Amino acid dipepetide frequency for Bartonella sp. JB15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.229AlaAla: 6.229 ± 0.155
0.903AlaCys: 0.903 ± 0.047
3.702AlaAsp: 3.702 ± 0.102
4.824AlaGlu: 4.824 ± 0.138
3.561AlaPhe: 3.561 ± 0.102
4.926AlaGly: 4.926 ± 0.122
1.999AlaHis: 1.999 ± 0.076
6.594AlaIle: 6.594 ± 0.12
4.635AlaLys: 4.635 ± 0.14
9.091AlaLeu: 9.091 ± 0.167
2.041AlaMet: 2.041 ± 0.079
2.919AlaAsn: 2.919 ± 0.091
2.352AlaPro: 2.352 ± 0.098
3.394AlaGln: 3.394 ± 0.115
4.284AlaArg: 4.284 ± 0.12
4.371AlaSer: 4.371 ± 0.132
3.556AlaThr: 3.556 ± 0.103
5.04AlaVal: 5.04 ± 0.139
0.666AlaTrp: 0.666 ± 0.043
2.143AlaTyr: 2.143 ± 0.093
0.0AlaXaa: 0.0 ± 0.0
Cys
0.811CysAla: 0.811 ± 0.05
0.154CysCys: 0.154 ± 0.019
0.622CysAsp: 0.622 ± 0.041
0.622CysGlu: 0.622 ± 0.042
0.629CysPhe: 0.629 ± 0.041
0.913CysGly: 0.913 ± 0.049
0.306CysHis: 0.306 ± 0.028
0.84CysIle: 0.84 ± 0.049
0.438CysLys: 0.438 ± 0.036
0.965CysLeu: 0.965 ± 0.058
0.209CysMet: 0.209 ± 0.021
0.453CysAsn: 0.453 ± 0.033
0.393CysPro: 0.393 ± 0.034
0.393CysGln: 0.393 ± 0.026
0.507CysArg: 0.507 ± 0.036
0.763CysSer: 0.763 ± 0.047
0.5CysThr: 0.5 ± 0.041
0.736CysVal: 0.736 ± 0.045
0.122CysTrp: 0.122 ± 0.018
0.301CysTyr: 0.301 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
3.715AspAla: 3.715 ± 0.094
0.555AspCys: 0.555 ± 0.043
2.385AspAsp: 2.385 ± 0.093
3.143AspGlu: 3.143 ± 0.087
2.494AspPhe: 2.494 ± 0.083
3.339AspGly: 3.339 ± 0.157
1.189AspHis: 1.189 ± 0.053
4.869AspIle: 4.869 ± 0.127
2.889AspLys: 2.889 ± 0.095
5.132AspLeu: 5.132 ± 0.116
1.189AspMet: 1.189 ± 0.06
2.22AspAsn: 2.22 ± 0.078
2.124AspPro: 2.124 ± 0.069
1.805AspGln: 1.805 ± 0.072
2.313AspArg: 2.313 ± 0.091
2.979AspSer: 2.979 ± 0.125
2.347AspThr: 2.347 ± 0.085
3.29AspVal: 3.29 ± 0.099
0.584AspTrp: 0.584 ± 0.039
1.661AspTyr: 1.661 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
4.819GluAla: 4.819 ± 0.152
0.525GluCys: 0.525 ± 0.036
2.534GluAsp: 2.534 ± 0.108
4.18GluGlu: 4.18 ± 0.114
1.84GluPhe: 1.84 ± 0.063
3.732GluGly: 3.732 ± 0.098
1.116GluHis: 1.116 ± 0.057
5.587GluIle: 5.587 ± 0.117
5.707GluLys: 5.707 ± 0.161
4.911GluLeu: 4.911 ± 0.117
1.785GluMet: 1.785 ± 0.073
3.576GluAsn: 3.576 ± 0.111
1.765GluPro: 1.765 ± 0.076
2.576GluGln: 2.576 ± 0.096
3.732GluArg: 3.732 ± 0.099
3.056GluSer: 3.056 ± 0.116
3.543GluThr: 3.543 ± 0.126
3.382GluVal: 3.382 ± 0.1
0.639GluTrp: 0.639 ± 0.045
1.514GluTyr: 1.514 ± 0.073
0.0GluXaa: 0.0 ± 0.0
Phe
3.049PheAla: 3.049 ± 0.097
0.651PheCys: 0.651 ± 0.044
2.748PheAsp: 2.748 ± 0.085
2.499PheGlu: 2.499 ± 0.084
2.598PhePhe: 2.598 ± 0.115
3.275PheGly: 3.275 ± 0.098
1.077PheHis: 1.077 ± 0.053
3.722PheIle: 3.722 ± 0.129
1.957PheLys: 1.957 ± 0.074
4.588PheLeu: 4.588 ± 0.14
1.159PheMet: 1.159 ± 0.062
2.054PheAsn: 2.054 ± 0.07
1.567PhePro: 1.567 ± 0.069
1.502PheGln: 1.502 ± 0.071
1.877PheArg: 1.877 ± 0.064
4.274PheSer: 4.274 ± 0.113
2.196PheThr: 2.196 ± 0.082
2.874PheVal: 2.874 ± 0.113
0.482PheTrp: 0.482 ± 0.04
1.504PheTyr: 1.504 ± 0.066
0.0PheXaa: 0.0 ± 0.0
Gly
4.938GlyAla: 4.938 ± 0.145
0.776GlyCys: 0.776 ± 0.053
3.155GlyAsp: 3.155 ± 0.1
3.658GlyGlu: 3.658 ± 0.128
3.205GlyPhe: 3.205 ± 0.104
5.003GlyGly: 5.003 ± 0.206
1.572GlyHis: 1.572 ± 0.073
5.717GlyIle: 5.717 ± 0.13
4.481GlyLys: 4.481 ± 0.141
6.403GlyLeu: 6.403 ± 0.143
1.606GlyMet: 1.606 ± 0.072
2.815GlyAsn: 2.815 ± 0.118
1.989GlyPro: 1.989 ± 0.073
2.638GlyGln: 2.638 ± 0.099
3.648GlyArg: 3.648 ± 0.117
4.058GlySer: 4.058 ± 0.124
3.571GlyThr: 3.571 ± 0.102
4.342GlyVal: 4.342 ± 0.121
0.756GlyTrp: 0.756 ± 0.048
2.206GlyTyr: 2.206 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.572HisAla: 1.572 ± 0.066
0.271HisCys: 0.271 ± 0.026
1.104HisAsp: 1.104 ± 0.051
1.206HisGlu: 1.206 ± 0.056
1.156HisPhe: 1.156 ± 0.068
1.457HisGly: 1.457 ± 0.064
0.704HisHis: 0.704 ± 0.049
1.912HisIle: 1.912 ± 0.07
1.278HisLys: 1.278 ± 0.063
2.365HisLeu: 2.365 ± 0.081
0.535HisMet: 0.535 ± 0.039
1.005HisAsn: 1.005 ± 0.064
1.121HisPro: 1.121 ± 0.059
0.88HisGln: 0.88 ± 0.049
1.166HisArg: 1.166 ± 0.061
1.405HisSer: 1.405 ± 0.064
1.017HisThr: 1.017 ± 0.054
1.345HisVal: 1.345 ± 0.054
0.249HisTrp: 0.249 ± 0.026
0.86HisTyr: 0.86 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
7.435IleAla: 7.435 ± 0.137
1.015IleCys: 1.015 ± 0.054
4.816IleAsp: 4.816 ± 0.108
5.299IleGlu: 5.299 ± 0.128
3.874IlePhe: 3.874 ± 0.129
6.117IleGly: 6.117 ± 0.143
1.751IleHis: 1.751 ± 0.071
7.049IleIle: 7.049 ± 0.18
4.54IleLys: 4.54 ± 0.125
8.158IleLeu: 8.158 ± 0.199
1.85IleMet: 1.85 ± 0.079
3.946IleAsn: 3.946 ± 0.108
3.238IlePro: 3.238 ± 0.099
2.748IleGln: 2.748 ± 0.1
3.894IleArg: 3.894 ± 0.109
6.027IleSer: 6.027 ± 0.147
4.719IleThr: 4.719 ± 0.14
5.207IleVal: 5.207 ± 0.124
0.783IleTrp: 0.783 ± 0.046
2.263IleTyr: 2.263 ± 0.082
0.0IleXaa: 0.0 ± 0.0
Lys
5.028LysAla: 5.028 ± 0.144
0.463LysCys: 0.463 ± 0.039
3.16LysAsp: 3.16 ± 0.106
4.255LysGlu: 4.255 ± 0.129
1.803LysPhe: 1.803 ± 0.076
3.924LysGly: 3.924 ± 0.122
1.233LysHis: 1.233 ± 0.048
5.451LysIle: 5.451 ± 0.124
5.51LysLys: 5.51 ± 0.146
5.503LysLeu: 5.503 ± 0.127
1.756LysMet: 1.756 ± 0.076
3.998LysAsn: 3.998 ± 0.128
2.211LysPro: 2.211 ± 0.071
2.603LysGln: 2.603 ± 0.088
3.561LysArg: 3.561 ± 0.086
3.695LysSer: 3.695 ± 0.104
3.762LysThr: 3.762 ± 0.101
3.668LysVal: 3.668 ± 0.146
0.572LysTrp: 0.572 ± 0.037
1.39LysTyr: 1.39 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
7.977LeuAla: 7.977 ± 0.176
1.102LeuCys: 1.102 ± 0.062
4.978LeuAsp: 4.978 ± 0.118
5.749LeuGlu: 5.749 ± 0.132
4.463LeuPhe: 4.463 ± 0.142
6.04LeuGly: 6.04 ± 0.136
2.089LeuHis: 2.089 ± 0.075
7.82LeuIle: 7.82 ± 0.18
6.676LeuLys: 6.676 ± 0.143
9.277LeuLeu: 9.277 ± 0.199
2.367LeuMet: 2.367 ± 0.085
4.411LeuAsn: 4.411 ± 0.118
4.344LeuPro: 4.344 ± 0.116
3.72LeuGln: 3.72 ± 0.105
4.931LeuArg: 4.931 ± 0.126
8.134LeuSer: 8.134 ± 0.151
5.316LeuThr: 5.316 ± 0.121
5.682LeuVal: 5.682 ± 0.145
0.95LeuTrp: 0.95 ± 0.064
2.795LeuTyr: 2.795 ± 0.096
0.0LeuXaa: 0.0 ± 0.0
Met
1.997MetAla: 1.997 ± 0.064
0.199MetCys: 0.199 ± 0.022
1.005MetAsp: 1.005 ± 0.051
1.278MetGlu: 1.278 ± 0.054
0.828MetPhe: 0.828 ± 0.047
1.581MetGly: 1.581 ± 0.072
0.49MetHis: 0.49 ± 0.037
2.076MetIle: 2.076 ± 0.078
1.636MetLys: 1.636 ± 0.076
2.29MetLeu: 2.29 ± 0.07
0.751MetMet: 0.751 ± 0.047
1.248MetAsn: 1.248 ± 0.062
1.102MetPro: 1.102 ± 0.052
1.131MetGln: 1.131 ± 0.051
1.616MetArg: 1.616 ± 0.069
1.661MetSer: 1.661 ± 0.069
1.529MetThr: 1.529 ± 0.068
1.559MetVal: 1.559 ± 0.062
0.169MetTrp: 0.169 ± 0.02
0.398MetTyr: 0.398 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.862AsnAla: 3.862 ± 0.133
0.41AsnCys: 0.41 ± 0.032
2.385AsnAsp: 2.385 ± 0.075
2.835AsnGlu: 2.835 ± 0.105
2.126AsnPhe: 2.126 ± 0.083
3.133AsnGly: 3.133 ± 0.106
1.139AsnHis: 1.139 ± 0.059
4.272AsnIle: 4.272 ± 0.116
2.884AsnLys: 2.884 ± 0.099
4.379AsnLeu: 4.379 ± 0.117
1.149AsnMet: 1.149 ± 0.05
2.626AsnAsn: 2.626 ± 0.116
2.056AsnPro: 2.056 ± 0.072
1.882AsnGln: 1.882 ± 0.083
2.171AsnArg: 2.171 ± 0.074
2.832AsnSer: 2.832 ± 0.105
2.352AsnThr: 2.352 ± 0.107
2.795AsnVal: 2.795 ± 0.089
0.532AsnTrp: 0.532 ± 0.041
1.519AsnTyr: 1.519 ± 0.074
0.0AsnXaa: 0.0 ± 0.0
Pro
2.26ProAla: 2.26 ± 0.089
0.338ProCys: 0.338 ± 0.028
2.036ProAsp: 2.036 ± 0.07
2.556ProGlu: 2.556 ± 0.088
2.027ProPhe: 2.027 ± 0.07
2.22ProGly: 2.22 ± 0.089
1.017ProHis: 1.017 ± 0.053
3.2ProIle: 3.2 ± 0.093
2.181ProLys: 2.181 ± 0.094
3.717ProLeu: 3.717 ± 0.11
0.781ProMet: 0.781 ± 0.041
1.726ProAsn: 1.726 ± 0.075
1.432ProPro: 1.432 ± 0.073
1.619ProGln: 1.619 ± 0.07
1.584ProArg: 1.584 ± 0.061
2.29ProSer: 2.29 ± 0.067
2.124ProThr: 2.124 ± 0.083
2.514ProVal: 2.514 ± 0.081
0.37ProTrp: 0.37 ± 0.035
1.203ProTyr: 1.203 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
3.086GlnAla: 3.086 ± 0.104
0.385GlnCys: 0.385 ± 0.029
1.499GlnAsp: 1.499 ± 0.057
2.477GlnGlu: 2.477 ± 0.078
1.542GlnPhe: 1.542 ± 0.063
2.163GlnGly: 2.163 ± 0.081
0.843GlnHis: 0.843 ± 0.044
3.439GlnIle: 3.439 ± 0.101
3.352GlnLys: 3.352 ± 0.101
3.854GlnLeu: 3.854 ± 0.114
1.059GlnMet: 1.059 ± 0.052
2.138GlnAsn: 2.138 ± 0.081
1.226GlnPro: 1.226 ± 0.061
1.589GlnGln: 1.589 ± 0.067
2.248GlnArg: 2.248 ± 0.081
2.4GlnSer: 2.4 ± 0.085
2.168GlnThr: 2.168 ± 0.089
2.158GlnVal: 2.158 ± 0.082
0.495GlnTrp: 0.495 ± 0.033
1.01GlnTyr: 1.01 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
3.717ArgAla: 3.717 ± 0.105
0.5ArgCys: 0.5 ± 0.034
2.668ArgAsp: 2.668 ± 0.075
3.188ArgGlu: 3.188 ± 0.114
2.628ArgPhe: 2.628 ± 0.082
2.984ArgGly: 2.984 ± 0.108
1.124ArgHis: 1.124 ± 0.051
4.361ArgIle: 4.361 ± 0.113
3.031ArgLys: 3.031 ± 0.089
5.572ArgLeu: 5.572 ± 0.15
1.293ArgMet: 1.293 ± 0.058
2.228ArgAsn: 2.228 ± 0.072
1.673ArgPro: 1.673 ± 0.065
2.126ArgGln: 2.126 ± 0.08
2.862ArgArg: 2.862 ± 0.091
3.24ArgSer: 3.24 ± 0.105
2.283ArgThr: 2.283 ± 0.078
3.339ArgVal: 3.339 ± 0.1
0.517ArgTrp: 0.517 ± 0.039
1.741ArgTyr: 1.741 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
4.938SerAla: 4.938 ± 0.122
0.689SerCys: 0.689 ± 0.047
3.581SerAsp: 3.581 ± 0.089
3.722SerGlu: 3.722 ± 0.125
3.61SerPhe: 3.61 ± 0.09
4.938SerGly: 4.938 ± 0.151
1.437SerHis: 1.437 ± 0.064
5.1SerIle: 5.1 ± 0.123
3.528SerLys: 3.528 ± 0.108
7.079SerLeu: 7.079 ± 0.144
1.42SerMet: 1.42 ± 0.062
2.897SerAsn: 2.897 ± 0.112
2.419SerPro: 2.419 ± 0.098
2.412SerGln: 2.412 ± 0.073
2.969SerArg: 2.969 ± 0.093
4.864SerSer: 4.864 ± 0.136
3.295SerThr: 3.295 ± 0.148
4.389SerVal: 4.389 ± 0.133
0.699SerTrp: 0.699 ± 0.042
2.143SerTyr: 2.143 ± 0.074
0.0SerXaa: 0.0 ± 0.0
Thr
3.993ThrAla: 3.993 ± 0.105
0.453ThrCys: 0.453 ± 0.036
2.482ThrAsp: 2.482 ± 0.089
2.942ThrGlu: 2.942 ± 0.153
2.464ThrPhe: 2.464 ± 0.092
3.834ThrGly: 3.834 ± 0.112
1.213ThrHis: 1.213 ± 0.063
4.627ThrIle: 4.627 ± 0.108
2.904ThrLys: 2.904 ± 0.083
5.664ThrLeu: 5.664 ± 0.121
1.146ThrMet: 1.146 ± 0.053
2.439ThrAsn: 2.439 ± 0.107
2.335ThrPro: 2.335 ± 0.087
2.114ThrGln: 2.114 ± 0.085
2.201ThrArg: 2.201 ± 0.072
3.029ThrSer: 3.029 ± 0.103
3.034ThrThr: 3.034 ± 0.107
3.79ThrVal: 3.79 ± 0.114
0.395ThrTrp: 0.395 ± 0.032
1.457ThrTyr: 1.457 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
4.844ValAla: 4.844 ± 0.162
0.761ValCys: 0.761 ± 0.048
3.364ValAsp: 3.364 ± 0.102
4.026ValGlu: 4.026 ± 0.123
2.932ValPhe: 2.932 ± 0.106
4.202ValGly: 4.202 ± 0.143
1.303ValHis: 1.303 ± 0.063
5.202ValIle: 5.202 ± 0.119
3.561ValLys: 3.561 ± 0.107
5.786ValLeu: 5.786 ± 0.153
1.591ValMet: 1.591 ± 0.069
2.683ValAsn: 2.683 ± 0.105
2.355ValPro: 2.355 ± 0.082
2.303ValGln: 2.303 ± 0.079
3.238ValArg: 3.238 ± 0.101
4.578ValSer: 4.578 ± 0.123
3.28ValThr: 3.28 ± 0.098
4.252ValVal: 4.252 ± 0.119
0.48ValTrp: 0.48 ± 0.038
1.748ValTyr: 1.748 ± 0.075
0.0ValXaa: 0.0 ± 0.0
Trp
0.684TrpAla: 0.684 ± 0.043
0.154TrpCys: 0.154 ± 0.018
0.37TrpAsp: 0.37 ± 0.026
0.38TrpGlu: 0.38 ± 0.032
0.5TrpPhe: 0.5 ± 0.042
0.562TrpGly: 0.562 ± 0.039
0.276TrpHis: 0.276 ± 0.025
0.776TrpIle: 0.776 ± 0.041
0.689TrpLys: 0.689 ± 0.046
1.213TrpLeu: 1.213 ± 0.068
0.239TrpMet: 0.239 ± 0.025
0.505TrpAsn: 0.505 ± 0.035
0.375TrpPro: 0.375 ± 0.032
0.42TrpGln: 0.42 ± 0.036
0.671TrpArg: 0.671 ± 0.039
0.671TrpSer: 0.671 ± 0.05
0.472TrpThr: 0.472 ± 0.036
0.53TrpVal: 0.53 ± 0.043
0.186TrpTrp: 0.186 ± 0.023
0.318TrpTyr: 0.318 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.28TyrAla: 2.28 ± 0.082
0.373TyrCys: 0.373 ± 0.03
1.626TyrAsp: 1.626 ± 0.071
1.683TyrGlu: 1.683 ± 0.083
1.373TyrPhe: 1.373 ± 0.062
2.191TyrGly: 2.191 ± 0.091
0.731TyrHis: 0.731 ± 0.045
2.114TyrIle: 2.114 ± 0.076
1.666TyrLys: 1.666 ± 0.07
2.872TyrLeu: 2.872 ± 0.092
0.617TyrMet: 0.617 ± 0.04
1.452TyrAsn: 1.452 ± 0.072
1.119TyrPro: 1.119 ± 0.06
1.276TyrGln: 1.276 ± 0.058
1.604TyrArg: 1.604 ± 0.066
1.803TyrSer: 1.803 ± 0.066
1.452TyrThr: 1.452 ± 0.061
1.599TyrVal: 1.599 ± 0.069
0.346TyrTrp: 0.346 ± 0.03
0.87TyrTyr: 0.87 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1265 proteins (402163 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski