Amino acid dipepetide frequency for Thioclava atlantica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.915AlaAla: 16.915 ± 0.16	1.048AlaCys: 1.048 ± 0.032	6.477AlaAsp: 6.477 ± 0.085	8.858AlaGlu: 8.858 ± 0.106	4.245AlaPhe: 4.245 ± 0.068	10.828AlaGly: 10.828 ± 0.141	2.374AlaHis: 2.374 ± 0.05	6.165AlaIle: 6.165 ± 0.071	4.222AlaLys: 4.222 ± 0.076	14.571AlaLeu: 14.571 ± 0.136	3.876AlaMet: 3.876 ± 0.06	2.592AlaAsn: 2.592 ± 0.061	6.484AlaPro: 6.484 ± 0.105	4.858AlaGln: 4.858 ± 0.06	10.038AlaArg: 10.038 ± 0.115	5.704AlaSer: 5.704 ± 0.083	5.907AlaThr: 5.907 ± 0.089	8.064AlaVal: 8.064 ± 0.094	1.413AlaTrp: 1.413 ± 0.039	2.421AlaTyr: 2.421 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.018CysAla: 1.018 ± 0.031	0.088CysCys: 0.088 ± 0.009	0.545CysAsp: 0.545 ± 0.023	0.461CysGlu: 0.461 ± 0.021	0.273CysPhe: 0.273 ± 0.017	0.852CysGly: 0.852 ± 0.032	0.252CysHis: 0.252 ± 0.015	0.359CysIle: 0.359 ± 0.019	0.178CysLys: 0.178 ± 0.011	0.802CysLeu: 0.802 ± 0.027	0.15CysMet: 0.15 ± 0.013	0.198CysAsn: 0.198 ± 0.015	0.532CysPro: 0.532 ± 0.022	0.196CysGln: 0.196 ± 0.013	0.531CysArg: 0.531 ± 0.023	0.436CysSer: 0.436 ± 0.023	0.39CysThr: 0.39 ± 0.019	0.551CysVal: 0.551 ± 0.022	0.097CysTrp: 0.097 ± 0.009	0.176CysTyr: 0.176 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.79AspAla: 6.79 ± 0.083	0.46AspCys: 0.46 ± 0.021	2.885AspAsp: 2.885 ± 0.069	3.5AspGlu: 3.5 ± 0.066	2.261AspPhe: 2.261 ± 0.043	5.088AspGly: 5.088 ± 0.092	1.289AspHis: 1.289 ± 0.036	2.696AspIle: 2.696 ± 0.049	1.725AspLys: 1.725 ± 0.043	6.571AspLeu: 6.571 ± 0.075	1.539AspMet: 1.539 ± 0.041	1.082AspAsn: 1.082 ± 0.035	3.972AspPro: 3.972 ± 0.065	1.868AspGln: 1.868 ± 0.046	4.224AspArg: 4.224 ± 0.069	1.862AspSer: 1.862 ± 0.045	2.58AspThr: 2.58 ± 0.054	3.585AspVal: 3.585 ± 0.057	1.215AspTrp: 1.215 ± 0.034	1.524AspTyr: 1.524 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	9.194GluAla: 9.194 ± 0.101	0.35GluCys: 0.35 ± 0.018	3.286GluAsp: 3.286 ± 0.062	4.14GluGlu: 4.14 ± 0.075	1.916GluPhe: 1.916 ± 0.044	5.534GluGly: 5.534 ± 0.081	1.192GluHis: 1.192 ± 0.035	4.137GluIle: 4.137 ± 0.067	2.467GluLys: 2.467 ± 0.055	5.539GluLeu: 5.539 ± 0.077	1.951GluMet: 1.951 ± 0.041	1.7GluAsn: 1.7 ± 0.038	2.797GluPro: 2.797 ± 0.053	1.923GluGln: 1.923 ± 0.042	4.8GluArg: 4.8 ± 0.075	2.25GluSer: 2.25 ± 0.046	4.02GluThr: 4.02 ± 0.069	4.378GluVal: 4.378 ± 0.068	0.704GluTrp: 0.704 ± 0.025	0.952GluTyr: 0.952 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.682PheAla: 4.682 ± 0.072	0.348PheCys: 0.348 ± 0.016	2.671PheAsp: 2.671 ± 0.048	2.303PheGlu: 2.303 ± 0.052	1.393PhePhe: 1.393 ± 0.044	3.694PheGly: 3.694 ± 0.064	0.74PheHis: 0.74 ± 0.027	1.555PheIle: 1.555 ± 0.04	0.892PheLys: 0.892 ± 0.029	3.538PheLeu: 3.538 ± 0.07	0.799PheMet: 0.799 ± 0.027	0.959PheAsn: 0.959 ± 0.034	1.546PhePro: 1.546 ± 0.039	0.899PheGln: 0.899 ± 0.025	2.078PheArg: 2.078 ± 0.048	2.127PheSer: 2.127 ± 0.047	2.065PheThr: 2.065 ± 0.044	2.697PheVal: 2.697 ± 0.047	0.581PheTrp: 0.581 ± 0.024	0.888PheTyr: 0.888 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.735GlyAla: 10.735 ± 0.139	0.831GlyCys: 0.831 ± 0.031	4.48GlyAsp: 4.48 ± 0.086	5.19GlyGlu: 5.19 ± 0.063	3.664GlyPhe: 3.664 ± 0.063	7.345GlyGly: 7.345 ± 0.138	1.946GlyHis: 1.946 ± 0.041	4.657GlyIle: 4.657 ± 0.072	3.344GlyLys: 3.344 ± 0.066	9.507GlyLeu: 9.507 ± 0.108	2.548GlyMet: 2.548 ± 0.052	2.079GlyAsn: 2.079 ± 0.056	3.838GlyPro: 3.838 ± 0.058	3.052GlyGln: 3.052 ± 0.06	6.129GlyArg: 6.129 ± 0.075	4.243GlySer: 4.243 ± 0.084	4.448GlyThr: 4.448 ± 0.085	6.239GlyVal: 6.239 ± 0.085	1.551GlyTrp: 1.551 ± 0.038	2.246GlyTyr: 2.246 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.313HisAla: 2.313 ± 0.051	0.216HisCys: 0.216 ± 0.014	1.353HisAsp: 1.353 ± 0.035	1.196HisGlu: 1.196 ± 0.03	0.811HisPhe: 0.811 ± 0.029	1.874HisGly: 1.874 ± 0.037	0.594HisHis: 0.594 ± 0.025	0.88HisIle: 0.88 ± 0.03	0.479HisLys: 0.479 ± 0.021	2.208HisLeu: 2.208 ± 0.041	0.513HisMet: 0.513 ± 0.021	0.406HisAsn: 0.406 ± 0.02	1.461HisPro: 1.461 ± 0.04	0.571HisGln: 0.571 ± 0.02	1.499HisArg: 1.499 ± 0.045	0.941HisSer: 0.941 ± 0.028	0.737HisThr: 0.737 ± 0.026	1.475HisVal: 1.475 ± 0.033	0.379HisTrp: 0.379 ± 0.018	0.556HisTyr: 0.556 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.495IleAla: 7.495 ± 0.087	0.571IleCys: 0.571 ± 0.025	3.35IleAsp: 3.35 ± 0.061	3.819IleGlu: 3.819 ± 0.068	1.849IlePhe: 1.849 ± 0.046	4.941IleGly: 4.941 ± 0.066	0.958IleHis: 0.958 ± 0.028	1.977IleIle: 1.977 ± 0.053	1.319IleLys: 1.319 ± 0.037	4.735IleLeu: 4.735 ± 0.075	0.985IleMet: 0.985 ± 0.032	1.221IleAsn: 1.221 ± 0.037	2.424IlePro: 2.424 ± 0.046	1.041IleGln: 1.041 ± 0.027	3.488IleArg: 3.488 ± 0.054	3.055IleSer: 3.055 ± 0.059	2.805IleThr: 2.805 ± 0.057	3.874IleVal: 3.874 ± 0.064	0.768IleTrp: 0.768 ± 0.028	1.147IleTyr: 1.147 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.041LysAla: 4.041 ± 0.069	0.188LysCys: 0.188 ± 0.013	1.726LysAsp: 1.726 ± 0.045	1.683LysGlu: 1.683 ± 0.038	0.922LysPhe: 0.922 ± 0.031	2.88LysGly: 2.88 ± 0.058	0.568LysHis: 0.568 ± 0.027	1.879LysIle: 1.879 ± 0.043	1.299LysLys: 1.299 ± 0.046	3.308LysLeu: 3.308 ± 0.065	0.921LysMet: 0.921 ± 0.026	0.779LysAsn: 0.779 ± 0.027	1.947LysPro: 1.947 ± 0.05	0.902LysGln: 0.902 ± 0.029	2.317LysArg: 2.317 ± 0.056	1.784LysSer: 1.784 ± 0.042	1.969LysThr: 1.969 ± 0.044	2.523LysVal: 2.523 ± 0.057	0.39LysTrp: 0.39 ± 0.019	0.644LysTyr: 0.644 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.82LeuAla: 13.82 ± 0.133	0.842LeuCys: 0.842 ± 0.029	5.924LeuAsp: 5.924 ± 0.078	5.944LeuGlu: 5.944 ± 0.077	3.51LeuPhe: 3.51 ± 0.065	8.988LeuGly: 8.988 ± 0.108	1.972LeuHis: 1.972 ± 0.051	5.398LeuIle: 5.398 ± 0.082	3.275LeuLys: 3.275 ± 0.063	9.027LeuLeu: 9.027 ± 0.124	2.696LeuMet: 2.696 ± 0.046	2.489LeuAsn: 2.489 ± 0.05	5.756LeuPro: 5.756 ± 0.076	2.578LeuGln: 2.578 ± 0.052	7.601LeuArg: 7.601 ± 0.092	6.712LeuSer: 6.712 ± 0.078	5.499LeuThr: 5.499 ± 0.079	7.121LeuVal: 7.121 ± 0.099	1.407LeuTrp: 1.407 ± 0.036	1.954LeuTyr: 1.954 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.393MetAla: 3.393 ± 0.058	0.16MetCys: 0.16 ± 0.014	1.232MetAsp: 1.232 ± 0.034	1.419MetGlu: 1.419 ± 0.037	0.755MetPhe: 0.755 ± 0.03	2.328MetGly: 2.328 ± 0.048	0.472MetHis: 0.472 ± 0.019	1.589MetIle: 1.589 ± 0.041	1.111MetLys: 1.111 ± 0.03	2.61MetLeu: 2.61 ± 0.051	0.777MetMet: 0.777 ± 0.03	0.79MetAsn: 0.79 ± 0.025	1.551MetPro: 1.551 ± 0.041	0.9MetGln: 0.9 ± 0.031	2.092MetArg: 2.092 ± 0.047	1.719MetSer: 1.719 ± 0.036	1.936MetThr: 1.936 ± 0.043	1.801MetVal: 1.801 ± 0.041	0.225MetTrp: 0.225 ± 0.014	0.288MetTyr: 0.288 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.985AsnAla: 2.985 ± 0.059	0.221AsnCys: 0.221 ± 0.014	1.334AsnAsp: 1.334 ± 0.043	1.173AsnGlu: 1.173 ± 0.029	0.924AsnPhe: 0.924 ± 0.029	2.182AsnGly: 2.182 ± 0.058	0.479AsnHis: 0.479 ± 0.02	1.229AsnIle: 1.229 ± 0.041	0.671AsnLys: 0.671 ± 0.025	2.443AsnLeu: 2.443 ± 0.042	0.652AsnMet: 0.652 ± 0.026	0.553AsnAsn: 0.553 ± 0.026	1.75AsnPro: 1.75 ± 0.039	0.617AsnGln: 0.617 ± 0.026	1.654AsnArg: 1.654 ± 0.039	1.089AsnSer: 1.089 ± 0.04	1.147AsnThr: 1.147 ± 0.037	1.659AsnVal: 1.659 ± 0.046	0.424AsnTrp: 0.424 ± 0.019	0.587AsnTyr: 0.587 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.228ProAla: 6.228 ± 0.097	0.366ProCys: 0.366 ± 0.019	3.763ProAsp: 3.763 ± 0.062	4.733ProGlu: 4.733 ± 0.073	1.987ProPhe: 1.987 ± 0.043	4.943ProGly: 4.943 ± 0.066	1.083ProHis: 1.083 ± 0.03	2.251ProIle: 2.251 ± 0.046	1.768ProLys: 1.768 ± 0.046	4.729ProLeu: 4.729 ± 0.062	1.279ProMet: 1.279 ± 0.031	1.205ProAsn: 1.205 ± 0.034	2.476ProPro: 2.476 ± 0.06	1.696ProGln: 1.696 ± 0.047	3.172ProArg: 3.172 ± 0.057	2.586ProSer: 2.586 ± 0.043	2.24ProThr: 2.24 ± 0.045	4.302ProVal: 4.302 ± 0.064	0.701ProTrp: 0.701 ± 0.024	1.13ProTyr: 1.13 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.058GlnAla: 4.058 ± 0.067	0.185GlnCys: 0.185 ± 0.012	1.444GlnAsp: 1.444 ± 0.039	1.506GlnGlu: 1.506 ± 0.034	1.053GlnPhe: 1.053 ± 0.028	2.757GlnGly: 2.757 ± 0.057	0.529GlnHis: 0.529 ± 0.024	2.1GlnIle: 2.1 ± 0.038	1.034GlnLys: 1.034 ± 0.031	2.79GlnLeu: 2.79 ± 0.056	1.017GlnMet: 1.017 ± 0.031	0.802GlnAsn: 0.802 ± 0.027	1.606GlnPro: 1.606 ± 0.033	1.024GlnGln: 1.024 ± 0.041	2.126GlnArg: 2.126 ± 0.054	1.732GlnSer: 1.732 ± 0.04	1.598GlnThr: 1.598 ± 0.035	2.337GlnVal: 2.337 ± 0.043	0.389GlnTrp: 0.389 ± 0.018	0.537GlnTyr: 0.537 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.055ArgAla: 9.055 ± 0.109	0.479ArgCys: 0.479 ± 0.024	4.485ArgAsp: 4.485 ± 0.067	4.636ArgGlu: 4.636 ± 0.075	2.833ArgPhe: 2.833 ± 0.048	4.973ArgGly: 4.973 ± 0.07	1.7ArgHis: 1.7 ± 0.042	4.021ArgIle: 4.021 ± 0.06	2.468ArgLys: 2.468 ± 0.048	7.759ArgLeu: 7.759 ± 0.103	2.021ArgMet: 2.021 ± 0.043	1.732ArgAsn: 1.732 ± 0.04	3.614ArgPro: 3.614 ± 0.058	2.249ArgGln: 2.249 ± 0.05	5.427ArgArg: 5.427 ± 0.087	3.334ArgSer: 3.334 ± 0.061	2.904ArgThr: 2.904 ± 0.053	4.732ArgVal: 4.732 ± 0.068	0.994ArgTrp: 0.994 ± 0.031	1.552ArgTyr: 1.552 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.861SerAla: 5.861 ± 0.091	0.403SerCys: 0.403 ± 0.02	3.135SerAsp: 3.135 ± 0.047	3.191SerGlu: 3.191 ± 0.052	2.091SerPhe: 2.091 ± 0.043	5.347SerGly: 5.347 ± 0.091	1.083SerHis: 1.083 ± 0.033	2.313SerIle: 2.313 ± 0.054	1.556SerLys: 1.556 ± 0.04	5.07SerLeu: 5.07 ± 0.072	1.257SerMet: 1.257 ± 0.037	1.268SerAsn: 1.268 ± 0.036	2.435SerPro: 2.435 ± 0.048	1.538SerGln: 1.538 ± 0.038	3.387SerArg: 3.387 ± 0.052	2.46SerSer: 2.46 ± 0.052	2.346SerThr: 2.346 ± 0.059	3.709SerVal: 3.709 ± 0.061	0.726SerTrp: 0.726 ± 0.026	1.252SerTyr: 1.252 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.7ThrAla: 5.7 ± 0.1	0.438ThrCys: 0.438 ± 0.021	2.806ThrAsp: 2.806 ± 0.054	2.985ThrGlu: 2.985 ± 0.057	1.811ThrPhe: 1.811 ± 0.037	5.248ThrGly: 5.248 ± 0.09	1.09ThrHis: 1.09 ± 0.03	2.653ThrIle: 2.653 ± 0.055	1.47ThrLys: 1.47 ± 0.039	5.859ThrLeu: 5.859 ± 0.08	1.21ThrMet: 1.21 ± 0.037	1.173ThrAsn: 1.173 ± 0.039	3.226ThrPro: 3.226 ± 0.056	1.573ThrGln: 1.573 ± 0.037	3.613ThrArg: 3.613 ± 0.059	2.361ThrSer: 2.361 ± 0.056	2.487ThrThr: 2.487 ± 0.073	3.974ThrVal: 3.974 ± 0.07	0.583ThrTrp: 0.583 ± 0.021	1.083ThrTyr: 1.083 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.0ValAla: 9.0 ± 0.097	0.544ValCys: 0.544 ± 0.022	3.68ValAsp: 3.68 ± 0.059	4.516ValGlu: 4.516 ± 0.062	2.728ValPhe: 2.728 ± 0.052	5.2ValGly: 5.2 ± 0.072	1.274ValHis: 1.274 ± 0.034	4.325ValIle: 4.325 ± 0.071	2.259ValLys: 2.259 ± 0.044	7.477ValLeu: 7.477 ± 0.097	2.108ValMet: 2.108 ± 0.049	1.793ValAsn: 1.793 ± 0.041	3.487ValPro: 3.487 ± 0.061	1.938ValGln: 1.938 ± 0.041	4.028ValArg: 4.028 ± 0.064	4.111ValSer: 4.111 ± 0.071	4.619ValThr: 4.619 ± 0.083	5.365ValVal: 5.365 ± 0.09	0.911ValTrp: 0.911 ± 0.031	1.393ValTyr: 1.393 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.375TrpAla: 1.375 ± 0.037	0.124TrpCys: 0.124 ± 0.01	0.71TrpAsp: 0.71 ± 0.025	0.694TrpGlu: 0.694 ± 0.026	0.563TrpPhe: 0.563 ± 0.025	1.067TrpGly: 1.067 ± 0.035	0.368TrpHis: 0.368 ± 0.019	0.774TrpIle: 0.774 ± 0.027	0.537TrpLys: 0.537 ± 0.022	1.71TrpLeu: 1.71 ± 0.037	0.401TrpMet: 0.401 ± 0.021	0.408TrpAsn: 0.408 ± 0.019	0.685TrpPro: 0.685 ± 0.025	0.573TrpGln: 0.573 ± 0.023	1.163TrpArg: 1.163 ± 0.035	0.824TrpSer: 0.824 ± 0.028	0.659TrpThr: 0.659 ± 0.023	0.909TrpVal: 0.909 ± 0.034	0.243TrpTrp: 0.243 ± 0.016	0.278TrpTyr: 0.278 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.402TyrAla: 2.402 ± 0.043	0.225TyrCys: 0.225 ± 0.013	1.43TyrAsp: 1.43 ± 0.033	1.283TyrGlu: 1.283 ± 0.03	0.866TyrPhe: 0.866 ± 0.031	2.002TyrGly: 2.002 ± 0.04	0.499TyrHis: 0.499 ± 0.02	0.864TyrIle: 0.864 ± 0.027	0.598TyrLys: 0.598 ± 0.025	2.258TyrLeu: 2.258 ± 0.045	0.449TyrMet: 0.449 ± 0.021	0.542TyrAsn: 0.542 ± 0.022	1.052TyrPro: 1.052 ± 0.033	0.628TyrGln: 0.628 ± 0.024	1.601TyrArg: 1.601 ± 0.039	1.097TyrSer: 1.097 ± 0.03	0.988TyrThr: 0.988 ± 0.034	1.462TyrVal: 1.462 ± 0.034	0.363TyrTrp: 0.363 ± 0.018	0.568TyrTyr: 0.568 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3767 proteins (1170515 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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