Amino acid dipepetide frequency for Equine encephalosis virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.754AlaAla: 5.754 ± 1.257
0.959AlaCys: 0.959 ± 0.325
3.037AlaAsp: 3.037 ± 0.919
2.877AlaGlu: 2.877 ± 0.513
1.918AlaPhe: 1.918 ± 0.447
3.517AlaGly: 3.517 ± 1.053
1.119AlaHis: 1.119 ± 0.503
4.316AlaIle: 4.316 ± 1.401
2.717AlaLys: 2.717 ± 0.769
6.394AlaLeu: 6.394 ± 1.237
2.717AlaMet: 2.717 ± 1.055
2.238AlaAsn: 2.238 ± 0.646
3.996AlaPro: 3.996 ± 1.019
1.918AlaGln: 1.918 ± 0.929
3.996AlaArg: 3.996 ± 0.728
4.476AlaSer: 4.476 ± 1.003
2.717AlaThr: 2.717 ± 0.571
5.115AlaVal: 5.115 ± 1.07
0.799AlaTrp: 0.799 ± 0.283
1.918AlaTyr: 1.918 ± 0.765
0.0AlaXaa: 0.0 ± 0.0
Cys
1.119CysAla: 1.119 ± 0.316
0.639CysCys: 0.639 ± 0.333
0.959CysAsp: 0.959 ± 0.353
0.32CysGlu: 0.32 ± 0.265
1.119CysPhe: 1.119 ± 0.49
0.639CysGly: 0.639 ± 0.251
0.16CysHis: 0.16 ± 0.17
1.758CysIle: 1.758 ± 0.531
0.48CysLys: 0.48 ± 0.303
1.119CysLeu: 1.119 ± 0.562
0.48CysMet: 0.48 ± 0.216
0.799CysAsn: 0.799 ± 0.376
0.16CysPro: 0.16 ± 0.17
0.0CysGln: 0.0 ± 0.0
0.959CysArg: 0.959 ± 0.356
0.639CysSer: 0.639 ± 0.306
0.639CysThr: 0.639 ± 0.291
1.439CysVal: 1.439 ± 0.509
0.0CysTrp: 0.0 ± 0.0
0.639CysTyr: 0.639 ± 0.237
0.0CysXaa: 0.0 ± 0.0
Asp
3.197AspAla: 3.197 ± 0.586
0.32AspCys: 0.32 ± 0.173
3.996AspAsp: 3.996 ± 0.688
4.316AspGlu: 4.316 ± 0.598
1.758AspPhe: 1.758 ± 0.71
4.476AspGly: 4.476 ± 1.403
0.639AspHis: 0.639 ± 0.231
4.316AspIle: 4.316 ± 0.591
2.238AspLys: 2.238 ± 0.542
6.554AspLeu: 6.554 ± 1.319
2.877AspMet: 2.877 ± 0.664
1.439AspAsn: 1.439 ± 0.477
3.197AspPro: 3.197 ± 0.803
1.279AspGln: 1.279 ± 0.318
4.795AspArg: 4.795 ± 1.197
3.037AspSer: 3.037 ± 0.465
2.238AspThr: 2.238 ± 0.571
4.955AspVal: 4.955 ± 0.85
0.799AspTrp: 0.799 ± 0.329
2.078AspTyr: 2.078 ± 0.409
0.0AspXaa: 0.0 ± 0.0
Glu
4.636GluAla: 4.636 ± 0.685
1.279GluCys: 1.279 ± 0.508
3.676GluAsp: 3.676 ± 0.927
6.074GluGlu: 6.074 ± 1.528
2.398GluPhe: 2.398 ± 0.782
4.316GluGly: 4.316 ± 1.32
1.758GluHis: 1.758 ± 0.609
4.316GluIle: 4.316 ± 0.679
5.754GluLys: 5.754 ± 1.061
3.676GluLeu: 3.676 ± 0.696
2.238GluMet: 2.238 ± 0.689
2.877GluAsn: 2.877 ± 0.696
1.918GluPro: 1.918 ± 0.686
2.558GluGln: 2.558 ± 0.409
6.074GluArg: 6.074 ± 1.228
2.717GluSer: 2.717 ± 0.615
3.197GluThr: 3.197 ± 0.937
5.115GluVal: 5.115 ± 1.097
0.959GluTrp: 0.959 ± 0.774
3.037GluTyr: 3.037 ± 0.574
0.0GluXaa: 0.0 ± 0.0
Phe
2.398PheAla: 2.398 ± 0.455
0.799PheCys: 0.799 ± 0.499
3.517PheAsp: 3.517 ± 0.828
2.398PheGlu: 2.398 ± 0.548
1.758PhePhe: 1.758 ± 0.601
2.238PheGly: 2.238 ± 0.525
0.799PheHis: 0.799 ± 0.346
2.717PheIle: 2.717 ± 0.427
1.598PheLys: 1.598 ± 0.487
3.836PheLeu: 3.836 ± 0.6
1.279PheMet: 1.279 ± 0.442
0.959PheAsn: 0.959 ± 0.357
1.119PhePro: 1.119 ± 0.588
1.439PheGln: 1.439 ± 0.338
3.197PheArg: 3.197 ± 0.806
2.238PheSer: 2.238 ± 0.518
2.717PheThr: 2.717 ± 0.725
2.078PheVal: 2.078 ± 0.439
0.959PheTrp: 0.959 ± 0.316
1.598PheTyr: 1.598 ± 0.506
0.0PheXaa: 0.0 ± 0.0
Gly
5.275GlyAla: 5.275 ± 1.262
1.279GlyCys: 1.279 ± 0.712
5.595GlyAsp: 5.595 ± 1.315
4.476GlyGlu: 4.476 ± 1.055
1.918GlyPhe: 1.918 ± 0.773
6.074GlyGly: 6.074 ± 2.155
2.398GlyHis: 2.398 ± 0.577
2.877GlyIle: 2.877 ± 0.556
3.517GlyLys: 3.517 ± 1.112
4.316GlyLeu: 4.316 ± 0.906
1.598GlyMet: 1.598 ± 0.314
3.037GlyAsn: 3.037 ± 0.796
2.238GlyPro: 2.238 ± 0.676
1.918GlyGln: 1.918 ± 0.366
5.115GlyArg: 5.115 ± 0.943
4.476GlySer: 4.476 ± 0.951
2.398GlyThr: 2.398 ± 0.659
4.955GlyVal: 4.955 ± 1.289
0.639GlyTrp: 0.639 ± 0.338
1.918GlyTyr: 1.918 ± 0.823
0.0GlyXaa: 0.0 ± 0.0
His
0.799HisAla: 0.799 ± 0.404
0.799HisCys: 0.799 ± 0.272
0.959HisAsp: 0.959 ± 0.343
1.439HisGlu: 1.439 ± 0.435
0.639HisPhe: 0.639 ± 0.288
1.598HisGly: 1.598 ± 0.447
0.32HisHis: 0.32 ± 0.202
1.439HisIle: 1.439 ± 0.518
1.119HisLys: 1.119 ± 0.419
3.197HisLeu: 3.197 ± 0.891
0.48HisMet: 0.48 ± 0.304
0.959HisAsn: 0.959 ± 0.258
1.279HisPro: 1.279 ± 0.411
0.959HisGln: 0.959 ± 0.419
1.439HisArg: 1.439 ± 0.375
0.959HisSer: 0.959 ± 0.378
1.598HisThr: 1.598 ± 0.186
1.439HisVal: 1.439 ± 0.373
0.48HisTrp: 0.48 ± 0.336
1.279HisTyr: 1.279 ± 0.364
0.0HisXaa: 0.0 ± 0.0
Ile
3.357IleAla: 3.357 ± 0.851
0.32IleCys: 0.32 ± 0.199
3.517IleAsp: 3.517 ± 0.626
4.316IleGlu: 4.316 ± 0.893
2.717IlePhe: 2.717 ± 0.713
2.877IleGly: 2.877 ± 0.616
1.598IleHis: 1.598 ± 0.327
3.836IleIle: 3.836 ± 0.85
5.115IleLys: 5.115 ± 1.36
6.234IleLeu: 6.234 ± 0.673
2.238IleMet: 2.238 ± 0.491
3.996IleAsn: 3.996 ± 0.76
1.598IlePro: 1.598 ± 0.66
2.877IleGln: 2.877 ± 0.74
2.877IleArg: 2.877 ± 0.614
6.074IleSer: 6.074 ± 0.931
4.955IleThr: 4.955 ± 0.989
4.316IleVal: 4.316 ± 0.738
0.639IleTrp: 0.639 ± 0.239
1.439IleTyr: 1.439 ± 0.401
0.0IleXaa: 0.0 ± 0.0
Lys
3.037LysAla: 3.037 ± 0.712
0.639LysCys: 0.639 ± 0.285
1.758LysAsp: 1.758 ± 0.696
4.156LysGlu: 4.156 ± 0.805
1.918LysPhe: 1.918 ± 0.515
3.517LysGly: 3.517 ± 1.129
1.758LysHis: 1.758 ± 0.561
3.996LysIle: 3.996 ± 0.729
4.156LysLys: 4.156 ± 1.025
4.476LysLeu: 4.476 ± 0.863
1.279LysMet: 1.279 ± 0.339
1.918LysAsn: 1.918 ± 0.483
1.918LysPro: 1.918 ± 0.495
1.918LysGln: 1.918 ± 0.717
4.316LysArg: 4.316 ± 1.25
2.717LysSer: 2.717 ± 0.659
1.918LysThr: 1.918 ± 0.601
4.476LysVal: 4.476 ± 0.75
0.639LysTrp: 0.639 ± 0.458
2.078LysTyr: 2.078 ± 0.423
0.0LysXaa: 0.0 ± 0.0
Leu
4.795LeuAla: 4.795 ± 0.809
0.799LeuCys: 0.799 ± 0.264
5.275LeuAsp: 5.275 ± 0.937
5.595LeuGlu: 5.595 ± 0.871
3.197LeuPhe: 3.197 ± 0.697
6.234LeuGly: 6.234 ± 1.146
0.799LeuHis: 0.799 ± 0.374
4.476LeuIle: 4.476 ± 0.588
5.914LeuLys: 5.914 ± 0.91
5.754LeuLeu: 5.754 ± 0.819
3.197LeuMet: 3.197 ± 1.422
4.316LeuAsn: 4.316 ± 0.764
4.476LeuPro: 4.476 ± 0.989
3.197LeuGln: 3.197 ± 0.614
7.033LeuArg: 7.033 ± 0.935
7.673LeuSer: 7.673 ± 0.73
5.595LeuThr: 5.595 ± 0.734
3.996LeuVal: 3.996 ± 0.802
0.799LeuTrp: 0.799 ± 0.469
1.598LeuTyr: 1.598 ± 0.408
0.0LeuXaa: 0.0 ± 0.0
Met
1.758MetAla: 1.758 ± 0.684
0.639MetCys: 0.639 ± 0.345
1.439MetAsp: 1.439 ± 0.337
2.078MetGlu: 2.078 ± 0.324
1.279MetPhe: 1.279 ± 0.595
1.598MetGly: 1.598 ± 0.353
0.639MetHis: 0.639 ± 0.319
1.758MetIle: 1.758 ± 0.504
1.439MetLys: 1.439 ± 0.631
5.275MetLeu: 5.275 ± 0.869
1.598MetMet: 1.598 ± 0.446
0.799MetAsn: 0.799 ± 0.345
1.598MetPro: 1.598 ± 0.559
1.918MetGln: 1.918 ± 0.407
2.398MetArg: 2.398 ± 0.409
1.918MetSer: 1.918 ± 0.429
1.598MetThr: 1.598 ± 0.602
3.676MetVal: 3.676 ± 0.467
0.32MetTrp: 0.32 ± 0.228
1.439MetTyr: 1.439 ± 0.45
0.0MetXaa: 0.0 ± 0.0
Asn
2.877AsnAla: 2.877 ± 0.977
0.639AsnCys: 0.639 ± 0.333
2.078AsnAsp: 2.078 ± 0.308
2.877AsnGlu: 2.877 ± 0.557
1.439AsnPhe: 1.439 ± 0.414
2.717AsnGly: 2.717 ± 0.697
0.799AsnHis: 0.799 ± 0.25
3.996AsnIle: 3.996 ± 1.024
1.119AsnLys: 1.119 ± 0.28
3.037AsnLeu: 3.037 ± 0.552
2.717AsnMet: 2.717 ± 0.736
0.959AsnAsn: 0.959 ± 0.209
2.717AsnPro: 2.717 ± 0.688
1.758AsnGln: 1.758 ± 0.528
2.398AsnArg: 2.398 ± 0.504
2.717AsnSer: 2.717 ± 0.754
2.238AsnThr: 2.238 ± 0.513
3.836AsnVal: 3.836 ± 0.487
0.32AsnTrp: 0.32 ± 0.183
1.119AsnTyr: 1.119 ± 0.182
0.0AsnXaa: 0.0 ± 0.0
Pro
1.439ProAla: 1.439 ± 0.611
1.119ProCys: 1.119 ± 0.323
3.197ProAsp: 3.197 ± 0.82
4.156ProGlu: 4.156 ± 0.697
1.758ProPhe: 1.758 ± 0.665
2.717ProGly: 2.717 ± 0.769
1.119ProHis: 1.119 ± 0.276
3.037ProIle: 3.037 ± 0.463
1.758ProLys: 1.758 ± 0.823
3.676ProLeu: 3.676 ± 0.899
1.758ProMet: 1.758 ± 0.517
2.078ProAsn: 2.078 ± 0.603
2.877ProPro: 2.877 ± 0.979
1.598ProGln: 1.598 ± 0.359
1.758ProArg: 1.758 ± 0.428
1.598ProSer: 1.598 ± 0.469
3.676ProThr: 3.676 ± 0.943
2.717ProVal: 2.717 ± 0.805
0.32ProTrp: 0.32 ± 0.26
2.398ProTyr: 2.398 ± 0.567
0.0ProXaa: 0.0 ± 0.0
Gln
1.758GlnAla: 1.758 ± 0.656
0.48GlnCys: 0.48 ± 0.205
1.598GlnAsp: 1.598 ± 0.651
2.717GlnGlu: 2.717 ± 0.6
2.238GlnPhe: 2.238 ± 0.483
2.078GlnGly: 2.078 ± 0.691
0.639GlnHis: 0.639 ± 0.288
2.717GlnIle: 2.717 ± 0.914
1.598GlnLys: 1.598 ± 0.543
3.197GlnLeu: 3.197 ± 0.627
0.959GlnMet: 0.959 ± 0.34
1.279GlnAsn: 1.279 ± 0.3
1.439GlnPro: 1.439 ± 0.614
0.799GlnGln: 0.799 ± 0.441
3.357GlnArg: 3.357 ± 0.841
2.078GlnSer: 2.078 ± 0.737
2.717GlnThr: 2.717 ± 0.588
2.078GlnVal: 2.078 ± 0.559
0.0GlnTrp: 0.0 ± 0.0
1.279GlnTyr: 1.279 ± 0.42
0.0GlnXaa: 0.0 ± 0.0
Arg
5.595ArgAla: 5.595 ± 0.872
1.119ArgCys: 1.119 ± 0.508
3.836ArgAsp: 3.836 ± 0.961
6.234ArgGlu: 6.234 ± 0.696
4.795ArgPhe: 4.795 ± 0.835
4.316ArgGly: 4.316 ± 1.395
0.959ArgHis: 0.959 ± 0.41
6.074ArgIle: 6.074 ± 0.812
2.398ArgLys: 2.398 ± 0.912
4.156ArgLeu: 4.156 ± 0.916
2.558ArgMet: 2.558 ± 0.353
2.238ArgAsn: 2.238 ± 0.604
1.598ArgPro: 1.598 ± 0.588
2.398ArgGln: 2.398 ± 0.586
6.074ArgArg: 6.074 ± 0.851
4.955ArgSer: 4.955 ± 0.631
3.517ArgThr: 3.517 ± 0.675
3.996ArgVal: 3.996 ± 0.485
1.279ArgTrp: 1.279 ± 0.548
2.238ArgTyr: 2.238 ± 0.508
0.0ArgXaa: 0.0 ± 0.0
Ser
4.955SerAla: 4.955 ± 1.256
0.16SerCys: 0.16 ± 0.17
4.795SerAsp: 4.795 ± 0.745
3.517SerGlu: 3.517 ± 0.661
3.197SerPhe: 3.197 ± 0.598
4.636SerGly: 4.636 ± 0.784
1.918SerHis: 1.918 ± 0.584
2.717SerIle: 2.717 ± 0.996
2.877SerLys: 2.877 ± 0.67
6.074SerLeu: 6.074 ± 1.075
1.918SerMet: 1.918 ± 0.493
2.877SerAsn: 2.877 ± 0.456
3.357SerPro: 3.357 ± 0.513
2.877SerGln: 2.877 ± 0.37
4.636SerArg: 4.636 ± 0.712
4.795SerSer: 4.795 ± 1.148
4.316SerThr: 4.316 ± 0.526
3.357SerVal: 3.357 ± 0.854
0.32SerTrp: 0.32 ± 0.176
2.558SerTyr: 2.558 ± 0.301
0.0SerXaa: 0.0 ± 0.0
Thr
2.238ThrAla: 2.238 ± 0.503
0.639ThrCys: 0.639 ± 0.367
2.717ThrAsp: 2.717 ± 0.583
2.877ThrGlu: 2.877 ± 0.862
1.119ThrPhe: 1.119 ± 0.438
4.316ThrGly: 4.316 ± 0.983
2.877ThrHis: 2.877 ± 0.296
4.156ThrIle: 4.156 ± 0.663
2.078ThrLys: 2.078 ± 0.751
5.435ThrLeu: 5.435 ± 0.356
1.598ThrMet: 1.598 ± 0.509
2.398ThrAsn: 2.398 ± 0.865
3.836ThrPro: 3.836 ± 0.759
2.398ThrGln: 2.398 ± 0.759
2.717ThrArg: 2.717 ± 0.534
4.156ThrSer: 4.156 ± 0.602
2.078ThrThr: 2.078 ± 0.726
3.357ThrVal: 3.357 ± 0.876
1.279ThrTrp: 1.279 ± 0.492
2.877ThrTyr: 2.877 ± 0.746
0.0ThrXaa: 0.0 ± 0.0
Val
4.636ValAla: 4.636 ± 0.625
0.799ValCys: 0.799 ± 0.34
3.836ValAsp: 3.836 ± 0.64
5.754ValGlu: 5.754 ± 1.363
2.398ValPhe: 2.398 ± 0.8
4.316ValGly: 4.316 ± 0.626
1.918ValHis: 1.918 ± 0.456
3.357ValIle: 3.357 ± 0.81
3.676ValLys: 3.676 ± 0.766
5.754ValLeu: 5.754 ± 1.113
1.918ValMet: 1.918 ± 0.385
4.156ValAsn: 4.156 ± 1.097
4.156ValPro: 4.156 ± 0.648
2.078ValGln: 2.078 ± 0.464
3.996ValArg: 3.996 ± 1.011
5.595ValSer: 5.595 ± 1.535
3.517ValThr: 3.517 ± 1.159
5.754ValVal: 5.754 ± 1.147
0.959ValTrp: 0.959 ± 0.29
2.238ValTyr: 2.238 ± 0.397
0.0ValXaa: 0.0 ± 0.0
Trp
0.639TrpAla: 0.639 ± 0.466
0.32TrpCys: 0.32 ± 0.167
0.799TrpAsp: 0.799 ± 0.454
0.0TrpGlu: 0.0 ± 0.0
0.48TrpPhe: 0.48 ± 0.209
0.639TrpGly: 0.639 ± 0.327
0.48TrpHis: 0.48 ± 0.292
1.439TrpIle: 1.439 ± 0.502
0.799TrpLys: 0.799 ± 0.294
0.639TrpLeu: 0.639 ± 0.301
0.32TrpMet: 0.32 ± 0.195
0.959TrpAsn: 0.959 ± 0.327
0.0TrpPro: 0.0 ± 0.0
0.32TrpGln: 0.32 ± 0.283
1.279TrpArg: 1.279 ± 0.405
0.799TrpSer: 0.799 ± 0.519
0.16TrpThr: 0.16 ± 0.154
1.439TrpVal: 1.439 ± 0.71
0.16TrpTrp: 0.16 ± 0.161
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.238TyrAla: 2.238 ± 0.585
0.32TyrCys: 0.32 ± 0.212
1.918TyrAsp: 1.918 ± 0.429
2.398TyrGlu: 2.398 ± 0.501
1.598TyrPhe: 1.598 ± 0.449
3.197TyrGly: 3.197 ± 0.672
0.48TyrHis: 0.48 ± 0.33
1.758TyrIle: 1.758 ± 0.251
2.238TyrLys: 2.238 ± 0.631
1.918TyrLeu: 1.918 ± 0.559
1.279TyrMet: 1.279 ± 0.373
2.078TyrAsn: 2.078 ± 0.7
1.279TyrPro: 1.279 ± 0.543
0.799TyrGln: 0.799 ± 0.324
1.918TyrArg: 1.918 ± 0.707
2.238TyrSer: 2.238 ± 0.695
3.357TyrThr: 3.357 ± 0.682
2.717TyrVal: 2.717 ± 0.443
0.0TyrTrp: 0.0 ± 0.0
0.48TyrTyr: 0.48 ± 0.216
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (6257 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski