: 0.818 ± 0.027
0.657CysPhe: 0.657 ± 0.028
2.005CysGly: 2.005 ± 0.047
0.341CysHis: 0.341 ± 0.02
0.848CysIle: 0.848 ± 0.033
0.663CysLys: 0.663 ± 0.027
1.47CysLeu: 1.47 ± 0.039
0.405CysMet: 0.405 ± 0.019
0.463CysAsn: 0.463 ± 0.021
0.91CysPro: 0.91 ± 0.034
0.511CysGln: 0.511 ± 0.024
1.307CysArg: 1.307 ± 0.035
0.85CysSer: 0.85 ± 0.027
0.887CysThr: 0.887 ± 0.028
1.213CysVal: 1.213 ± 0.035
0.206CysTrp: 0.206 ± 0.014
0.468CysTyr: 0.468 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
5.329AspAla: 5.329 ± 0.083
0.954AspCys: 0.954 ± 0.033
2.557AspAsp: 2.557 ± 0.066
3.624AspGlu: 3.624 ± 0.08
2.506AspPhe: 2.506 ± 0.056
5.089AspGly: 5.089 ± 0.1
1.083AspHis: 1.083 ± 0.034
3.389AspIle: 3.389 ± 0.061
2.181AspLys: 2.181 ± 0.046
5.596AspLeu: 5.596 ± 0.082
1.533AspMet: 1.533 ± 0.04
1.523AspAsn: 1.523 ± 0.041
2.611AspPro: 2.611 ± 0.057
1.743AspGln: 1.743 ± 0.044
3.422AspArg: 3.422 ± 0.057
2.671AspSer: 2.671 ± 0.05
3.193AspThr: 3.193 ± 0.064
3.748AspVal: 3.748 ± 0.065
0.789AspTrp: 0.789 ± 0.034
2.254AspTyr: 2.254 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
6.808GluAla: 6.808 ± 0.091
0.697GluCys: 0.697 ± 0.025
4.039GluAsp: 4.039 ± 0.067
5.646GluGlu: 5.646 ± 0.086
1.983GluPhe: 1.983 ± 0.046
4.449GluGly: 4.449 ± 0.069
1.382GluHis: 1.382 ± 0.032
4.032GluIle: 4.032 ± 0.065
4.156GluLys: 4.156 ± 0.064
6.688GluLeu: 6.688 ± 0.08
2.016GluMet: 2.016 ± 0.047
2.884GluAsn: 2.884 ± 0.055
2.345GluPro: 2.345 ± 0.046
3.047GluGln: 3.047 ± 0.065
4.365GluArg: 4.365 ± 0.078
2.934GluSer: 2.934 ± 0.055
3.979GluThr: 3.979 ± 0.063
4.0GluVal: 4.0 ± 0.062
0.606GluTrp: 0.606 ± 0.028
2.071GluTyr: 2.071 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
3.558PheAla: 3.558 ± 0.067
0.895PheCys: 0.895 ± 0.028
2.27PheAsp: 2.27 ± 0.044
1.841PheGlu: 1.841 ± 0.044
1.795PhePhe: 1.795 ± 0.044
3.081PheGly: 3.081 ± 0.06
0.861PheHis: 0.861 ± 0.03
1.758PheIle: 1.758 ± 0.041
1.189PheLys: 1.189 ± 0.034
4.129PheLeu: 4.129 ± 0.068
0.813PheMet: 0.813 ± 0.031
1.094PheAsn: 1.094 ± 0.034
1.782PhePro: 1.782 ± 0.046
1.447PheGln: 1.447 ± 0.039
2.225PheArg: 2.225 ± 0.049
2.737PheSer: 2.737 ± 0.05
2.368PheThr: 2.368 ± 0.047
2.372PheVal: 2.372 ± 0.051
0.528PheTrp: 0.528 ± 0.024
1.437PheTyr: 1.437 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
7.1GlyAla: 7.1 ± 0.108
1.493GlyCys: 1.493 ± 0.041
4.158GlyAsp: 4.158 ± 0.074
5.254GlyGlu: 5.254 ± 0.067
3.015GlyPhe: 3.015 ± 0.057
6.874GlyGly: 6.874 ± 0.123
1.469GlyHis: 1.469 ± 0.039
4.812GlyIle: 4.812 ± 0.066
4.233GlyLys: 4.233 ± 0.062
7.217GlyLeu: 7.217 ± 0.092
2.414GlyMet: 2.414 ± 0.046
2.456GlyAsn: 2.456 ± 0.054
2.192GlyPro: 2.192 ± 0.047
2.624GlyGln: 2.624 ± 0.053
4.974GlyArg: 4.974 ± 0.089
4.306GlySer: 4.306 ± 0.078
5.124GlyThr: 5.124 ± 0.085
5.895GlyVal: 5.895 ± 0.08
1.027GlyTrp: 1.027 ± 0.035
2.933GlyTyr: 2.933 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.427HisAla: 1.427 ± 0.03
0.378HisCys: 0.378 ± 0.02
0.961HisAsp: 0.961 ± 0.033
0.924HisGlu: 0.924 ± 0.025
0.82HisPhe: 0.82 ± 0.028
1.517HisGly: 1.517 ± 0.039
0.436HisHis: 0.436 ± 0.025
1.232HisIle: 1.232 ± 0.035
0.724HisLys: 0.724 ± 0.025
1.809HisLeu: 1.809 ± 0.043
0.47HisMet: 0.47 ± 0.02
0.593HisAsn: 0.593 ± 0.021
1.136HisPro: 1.136 ± 0.034
0.633HisGln: 0.633 ± 0.026
1.135HisArg: 1.135 ± 0.034
0.965HisSer: 0.965 ± 0.033
1.132HisThr: 1.132 ± 0.031
1.19HisVal: 1.19 ± 0.036
0.223HisTrp: 0.223 ± 0.013
0.694HisTyr: 0.694 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.197IleAla: 5.197 ± 0.074
1.072IleCys: 1.072 ± 0.035
3.015IleAsp: 3.015 ± 0.061
2.85IleGlu: 2.85 ± 0.055
2.114IlePhe: 2.114 ± 0.046
4.055IleGly: 4.055 ± 0.074
1.068IleHis: 1.068 ± 0.031
2.878IleIle: 2.878 ± 0.066
1.931IleLys: 1.931 ± 0.045
5.607IleLeu: 5.607 ± 0.08
1.271IleMet: 1.271 ± 0.037
1.736IleAsn: 1.736 ± 0.043
2.966IlePro: 2.966 ± 0.057
2.079IleGln: 2.079 ± 0.045
3.547IleArg: 3.547 ± 0.059
3.491IleSer: 3.491 ± 0.065
3.382IleThr: 3.382 ± 0.063
3.723IleVal: 3.723 ± 0.066
0.61IleTrp: 0.61 ± 0.027
1.804IleTyr: 1.804 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.187LysAla: 4.187 ± 0.071
0.515LysCys: 0.515 ± 0.023
2.345LysAsp: 2.345 ± 0.061
3.382LysGlu: 3.382 ± 0.064
1.378LysPhe: 1.378 ± 0.035
3.018LysGly: 3.018 ± 0.058
0.767LysHis: 0.767 ± 0.03
2.685LysIle: 2.685 ± 0.054
3.108LysLys: 3.108 ± 0.069
4.1LysLeu: 4.1 ± 0.068
1.403LysMet: 1.403 ± 0.04
1.832LysAsn: 1.832 ± 0.045
1.79LysPro: 1.79 ± 0.041
1.719LysGln: 1.719 ± 0.039
2.935LysArg: 2.935 ± 0.061
2.402LysSer: 2.402 ± 0.05
2.782LysThr: 2.782 ± 0.056
2.869LysVal: 2.869 ± 0.056
0.481LysTrp: 0.481 ± 0.022
1.591LysTyr: 1.591 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
9.767LeuAla: 9.767 ± 0.123
2.035LeuCys: 2.035 ± 0.049
5.57LeuAsp: 5.57 ± 0.069
6.595LeuGlu: 6.595 ± 0.086
3.872LeuPhe: 3.872 ± 0.077
7.079LeuGly: 7.079 ± 0.1
1.751LeuHis: 1.751 ± 0.044
4.48LeuIle: 4.48 ± 0.072
4.163LeuLys: 4.163 ± 0.072
10.835LeuLeu: 10.835 ± 0.137
2.544LeuMet: 2.544 ± 0.057
2.868LeuAsn: 2.868 ± 0.051
4.94LeuPro: 4.94 ± 0.077
3.089LeuGln: 3.089 ± 0.058
6.435LeuArg: 6.435 ± 0.088
6.458LeuSer: 6.458 ± 0.086
6.186LeuThr: 6.186 ± 0.082
6.073LeuVal: 6.073 ± 0.08
1.113LeuTrp: 1.113 ± 0.037
3.187LeuTyr: 3.187 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.756MetAla: 2.756 ± 0.055
0.327MetCys: 0.327 ± 0.017
1.779MetAsp: 1.779 ± 0.045
2.294MetGlu: 2.294 ± 0.049
0.794MetPhe: 0.794 ± 0.029
2.126MetGly: 2.126 ± 0.052
0.346MetHis: 0.346 ± 0.02
1.361MetIle: 1.361 ± 0.037
1.709MetLys: 1.709 ± 0.044
2.536MetLeu: 2.536 ± 0.053
0.774MetMet: 0.774 ± 0.029
1.014MetAsn: 1.014 ± 0.03
1.145MetPro: 1.145 ± 0.032
0.906MetGln: 0.906 ± 0.029
1.551MetArg: 1.551 ± 0.044
1.524MetSer: 1.524 ± 0.042
1.739MetThr: 1.739 ± 0.042
1.801MetVal: 1.801 ± 0.044
0.233MetTrp: 0.233 ± 0.014
0.635MetTyr: 0.635 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.002AsnAla: 3.002 ± 0.056
0.563AsnCys: 0.563 ± 0.023
1.547AsnAsp: 1.547 ± 0.037
1.638AsnGlu: 1.638 ± 0.043
1.174AsnPhe: 1.174 ± 0.036
2.935AsnGly: 2.935 ± 0.066
0.674AsnHis: 0.674 ± 0.026
2.007AsnIle: 2.007 ± 0.047
1.222AsnLys: 1.222 ± 0.036
2.978AsnLeu: 2.978 ± 0.053
0.879AsnMet: 0.879 ± 0.027
0.949AsnAsn: 0.949 ± 0.032
1.761AsnPro: 1.761 ± 0.046
1.085AsnGln: 1.085 ± 0.033
1.9AsnArg: 1.9 ± 0.049
1.629AsnSer: 1.629 ± 0.041
1.802AsnThr: 1.802 ± 0.04
2.061AsnVal: 2.061 ± 0.047
0.399AsnTrp: 0.399 ± 0.021
1.08AsnTyr: 1.08 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
4.593ProAla: 4.593 ± 0.079
0.631ProCys: 0.631 ± 0.023
2.881ProAsp: 2.881 ± 0.064
4.127ProGlu: 4.127 ± 0.066
1.584ProPhe: 1.584 ± 0.038
3.528ProGly: 3.528 ± 0.057
0.806ProHis: 0.806 ± 0.031
2.087ProIle: 2.087 ± 0.041
1.68ProLys: 1.68 ± 0.044
3.716ProLeu: 3.716 ± 0.06
1.129ProMet: 1.129 ± 0.036
1.209ProAsn: 1.209 ± 0.031
1.76ProPro: 1.76 ± 0.056
1.535ProGln: 1.535 ± 0.04
1.963ProArg: 1.963 ± 0.05
2.206ProSer: 2.206 ± 0.045
2.019ProThr: 2.019 ± 0.042
3.608ProVal: 3.608 ± 0.058
0.511ProTrp: 0.511 ± 0.025
1.474ProTyr: 1.474 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
3.634GlnAla: 3.634 ± 0.066
0.423GlnCys: 0.423 ± 0.021
1.716GlnAsp: 1.716 ± 0.04
2.773GlnGlu: 2.773 ± 0.061
1.183GlnPhe: 1.183 ± 0.031
2.449GlnGly: 2.449 ± 0.044
0.613GlnHis: 0.613 ± 0.025
2.127GlnIle: 2.127 ± 0.043
2.086GlnLys: 2.086 ± 0.054
3.272GlnLeu: 3.272 ± 0.062
1.147GlnMet: 1.147 ± 0.031
1.326GlnAsn: 1.326 ± 0.038
1.295GlnPro: 1.295 ± 0.038
1.504GlnGln: 1.504 ± 0.048
2.28GlnArg: 2.28 ± 0.048
1.72GlnSer: 1.72 ± 0.037
1.958GlnThr: 1.958 ± 0.048
2.494GlnVal: 2.494 ± 0.051
0.419GlnTrp: 0.419 ± 0.02
1.266GlnTyr: 1.266 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
4.993ArgAla: 4.993 ± 0.083
0.981ArgCys: 0.981 ± 0.034
3.268ArgAsp: 3.268 ± 0.061
4.869ArgGlu: 4.869 ± 0.088
2.307ArgPhe: 2.307 ± 0.043
3.909ArgGly: 3.909 ± 0.064
1.216ArgHis: 1.216 ± 0.035
3.387ArgIle: 3.387 ± 0.052
3.123ArgLys: 3.123 ± 0.058
6.044ArgLeu: 6.044 ± 0.085
1.872ArgMet: 1.872 ± 0.043
1.938ArgAsn: 1.938 ± 0.044
2.611ArgPro: 2.611 ± 0.055
2.83ArgGln: 2.83 ± 0.057
5.034ArgArg: 5.034 ± 0.092
3.056ArgSer: 3.056 ± 0.066
3.316ArgThr: 3.316 ± 0.06
3.422ArgVal: 3.422 ± 0.062
0.804ArgTrp: 0.804 ± 0.032
2.179ArgTyr: 2.179 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.389SerAla: 5.389 ± 0.072
0.874SerCys: 0.874 ± 0.028
2.835SerAsp: 2.835 ± 0.055
2.843SerGlu: 2.843 ± 0.055
2.359SerPhe: 2.359 ± 0.052
5.497SerGly: 5.497 ± 0.084
1.026SerHis: 1.026 ± 0.034
3.003SerIle: 3.003 ± 0.055
2.125SerLys: 2.125 ± 0.052
5.234SerLeu: 5.234 ± 0.076
1.487SerMet: 1.487 ± 0.038
1.577SerAsn: 1.577 ± 0.039
2.402SerPro: 2.402 ± 0.045
1.866SerGln: 1.866 ± 0.042
3.399SerArg: 3.399 ± 0.064
3.095SerSer: 3.095 ± 0.068
2.722SerThr: 2.722 ± 0.057
4.032SerVal: 4.032 ± 0.068
0.639SerTrp: 0.639 ± 0.026
1.914SerTyr: 1.914 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
6.477ThrAla: 6.477 ± 0.096
0.762ThrCys: 0.762 ± 0.029
3.188ThrAsp: 3.188 ± 0.056
3.572ThrGlu: 3.572 ± 0.058
2.271ThrPhe: 2.271 ± 0.05
5.198ThrGly: 5.198 ± 0.076
0.967ThrHis: 0.967 ± 0.027
3.231ThrIle: 3.231 ± 0.072
1.961ThrLys: 1.961 ± 0.044
5.566ThrLeu: 5.566 ± 0.08
1.486ThrMet: 1.486 ± 0.042
1.51ThrAsn: 1.51 ± 0.045
2.804ThrPro: 2.804 ± 0.047
1.584ThrGln: 1.584 ± 0.039
2.729ThrArg: 2.729 ± 0.055
2.665ThrSer: 2.665 ± 0.058
2.869ThrThr: 2.869 ± 0.065
5.383ThrVal: 5.383 ± 0.09
0.649ThrTrp: 0.649 ± 0.026
1.95ThrTyr: 1.95 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
5.721ValAla: 5.721 ± 0.081
1.428ValCys: 1.428 ± 0.046
3.973ValAsp: 3.973 ± 0.072
4.679ValGlu: 4.679 ± 0.071
2.956ValPhe: 2.956 ± 0.058
4.763ValGly: 4.763 ± 0.08
1.126ValHis: 1.126 ± 0.033
3.791ValIle: 3.791 ± 0.068
3.195ValLys: 3.195 ± 0.059
7.399ValLeu: 7.399 ± 0.096
1.817ValMet: 1.817 ± 0.041
2.274ValAsn: 2.274 ± 0.051
3.193ValPro: 3.193 ± 0.066
2.161ValGln: 2.161 ± 0.043
4.075ValArg: 4.075 ± 0.066
4.675ValSer: 4.675 ± 0.074
4.725ValThr: 4.725 ± 0.083
5.055ValVal: 5.055 ± 0.083
0.816ValTrp: 0.816 ± 0.026
2.343ValTyr: 2.343 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.944TrpAla: 0.944 ± 0.028
0.229TrpCys: 0.229 ± 0.016
0.687TrpAsp: 0.687 ± 0.025
0.868TrpGlu: 0.868 ± 0.03
0.469TrpPhe: 0.469 ± 0.026
0.872TrpGly: 0.872 ± 0.033
0.199TrpHis: 0.199 ± 0.015
0.515TrpIle: 0.515 ± 0.022
0.636TrpLys: 0.636 ± 0.022
1.199TrpLeu: 1.199 ± 0.037
0.337TrpMet: 0.337 ± 0.019
0.489TrpAsn: 0.489 ± 0.022
0.387TrpPro: 0.387 ± 0.021
0.516TrpGln: 0.516 ± 0.02
0.726TrpArg: 0.726 ± 0.028
0.641TrpSer: 0.641 ± 0.024
0.639TrpThr: 0.639 ± 0.028
0.684TrpVal: 0.684 ± 0.028
0.164TrpTrp: 0.164 ± 0.014
0.457TrpTyr: 0.457 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.001TyrAla: 3.001 ± 0.061
0.603TyrCys: 0.603 ± 0.021
2.232TyrAsp: 2.232 ± 0.052
2.13TyrGlu: 2.13 ± 0.044
1.407TyrPhe: 1.407 ± 0.038
2.791TyrGly: 2.791 ± 0.05
0.779TyrHis: 0.779 ± 0.029
1.821TyrIle: 1.821 ± 0.039
1.16TyrLys: 1.16 ± 0.035
3.48TyrLeu: 3.48 ± 0.054
0.711TyrMet: 0.711 ± 0.024
1.197TyrAsn: 1.197 ± 0.04
1.381TyrPro: 1.381 ± 0.036
1.421TyrGln: 1.421 ± 0.038
2.186TyrArg: 2.186 ± 0.049
1.743TyrSer: 1.743 ± 0.047
2.184TyrThr: 2.184 ± 0.056
2.077TyrVal: 2.077 ± 0.048
0.361TyrTrp: 0.361 ± 0.019
1.311TyrTyr: 1.311 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4287 proteins (1076406 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski