Amino acid dipepetide frequency for Devosia limi DSM 17137

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.233AlaAla: 17.233 ± 0.164
0.783AlaCys: 0.783 ± 0.027
7.113AlaAsp: 7.113 ± 0.081
7.516AlaGlu: 7.516 ± 0.102
4.553AlaPhe: 4.553 ± 0.078
10.884AlaGly: 10.884 ± 0.115
2.162AlaHis: 2.162 ± 0.046
7.413AlaIle: 7.413 ± 0.085
3.617AlaLys: 3.617 ± 0.062
14.022AlaLeu: 14.022 ± 0.148
3.863AlaMet: 3.863 ± 0.065
3.31AlaAsn: 3.31 ± 0.055
5.412AlaPro: 5.412 ± 0.091
4.189AlaGln: 4.189 ± 0.08
8.023AlaArg: 8.023 ± 0.102
6.467AlaSer: 6.467 ± 0.094
6.142AlaThr: 6.142 ± 0.07
9.139AlaVal: 9.139 ± 0.095
1.42AlaTrp: 1.42 ± 0.035
2.608AlaTyr: 2.608 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.811CysAla: 0.811 ± 0.029
0.072CysCys: 0.072 ± 0.009
0.417CysAsp: 0.417 ± 0.018
0.321CysGlu: 0.321 ± 0.016
0.257CysPhe: 0.257 ± 0.014
0.719CysGly: 0.719 ± 0.032
0.223CysHis: 0.223 ± 0.014
0.369CysIle: 0.369 ± 0.018
0.154CysLys: 0.154 ± 0.012
0.668CysLeu: 0.668 ± 0.025
0.114CysMet: 0.114 ± 0.011
0.181CysAsn: 0.181 ± 0.014
0.361CysPro: 0.361 ± 0.018
0.183CysGln: 0.183 ± 0.013
0.436CysArg: 0.436 ± 0.021
0.381CysSer: 0.381 ± 0.018
0.357CysThr: 0.357 ± 0.018
0.517CysVal: 0.517 ± 0.024
0.086CysTrp: 0.086 ± 0.008
0.181CysTyr: 0.181 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.873AspAla: 6.873 ± 0.082
0.384AspCys: 0.384 ± 0.017
3.003AspAsp: 3.003 ± 0.063
3.326AspGlu: 3.326 ± 0.06
2.246AspPhe: 2.246 ± 0.046
5.234AspGly: 5.234 ± 0.083
1.169AspHis: 1.169 ± 0.034
3.438AspIle: 3.438 ± 0.06
1.757AspLys: 1.757 ± 0.044
5.944AspLeu: 5.944 ± 0.066
1.467AspMet: 1.467 ± 0.035
1.459AspAsn: 1.459 ± 0.039
3.335AspPro: 3.335 ± 0.057
1.805AspGln: 1.805 ± 0.039
3.738AspArg: 3.738 ± 0.062
2.217AspSer: 2.217 ± 0.042
2.647AspThr: 2.647 ± 0.054
4.138AspVal: 4.138 ± 0.065
0.968AspTrp: 0.968 ± 0.029
1.502AspTyr: 1.502 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
7.263GluAla: 7.263 ± 0.095
0.288GluCys: 0.288 ± 0.016
2.528GluAsp: 2.528 ± 0.052
2.671GluGlu: 2.671 ± 0.056
1.82GluPhe: 1.82 ± 0.039
4.142GluGly: 4.142 ± 0.059
1.186GluHis: 1.186 ± 0.037
3.435GluIle: 3.435 ± 0.061
1.87GluLys: 1.87 ± 0.054
5.391GluLeu: 5.391 ± 0.069
1.541GluMet: 1.541 ± 0.04
1.519GluAsn: 1.519 ± 0.039
2.657GluPro: 2.657 ± 0.066
2.178GluGln: 2.178 ± 0.044
4.453GluArg: 4.453 ± 0.07
2.142GluSer: 2.142 ± 0.045
3.394GluThr: 3.394 ± 0.053
3.686GluVal: 3.686 ± 0.063
0.647GluTrp: 0.647 ± 0.025
0.926GluTyr: 0.926 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.862PheAla: 4.862 ± 0.068
0.329PheCys: 0.329 ± 0.018
2.635PheAsp: 2.635 ± 0.05
2.128PheGlu: 2.128 ± 0.049
1.517PhePhe: 1.517 ± 0.046
3.946PheGly: 3.946 ± 0.059
0.704PheHis: 0.704 ± 0.023
1.914PheIle: 1.914 ± 0.045
1.079PheLys: 1.079 ± 0.032
3.427PheLeu: 3.427 ± 0.067
0.872PheMet: 0.872 ± 0.029
1.176PheAsn: 1.176 ± 0.032
1.57PhePro: 1.57 ± 0.039
1.046PheGln: 1.046 ± 0.028
1.962PheArg: 1.962 ± 0.04
2.358PheSer: 2.358 ± 0.05
2.097PheThr: 2.097 ± 0.042
3.125PheVal: 3.125 ± 0.049
0.61PheTrp: 0.61 ± 0.026
0.949PheTyr: 0.949 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
9.536GlyAla: 9.536 ± 0.1
0.667GlyCys: 0.667 ± 0.022
4.544GlyAsp: 4.544 ± 0.08
4.694GlyGlu: 4.694 ± 0.065
3.747GlyPhe: 3.747 ± 0.057
7.281GlyGly: 7.281 ± 0.097
1.817GlyHis: 1.817 ± 0.041
5.05GlyIle: 5.05 ± 0.068
3.437GlyLys: 3.437 ± 0.058
9.388GlyLeu: 9.388 ± 0.104
2.425GlyMet: 2.425 ± 0.048
2.415GlyAsn: 2.415 ± 0.057
3.452GlyPro: 3.452 ± 0.054
3.163GlyGln: 3.163 ± 0.052
5.572GlyArg: 5.572 ± 0.068
4.691GlySer: 4.691 ± 0.072
4.815GlyThr: 4.815 ± 0.071
6.438GlyVal: 6.438 ± 0.08
1.385GlyTrp: 1.385 ± 0.038
2.275GlyTyr: 2.275 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
2.237HisAla: 2.237 ± 0.045
0.184HisCys: 0.184 ± 0.014
1.239HisAsp: 1.239 ± 0.038
0.984HisGlu: 0.984 ± 0.032
0.891HisPhe: 0.891 ± 0.027
1.88HisGly: 1.88 ± 0.04
0.571HisHis: 0.571 ± 0.025
1.015HisIle: 1.015 ± 0.03
0.544HisLys: 0.544 ± 0.022
2.032HisLeu: 2.032 ± 0.041
0.505HisMet: 0.505 ± 0.024
0.527HisAsn: 0.527 ± 0.024
1.162HisPro: 1.162 ± 0.034
0.633HisGln: 0.633 ± 0.024
1.309HisArg: 1.309 ± 0.037
0.878HisSer: 0.878 ± 0.026
0.842HisThr: 0.842 ± 0.03
1.374HisVal: 1.374 ± 0.037
0.322HisTrp: 0.322 ± 0.019
0.552HisTyr: 0.552 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
8.458IleAla: 8.458 ± 0.092
0.483IleCys: 0.483 ± 0.02
3.917IleAsp: 3.917 ± 0.057
3.693IleGlu: 3.693 ± 0.063
1.897IlePhe: 1.897 ± 0.045
5.593IleGly: 5.593 ± 0.074
0.919IleHis: 0.919 ± 0.027
2.95IleIle: 2.95 ± 0.048
1.609IleLys: 1.609 ± 0.04
4.762IleLeu: 4.762 ± 0.072
1.164IleMet: 1.164 ± 0.037
1.743IleAsn: 1.743 ± 0.04
2.349IlePro: 2.349 ± 0.047
1.293IleGln: 1.293 ± 0.036
3.021IleArg: 3.021 ± 0.049
3.107IleSer: 3.107 ± 0.054
3.028IleThr: 3.028 ± 0.053
4.838IleVal: 4.838 ± 0.068
0.668IleTrp: 0.668 ± 0.026
1.314IleTyr: 1.314 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
4.096LysAla: 4.096 ± 0.065
0.142LysCys: 0.142 ± 0.011
1.542LysAsp: 1.542 ± 0.041
1.259LysGlu: 1.259 ± 0.04
0.951LysPhe: 0.951 ± 0.027
2.489LysGly: 2.489 ± 0.051
0.564LysHis: 0.564 ± 0.023
1.619LysIle: 1.619 ± 0.043
1.03LysLys: 1.03 ± 0.037
3.169LysLeu: 3.169 ± 0.059
0.687LysMet: 0.687 ± 0.024
0.729LysAsn: 0.729 ± 0.024
1.927LysPro: 1.927 ± 0.051
0.916LysGln: 0.916 ± 0.025
2.191LysArg: 2.191 ± 0.046
1.913LysSer: 1.913 ± 0.041
1.851LysThr: 1.851 ± 0.046
2.426LysVal: 2.426 ± 0.054
0.357LysTrp: 0.357 ± 0.017
0.549LysTyr: 0.549 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.08LeuAla: 14.08 ± 0.137
0.778LeuCys: 0.778 ± 0.028
6.26LeuAsp: 6.26 ± 0.083
5.251LeuGlu: 5.251 ± 0.069
3.752LeuPhe: 3.752 ± 0.066
8.865LeuGly: 8.865 ± 0.104
1.775LeuHis: 1.775 ± 0.044
5.539LeuIle: 5.539 ± 0.08
3.305LeuLys: 3.305 ± 0.06
10.008LeuLeu: 10.008 ± 0.13
2.485LeuMet: 2.485 ± 0.045
2.811LeuAsn: 2.811 ± 0.05
5.453LeuPro: 5.453 ± 0.082
2.945LeuGln: 2.945 ± 0.049
6.241LeuArg: 6.241 ± 0.075
6.599LeuSer: 6.599 ± 0.087
6.125LeuThr: 6.125 ± 0.076
8.252LeuVal: 8.252 ± 0.11
1.136LeuTrp: 1.136 ± 0.029
2.101LeuTyr: 2.101 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.476MetAla: 3.476 ± 0.065
0.119MetCys: 0.119 ± 0.011
1.185MetAsp: 1.185 ± 0.033
1.006MetGlu: 1.006 ± 0.03
0.793MetPhe: 0.793 ± 0.026
2.055MetGly: 2.055 ± 0.046
0.427MetHis: 0.427 ± 0.021
1.465MetIle: 1.465 ± 0.037
0.766MetLys: 0.766 ± 0.021
2.722MetLeu: 2.722 ± 0.05
0.671MetMet: 0.671 ± 0.026
0.763MetAsn: 0.763 ± 0.026
1.478MetPro: 1.478 ± 0.034
0.903MetGln: 0.903 ± 0.029
1.755MetArg: 1.755 ± 0.04
1.789MetSer: 1.789 ± 0.04
2.036MetThr: 2.036 ± 0.039
2.069MetVal: 2.069 ± 0.047
0.229MetTrp: 0.229 ± 0.014
0.301MetTyr: 0.301 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.499AsnAla: 3.499 ± 0.061
0.199AsnCys: 0.199 ± 0.014
1.391AsnAsp: 1.391 ± 0.037
1.277AsnGlu: 1.277 ± 0.037
1.064AsnPhe: 1.064 ± 0.033
2.669AsnGly: 2.669 ± 0.056
0.533AsnHis: 0.533 ± 0.022
1.483AsnIle: 1.483 ± 0.033
0.734AsnLys: 0.734 ± 0.023
2.826AsnLeu: 2.826 ± 0.054
0.648AsnMet: 0.648 ± 0.022
0.762AsnAsn: 0.762 ± 0.026
1.904AsnPro: 1.904 ± 0.042
0.89AsnGln: 0.89 ± 0.028
1.771AsnArg: 1.771 ± 0.042
1.322AsnSer: 1.322 ± 0.036
1.389AsnThr: 1.389 ± 0.034
2.131AsnVal: 2.131 ± 0.05
0.446AsnTrp: 0.446 ± 0.023
0.739AsnTyr: 0.739 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
6.223ProAla: 6.223 ± 0.098
0.26ProCys: 0.26 ± 0.016
3.463ProAsp: 3.463 ± 0.057
3.419ProGlu: 3.419 ± 0.06
1.912ProPhe: 1.912 ± 0.042
4.303ProGly: 4.303 ± 0.07
1.029ProHis: 1.029 ± 0.031
2.605ProIle: 2.605 ± 0.051
1.528ProLys: 1.528 ± 0.04
4.798ProLeu: 4.798 ± 0.063
1.25ProMet: 1.25 ± 0.034
1.459ProAsn: 1.459 ± 0.033
2.177ProPro: 2.177 ± 0.053
1.604ProGln: 1.604 ± 0.039
2.559ProArg: 2.559 ± 0.045
2.696ProSer: 2.696 ± 0.045
2.647ProThr: 2.647 ± 0.06
4.17ProVal: 4.17 ± 0.065
0.598ProTrp: 0.598 ± 0.025
1.181ProTyr: 1.181 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.005GlnAla: 4.005 ± 0.068
0.194GlnCys: 0.194 ± 0.013
1.542GlnAsp: 1.542 ± 0.038
1.292GlnGlu: 1.292 ± 0.04
1.254GlnPhe: 1.254 ± 0.032
2.488GlnGly: 2.488 ± 0.051
0.706GlnHis: 0.706 ± 0.025
1.925GlnIle: 1.925 ± 0.046
0.973GlnLys: 0.973 ± 0.031
3.355GlnLeu: 3.355 ± 0.057
1.037GlnMet: 1.037 ± 0.032
0.868GlnAsn: 0.868 ± 0.029
1.737GlnPro: 1.737 ± 0.037
1.369GlnGln: 1.369 ± 0.047
2.567GlnArg: 2.567 ± 0.059
1.964GlnSer: 1.964 ± 0.043
1.858GlnThr: 1.858 ± 0.042
2.434GlnVal: 2.434 ± 0.043
0.397GlnTrp: 0.397 ± 0.021
0.66GlnTyr: 0.66 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
7.135ArgAla: 7.135 ± 0.09
0.372ArgCys: 0.372 ± 0.02
3.76ArgAsp: 3.76 ± 0.056
3.5ArgGlu: 3.5 ± 0.061
2.708ArgPhe: 2.708 ± 0.055
4.395ArgGly: 4.395 ± 0.06
1.528ArgHis: 1.528 ± 0.031
3.879ArgIle: 3.879 ± 0.065
2.009ArgLys: 2.009 ± 0.054
7.235ArgLeu: 7.235 ± 0.084
1.659ArgMet: 1.659 ± 0.036
1.845ArgAsn: 1.845 ± 0.034
3.14ArgPro: 3.14 ± 0.058
2.722ArgGln: 2.722 ± 0.055
4.596ArgArg: 4.596 ± 0.084
3.477ArgSer: 3.477 ± 0.053
3.155ArgThr: 3.155 ± 0.061
4.368ArgVal: 4.368 ± 0.063
0.828ArgTrp: 0.828 ± 0.028
1.627ArgTyr: 1.627 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
6.302SerAla: 6.302 ± 0.075
0.327SerCys: 0.327 ± 0.015
2.874SerAsp: 2.874 ± 0.052
2.627SerGlu: 2.627 ± 0.053
2.37SerPhe: 2.37 ± 0.043
5.573SerGly: 5.573 ± 0.082
1.092SerHis: 1.092 ± 0.033
3.193SerIle: 3.193 ± 0.053
1.483SerLys: 1.483 ± 0.037
5.633SerLeu: 5.633 ± 0.092
1.427SerMet: 1.427 ± 0.038
1.504SerAsn: 1.504 ± 0.037
2.662SerPro: 2.662 ± 0.046
1.833SerGln: 1.833 ± 0.041
3.338SerArg: 3.338 ± 0.053
3.004SerSer: 3.004 ± 0.047
2.765SerThr: 2.765 ± 0.053
4.341SerVal: 4.341 ± 0.065
0.727SerTrp: 0.727 ± 0.026
1.263SerTyr: 1.263 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
6.443ThrAla: 6.443 ± 0.09
0.353ThrCys: 0.353 ± 0.018
2.889ThrAsp: 2.889 ± 0.054
2.674ThrGlu: 2.674 ± 0.051
2.031ThrPhe: 2.031 ± 0.047
5.2ThrGly: 5.2 ± 0.065
1.133ThrHis: 1.133 ± 0.031
3.454ThrIle: 3.454 ± 0.053
1.495ThrLys: 1.495 ± 0.039
6.215ThrLeu: 6.215 ± 0.079
1.392ThrMet: 1.392 ± 0.035
1.47ThrAsn: 1.47 ± 0.035
3.356ThrPro: 3.356 ± 0.056
1.485ThrGln: 1.485 ± 0.033
3.165ThrArg: 3.165 ± 0.056
2.924ThrSer: 2.924 ± 0.06
3.011ThrThr: 3.011 ± 0.061
4.265ThrVal: 4.265 ± 0.065
0.61ThrTrp: 0.61 ± 0.022
1.246ThrTyr: 1.246 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
9.475ValAla: 9.475 ± 0.099
0.54ValCys: 0.54 ± 0.025
4.298ValAsp: 4.298 ± 0.072
4.356ValGlu: 4.356 ± 0.071
2.941ValPhe: 2.941 ± 0.054
5.986ValGly: 5.986 ± 0.091
1.387ValHis: 1.387 ± 0.033
4.462ValIle: 4.462 ± 0.068
2.063ValLys: 2.063 ± 0.04
8.272ValLeu: 8.272 ± 0.09
2.021ValMet: 2.021 ± 0.045
2.078ValAsn: 2.078 ± 0.051
3.913ValPro: 3.913 ± 0.059
2.119ValGln: 2.119 ± 0.047
4.609ValArg: 4.609 ± 0.066
4.408ValSer: 4.408 ± 0.064
4.866ValThr: 4.866 ± 0.074
6.281ValVal: 6.281 ± 0.092
0.939ValTrp: 0.939 ± 0.033
1.541ValTyr: 1.541 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.263TrpAla: 1.263 ± 0.038
0.134TrpCys: 0.134 ± 0.009
0.645TrpAsp: 0.645 ± 0.024
0.52TrpGlu: 0.52 ± 0.021
0.553TrpPhe: 0.553 ± 0.023
0.893TrpGly: 0.893 ± 0.027
0.285TrpHis: 0.285 ± 0.017
0.655TrpIle: 0.655 ± 0.028
0.396TrpLys: 0.396 ± 0.019
1.574TrpLeu: 1.574 ± 0.035
0.346TrpMet: 0.346 ± 0.018
0.464TrpAsn: 0.464 ± 0.025
0.693TrpPro: 0.693 ± 0.027
0.609TrpGln: 0.609 ± 0.026
1.003TrpArg: 1.003 ± 0.028
0.824TrpSer: 0.824 ± 0.033
0.744TrpThr: 0.744 ± 0.027
0.843TrpVal: 0.843 ± 0.027
0.243TrpTrp: 0.243 ± 0.016
0.284TrpTyr: 0.284 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.6TyrAla: 2.6 ± 0.05
0.204TyrCys: 0.204 ± 0.013
1.405TyrAsp: 1.405 ± 0.037
1.224TyrGlu: 1.224 ± 0.035
1.049TyrPhe: 1.049 ± 0.031
2.199TyrGly: 2.199 ± 0.043
0.47TyrHis: 0.47 ± 0.023
0.94TyrIle: 0.94 ± 0.026
0.558TyrLys: 0.558 ± 0.023
2.321TyrLeu: 2.321 ± 0.053
0.433TyrMet: 0.433 ± 0.018
0.598TyrAsn: 0.598 ± 0.021
1.144TyrPro: 1.144 ± 0.027
0.738TyrGln: 0.738 ± 0.023
1.629TyrArg: 1.629 ± 0.04
1.176TyrSer: 1.176 ± 0.032
1.04TyrThr: 1.04 ± 0.032
1.718TyrVal: 1.718 ± 0.033
0.352TyrTrp: 0.352 ± 0.018
0.582TyrTyr: 0.582 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3824 proteins (1172979 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski