Amino acid dipepetide frequency for Gordonia phage Utz

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.424AlaAla: 16.424 ± 1.309
0.434AlaCys: 0.434 ± 0.193
7.747AlaAsp: 7.747 ± 0.731
6.136AlaGlu: 6.136 ± 0.512
3.285AlaPhe: 3.285 ± 0.6
8.987AlaGly: 8.987 ± 0.945
2.045AlaHis: 2.045 ± 0.354
5.454AlaIle: 5.454 ± 0.504
3.471AlaLys: 3.471 ± 0.629
11.032AlaLeu: 11.032 ± 0.794
2.355AlaMet: 2.355 ± 0.488
3.409AlaAsn: 3.409 ± 0.528
5.64AlaPro: 5.64 ± 0.74
4.462AlaGln: 4.462 ± 0.59
8.553AlaArg: 8.553 ± 0.935
6.198AlaSer: 6.198 ± 0.634
7.809AlaThr: 7.809 ± 0.753
8.057AlaVal: 8.057 ± 0.95
2.293AlaTrp: 2.293 ± 0.37
2.417AlaTyr: 2.417 ± 0.431
0.0AlaXaa: 0.0 ± 0.0
Cys
0.434CysAla: 0.434 ± 0.181
0.124CysCys: 0.124 ± 0.128
0.992CysAsp: 0.992 ± 0.371
0.372CysGlu: 0.372 ± 0.151
0.062CysPhe: 0.062 ± 0.055
0.744CysGly: 0.744 ± 0.239
0.372CysHis: 0.372 ± 0.148
0.186CysIle: 0.186 ± 0.131
0.186CysLys: 0.186 ± 0.092
0.31CysLeu: 0.31 ± 0.149
0.248CysMet: 0.248 ± 0.118
0.372CysAsn: 0.372 ± 0.158
0.744CysPro: 0.744 ± 0.207
0.434CysGln: 0.434 ± 0.17
0.682CysArg: 0.682 ± 0.278
0.372CysSer: 0.372 ± 0.168
0.62CysThr: 0.62 ± 0.214
0.434CysVal: 0.434 ± 0.193
0.186CysTrp: 0.186 ± 0.158
0.186CysTyr: 0.186 ± 0.097
0.0CysXaa: 0.0 ± 0.0
Asp
7.499AspAla: 7.499 ± 0.645
0.31AspCys: 0.31 ± 0.133
5.764AspAsp: 5.764 ± 0.73
4.71AspGlu: 4.71 ± 0.639
1.859AspPhe: 1.859 ± 0.329
7.251AspGly: 7.251 ± 0.878
2.107AspHis: 2.107 ± 0.411
3.409AspIle: 3.409 ± 0.519
1.673AspLys: 1.673 ± 0.37
5.95AspLeu: 5.95 ± 0.731
0.992AspMet: 0.992 ± 0.282
1.983AspAsn: 1.983 ± 0.372
4.462AspPro: 4.462 ± 0.49
2.603AspGln: 2.603 ± 0.362
4.276AspArg: 4.276 ± 0.722
3.099AspSer: 3.099 ± 0.337
3.967AspThr: 3.967 ± 0.515
5.888AspVal: 5.888 ± 0.591
0.93AspTrp: 0.93 ± 0.256
1.983AspTyr: 1.983 ± 0.392
0.0AspXaa: 0.0 ± 0.0
Glu
5.826GluAla: 5.826 ± 0.547
0.248GluCys: 0.248 ± 0.137
3.037GluAsp: 3.037 ± 0.46
2.293GluGlu: 2.293 ± 0.489
1.859GluPhe: 1.859 ± 0.332
4.152GluGly: 4.152 ± 0.569
1.425GluHis: 1.425 ± 0.272
2.665GluIle: 2.665 ± 0.354
1.921GluLys: 1.921 ± 0.273
4.586GluLeu: 4.586 ± 0.728
1.363GluMet: 1.363 ± 0.267
1.302GluAsn: 1.302 ± 0.25
3.533GluPro: 3.533 ± 0.636
2.789GluGln: 2.789 ± 0.435
4.524GluArg: 4.524 ± 0.692
2.355GluSer: 2.355 ± 0.447
2.603GluThr: 2.603 ± 0.342
4.71GluVal: 4.71 ± 0.6
1.054GluTrp: 1.054 ± 0.249
1.611GluTyr: 1.611 ± 0.307
0.0GluXaa: 0.0 ± 0.0
Phe
2.789PheAla: 2.789 ± 0.402
0.186PheCys: 0.186 ± 0.122
2.045PheAsp: 2.045 ± 0.249
1.425PheGlu: 1.425 ± 0.291
0.868PhePhe: 0.868 ± 0.194
2.603PheGly: 2.603 ± 0.387
0.31PheHis: 0.31 ± 0.15
0.868PheIle: 0.868 ± 0.276
0.868PheLys: 0.868 ± 0.305
1.673PheLeu: 1.673 ± 0.375
0.558PheMet: 0.558 ± 0.158
0.744PheAsn: 0.744 ± 0.21
1.611PhePro: 1.611 ± 0.221
0.62PheGln: 0.62 ± 0.152
2.045PheArg: 2.045 ± 0.316
1.487PheSer: 1.487 ± 0.348
2.603PheThr: 2.603 ± 0.421
2.665PheVal: 2.665 ± 0.381
0.248PheTrp: 0.248 ± 0.122
0.62PheTyr: 0.62 ± 0.195
0.0PheXaa: 0.0 ± 0.0
Gly
8.553GlyAla: 8.553 ± 1.011
0.62GlyCys: 0.62 ± 0.192
6.198GlyAsp: 6.198 ± 0.513
4.834GlyGlu: 4.834 ± 0.628
2.169GlyPhe: 2.169 ± 0.443
7.251GlyGly: 7.251 ± 1.005
1.549GlyHis: 1.549 ± 0.239
3.843GlyIle: 3.843 ± 0.65
3.285GlyLys: 3.285 ± 0.491
7.747GlyLeu: 7.747 ± 1.088
1.797GlyMet: 1.797 ± 0.263
2.727GlyAsn: 2.727 ± 0.38
4.029GlyPro: 4.029 ± 0.504
3.471GlyGln: 3.471 ± 0.362
6.879GlyArg: 6.879 ± 0.755
4.834GlySer: 4.834 ± 0.594
4.586GlyThr: 4.586 ± 0.531
5.578GlyVal: 5.578 ± 0.724
2.479GlyTrp: 2.479 ± 0.35
2.541GlyTyr: 2.541 ± 0.345
0.0GlyXaa: 0.0 ± 0.0
His
2.231HisAla: 2.231 ± 0.39
0.186HisCys: 0.186 ± 0.087
1.797HisAsp: 1.797 ± 0.274
1.116HisGlu: 1.116 ± 0.297
0.434HisPhe: 0.434 ± 0.173
1.673HisGly: 1.673 ± 0.338
0.434HisHis: 0.434 ± 0.194
0.744HisIle: 0.744 ± 0.215
0.806HisLys: 0.806 ± 0.228
1.549HisLeu: 1.549 ± 0.264
0.186HisMet: 0.186 ± 0.101
0.434HisAsn: 0.434 ± 0.177
1.673HisPro: 1.673 ± 0.309
0.682HisGln: 0.682 ± 0.178
1.921HisArg: 1.921 ± 0.332
0.806HisSer: 0.806 ± 0.193
1.487HisThr: 1.487 ± 0.293
1.425HisVal: 1.425 ± 0.303
0.496HisTrp: 0.496 ± 0.182
0.496HisTyr: 0.496 ± 0.172
0.0HisXaa: 0.0 ± 0.0
Ile
5.888IleAla: 5.888 ± 0.573
0.248IleCys: 0.248 ± 0.106
4.214IleAsp: 4.214 ± 0.603
2.603IleGlu: 2.603 ± 0.379
0.868IlePhe: 0.868 ± 0.249
4.4IleGly: 4.4 ± 0.665
0.744IleHis: 0.744 ± 0.235
1.363IleIle: 1.363 ± 0.32
1.549IleLys: 1.549 ± 0.381
2.169IleLeu: 2.169 ± 0.33
0.186IleMet: 0.186 ± 0.092
1.178IleAsn: 1.178 ± 0.203
2.851IlePro: 2.851 ± 0.444
0.682IleGln: 0.682 ± 0.165
3.843IleArg: 3.843 ± 0.549
2.417IleSer: 2.417 ± 0.4
3.967IleThr: 3.967 ± 0.426
4.214IleVal: 4.214 ± 0.471
0.31IleTrp: 0.31 ± 0.118
0.93IleTyr: 0.93 ± 0.2
0.0IleXaa: 0.0 ± 0.0
Lys
3.409LysAla: 3.409 ± 0.468
0.124LysCys: 0.124 ± 0.084
1.859LysAsp: 1.859 ± 0.43
1.363LysGlu: 1.363 ± 0.295
0.806LysPhe: 0.806 ± 0.241
2.603LysGly: 2.603 ± 0.453
0.434LysHis: 0.434 ± 0.204
1.797LysIle: 1.797 ± 0.393
1.859LysLys: 1.859 ± 0.415
3.161LysLeu: 3.161 ± 0.449
0.62LysMet: 0.62 ± 0.319
1.178LysAsn: 1.178 ± 0.332
2.479LysPro: 2.479 ± 0.398
0.868LysGln: 0.868 ± 0.272
1.549LysArg: 1.549 ± 0.322
2.231LysSer: 2.231 ± 0.365
2.479LysThr: 2.479 ± 0.394
2.541LysVal: 2.541 ± 0.44
0.682LysTrp: 0.682 ± 0.19
0.868LysTyr: 0.868 ± 0.24
0.0LysXaa: 0.0 ± 0.0
Leu
11.218LeuAla: 11.218 ± 0.901
0.682LeuCys: 0.682 ± 0.236
5.826LeuAsp: 5.826 ± 0.741
3.657LeuGlu: 3.657 ± 0.539
2.107LeuPhe: 2.107 ± 0.258
5.764LeuGly: 5.764 ± 0.79
0.93LeuHis: 0.93 ± 0.21
3.161LeuIle: 3.161 ± 0.419
1.859LeuLys: 1.859 ± 0.298
4.338LeuLeu: 4.338 ± 0.578
1.921LeuMet: 1.921 ± 0.33
1.983LeuAsn: 1.983 ± 0.331
4.338LeuPro: 4.338 ± 0.54
1.983LeuGln: 1.983 ± 0.336
5.206LeuArg: 5.206 ± 0.676
5.02LeuSer: 5.02 ± 0.588
5.764LeuThr: 5.764 ± 0.601
6.694LeuVal: 6.694 ± 0.777
2.355LeuTrp: 2.355 ± 0.321
1.425LeuTyr: 1.425 ± 0.293
0.0LeuXaa: 0.0 ± 0.0
Met
3.347MetAla: 3.347 ± 0.591
0.248MetCys: 0.248 ± 0.111
0.558MetAsp: 0.558 ± 0.185
0.744MetGlu: 0.744 ± 0.199
0.682MetPhe: 0.682 ± 0.165
1.549MetGly: 1.549 ± 0.336
0.248MetHis: 0.248 ± 0.117
0.744MetIle: 0.744 ± 0.215
0.496MetLys: 0.496 ± 0.163
1.487MetLeu: 1.487 ± 0.287
0.248MetMet: 0.248 ± 0.132
0.372MetAsn: 0.372 ± 0.149
1.735MetPro: 1.735 ± 0.336
0.558MetGln: 0.558 ± 0.237
1.921MetArg: 1.921 ± 0.572
1.735MetSer: 1.735 ± 0.288
2.293MetThr: 2.293 ± 0.348
0.744MetVal: 0.744 ± 0.214
0.744MetTrp: 0.744 ± 0.23
0.434MetTyr: 0.434 ± 0.151
0.0MetXaa: 0.0 ± 0.0
Asn
2.789AsnAla: 2.789 ± 0.495
0.31AsnCys: 0.31 ± 0.138
1.673AsnAsp: 1.673 ± 0.231
1.054AsnGlu: 1.054 ± 0.223
0.496AsnPhe: 0.496 ± 0.149
3.409AsnGly: 3.409 ± 0.506
0.682AsnHis: 0.682 ± 0.204
0.62AsnIle: 0.62 ± 0.219
0.868AsnLys: 0.868 ± 0.233
2.169AsnLeu: 2.169 ± 0.323
0.434AsnMet: 0.434 ± 0.16
0.62AsnAsn: 0.62 ± 0.241
3.223AsnPro: 3.223 ± 0.435
0.93AsnGln: 0.93 ± 0.228
1.921AsnArg: 1.921 ± 0.412
1.797AsnSer: 1.797 ± 0.336
2.355AsnThr: 2.355 ± 0.43
1.859AsnVal: 1.859 ± 0.311
0.372AsnTrp: 0.372 ± 0.124
0.992AsnTyr: 0.992 ± 0.256
0.0AsnXaa: 0.0 ± 0.0
Pro
6.694ProAla: 6.694 ± 0.854
0.868ProCys: 0.868 ± 0.297
4.462ProAsp: 4.462 ± 0.511
3.781ProGlu: 3.781 ± 0.5
1.797ProPhe: 1.797 ± 0.326
5.454ProGly: 5.454 ± 0.53
1.549ProHis: 1.549 ± 0.369
3.037ProIle: 3.037 ± 0.411
2.727ProLys: 2.727 ± 0.378
3.099ProLeu: 3.099 ± 0.429
1.116ProMet: 1.116 ± 0.419
2.355ProAsn: 2.355 ± 0.355
3.781ProPro: 3.781 ± 0.637
2.045ProGln: 2.045 ± 0.325
3.161ProArg: 3.161 ± 0.477
3.533ProSer: 3.533 ± 0.529
4.462ProThr: 4.462 ± 0.656
3.781ProVal: 3.781 ± 0.439
1.302ProTrp: 1.302 ± 0.228
1.178ProTyr: 1.178 ± 0.239
0.0ProXaa: 0.0 ± 0.0
Gln
3.409GlnAla: 3.409 ± 0.499
0.186GlnCys: 0.186 ± 0.103
1.425GlnAsp: 1.425 ± 0.276
1.425GlnGlu: 1.425 ± 0.321
0.93GlnPhe: 0.93 ± 0.239
2.231GlnGly: 2.231 ± 0.466
1.24GlnHis: 1.24 ± 0.267
1.302GlnIle: 1.302 ± 0.322
0.744GlnLys: 0.744 ± 0.157
3.471GlnLeu: 3.471 ± 0.434
0.868GlnMet: 0.868 ± 0.22
0.992GlnAsn: 0.992 ± 0.203
2.603GlnPro: 2.603 ± 0.44
1.549GlnGln: 1.549 ± 0.37
3.161GlnArg: 3.161 ± 0.392
1.735GlnSer: 1.735 ± 0.339
2.231GlnThr: 2.231 ± 0.399
2.417GlnVal: 2.417 ± 0.484
0.992GlnTrp: 0.992 ± 0.274
0.93GlnTyr: 0.93 ± 0.209
0.0GlnXaa: 0.0 ± 0.0
Arg
7.871ArgAla: 7.871 ± 0.927
1.054ArgCys: 1.054 ± 0.286
5.888ArgAsp: 5.888 ± 0.54
3.905ArgGlu: 3.905 ± 0.604
1.983ArgPhe: 1.983 ± 0.323
6.508ArgGly: 6.508 ± 0.733
1.487ArgHis: 1.487 ± 0.348
3.719ArgIle: 3.719 ± 0.426
2.417ArgLys: 2.417 ± 0.298
5.702ArgLeu: 5.702 ± 0.623
1.983ArgMet: 1.983 ± 0.396
2.169ArgAsn: 2.169 ± 0.347
3.471ArgPro: 3.471 ± 0.544
2.355ArgGln: 2.355 ± 0.44
7.623ArgArg: 7.623 ± 1.031
3.843ArgSer: 3.843 ± 0.401
4.648ArgThr: 4.648 ± 0.46
5.454ArgVal: 5.454 ± 0.667
1.735ArgTrp: 1.735 ± 0.365
1.611ArgTyr: 1.611 ± 0.359
0.0ArgXaa: 0.0 ± 0.0
Ser
6.322SerAla: 6.322 ± 0.827
0.186SerCys: 0.186 ± 0.126
3.161SerAsp: 3.161 ± 0.488
3.285SerGlu: 3.285 ± 0.512
1.673SerPhe: 1.673 ± 0.292
5.95SerGly: 5.95 ± 0.73
0.992SerHis: 0.992 ± 0.195
2.789SerIle: 2.789 ± 0.455
1.425SerLys: 1.425 ± 0.235
2.851SerLeu: 2.851 ± 0.431
1.673SerMet: 1.673 ± 0.241
1.363SerAsn: 1.363 ± 0.33
3.347SerPro: 3.347 ± 0.399
1.24SerGln: 1.24 ± 0.308
4.029SerArg: 4.029 ± 0.584
2.913SerSer: 2.913 ± 0.61
4.029SerThr: 4.029 ± 0.433
4.276SerVal: 4.276 ± 0.511
1.611SerTrp: 1.611 ± 0.244
0.806SerTyr: 0.806 ± 0.218
0.0SerXaa: 0.0 ± 0.0
Thr
8.491ThrAla: 8.491 ± 0.577
0.558ThrCys: 0.558 ± 0.198
5.206ThrAsp: 5.206 ± 0.615
4.276ThrGlu: 4.276 ± 0.541
2.107ThrPhe: 2.107 ± 0.533
6.012ThrGly: 6.012 ± 0.779
1.487ThrHis: 1.487 ± 0.282
3.347ThrIle: 3.347 ± 0.468
2.541ThrLys: 2.541 ± 0.423
5.764ThrLeu: 5.764 ± 0.596
0.992ThrMet: 0.992 ± 0.231
2.107ThrAsn: 2.107 ± 0.341
4.029ThrPro: 4.029 ± 0.484
2.169ThrGln: 2.169 ± 0.313
4.524ThrArg: 4.524 ± 0.586
3.037ThrSer: 3.037 ± 0.417
5.02ThrThr: 5.02 ± 0.694
6.136ThrVal: 6.136 ± 0.59
1.24ThrTrp: 1.24 ± 0.282
1.054ThrTyr: 1.054 ± 0.307
0.0ThrXaa: 0.0 ± 0.0
Val
9.049ValAla: 9.049 ± 0.834
0.992ValCys: 0.992 ± 0.307
6.26ValAsp: 6.26 ± 0.702
4.586ValGlu: 4.586 ± 0.536
1.487ValPhe: 1.487 ± 0.299
5.702ValGly: 5.702 ± 0.749
1.24ValHis: 1.24 ± 0.228
3.595ValIle: 3.595 ± 0.452
2.541ValLys: 2.541 ± 0.392
5.144ValLeu: 5.144 ± 0.619
2.231ValMet: 2.231 ± 0.389
1.673ValAsn: 1.673 ± 0.339
3.843ValPro: 3.843 ± 0.52
2.789ValGln: 2.789 ± 0.388
6.198ValArg: 6.198 ± 0.737
3.905ValSer: 3.905 ± 0.627
5.764ValThr: 5.764 ± 0.713
7.313ValVal: 7.313 ± 0.774
1.549ValTrp: 1.549 ± 0.415
1.673ValTyr: 1.673 ± 0.257
0.0ValXaa: 0.0 ± 0.0
Trp
1.487TrpAla: 1.487 ± 0.345
0.186TrpCys: 0.186 ± 0.121
1.302TrpAsp: 1.302 ± 0.311
0.806TrpGlu: 0.806 ± 0.252
0.744TrpPhe: 0.744 ± 0.226
0.93TrpGly: 0.93 ± 0.256
0.496TrpHis: 0.496 ± 0.157
1.054TrpIle: 1.054 ± 0.276
0.682TrpLys: 0.682 ± 0.217
2.417TrpLeu: 2.417 ± 0.315
0.496TrpMet: 0.496 ± 0.195
0.93TrpAsn: 0.93 ± 0.366
1.425TrpPro: 1.425 ± 0.236
1.054TrpGln: 1.054 ± 0.264
1.797TrpArg: 1.797 ± 0.284
1.302TrpSer: 1.302 ± 0.267
1.549TrpThr: 1.549 ± 0.319
1.735TrpVal: 1.735 ± 0.304
0.558TrpTrp: 0.558 ± 0.171
0.558TrpTyr: 0.558 ± 0.17
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.541TyrAla: 2.541 ± 0.344
0.31TyrCys: 0.31 ± 0.137
1.302TyrAsp: 1.302 ± 0.229
1.487TyrGlu: 1.487 ± 0.326
0.62TyrPhe: 0.62 ± 0.211
1.797TyrGly: 1.797 ± 0.346
0.806TyrHis: 0.806 ± 0.208
0.93TyrIle: 0.93 ± 0.303
0.992TyrLys: 0.992 ± 0.226
1.611TyrLeu: 1.611 ± 0.325
0.558TyrMet: 0.558 ± 0.176
0.682TyrAsn: 0.682 ± 0.202
1.363TyrPro: 1.363 ± 0.23
0.558TyrGln: 0.558 ± 0.225
1.611TyrArg: 1.611 ± 0.281
1.302TyrSer: 1.302 ± 0.267
1.859TyrThr: 1.859 ± 0.399
1.611TyrVal: 1.611 ± 0.329
0.372TyrTrp: 0.372 ± 0.127
0.744TyrTyr: 0.744 ± 0.204
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (16136 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski