Amino acid dipepetide frequency for Desulfoglaeba alkanexedens ALDC

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.859AlaAla: 10.859 ± 0.168	1.314AlaCys: 1.314 ± 0.041	4.688AlaAsp: 4.688 ± 0.08	6.614AlaGlu: 6.614 ± 0.093	4.218AlaPhe: 4.218 ± 0.067	8.004AlaGly: 8.004 ± 0.106	1.936AlaHis: 1.936 ± 0.047	4.208AlaIle: 4.208 ± 0.077	3.309AlaLys: 3.309 ± 0.064	10.442AlaLeu: 10.442 ± 0.131	2.558AlaMet: 2.558 ± 0.056	1.88AlaAsn: 1.88 ± 0.049	3.647AlaPro: 3.647 ± 0.065	2.733AlaGln: 2.733 ± 0.056	7.01AlaArg: 7.01 ± 0.109	4.662AlaSer: 4.662 ± 0.077	3.703AlaThr: 3.703 ± 0.063	8.858AlaVal: 8.858 ± 0.11	1.197AlaTrp: 1.197 ± 0.038	2.395AlaTyr: 2.395 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.071CysAla: 1.071 ± 0.031	0.233CysCys: 0.233 ± 0.018	0.623CysAsp: 0.623 ± 0.025	0.712CysGlu: 0.712 ± 0.031	0.515CysPhe: 0.515 ± 0.026	1.461CysGly: 1.461 ± 0.049	0.421CysHis: 0.421 ± 0.025	0.565CysIle: 0.565 ± 0.028	0.343CysLys: 0.343 ± 0.02	1.323CysLeu: 1.323 ± 0.037	0.265CysMet: 0.265 ± 0.02	0.282CysAsn: 0.282 ± 0.017	0.938CysPro: 0.938 ± 0.034	0.33CysGln: 0.33 ± 0.019	1.269CysArg: 1.269 ± 0.042	0.718CysSer: 0.718 ± 0.032	0.572CysThr: 0.572 ± 0.025	0.829CysVal: 0.829 ± 0.033	0.162CysTrp: 0.162 ± 0.014	0.351CysTyr: 0.351 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.968AspAla: 4.968 ± 0.08	0.636AspCys: 0.636 ± 0.024	2.441AspAsp: 2.441 ± 0.057	3.739AspGlu: 3.739 ± 0.071	2.421AspPhe: 2.421 ± 0.056	4.062AspGly: 4.062 ± 0.064	1.323AspHis: 1.323 ± 0.042	2.91AspIle: 2.91 ± 0.056	1.656AspLys: 1.656 ± 0.048	6.307AspLeu: 6.307 ± 0.085	1.132AspMet: 1.132 ± 0.033	1.048AspAsn: 1.048 ± 0.04	3.615AspPro: 3.615 ± 0.074	1.517AspGln: 1.517 ± 0.043	4.568AspArg: 4.568 ± 0.074	2.139AspSer: 2.139 ± 0.049	2.18AspThr: 2.18 ± 0.058	4.029AspVal: 4.029 ± 0.069	0.821AspTrp: 0.821 ± 0.031	1.526AspTyr: 1.526 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	8.021GluAla: 8.021 ± 0.111	0.655GluCys: 0.655 ± 0.029	3.876GluAsp: 3.876 ± 0.071	5.672GluGlu: 5.672 ± 0.107	2.031GluPhe: 2.031 ± 0.051	5.221GluGly: 5.221 ± 0.081	1.424GluHis: 1.424 ± 0.042	4.372GluIle: 4.372 ± 0.064	4.162GluLys: 4.162 ± 0.071	6.768GluLeu: 6.768 ± 0.088	1.729GluMet: 1.729 ± 0.045	2.197GluAsn: 2.197 ± 0.058	3.028GluPro: 3.028 ± 0.063	2.132GluGln: 2.132 ± 0.051	6.471GluArg: 6.471 ± 0.088	3.624GluSer: 3.624 ± 0.065	4.025GluThr: 4.025 ± 0.065	5.178GluVal: 5.178 ± 0.076	0.828GluTrp: 0.828 ± 0.03	1.479GluTyr: 1.479 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.172PheAla: 3.172 ± 0.064	0.667PheCys: 0.667 ± 0.03	2.358PheAsp: 2.358 ± 0.05	2.618PheGlu: 2.618 ± 0.051	1.973PhePhe: 1.973 ± 0.048	3.112PheGly: 3.112 ± 0.068	1.049PheHis: 1.049 ± 0.034	1.886PheIle: 1.886 ± 0.047	1.402PheLys: 1.402 ± 0.038	4.5PheLeu: 4.5 ± 0.08	0.912PheMet: 0.912 ± 0.031	1.074PheAsn: 1.074 ± 0.034	2.085PhePro: 2.085 ± 0.058	1.459PheGln: 1.459 ± 0.041	3.043PheArg: 3.043 ± 0.061	2.583PheSer: 2.583 ± 0.054	1.941PheThr: 1.941 ± 0.051	2.861PheVal: 2.861 ± 0.058	0.598PheTrp: 0.598 ± 0.026	1.177PheTyr: 1.177 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.588GlyAla: 6.588 ± 0.105	1.305GlyCys: 1.305 ± 0.038	4.058GlyAsp: 4.058 ± 0.077	4.91GlyGlu: 4.91 ± 0.072	3.494GlyPhe: 3.494 ± 0.062	6.27GlyGly: 6.27 ± 0.108	1.711GlyHis: 1.711 ± 0.04	4.904GlyIle: 4.904 ± 0.079	4.025GlyLys: 4.025 ± 0.072	7.831GlyLeu: 7.831 ± 0.104	2.068GlyMet: 2.068 ± 0.047	2.038GlyAsn: 2.038 ± 0.05	3.061GlyPro: 3.061 ± 0.053	1.953GlyGln: 1.953 ± 0.044	6.686GlyArg: 6.686 ± 0.078	4.428GlySer: 4.428 ± 0.066	4.315GlyThr: 4.315 ± 0.086	5.939GlyVal: 5.939 ± 0.093	1.113GlyTrp: 1.113 ± 0.038	2.406GlyTyr: 2.406 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.808HisAla: 1.808 ± 0.049	0.365HisCys: 0.365 ± 0.023	0.98HisAsp: 0.98 ± 0.034	1.3HisGlu: 1.3 ± 0.037	1.084HisPhe: 1.084 ± 0.036	1.87HisGly: 1.87 ± 0.044	0.655HisHis: 0.655 ± 0.027	1.085HisIle: 1.085 ± 0.037	0.674HisLys: 0.674 ± 0.03	2.552HisLeu: 2.552 ± 0.053	0.437HisMet: 0.437 ± 0.019	0.551HisAsn: 0.551 ± 0.029	1.664HisPro: 1.664 ± 0.041	0.745HisGln: 0.745 ± 0.03	2.056HisArg: 2.056 ± 0.055	1.007HisSer: 1.007 ± 0.032	0.948HisThr: 0.948 ± 0.032	1.641HisVal: 1.641 ± 0.041	0.324HisTrp: 0.324 ± 0.019	0.743HisTyr: 0.743 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	4.705IleAla: 4.705 ± 0.077	0.627IleCys: 0.627 ± 0.025	2.934IleAsp: 2.934 ± 0.066	3.817IleGlu: 3.817 ± 0.064	2.031IlePhe: 2.031 ± 0.052	4.053IleGly: 4.053 ± 0.078	1.387IleHis: 1.387 ± 0.035	2.412IleIle: 2.412 ± 0.069	1.836IleLys: 1.836 ± 0.047	5.668IleLeu: 5.668 ± 0.092	0.947IleMet: 0.947 ± 0.036	1.379IleAsn: 1.379 ± 0.045	2.979IlePro: 2.979 ± 0.055	2.006IleGln: 2.006 ± 0.049	4.351IleArg: 4.351 ± 0.07	2.723IleSer: 2.723 ± 0.055	2.489IleThr: 2.489 ± 0.052	3.946IleVal: 3.946 ± 0.075	0.511IleTrp: 0.511 ± 0.024	1.365IleTyr: 1.365 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.317LysAla: 4.317 ± 0.069	0.414LysCys: 0.414 ± 0.021	2.449LysAsp: 2.449 ± 0.057	3.449LysGlu: 3.449 ± 0.074	1.002LysPhe: 1.002 ± 0.037	3.187LysGly: 3.187 ± 0.058	0.797LysHis: 0.797 ± 0.027	2.614LysIle: 2.614 ± 0.061	2.27LysLys: 2.27 ± 0.06	3.478LysLeu: 3.478 ± 0.062	0.985LysMet: 0.985 ± 0.034	1.215LysAsn: 1.215 ± 0.041	2.184LysPro: 2.184 ± 0.058	1.231LysGln: 1.231 ± 0.035	3.181LysArg: 3.181 ± 0.064	2.041LysSer: 2.041 ± 0.052	2.388LysThr: 2.388 ± 0.047	3.141LysVal: 3.141 ± 0.064	0.423LysTrp: 0.423 ± 0.021	0.928LysTyr: 0.928 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	10.331LeuAla: 10.331 ± 0.118	1.322LeuCys: 1.322 ± 0.04	6.019LeuAsp: 6.019 ± 0.095	8.644LeuGlu: 8.644 ± 0.132	4.085LeuPhe: 4.085 ± 0.069	8.012LeuGly: 8.012 ± 0.098	2.247LeuHis: 2.247 ± 0.056	4.701LeuIle: 4.701 ± 0.08	4.983LeuLys: 4.983 ± 0.08	10.492LeuLeu: 10.492 ± 0.158	2.198LeuMet: 2.198 ± 0.049	2.884LeuAsn: 2.884 ± 0.062	5.385LeuPro: 5.385 ± 0.08	3.682LeuGln: 3.682 ± 0.062	7.667LeuArg: 7.667 ± 0.106	6.194LeuSer: 6.194 ± 0.083	4.761LeuThr: 4.761 ± 0.079	7.752LeuVal: 7.752 ± 0.107	1.196LeuTrp: 1.196 ± 0.036	2.479LeuTyr: 2.479 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.569MetAla: 2.569 ± 0.059	0.179MetCys: 0.179 ± 0.015	1.425MetAsp: 1.425 ± 0.042	2.032MetGlu: 2.032 ± 0.045	0.57MetPhe: 0.57 ± 0.027	1.915MetGly: 1.915 ± 0.049	0.407MetHis: 0.407 ± 0.021	1.214MetIle: 1.214 ± 0.036	1.38MetLys: 1.38 ± 0.041	2.021MetLeu: 2.021 ± 0.048	0.573MetMet: 0.573 ± 0.025	0.792MetAsn: 0.792 ± 0.03	1.169MetPro: 1.169 ± 0.034	0.62MetGln: 0.62 ± 0.03	1.507MetArg: 1.507 ± 0.041	1.21MetSer: 1.21 ± 0.037	1.364MetThr: 1.364 ± 0.038	1.806MetVal: 1.806 ± 0.046	0.17MetTrp: 0.17 ± 0.013	0.325MetTyr: 0.325 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.341AsnAla: 2.341 ± 0.06	0.337AsnCys: 0.337 ± 0.019	1.21AsnAsp: 1.21 ± 0.039	1.448AsnGlu: 1.448 ± 0.038	0.998AsnPhe: 0.998 ± 0.038	1.973AsnGly: 1.973 ± 0.051	0.615AsnHis: 0.615 ± 0.026	1.571AsnIle: 1.571 ± 0.039	0.788AsnLys: 0.788 ± 0.029	3.061AsnLeu: 3.061 ± 0.062	0.546AsnMet: 0.546 ± 0.027	0.623AsnAsn: 0.623 ± 0.031	2.058AsnPro: 2.058 ± 0.045	0.753AsnGln: 0.753 ± 0.026	2.223AsnArg: 2.223 ± 0.053	0.97AsnSer: 0.97 ± 0.034	1.179AsnThr: 1.179 ± 0.04	1.926AsnVal: 1.926 ± 0.05	0.315AsnTrp: 0.315 ± 0.02	0.731AsnTyr: 0.731 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.512ProAla: 4.512 ± 0.085	0.627ProCys: 0.627 ± 0.025	3.153ProAsp: 3.153 ± 0.062	4.882ProGlu: 4.882 ± 0.072	2.188ProPhe: 2.188 ± 0.046	4.39ProGly: 4.39 ± 0.071	1.202ProHis: 1.202 ± 0.035	2.141ProIle: 2.141 ± 0.049	1.868ProLys: 1.868 ± 0.048	4.892ProLeu: 4.892 ± 0.072	1.18ProMet: 1.18 ± 0.038	1.232ProAsn: 1.232 ± 0.04	2.827ProPro: 2.827 ± 0.074	1.577ProGln: 1.577 ± 0.042	3.229ProArg: 3.229 ± 0.061	2.728ProSer: 2.728 ± 0.064	2.001ProThr: 2.001 ± 0.054	4.375ProVal: 4.375 ± 0.068	0.749ProTrp: 0.749 ± 0.032	1.402ProTyr: 1.402 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	3.31GlnAla: 3.31 ± 0.067	0.355GlnCys: 0.355 ± 0.021	1.522GlnAsp: 1.522 ± 0.046	2.319GlnGlu: 2.319 ± 0.059	0.946GlnPhe: 0.946 ± 0.036	2.433GlnGly: 2.433 ± 0.061	0.559GlnHis: 0.559 ± 0.023	1.654GlnIle: 1.654 ± 0.045	1.592GlnLys: 1.592 ± 0.047	2.779GlnLeu: 2.779 ± 0.07	0.793GlnMet: 0.793 ± 0.032	0.851GlnAsn: 0.851 ± 0.03	1.391GlnPro: 1.391 ± 0.039	1.052GlnGln: 1.052 ± 0.035	2.594GlnArg: 2.594 ± 0.058	1.447GlnSer: 1.447 ± 0.038	1.362GlnThr: 1.362 ± 0.036	2.587GlnVal: 2.587 ± 0.061	0.455GlnTrp: 0.455 ± 0.022	0.622GlnTyr: 0.622 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.13ArgAla: 6.13 ± 0.081	1.115ArgCys: 1.115 ± 0.04	4.029ArgAsp: 4.029 ± 0.071	6.221ArgGlu: 6.221 ± 0.092	3.723ArgPhe: 3.723 ± 0.069	4.944ArgGly: 4.944 ± 0.073	1.842ArgHis: 1.842 ± 0.045	4.745ArgIle: 4.745 ± 0.071	3.705ArgLys: 3.705 ± 0.063	9.243ArgLeu: 9.243 ± 0.12	1.956ArgMet: 1.956 ± 0.049	2.164ArgAsn: 2.164 ± 0.052	3.737ArgPro: 3.737 ± 0.065	2.428ArgGln: 2.428 ± 0.054	7.361ArgArg: 7.361 ± 0.139	4.246ArgSer: 4.246 ± 0.072	3.494ArgThr: 3.494 ± 0.06	5.596ArgVal: 5.596 ± 0.075	1.154ArgTrp: 1.154 ± 0.041	2.298ArgTyr: 2.298 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	4.618SerAla: 4.618 ± 0.075	0.604SerCys: 0.604 ± 0.03	2.621SerAsp: 2.621 ± 0.056	3.556SerGlu: 3.556 ± 0.066	2.291SerPhe: 2.291 ± 0.043	4.944SerGly: 4.944 ± 0.077	1.133SerHis: 1.133 ± 0.033	2.554SerIle: 2.554 ± 0.058	1.835SerLys: 1.835 ± 0.05	5.75SerLeu: 5.75 ± 0.086	1.436SerMet: 1.436 ± 0.047	1.149SerAsn: 1.149 ± 0.041	2.84SerPro: 2.84 ± 0.063	1.503SerGln: 1.503 ± 0.041	4.428SerArg: 4.428 ± 0.072	2.743SerSer: 2.743 ± 0.059	2.239SerThr: 2.239 ± 0.049	3.653SerVal: 3.653 ± 0.067	0.747SerTrp: 0.747 ± 0.026	1.287SerTyr: 1.287 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.725ThrAla: 4.725 ± 0.078	0.614ThrCys: 0.614 ± 0.029	2.269ThrAsp: 2.269 ± 0.055	2.832ThrGlu: 2.832 ± 0.057	1.963ThrPhe: 1.963 ± 0.047	4.559ThrGly: 4.559 ± 0.078	1.042ThrHis: 1.042 ± 0.033	2.419ThrIle: 2.419 ± 0.053	1.364ThrLys: 1.364 ± 0.037	5.418ThrLeu: 5.418 ± 0.077	0.982ThrMet: 0.982 ± 0.03	1.066ThrAsn: 1.066 ± 0.038	2.643ThrPro: 2.643 ± 0.06	1.228ThrGln: 1.228 ± 0.041	3.165ThrArg: 3.165 ± 0.059	2.242ThrSer: 2.242 ± 0.056	2.242ThrThr: 2.242 ± 0.055	4.211ThrVal: 4.211 ± 0.071	0.605ThrTrp: 0.605 ± 0.025	1.253ThrTyr: 1.253 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.026ValAla: 7.026 ± 0.095	1.067ValCys: 1.067 ± 0.039	4.24ValAsp: 4.24 ± 0.065	5.448ValGlu: 5.448 ± 0.084	3.332ValPhe: 3.332 ± 0.063	5.517ValGly: 5.517 ± 0.08	1.709ValHis: 1.709 ± 0.044	4.302ValIle: 4.302 ± 0.077	3.028ValLys: 3.028 ± 0.062	8.32ValLeu: 8.32 ± 0.094	1.768ValMet: 1.768 ± 0.04	2.135ValAsn: 2.135 ± 0.052	3.982ValPro: 3.982 ± 0.078	2.381ValGln: 2.381 ± 0.056	5.805ValArg: 5.805 ± 0.085	4.348ValSer: 4.348 ± 0.068	3.903ValThr: 3.903 ± 0.068	6.653ValVal: 6.653 ± 0.083	0.857ValTrp: 0.857 ± 0.033	1.886ValTyr: 1.886 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.974TrpAla: 0.974 ± 0.031	0.17TrpCys: 0.17 ± 0.017	0.723TrpAsp: 0.723 ± 0.029	0.918TrpGlu: 0.918 ± 0.029	0.501TrpPhe: 0.501 ± 0.026	0.932TrpGly: 0.932 ± 0.034	0.309TrpHis: 0.309 ± 0.021	0.817TrpIle: 0.817 ± 0.029	0.628TrpLys: 0.628 ± 0.026	1.325TrpLeu: 1.325 ± 0.046	0.325TrpMet: 0.325 ± 0.02	0.47TrpAsn: 0.47 ± 0.024	0.583TrpPro: 0.583 ± 0.029	0.434TrpGln: 0.434 ± 0.026	1.037TrpArg: 1.037 ± 0.039	0.636TrpSer: 0.636 ± 0.028	0.577TrpThr: 0.577 ± 0.027	0.947TrpVal: 0.947 ± 0.028	0.208TrpTrp: 0.208 ± 0.015	0.292TrpTyr: 0.292 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.188TyrAla: 2.188 ± 0.047	0.377TyrCys: 0.377 ± 0.018	1.419TyrAsp: 1.419 ± 0.038	1.762TyrGlu: 1.762 ± 0.045	1.107TyrPhe: 1.107 ± 0.037	2.248TyrGly: 2.248 ± 0.055	0.722TyrHis: 0.722 ± 0.027	1.089TyrIle: 1.089 ± 0.038	0.845TyrLys: 0.845 ± 0.036	2.866TyrLeu: 2.866 ± 0.066	0.454TyrMet: 0.454 ± 0.024	0.635TyrAsn: 0.635 ± 0.03	1.339TyrPro: 1.339 ± 0.039	0.86TyrGln: 0.86 ± 0.028	2.479TyrArg: 2.479 ± 0.061	1.24TyrSer: 1.24 ± 0.036	1.159TyrThr: 1.159 ± 0.036	1.78TyrVal: 1.78 ± 0.046	0.373TyrTrp: 0.373 ± 0.021	0.836TyrTyr: 0.836 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2850 proteins (914423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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