Amino acid dipepetide frequency for Aquimonas voraii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.867AlaAla: 18.867 ± 0.205
1.313AlaCys: 1.313 ± 0.029
6.861AlaAsp: 6.861 ± 0.086
9.058AlaGlu: 9.058 ± 0.103
4.077AlaPhe: 4.077 ± 0.057
11.416AlaGly: 11.416 ± 0.122
2.471AlaHis: 2.471 ± 0.045
4.993AlaIle: 4.993 ± 0.063
2.844AlaLys: 2.844 ± 0.068
17.754AlaLeu: 17.754 ± 0.176
2.711AlaMet: 2.711 ± 0.052
2.882AlaAsn: 2.882 ± 0.062
6.946AlaPro: 6.946 ± 0.1
5.656AlaGln: 5.656 ± 0.074
10.921AlaArg: 10.921 ± 0.126
7.336AlaSer: 7.336 ± 0.102
5.432AlaThr: 5.432 ± 0.091
8.769AlaVal: 8.769 ± 0.09
1.938AlaTrp: 1.938 ± 0.043
2.289AlaTyr: 2.289 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
1.271CysAla: 1.271 ± 0.037
0.127CysCys: 0.127 ± 0.01
0.483CysAsp: 0.483 ± 0.02
0.546CysGlu: 0.546 ± 0.02
0.325CysPhe: 0.325 ± 0.018
0.944CysGly: 0.944 ± 0.027
0.22CysHis: 0.22 ± 0.016
0.334CysIle: 0.334 ± 0.015
0.127CysLys: 0.127 ± 0.01
0.932CysLeu: 0.932 ± 0.025
0.154CysMet: 0.154 ± 0.011
0.199CysAsn: 0.199 ± 0.014
0.452CysPro: 0.452 ± 0.02
0.214CysGln: 0.214 ± 0.016
0.684CysArg: 0.684 ± 0.023
0.602CysSer: 0.602 ± 0.028
0.465CysThr: 0.465 ± 0.026
0.686CysVal: 0.686 ± 0.023
0.112CysTrp: 0.112 ± 0.011
0.182CysTyr: 0.182 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.849AspAla: 7.849 ± 0.099
0.518AspCys: 0.518 ± 0.022
2.525AspAsp: 2.525 ± 0.051
3.142AspGlu: 3.142 ± 0.062
2.14AspPhe: 2.14 ± 0.042
5.131AspGly: 5.131 ± 0.097
0.976AspHis: 0.976 ± 0.026
2.175AspIle: 2.175 ± 0.041
0.959AspLys: 0.959 ± 0.037
5.866AspLeu: 5.866 ± 0.071
0.915AspMet: 0.915 ± 0.027
1.079AspAsn: 1.079 ± 0.034
3.507AspPro: 3.507 ± 0.059
1.531AspGln: 1.531 ± 0.038
3.822AspArg: 3.822 ± 0.055
2.924AspSer: 2.924 ± 0.051
2.378AspThr: 2.378 ± 0.043
3.484AspVal: 3.484 ± 0.057
1.065AspTrp: 1.065 ± 0.03
1.373AspTyr: 1.373 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
9.185GluAla: 9.185 ± 0.111
0.395GluCys: 0.395 ± 0.019
2.937GluAsp: 2.937 ± 0.063
2.576GluGlu: 2.576 ± 0.056
2.059GluPhe: 2.059 ± 0.042
4.852GluGly: 4.852 ± 0.067
1.434GluHis: 1.434 ± 0.037
2.707GluIle: 2.707 ± 0.054
1.233GluLys: 1.233 ± 0.045
7.32GluLeu: 7.32 ± 0.097
0.933GluMet: 0.933 ± 0.03
1.219GluAsn: 1.219 ± 0.028
2.982GluPro: 2.982 ± 0.054
2.732GluGln: 2.732 ± 0.048
6.421GluArg: 6.421 ± 0.09
3.042GluSer: 3.042 ± 0.046
2.651GluThr: 2.651 ± 0.054
4.572GluVal: 4.572 ± 0.058
0.755GluTrp: 0.755 ± 0.027
1.026GluTyr: 1.026 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
4.604PheAla: 4.604 ± 0.066
0.34PheCys: 0.34 ± 0.016
2.556PheAsp: 2.556 ± 0.042
2.698PheGlu: 2.698 ± 0.048
1.131PhePhe: 1.131 ± 0.033
3.485PheGly: 3.485 ± 0.061
0.71PheHis: 0.71 ± 0.027
1.199PheIle: 1.199 ± 0.03
0.761PheLys: 0.761 ± 0.026
2.952PheLeu: 2.952 ± 0.057
0.547PheMet: 0.547 ± 0.019
1.038PheAsn: 1.038 ± 0.031
1.368PhePro: 1.368 ± 0.03
0.945PheGln: 0.945 ± 0.028
2.249PheArg: 2.249 ± 0.042
2.2PheSer: 2.2 ± 0.053
1.657PheThr: 1.657 ± 0.053
2.506PheVal: 2.506 ± 0.049
0.432PheTrp: 0.432 ± 0.019
0.688PheTyr: 0.688 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
9.881GlyAla: 9.881 ± 0.104
0.896GlyCys: 0.896 ± 0.03
4.362GlyAsp: 4.362 ± 0.063
5.751GlyGlu: 5.751 ± 0.067
3.696GlyPhe: 3.696 ± 0.054
7.485GlyGly: 7.485 ± 0.12
1.824GlyHis: 1.824 ± 0.044
3.513GlyIle: 3.513 ± 0.059
2.068GlyLys: 2.068 ± 0.059
10.257GlyLeu: 10.257 ± 0.1
1.94GlyMet: 1.94 ± 0.044
2.145GlyAsn: 2.145 ± 0.063
3.374GlyPro: 3.374 ± 0.063
3.291GlyGln: 3.291 ± 0.05
6.753GlyArg: 6.753 ± 0.081
5.542GlySer: 5.542 ± 0.113
3.971GlyThr: 3.971 ± 0.085
6.198GlyVal: 6.198 ± 0.075
1.436GlyTrp: 1.436 ± 0.033
2.023GlyTyr: 2.023 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.914HisAla: 2.914 ± 0.062
0.277HisCys: 0.277 ± 0.017
0.925HisAsp: 0.925 ± 0.031
1.081HisGlu: 1.081 ± 0.039
0.802HisPhe: 0.802 ± 0.025
1.977HisGly: 1.977 ± 0.044
0.484HisHis: 0.484 ± 0.023
0.734HisIle: 0.734 ± 0.026
0.341HisLys: 0.341 ± 0.016
2.188HisLeu: 2.188 ± 0.044
0.319HisMet: 0.319 ± 0.016
0.384HisAsn: 0.384 ± 0.018
1.42HisPro: 1.42 ± 0.038
0.57HisGln: 0.57 ± 0.023
1.649HisArg: 1.649 ± 0.038
1.044HisSer: 1.044 ± 0.031
0.833HisThr: 0.833 ± 0.025
1.376HisVal: 1.376 ± 0.03
0.415HisTrp: 0.415 ± 0.019
0.544HisTyr: 0.544 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.983IleAla: 5.983 ± 0.065
0.355IleCys: 0.355 ± 0.016
3.246IleAsp: 3.246 ± 0.054
4.036IleGlu: 4.036 ± 0.052
0.909IlePhe: 0.909 ± 0.028
3.948IleGly: 3.948 ± 0.058
0.769IleHis: 0.769 ± 0.026
1.077IleIle: 1.077 ± 0.035
0.908IleLys: 0.908 ± 0.032
3.023IleLeu: 3.023 ± 0.052
0.388IleMet: 0.388 ± 0.021
1.176IleAsn: 1.176 ± 0.035
1.755IlePro: 1.755 ± 0.039
1.127IleGln: 1.127 ± 0.034
2.733IleArg: 2.733 ± 0.05
2.109IleSer: 2.109 ± 0.04
2.124IleThr: 2.124 ± 0.048
2.757IleVal: 2.757 ± 0.055
0.361IleTrp: 0.361 ± 0.016
0.714IleTyr: 0.714 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
2.698LysAla: 2.698 ± 0.07
0.121LysCys: 0.121 ± 0.011
0.988LysAsp: 0.988 ± 0.036
0.917LysGlu: 0.917 ± 0.038
0.563LysPhe: 0.563 ± 0.023
1.459LysGly: 1.459 ± 0.042
0.473LysHis: 0.473 ± 0.02
0.889LysIle: 0.889 ± 0.035
0.685LysLys: 0.685 ± 0.045
2.594LysLeu: 2.594 ± 0.061
0.365LysMet: 0.365 ± 0.02
0.459LysAsn: 0.459 ± 0.02
1.608LysPro: 1.608 ± 0.044
0.9LysGln: 0.9 ± 0.03
2.116LysArg: 2.116 ± 0.053
1.149LysSer: 1.149 ± 0.035
1.135LysThr: 1.135 ± 0.034
1.553LysVal: 1.553 ± 0.045
0.165LysTrp: 0.165 ± 0.01
0.425LysTyr: 0.425 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
16.072LeuAla: 16.072 ± 0.162
1.079LeuCys: 1.079 ± 0.029
6.923LeuAsp: 6.923 ± 0.088
6.218LeuGlu: 6.218 ± 0.089
3.6LeuPhe: 3.6 ± 0.065
9.713LeuGly: 9.713 ± 0.1
2.342LeuHis: 2.342 ± 0.049
4.467LeuIle: 4.467 ± 0.062
3.081LeuLys: 3.081 ± 0.063
13.764LeuLeu: 13.764 ± 0.195
2.13LeuMet: 2.13 ± 0.05
2.544LeuAsn: 2.544 ± 0.047
7.331LeuPro: 7.331 ± 0.089
4.571LeuGln: 4.571 ± 0.074
10.612LeuArg: 10.612 ± 0.124
7.1LeuSer: 7.1 ± 0.083
4.602LeuThr: 4.602 ± 0.074
7.568LeuVal: 7.568 ± 0.097
1.625LeuTrp: 1.625 ± 0.052
2.086LeuTyr: 2.086 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
2.349MetAla: 2.349 ± 0.043
0.106MetCys: 0.106 ± 0.009
0.943MetAsp: 0.943 ± 0.029
0.822MetGlu: 0.822 ± 0.029
0.525MetPhe: 0.525 ± 0.023
1.423MetGly: 1.423 ± 0.034
0.405MetHis: 0.405 ± 0.016
0.702MetIle: 0.702 ± 0.024
0.598MetLys: 0.598 ± 0.022
2.029MetLeu: 2.029 ± 0.043
0.293MetMet: 0.293 ± 0.016
0.627MetAsn: 0.627 ± 0.02
1.165MetPro: 1.165 ± 0.036
0.847MetGln: 0.847 ± 0.029
1.645MetArg: 1.645 ± 0.043
1.51MetSer: 1.51 ± 0.034
0.906MetThr: 0.906 ± 0.026
1.1MetVal: 1.1 ± 0.031
0.156MetTrp: 0.156 ± 0.01
0.266MetTyr: 0.266 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.186AsnAla: 3.186 ± 0.052
0.231AsnCys: 0.231 ± 0.017
1.116AsnAsp: 1.116 ± 0.035
1.111AsnGlu: 1.111 ± 0.028
0.87AsnPhe: 0.87 ± 0.025
2.22AsnGly: 2.22 ± 0.066
0.428AsnHis: 0.428 ± 0.019
0.87AsnIle: 0.87 ± 0.027
0.404AsnLys: 0.404 ± 0.019
2.587AsnLeu: 2.587 ± 0.047
0.311AsnMet: 0.311 ± 0.016
0.64AsnAsn: 0.64 ± 0.028
1.753AsnPro: 1.753 ± 0.052
0.756AsnGln: 0.756 ± 0.022
1.818AsnArg: 1.818 ± 0.044
1.168AsnSer: 1.168 ± 0.037
1.23AsnThr: 1.23 ± 0.039
1.59AsnVal: 1.59 ± 0.044
0.325AsnTrp: 0.325 ± 0.017
0.563AsnTyr: 0.563 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
7.73ProAla: 7.73 ± 0.103
0.372ProCys: 0.372 ± 0.021
3.165ProAsp: 3.165 ± 0.056
4.093ProGlu: 4.093 ± 0.055
1.574ProPhe: 1.574 ± 0.035
5.03ProGly: 5.03 ± 0.081
0.956ProHis: 0.956 ± 0.031
1.968ProIle: 1.968 ± 0.043
1.185ProLys: 1.185 ± 0.039
5.771ProLeu: 5.771 ± 0.073
1.169ProMet: 1.169 ± 0.036
1.304ProAsn: 1.304 ± 0.038
3.209ProPro: 3.209 ± 0.074
2.181ProGln: 2.181 ± 0.038
3.79ProArg: 3.79 ± 0.058
3.045ProSer: 3.045 ± 0.057
2.44ProThr: 2.44 ± 0.05
4.058ProVal: 4.058 ± 0.064
0.805ProTrp: 0.805 ± 0.026
0.982ProTyr: 0.982 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
5.481GlnAla: 5.481 ± 0.081
0.237GlnCys: 0.237 ± 0.015
1.422GlnAsp: 1.422 ± 0.037
1.27GlnGlu: 1.27 ± 0.032
1.081GlnPhe: 1.081 ± 0.029
3.014GlnGly: 3.014 ± 0.048
0.816GlnHis: 0.816 ± 0.027
1.686GlnIle: 1.686 ± 0.038
0.701GlnLys: 0.701 ± 0.027
4.417GlnLeu: 4.417 ± 0.061
0.778GlnMet: 0.778 ± 0.025
0.76GlnAsn: 0.76 ± 0.026
2.429GlnPro: 2.429 ± 0.044
1.858GlnGln: 1.858 ± 0.041
4.183GlnArg: 4.183 ± 0.068
1.905GlnSer: 1.905 ± 0.038
1.71GlnThr: 1.71 ± 0.042
2.755GlnVal: 2.755 ± 0.047
0.496GlnTrp: 0.496 ± 0.019
0.603GlnTyr: 0.603 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
10.449ArgAla: 10.449 ± 0.116
0.724ArgCys: 0.724 ± 0.027
4.046ArgAsp: 4.046 ± 0.057
5.677ArgGlu: 5.677 ± 0.091
3.352ArgPhe: 3.352 ± 0.053
6.227ArgGly: 6.227 ± 0.083
1.807ArgHis: 1.807 ± 0.038
4.109ArgIle: 4.109 ± 0.067
1.478ArgLys: 1.478 ± 0.045
10.529ArgLeu: 10.529 ± 0.113
1.877ArgMet: 1.877 ± 0.038
1.665ArgAsn: 1.665 ± 0.032
3.803ArgPro: 3.803 ± 0.062
2.925ArgGln: 2.925 ± 0.059
6.681ArgArg: 6.681 ± 0.084
4.54ArgSer: 4.54 ± 0.064
3.021ArgThr: 3.021 ± 0.045
5.942ArgVal: 5.942 ± 0.068
1.461ArgTrp: 1.461 ± 0.034
2.054ArgTyr: 2.054 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
7.761SerAla: 7.761 ± 0.094
0.506SerCys: 0.506 ± 0.032
2.695SerAsp: 2.695 ± 0.047
3.246SerGlu: 3.246 ± 0.06
2.16SerPhe: 2.16 ± 0.057
5.894SerGly: 5.894 ± 0.111
1.066SerHis: 1.066 ± 0.032
2.206SerIle: 2.206 ± 0.044
1.109SerLys: 1.109 ± 0.034
6.663SerLeu: 6.663 ± 0.085
1.005SerMet: 1.005 ± 0.029
1.38SerAsn: 1.38 ± 0.036
3.289SerPro: 3.289 ± 0.06
1.847SerGln: 1.847 ± 0.045
3.998SerArg: 3.998 ± 0.062
3.269SerSer: 3.269 ± 0.064
3.032SerThr: 3.032 ± 0.065
3.896SerVal: 3.896 ± 0.075
0.749SerTrp: 0.749 ± 0.026
1.222SerTyr: 1.222 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
5.699ThrAla: 5.699 ± 0.087
0.422ThrCys: 0.422 ± 0.02
2.262ThrAsp: 2.262 ± 0.042
2.339ThrGlu: 2.339 ± 0.044
1.333ThrPhe: 1.333 ± 0.041
4.164ThrGly: 4.164 ± 0.087
0.977ThrHis: 0.977 ± 0.029
1.568ThrIle: 1.568 ± 0.051
0.65ThrLys: 0.65 ± 0.025
5.666ThrLeu: 5.666 ± 0.069
0.599ThrMet: 0.599 ± 0.021
0.937ThrAsn: 0.937 ± 0.034
3.229ThrPro: 3.229 ± 0.067
1.572ThrGln: 1.572 ± 0.036
3.436ThrArg: 3.436 ± 0.061
2.303ThrSer: 2.303 ± 0.051
2.136ThrThr: 2.136 ± 0.06
3.832ThrVal: 3.832 ± 0.098
0.587ThrTrp: 0.587 ± 0.024
0.91ThrTyr: 0.91 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.378ValAla: 8.378 ± 0.093
0.696ValCys: 0.696 ± 0.026
4.33ValAsp: 4.33 ± 0.064
4.87ValGlu: 4.87 ± 0.063
2.634ValPhe: 2.634 ± 0.045
5.326ValGly: 5.326 ± 0.077
1.436ValHis: 1.436 ± 0.035
2.999ValIle: 2.999 ± 0.052
1.436ValLys: 1.436 ± 0.044
8.714ValLeu: 8.714 ± 0.105
1.323ValMet: 1.323 ± 0.039
1.832ValAsn: 1.832 ± 0.046
3.424ValPro: 3.424 ± 0.06
2.608ValGln: 2.608 ± 0.048
5.333ValArg: 5.333 ± 0.061
4.179ValSer: 4.179 ± 0.073
3.098ValThr: 3.098 ± 0.081
5.405ValVal: 5.405 ± 0.089
0.956ValTrp: 0.956 ± 0.026
1.458ValTyr: 1.458 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.397TrpAla: 1.397 ± 0.037
0.153TrpCys: 0.153 ± 0.012
0.61TrpAsp: 0.61 ± 0.026
0.531TrpGlu: 0.531 ± 0.023
0.499TrpPhe: 0.499 ± 0.023
0.869TrpGly: 0.869 ± 0.033
0.294TrpHis: 0.294 ± 0.016
0.65TrpIle: 0.65 ± 0.024
0.333TrpLys: 0.333 ± 0.017
2.217TrpLeu: 2.217 ± 0.047
0.365TrpMet: 0.365 ± 0.017
0.434TrpAsn: 0.434 ± 0.018
0.75TrpPro: 0.75 ± 0.022
0.765TrpGln: 0.765 ± 0.026
1.444TrpArg: 1.444 ± 0.037
0.851TrpSer: 0.851 ± 0.027
0.702TrpThr: 0.702 ± 0.029
0.991TrpVal: 0.991 ± 0.032
0.266TrpTrp: 0.266 ± 0.016
0.302TrpTyr: 0.302 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.776TyrAla: 2.776 ± 0.049
0.193TyrCys: 0.193 ± 0.012
0.963TyrAsp: 0.963 ± 0.038
1.047TyrGlu: 1.047 ± 0.029
0.736TyrPhe: 0.736 ± 0.022
1.83TyrGly: 1.83 ± 0.041
0.389TyrHis: 0.389 ± 0.018
0.65TyrIle: 0.65 ± 0.024
0.362TyrLys: 0.362 ± 0.02
2.189TyrLeu: 2.189 ± 0.041
0.295TyrMet: 0.295 ± 0.017
0.475TyrAsn: 0.475 ± 0.021
1.033TyrPro: 1.033 ± 0.028
0.705TyrGln: 0.705 ± 0.024
2.079TyrArg: 2.079 ± 0.04
1.177TyrSer: 1.177 ± 0.037
1.099TyrThr: 1.099 ± 0.034
1.395TyrVal: 1.395 ± 0.037
0.318TyrTrp: 0.318 ± 0.015
0.513TyrTyr: 0.513 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3593 proteins (1297485 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski