Amino acid dipepetide frequency for Leucobacter luti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.31AlaAla: 21.31 ± 0.204	0.747AlaCys: 0.747 ± 0.028	7.32AlaAsp: 7.32 ± 0.091	9.154AlaGlu: 9.154 ± 0.112	3.771AlaPhe: 3.771 ± 0.059	12.317AlaGly: 12.317 ± 0.124	2.695AlaHis: 2.695 ± 0.068	6.106AlaIle: 6.106 ± 0.071	2.837AlaLys: 2.837 ± 0.078	14.324AlaLeu: 14.324 ± 0.162	2.603AlaMet: 2.603 ± 0.056	2.557AlaAsn: 2.557 ± 0.055	6.867AlaPro: 6.867 ± 0.114	4.69AlaGln: 4.69 ± 0.073	8.423AlaArg: 8.423 ± 0.108	7.322AlaSer: 7.322 ± 0.09	7.524AlaThr: 7.524 ± 0.09	10.61AlaVal: 10.61 ± 0.103	1.703AlaTrp: 1.703 ± 0.039	2.279AlaTyr: 2.279 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.829CysAla: 0.829 ± 0.031	0.06CysCys: 0.06 ± 0.008	0.357CysAsp: 0.357 ± 0.019	0.327CysGlu: 0.327 ± 0.017	0.172CysPhe: 0.172 ± 0.012	0.645CysGly: 0.645 ± 0.026	0.114CysHis: 0.114 ± 0.01	0.19CysIle: 0.19 ± 0.013	0.069CysLys: 0.069 ± 0.008	0.432CysLeu: 0.432 ± 0.022	0.097CysMet: 0.097 ± 0.008	0.112CysAsn: 0.112 ± 0.012	0.272CysPro: 0.272 ± 0.019	0.13CysGln: 0.13 ± 0.01	0.303CysArg: 0.303 ± 0.019	0.367CysSer: 0.367 ± 0.017	0.414CysThr: 0.414 ± 0.019	0.48CysVal: 0.48 ± 0.022	0.069CysTrp: 0.069 ± 0.009	0.116CysTyr: 0.116 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.595AspAla: 7.595 ± 0.095	0.262AspCys: 0.262 ± 0.015	2.951AspAsp: 2.951 ± 0.072	3.755AspGlu: 3.755 ± 0.073	1.727AspPhe: 1.727 ± 0.04	5.084AspGly: 5.084 ± 0.09	1.115AspHis: 1.115 ± 0.029	2.126AspIle: 2.126 ± 0.041	0.815AspLys: 0.815 ± 0.034	5.402AspLeu: 5.402 ± 0.069	0.812AspMet: 0.812 ± 0.031	0.854AspAsn: 0.854 ± 0.031	4.508AspPro: 4.508 ± 0.113	1.621AspGln: 1.621 ± 0.043	4.211AspArg: 4.211 ± 0.08	2.817AspSer: 2.817 ± 0.058	3.235AspThr: 3.235 ± 0.068	4.315AspVal: 4.315 ± 0.062	0.815AspTrp: 0.815 ± 0.031	1.158AspTyr: 1.158 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.386GluAla: 7.386 ± 0.087	0.297GluCys: 0.297 ± 0.017	2.627GluAsp: 2.627 ± 0.059	3.075GluGlu: 3.075 ± 0.062	2.086GluPhe: 2.086 ± 0.043	3.736GluGly: 3.736 ± 0.068	1.689GluHis: 1.689 ± 0.042	3.055GluIle: 3.055 ± 0.058	1.284GluLys: 1.284 ± 0.04	7.795GluLeu: 7.795 ± 0.098	1.141GluMet: 1.141 ± 0.034	1.322GluAsn: 1.322 ± 0.038	2.998GluPro: 2.998 ± 0.058	2.72GluGln: 2.72 ± 0.049	5.521GluArg: 5.521 ± 0.102	3.314GluSer: 3.314 ± 0.055	3.39GluThr: 3.39 ± 0.06	4.491GluVal: 4.491 ± 0.074	0.909GluTrp: 0.909 ± 0.028	1.234GluTyr: 1.234 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.381PheAla: 4.381 ± 0.066	0.19PheCys: 0.19 ± 0.015	2.078PheAsp: 2.078 ± 0.044	1.88PheGlu: 1.88 ± 0.041	1.099PhePhe: 1.099 ± 0.038	3.458PheGly: 3.458 ± 0.057	0.499PheHis: 0.499 ± 0.024	1.353PheIle: 1.353 ± 0.038	0.464PheLys: 0.464 ± 0.019	2.746PheLeu: 2.746 ± 0.049	0.51PheMet: 0.51 ± 0.023	0.66PheAsn: 0.66 ± 0.027	1.609PhePro: 1.609 ± 0.038	0.833PheGln: 0.833 ± 0.032	1.718PheArg: 1.718 ± 0.036	1.978PheSer: 1.978 ± 0.041	2.414PheThr: 2.414 ± 0.049	2.678PheVal: 2.678 ± 0.054	0.49PheTrp: 0.49 ± 0.02	0.58PheTyr: 0.58 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.314GlyAla: 11.314 ± 0.123	0.603GlyCys: 0.603 ± 0.022	4.584GlyAsp: 4.584 ± 0.066	5.196GlyGlu: 5.196 ± 0.069	3.231GlyPhe: 3.231 ± 0.058	7.731GlyGly: 7.731 ± 0.142	1.665GlyHis: 1.665 ± 0.037	5.123GlyIle: 5.123 ± 0.075	2.301GlyLys: 2.301 ± 0.055	8.704GlyLeu: 8.704 ± 0.092	1.893GlyMet: 1.893 ± 0.047	1.913GlyAsn: 1.913 ± 0.051	3.709GlyPro: 3.709 ± 0.065	2.521GlyGln: 2.521 ± 0.051	5.527GlyArg: 5.527 ± 0.085	5.861GlySer: 5.861 ± 0.08	5.987GlyThr: 5.987 ± 0.126	7.795GlyVal: 7.795 ± 0.089	1.527GlyTrp: 1.527 ± 0.043	2.144GlyTyr: 2.144 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.592HisAla: 2.592 ± 0.052	0.121HisCys: 0.121 ± 0.009	1.19HisAsp: 1.19 ± 0.033	1.297HisGlu: 1.297 ± 0.033	0.582HisPhe: 0.582 ± 0.019	1.927HisGly: 1.927 ± 0.046	0.514HisHis: 0.514 ± 0.023	0.762HisIle: 0.762 ± 0.027	0.284HisLys: 0.284 ± 0.016	2.018HisLeu: 2.018 ± 0.048	0.352HisMet: 0.352 ± 0.018	0.376HisAsn: 0.376 ± 0.02	1.448HisPro: 1.448 ± 0.039	0.59HisGln: 0.59 ± 0.024	1.554HisArg: 1.554 ± 0.035	1.146HisSer: 1.146 ± 0.032	1.292HisThr: 1.292 ± 0.034	1.465HisVal: 1.465 ± 0.038	0.294HisTrp: 0.294 ± 0.015	0.409HisTyr: 0.409 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.541IleAla: 7.541 ± 0.085	0.3IleCys: 0.3 ± 0.017	3.233IleAsp: 3.233 ± 0.055	3.094IleGlu: 3.094 ± 0.058	1.209IlePhe: 1.209 ± 0.038	4.759IleGly: 4.759 ± 0.078	0.701IleHis: 0.701 ± 0.026	2.034IleIle: 2.034 ± 0.054	0.743IleLys: 0.743 ± 0.029	3.987IleLeu: 3.987 ± 0.073	0.702IleMet: 0.702 ± 0.028	0.984IleAsn: 0.984 ± 0.03	2.674IlePro: 2.674 ± 0.046	1.058IleGln: 1.058 ± 0.031	2.739IleArg: 2.739 ± 0.055	2.833IleSer: 2.833 ± 0.049	3.224IleThr: 3.224 ± 0.063	4.536IleVal: 4.536 ± 0.071	0.532IleTrp: 0.532 ± 0.023	0.706IleTyr: 0.706 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.082LysAla: 2.082 ± 0.057	0.089LysCys: 0.089 ± 0.009	1.063LysAsp: 1.063 ± 0.036	0.893LysGlu: 0.893 ± 0.033	0.596LysPhe: 0.596 ± 0.024	1.297LysGly: 1.297 ± 0.045	0.479LysHis: 0.479 ± 0.022	1.115LysIle: 1.115 ± 0.039	0.762LysLys: 0.762 ± 0.038	2.195LysLeu: 2.195 ± 0.053	0.407LysMet: 0.407 ± 0.021	0.589LysAsn: 0.589 ± 0.026	1.283LysPro: 1.283 ± 0.042	0.819LysGln: 0.819 ± 0.034	1.739LysArg: 1.739 ± 0.043	1.281LysSer: 1.281 ± 0.042	1.343LysThr: 1.343 ± 0.039	1.468LysVal: 1.468 ± 0.042	0.251LysTrp: 0.251 ± 0.016	0.473LysTyr: 0.473 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.632LeuAla: 14.632 ± 0.148	0.554LeuCys: 0.554 ± 0.021	6.021LeuAsp: 6.021 ± 0.077	5.107LeuGlu: 5.107 ± 0.073	2.92LeuPhe: 2.92 ± 0.065	9.697LeuGly: 9.697 ± 0.115	1.866LeuHis: 1.866 ± 0.042	4.998LeuIle: 4.998 ± 0.085	1.816LeuLys: 1.816 ± 0.049	10.455LeuLeu: 10.455 ± 0.158	1.667LeuMet: 1.667 ± 0.044	2.1LeuAsn: 2.1 ± 0.047	5.489LeuPro: 5.489 ± 0.075	2.7LeuGln: 2.7 ± 0.045	7.387LeuArg: 7.387 ± 0.108	6.516LeuSer: 6.516 ± 0.087	6.81LeuThr: 6.81 ± 0.075	8.436LeuVal: 8.436 ± 0.111	1.205LeuTrp: 1.205 ± 0.029	1.531LeuTyr: 1.531 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	1.872MetAla: 1.872 ± 0.043	0.107MetCys: 0.107 ± 0.01	0.744MetAsp: 0.744 ± 0.026	0.67MetGlu: 0.67 ± 0.025	0.551MetPhe: 0.551 ± 0.024	1.363MetGly: 1.363 ± 0.036	0.4MetHis: 0.4 ± 0.017	0.941MetIle: 0.941 ± 0.031	0.432MetLys: 0.432 ± 0.02	2.038MetLeu: 2.038 ± 0.049	0.318MetMet: 0.318 ± 0.018	0.584MetAsn: 0.584 ± 0.024	1.029MetPro: 1.029 ± 0.035	0.644MetGln: 0.644 ± 0.026	1.375MetArg: 1.375 ± 0.038	1.591MetSer: 1.591 ± 0.036	1.606MetThr: 1.606 ± 0.033	1.278MetVal: 1.278 ± 0.038	0.203MetTrp: 0.203 ± 0.013	0.326MetTyr: 0.326 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.714AsnAla: 2.714 ± 0.049	0.135AsnCys: 0.135 ± 0.012	1.1AsnAsp: 1.1 ± 0.033	1.138AsnGlu: 1.138 ± 0.033	0.688AsnPhe: 0.688 ± 0.022	1.992AsnGly: 1.992 ± 0.043	0.392AsnHis: 0.392 ± 0.019	0.917AsnIle: 0.917 ± 0.029	0.389AsnLys: 0.389 ± 0.021	1.957AsnLeu: 1.957 ± 0.041	0.397AsnMet: 0.397 ± 0.019	0.506AsnAsn: 0.506 ± 0.022	1.647AsnPro: 1.647 ± 0.042	0.632AsnGln: 0.632 ± 0.022	1.438AsnArg: 1.438 ± 0.039	1.227AsnSer: 1.227 ± 0.04	1.396AsnThr: 1.396 ± 0.048	1.737AsnVal: 1.737 ± 0.047	0.367AsnTrp: 0.367 ± 0.02	0.508AsnTyr: 0.508 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.353ProAla: 7.353 ± 0.105	0.192ProCys: 0.192 ± 0.012	3.399ProAsp: 3.399 ± 0.061	4.576ProGlu: 4.576 ± 0.073	1.645ProPhe: 1.645 ± 0.033	5.443ProGly: 5.443 ± 0.127	1.214ProHis: 1.214 ± 0.035	2.302ProIle: 2.302 ± 0.047	1.202ProLys: 1.202 ± 0.042	4.839ProLeu: 4.839 ± 0.081	0.877ProMet: 0.877 ± 0.028	1.245ProAsn: 1.245 ± 0.037	2.203ProPro: 2.203 ± 0.062	1.758ProGln: 1.758 ± 0.037	3.214ProArg: 3.214 ± 0.056	3.159ProSer: 3.159 ± 0.064	3.261ProThr: 3.261 ± 0.066	4.774ProVal: 4.774 ± 0.071	0.762ProTrp: 0.762 ± 0.025	0.977ProTyr: 0.977 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.77GlnAla: 3.77 ± 0.061	0.149GlnCys: 0.149 ± 0.013	1.381GlnAsp: 1.381 ± 0.037	1.633GlnGlu: 1.633 ± 0.046	0.951GlnPhe: 0.951 ± 0.028	2.237GlnGly: 2.237 ± 0.048	0.817GlnHis: 0.817 ± 0.025	1.666GlnIle: 1.666 ± 0.038	0.665GlnLys: 0.665 ± 0.029	3.879GlnLeu: 3.879 ± 0.059	0.617GlnMet: 0.617 ± 0.024	0.769GlnAsn: 0.769 ± 0.028	1.749GlnPro: 1.749 ± 0.047	1.478GlnGln: 1.478 ± 0.039	2.806GlnArg: 2.806 ± 0.057	1.754GlnSer: 1.754 ± 0.042	1.592GlnThr: 1.592 ± 0.037	2.282GlnVal: 2.282 ± 0.044	0.438GlnTrp: 0.438 ± 0.021	0.637GlnTyr: 0.637 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.94ArgAla: 8.94 ± 0.116	0.314ArgCys: 0.314 ± 0.018	3.921ArgAsp: 3.921 ± 0.071	4.762ArgGlu: 4.762 ± 0.081	2.398ArgPhe: 2.398 ± 0.048	5.492ArgGly: 5.492 ± 0.088	1.385ArgHis: 1.385 ± 0.041	3.722ArgIle: 3.722 ± 0.065	1.517ArgLys: 1.517 ± 0.037	6.526ArgLeu: 6.526 ± 0.096	1.493ArgMet: 1.493 ± 0.042	1.438ArgAsn: 1.438 ± 0.034	3.259ArgPro: 3.259 ± 0.063	1.953ArgGln: 1.953 ± 0.048	5.41ArgArg: 5.41 ± 0.09	4.169ArgSer: 4.169 ± 0.072	4.288ArgThr: 4.288 ± 0.066	5.955ArgVal: 5.955 ± 0.085	1.057ArgTrp: 1.057 ± 0.029	1.446ArgTyr: 1.446 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	7.772SerAla: 7.772 ± 0.111	0.378SerCys: 0.378 ± 0.019	3.369SerAsp: 3.369 ± 0.058	3.721SerGlu: 3.721 ± 0.067	2.111SerPhe: 2.111 ± 0.05	6.651SerGly: 6.651 ± 0.102	1.141SerHis: 1.141 ± 0.031	2.621SerIle: 2.621 ± 0.05	1.254SerLys: 1.254 ± 0.034	5.383SerLeu: 5.383 ± 0.08	1.181SerMet: 1.181 ± 0.033	1.293SerAsn: 1.293 ± 0.036	3.157SerPro: 3.157 ± 0.064	1.683SerGln: 1.683 ± 0.044	3.909SerArg: 3.909 ± 0.064	3.668SerSer: 3.668 ± 0.071	3.652SerThr: 3.652 ± 0.065	4.724SerVal: 4.724 ± 0.064	0.982SerTrp: 0.982 ± 0.029	1.293SerTyr: 1.293 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	8.334ThrAla: 8.334 ± 0.103	0.283ThrCys: 0.283 ± 0.015	3.424ThrAsp: 3.424 ± 0.092	3.639ThrGlu: 3.639 ± 0.065	1.778ThrPhe: 1.778 ± 0.04	6.217ThrGly: 6.217 ± 0.093	1.309ThrHis: 1.309 ± 0.035	3.014ThrIle: 3.014 ± 0.057	1.242ThrLys: 1.242 ± 0.039	6.396ThrLeu: 6.396 ± 0.077	1.006ThrMet: 1.006 ± 0.03	1.341ThrAsn: 1.341 ± 0.041	4.347ThrPro: 4.347 ± 0.064	1.872ThrGln: 1.872 ± 0.04	3.946ThrArg: 3.946 ± 0.064	3.539ThrSer: 3.539 ± 0.051	3.71ThrThr: 3.71 ± 0.081	5.755ThrVal: 5.755 ± 0.089	0.807ThrTrp: 0.807 ± 0.03	0.986ThrTyr: 0.986 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	10.863ValAla: 10.863 ± 0.122	0.541ValCys: 0.541 ± 0.026	4.48ValAsp: 4.48 ± 0.068	4.384ValGlu: 4.384 ± 0.077	2.876ValPhe: 2.876 ± 0.053	6.356ValGly: 6.356 ± 0.081	1.614ValHis: 1.614 ± 0.041	4.194ValIle: 4.194 ± 0.066	1.537ValLys: 1.537 ± 0.042	9.169ValLeu: 9.169 ± 0.125	1.418ValMet: 1.418 ± 0.04	1.824ValAsn: 1.824 ± 0.042	4.506ValPro: 4.506 ± 0.073	2.446ValGln: 2.446 ± 0.045	5.484ValArg: 5.484 ± 0.077	5.389ValSer: 5.389 ± 0.065	5.865ValThr: 5.865 ± 0.082	7.194ValVal: 7.194 ± 0.093	1.104ValTrp: 1.104 ± 0.032	1.48ValTyr: 1.48 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.561TrpAla: 1.561 ± 0.043	0.106TrpCys: 0.106 ± 0.009	0.738TrpAsp: 0.738 ± 0.024	0.694TrpGlu: 0.694 ± 0.027	0.557TrpPhe: 0.557 ± 0.022	1.114TrpGly: 1.114 ± 0.038	0.303TrpHis: 0.303 ± 0.018	0.7TrpIle: 0.7 ± 0.027	0.313TrpLys: 0.313 ± 0.016	1.627TrpLeu: 1.627 ± 0.043	0.294TrpMet: 0.294 ± 0.016	0.401TrpAsn: 0.401 ± 0.023	0.659TrpPro: 0.659 ± 0.024	0.529TrpGln: 0.529 ± 0.02	1.117TrpArg: 1.117 ± 0.036	0.869TrpSer: 0.869 ± 0.025	0.769TrpThr: 0.769 ± 0.032	1.208TrpVal: 1.208 ± 0.035	0.313TrpTrp: 0.313 ± 0.018	0.255TrpTyr: 0.255 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.317TyrAla: 2.317 ± 0.041	0.128TyrCys: 0.128 ± 0.01	1.2TyrAsp: 1.2 ± 0.036	1.075TyrGlu: 1.075 ± 0.034	0.668TyrPhe: 0.668 ± 0.024	1.815TyrGly: 1.815 ± 0.04	0.298TyrHis: 0.298 ± 0.019	0.651TyrIle: 0.651 ± 0.029	0.3TyrLys: 0.3 ± 0.018	2.035TyrLeu: 2.035 ± 0.045	0.286TyrMet: 0.286 ± 0.017	0.41TyrAsn: 0.41 ± 0.021	0.982TyrPro: 0.982 ± 0.027	0.594TyrGln: 0.594 ± 0.023	1.626TyrArg: 1.626 ± 0.042	1.14TyrSer: 1.14 ± 0.036	1.176TyrThr: 1.176 ± 0.036	1.544TyrVal: 1.544 ± 0.037	0.298TyrTrp: 0.298 ± 0.017	0.421TyrTyr: 0.421 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3417 proteins (1145008 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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