Amino acid dipepetide frequency for Grapevine virus H

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.679AlaAla: 3.679 ± 1.141
1.226AlaCys: 1.226 ± 0.674
3.679AlaAsp: 3.679 ± 1.128
3.271AlaGlu: 3.271 ± 0.555
2.453AlaPhe: 2.453 ± 0.749
2.453AlaGly: 2.453 ± 0.892
2.862AlaHis: 2.862 ± 0.734
4.088AlaIle: 4.088 ± 1.107
7.359AlaLys: 7.359 ± 1.683
9.812AlaLeu: 9.812 ± 1.335
0.818AlaMet: 0.818 ± 0.45
1.226AlaAsn: 1.226 ± 0.73
2.044AlaPro: 2.044 ± 0.846
2.044AlaGln: 2.044 ± 0.761
2.862AlaArg: 2.862 ± 1.896
2.862AlaSer: 2.862 ± 1.333
3.271AlaThr: 3.271 ± 2.929
2.044AlaVal: 2.044 ± 0.723
0.409AlaTrp: 0.409 ± 0.225
2.453AlaTyr: 2.453 ± 0.574
0.0AlaXaa: 0.0 ± 0.0
Cys
1.226CysAla: 1.226 ± 0.557
0.818CysCys: 0.818 ± 0.45
1.635CysAsp: 1.635 ± 1.198
0.818CysGlu: 0.818 ± 0.732
2.044CysPhe: 2.044 ± 1.124
1.635CysGly: 1.635 ± 0.721
0.409CysHis: 0.409 ± 0.225
1.226CysIle: 1.226 ± 0.507
1.635CysLys: 1.635 ± 0.606
1.635CysLeu: 1.635 ± 0.606
0.818CysMet: 0.818 ± 0.45
1.635CysAsn: 1.635 ± 0.721
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.818CysArg: 0.818 ± 0.599
2.044CysSer: 2.044 ± 1.124
0.409CysThr: 0.409 ± 0.225
1.635CysVal: 1.635 ± 1.593
0.409CysTrp: 0.409 ± 0.225
0.818CysTyr: 0.818 ± 0.45
0.0CysXaa: 0.0 ± 0.0
Asp
5.315AspAla: 5.315 ± 1.673
0.818AspCys: 0.818 ± 0.45
5.315AspAsp: 5.315 ± 1.483
7.768AspGlu: 7.768 ± 2.118
3.271AspPhe: 3.271 ± 0.555
4.906AspGly: 4.906 ± 2.03
2.862AspHis: 2.862 ± 1.142
2.453AspIle: 2.453 ± 1.697
2.453AspLys: 2.453 ± 1.329
9.812AspLeu: 9.812 ± 3.055
0.818AspMet: 0.818 ± 0.527
2.453AspAsn: 2.453 ± 0.909
2.453AspPro: 2.453 ± 0.892
2.453AspGln: 2.453 ± 1.341
3.679AspArg: 3.679 ± 1.403
2.044AspSer: 2.044 ± 0.683
0.409AspThr: 0.409 ± 0.225
4.088AspVal: 4.088 ± 3.248
2.044AspTrp: 2.044 ± 0.846
2.862AspTyr: 2.862 ± 1.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.497GluAla: 4.497 ± 1.643
0.818GluCys: 0.818 ± 0.594
4.088GluAsp: 4.088 ± 1.335
4.906GluGlu: 4.906 ± 1.52
1.226GluPhe: 1.226 ± 0.674
4.497GluGly: 4.497 ± 0.908
0.818GluHis: 0.818 ± 0.732
2.453GluIle: 2.453 ± 1.015
2.453GluLys: 2.453 ± 0.749
6.132GluLeu: 6.132 ± 1.517
1.635GluMet: 1.635 ± 0.604
2.862GluAsn: 2.862 ± 1.055
4.088GluPro: 4.088 ± 1.209
3.271GluGln: 3.271 ± 0.767
3.271GluArg: 3.271 ± 1.015
3.679GluSer: 3.679 ± 1.087
4.497GluThr: 4.497 ± 1.391
8.177GluVal: 8.177 ± 1.741
0.409GluTrp: 0.409 ± 0.225
3.679GluTyr: 3.679 ± 1.556
0.0GluXaa: 0.0 ± 0.0
Phe
3.679PheAla: 3.679 ± 0.421
1.635PheCys: 1.635 ± 0.899
3.679PheAsp: 3.679 ± 1.433
3.679PheGlu: 3.679 ± 1.403
2.453PhePhe: 2.453 ± 1.349
2.862PheGly: 2.862 ± 0.734
2.044PheHis: 2.044 ± 0.599
1.635PheIle: 1.635 ± 0.606
1.226PheLys: 1.226 ± 0.507
4.497PheLeu: 4.497 ± 1.26
0.818PheMet: 0.818 ± 0.45
2.862PheAsn: 2.862 ± 1.345
0.818PhePro: 0.818 ± 1.498
1.226PheGln: 1.226 ± 0.507
2.044PheArg: 2.044 ± 0.683
2.044PheSer: 2.044 ± 1.087
2.862PheThr: 2.862 ± 1.333
1.635PheVal: 1.635 ± 0.507
0.0PheTrp: 0.0 ± 0.0
0.818PheTyr: 0.818 ± 0.45
0.0PheXaa: 0.0 ± 0.0
Gly
4.497GlyAla: 4.497 ± 2.605
1.226GlyCys: 1.226 ± 1.852
4.088GlyAsp: 4.088 ± 1.198
6.132GlyGlu: 6.132 ± 1.12
2.044GlyPhe: 2.044 ± 0.599
4.497GlyGly: 4.497 ± 1.211
0.818GlyHis: 0.818 ± 1.185
3.271GlyIle: 3.271 ± 0.817
6.95GlyLys: 6.95 ± 1.659
5.315GlyLeu: 5.315 ± 1.832
0.818GlyMet: 0.818 ± 0.543
2.862GlyAsn: 2.862 ± 1.507
1.635GlyPro: 1.635 ± 0.84
1.226GlyGln: 1.226 ± 0.557
3.679GlyArg: 3.679 ± 2.974
4.088GlySer: 4.088 ± 1.107
4.088GlyThr: 4.088 ± 0.385
3.271GlyVal: 3.271 ± 1.212
1.226GlyTrp: 1.226 ± 0.674
4.497GlyTyr: 4.497 ± 1.643
0.0GlyXaa: 0.0 ± 0.0
His
1.226HisAla: 1.226 ± 1.003
0.409HisCys: 0.409 ± 0.225
1.226HisAsp: 1.226 ± 0.674
2.044HisGlu: 2.044 ± 0.761
0.0HisPhe: 0.0 ± 0.0
2.453HisGly: 2.453 ± 0.649
0.818HisHis: 0.818 ± 0.594
0.818HisIle: 0.818 ± 0.45
2.044HisLys: 2.044 ± 0.599
3.679HisLeu: 3.679 ± 1.023
1.226HisMet: 1.226 ± 0.674
2.044HisAsn: 2.044 ± 0.846
1.635HisPro: 1.635 ± 0.991
0.409HisGln: 0.409 ± 0.225
2.044HisArg: 2.044 ± 0.725
2.453HisSer: 2.453 ± 1.349
0.818HisThr: 0.818 ± 0.45
2.044HisVal: 2.044 ± 0.599
0.409HisTrp: 0.409 ± 0.706
2.044HisTyr: 2.044 ± 0.723
0.0HisXaa: 0.0 ± 0.0
Ile
2.862IleAla: 2.862 ± 1.857
0.818IleCys: 0.818 ± 0.805
2.862IleAsp: 2.862 ± 1.094
3.271IleGlu: 3.271 ± 1.126
2.044IlePhe: 2.044 ± 1.386
3.271IleGly: 3.271 ± 0.767
2.044IleHis: 2.044 ± 1.124
1.635IleIle: 1.635 ± 1.667
5.315IleLys: 5.315 ± 1.413
5.315IleLeu: 5.315 ± 2.495
0.818IleMet: 0.818 ± 0.805
2.862IleAsn: 2.862 ± 0.698
0.818IlePro: 0.818 ± 0.45
2.044IleGln: 2.044 ± 0.761
0.409IleArg: 0.409 ± 0.225
5.315IleSer: 5.315 ± 2.923
2.862IleThr: 2.862 ± 0.542
3.679IleVal: 3.679 ± 0.813
0.409IleTrp: 0.409 ± 0.225
0.818IleTyr: 0.818 ± 0.594
0.0IleXaa: 0.0 ± 0.0
Lys
8.994LysAla: 8.994 ± 2.5
1.635LysCys: 1.635 ± 0.899
4.088LysAsp: 4.088 ± 1.198
3.271LysGlu: 3.271 ± 0.956
2.044LysPhe: 2.044 ± 0.779
6.132LysGly: 6.132 ± 2.633
2.453LysHis: 2.453 ± 1.349
4.497LysIle: 4.497 ± 1.843
5.724LysLys: 5.724 ± 0.649
6.132LysLeu: 6.132 ± 1.486
1.635LysMet: 1.635 ± 0.681
2.044LysAsn: 2.044 ± 0.683
1.635LysPro: 1.635 ± 1.198
2.044LysGln: 2.044 ± 0.599
3.679LysArg: 3.679 ± 0.839
5.724LysSer: 5.724 ± 1.383
4.497LysThr: 4.497 ± 1.0
6.541LysVal: 6.541 ± 2.209
0.0LysTrp: 0.0 ± 0.0
0.818LysTyr: 0.818 ± 1.348
0.0LysXaa: 0.0 ± 0.0
Leu
5.724LeuAla: 5.724 ± 1.663
2.862LeuCys: 2.862 ± 0.734
9.812LeuAsp: 9.812 ± 3.062
6.132LeuGlu: 6.132 ± 1.223
6.132LeuPhe: 6.132 ± 0.939
8.994LeuGly: 8.994 ± 4.034
0.818LeuHis: 0.818 ± 1.185
4.906LeuIle: 4.906 ± 1.407
11.038LeuLys: 11.038 ± 4.669
10.221LeuLeu: 10.221 ± 2.226
2.044LeuMet: 2.044 ± 0.599
4.497LeuAsn: 4.497 ± 2.562
3.271LeuPro: 3.271 ± 1.268
2.044LeuGln: 2.044 ± 0.683
5.724LeuArg: 5.724 ± 1.021
10.63LeuSer: 10.63 ± 2.069
6.541LeuThr: 6.541 ± 2.48
6.132LeuVal: 6.132 ± 1.714
0.818LeuTrp: 0.818 ± 0.45
3.271LeuTyr: 3.271 ± 1.799
0.0LeuXaa: 0.0 ± 0.0
Met
0.818MetAla: 0.818 ± 0.45
0.409MetCys: 0.409 ± 0.851
1.635MetAsp: 1.635 ± 0.842
2.453MetGlu: 2.453 ± 0.892
0.818MetPhe: 0.818 ± 0.732
0.818MetGly: 0.818 ± 0.732
0.818MetHis: 0.818 ± 0.805
0.818MetIle: 0.818 ± 0.45
0.409MetLys: 0.409 ± 0.225
2.453MetLeu: 2.453 ± 0.574
0.409MetMet: 0.409 ± 0.225
0.409MetAsn: 0.409 ± 0.225
1.226MetPro: 1.226 ± 1.835
0.409MetGln: 0.409 ± 0.749
2.453MetArg: 2.453 ± 0.574
1.226MetSer: 1.226 ± 0.674
0.818MetThr: 0.818 ± 0.45
0.409MetVal: 0.409 ± 0.225
0.409MetTrp: 0.409 ± 0.225
0.818MetTyr: 0.818 ± 0.732
0.0MetXaa: 0.0 ± 0.0
Asn
2.453AsnAla: 2.453 ± 2.054
0.818AsnCys: 0.818 ± 0.805
1.635AsnAsp: 1.635 ± 0.507
1.635AsnGlu: 1.635 ± 0.899
1.635AsnPhe: 1.635 ± 0.507
2.453AsnGly: 2.453 ± 1.796
0.818AsnHis: 0.818 ± 0.45
2.453AsnIle: 2.453 ± 0.909
3.271AsnLys: 3.271 ± 1.299
4.906AsnLeu: 4.906 ± 0.914
0.818AsnMet: 0.818 ± 0.45
1.635AsnAsn: 1.635 ± 0.606
2.453AsnPro: 2.453 ± 1.349
1.226AsnGln: 1.226 ± 0.557
2.862AsnArg: 2.862 ± 1.055
2.862AsnSer: 2.862 ± 1.896
2.862AsnThr: 2.862 ± 0.93
2.044AsnVal: 2.044 ± 0.683
0.0AsnTrp: 0.0 ± 0.0
1.635AsnTyr: 1.635 ± 0.842
0.0AsnXaa: 0.0 ± 0.0
Pro
1.226ProAla: 1.226 ± 0.67
0.409ProCys: 0.409 ± 0.225
4.497ProAsp: 4.497 ± 1.757
4.497ProGlu: 4.497 ± 1.325
0.818ProPhe: 0.818 ± 1.219
0.818ProGly: 0.818 ± 0.45
1.226ProHis: 1.226 ± 0.507
2.044ProIle: 2.044 ± 0.725
2.453ProLys: 2.453 ± 0.574
3.271ProLeu: 3.271 ± 1.126
0.409ProMet: 0.409 ± 0.851
1.226ProAsn: 1.226 ± 1.337
1.226ProPro: 1.226 ± 0.993
1.226ProGln: 1.226 ± 0.67
1.226ProArg: 1.226 ± 0.73
2.862ProSer: 2.862 ± 0.698
2.044ProThr: 2.044 ± 0.725
2.044ProVal: 2.044 ± 0.988
0.409ProTrp: 0.409 ± 0.225
2.044ProTyr: 2.044 ± 0.599
0.0ProXaa: 0.0 ± 0.0
Gln
2.044GlnAla: 2.044 ± 1.613
1.226GlnCys: 1.226 ± 0.507
1.226GlnAsp: 1.226 ± 0.674
1.635GlnGlu: 1.635 ± 0.681
0.0GlnPhe: 0.0 ± 0.0
1.635GlnGly: 1.635 ± 1.783
0.409GlnHis: 0.409 ± 0.706
1.635GlnIle: 1.635 ± 0.899
2.044GlnLys: 2.044 ± 0.599
4.088GlnLeu: 4.088 ± 0.799
1.226GlnMet: 1.226 ± 1.571
0.409GlnAsn: 0.409 ± 0.225
1.226GlnPro: 1.226 ± 0.507
1.226GlnGln: 1.226 ± 0.674
2.862GlnArg: 2.862 ± 1.071
2.862GlnSer: 2.862 ± 0.93
0.818GlnThr: 0.818 ± 0.45
2.044GlnVal: 2.044 ± 0.723
0.0GlnTrp: 0.0 ± 0.0
0.818GlnTyr: 0.818 ± 0.45
0.0GlnXaa: 0.0 ± 0.0
Arg
2.453ArgAla: 2.453 ± 0.912
0.409ArgCys: 0.409 ± 0.225
4.088ArgAsp: 4.088 ± 2.462
3.679ArgGlu: 3.679 ± 0.901
3.271ArgPhe: 3.271 ± 0.732
2.862ArgGly: 2.862 ± 2.296
1.226ArgHis: 1.226 ± 0.73
2.044ArgIle: 2.044 ± 0.779
2.862ArgLys: 2.862 ± 1.055
9.403ArgLeu: 9.403 ± 2.604
1.635ArgMet: 1.635 ± 0.84
1.635ArgAsn: 1.635 ± 0.899
1.226ArgPro: 1.226 ± 0.674
2.044ArgGln: 2.044 ± 0.761
4.497ArgArg: 4.497 ± 2.537
3.679ArgSer: 3.679 ± 1.739
1.635ArgThr: 1.635 ± 0.681
2.044ArgVal: 2.044 ± 1.928
0.818ArgTrp: 0.818 ± 0.45
2.453ArgTyr: 2.453 ± 0.749
0.0ArgXaa: 0.0 ± 0.0
Ser
4.088SerAla: 4.088 ± 1.517
1.226SerCys: 1.226 ± 0.674
5.724SerAsp: 5.724 ± 1.233
2.453SerGlu: 2.453 ± 1.256
5.315SerPhe: 5.315 ± 0.993
5.724SerGly: 5.724 ± 1.192
2.044SerHis: 2.044 ± 1.124
2.862SerIle: 2.862 ± 1.271
5.315SerLys: 5.315 ± 1.483
7.768SerLeu: 7.768 ± 2.619
0.409SerMet: 0.409 ± 0.749
3.679SerAsn: 3.679 ± 1.332
2.862SerPro: 2.862 ± 1.042
3.271SerGln: 3.271 ± 1.015
3.679SerArg: 3.679 ± 2.437
4.906SerSer: 4.906 ± 2.434
4.906SerThr: 4.906 ± 1.522
3.679SerVal: 3.679 ± 0.725
0.409SerTrp: 0.409 ± 0.929
2.453SerTyr: 2.453 ± 0.742
0.0SerXaa: 0.0 ± 0.0
Thr
1.635ThrAla: 1.635 ± 0.681
2.453ThrCys: 2.453 ± 1.349
2.044ThrAsp: 2.044 ± 0.717
2.862ThrGlu: 2.862 ± 0.542
2.453ThrPhe: 2.453 ± 1.349
4.088ThrGly: 4.088 ± 1.447
2.453ThrHis: 2.453 ± 0.749
5.315ThrIle: 5.315 ± 1.093
4.906ThrLys: 4.906 ± 1.974
5.724ThrLeu: 5.724 ± 1.609
0.818ThrMet: 0.818 ± 0.45
1.226ThrAsn: 1.226 ± 0.67
2.453ThrPro: 2.453 ± 0.909
0.818ThrGln: 0.818 ± 0.732
2.862ThrArg: 2.862 ± 1.578
2.862ThrSer: 2.862 ± 2.296
1.635ThrThr: 1.635 ± 0.507
2.044ThrVal: 2.044 ± 0.761
0.409ThrTrp: 0.409 ± 0.225
1.226ThrTyr: 1.226 ± 0.674
0.0ThrXaa: 0.0 ± 0.0
Val
2.044ValAla: 2.044 ± 0.779
2.044ValCys: 2.044 ± 0.97
3.271ValAsp: 3.271 ± 1.451
4.497ValGlu: 4.497 ± 0.47
3.679ValPhe: 3.679 ± 1.515
3.679ValGly: 3.679 ± 0.725
3.271ValHis: 3.271 ± 1.015
3.679ValIle: 3.679 ± 1.59
4.497ValLys: 4.497 ± 2.242
5.315ValLeu: 5.315 ± 1.216
1.635ValMet: 1.635 ± 1.578
1.635ValAsn: 1.635 ± 0.899
2.044ValPro: 2.044 ± 0.761
1.226ValGln: 1.226 ± 0.674
3.679ValArg: 3.679 ± 1.844
5.315ValSer: 5.315 ± 1.447
2.453ValThr: 2.453 ± 1.329
4.906ValVal: 4.906 ± 1.245
0.0ValTrp: 0.0 ± 0.0
1.635ValTyr: 1.635 ± 1.198
0.0ValXaa: 0.0 ± 0.0
Trp
0.818TrpAla: 0.818 ± 0.45
0.409TrpCys: 0.409 ± 0.225
0.409TrpAsp: 0.409 ± 0.225
0.818TrpGlu: 0.818 ± 0.594
0.0TrpPhe: 0.0 ± 0.0
0.409TrpGly: 0.409 ± 0.749
0.409TrpHis: 0.409 ± 0.225
0.0TrpIle: 0.0 ± 0.0
0.409TrpLys: 0.409 ± 0.225
0.409TrpLeu: 0.409 ± 0.225
0.409TrpMet: 0.409 ± 0.736
0.409TrpAsn: 0.409 ± 0.225
1.226TrpPro: 1.226 ± 0.674
0.0TrpGln: 0.0 ± 0.0
0.818TrpArg: 0.818 ± 0.45
0.818TrpSer: 0.818 ± 0.45
0.409TrpThr: 0.409 ± 0.225
0.409TrpVal: 0.409 ± 0.929
0.0TrpTrp: 0.0 ± 0.0
0.409TrpTyr: 0.409 ± 0.225
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.635TyrAla: 1.635 ± 0.991
0.0TyrCys: 0.0 ± 0.0
3.679TyrAsp: 3.679 ± 0.725
1.635TyrGlu: 1.635 ± 0.507
0.818TyrPhe: 0.818 ± 0.599
2.044TyrGly: 2.044 ± 1.37
1.226TyrHis: 1.226 ± 0.674
1.635TyrIle: 1.635 ± 0.681
1.226TyrLys: 1.226 ± 0.674
5.724TyrLeu: 5.724 ± 1.856
0.409TyrMet: 0.409 ± 0.225
2.862TyrAsn: 2.862 ± 0.909
1.635TyrPro: 1.635 ± 0.899
1.226TyrGln: 1.226 ± 1.337
0.818TyrArg: 0.818 ± 0.45
4.497TyrSer: 4.497 ± 1.362
2.453TyrThr: 2.453 ± 0.887
1.635TyrVal: 1.635 ± 0.84
0.409TyrTrp: 0.409 ± 0.225
0.409TyrTyr: 0.409 ± 0.929
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (2447 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski