Amino acid dipepetide frequency for Mycobacterium phage Indlulamithi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.247AlaAla: 8.247 ± 0.899
0.27AlaCys: 0.27 ± 0.118
5.949AlaAsp: 5.949 ± 0.556
6.174AlaGlu: 6.174 ± 0.71
2.794AlaPhe: 2.794 ± 0.373
6.084AlaGly: 6.084 ± 0.813
1.577AlaHis: 1.577 ± 0.269
5.678AlaIle: 5.678 ± 0.564
5.228AlaLys: 5.228 ± 0.555
7.841AlaLeu: 7.841 ± 0.724
2.614AlaMet: 2.614 ± 0.302
3.966AlaAsn: 3.966 ± 0.33
3.2AlaPro: 3.2 ± 0.494
3.56AlaGln: 3.56 ± 0.487
5.047AlaArg: 5.047 ± 0.487
5.498AlaSer: 5.498 ± 0.802
5.318AlaThr: 5.318 ± 0.569
5.949AlaVal: 5.949 ± 0.507
1.127AlaTrp: 1.127 ± 0.287
2.659AlaTyr: 2.659 ± 0.272
0.0AlaXaa: 0.0 ± 0.0
Cys
0.766CysAla: 0.766 ± 0.255
0.135CysCys: 0.135 ± 0.101
0.946CysAsp: 0.946 ± 0.234
0.856CysGlu: 0.856 ± 0.228
0.225CysPhe: 0.225 ± 0.11
1.127CysGly: 1.127 ± 0.231
0.135CysHis: 0.135 ± 0.105
0.27CysIle: 0.27 ± 0.125
0.451CysLys: 0.451 ± 0.151
0.361CysLeu: 0.361 ± 0.118
0.135CysMet: 0.135 ± 0.076
0.315CysAsn: 0.315 ± 0.115
0.451CysPro: 0.451 ± 0.148
0.361CysGln: 0.361 ± 0.148
0.676CysArg: 0.676 ± 0.194
0.766CysSer: 0.766 ± 0.229
0.315CysThr: 0.315 ± 0.123
0.451CysVal: 0.451 ± 0.132
0.18CysTrp: 0.18 ± 0.087
0.721CysTyr: 0.721 ± 0.185
0.0CysXaa: 0.0 ± 0.0
Asp
6.084AspAla: 6.084 ± 0.637
0.901AspCys: 0.901 ± 0.291
5.949AspAsp: 5.949 ± 0.823
5.768AspGlu: 5.768 ± 0.642
2.569AspPhe: 2.569 ± 0.337
5.678AspGly: 5.678 ± 0.512
1.262AspHis: 1.262 ± 0.326
3.425AspIle: 3.425 ± 0.431
3.11AspLys: 3.11 ± 0.407
5.498AspLeu: 5.498 ± 0.424
1.487AspMet: 1.487 ± 0.314
2.118AspAsn: 2.118 ± 0.329
4.912AspPro: 4.912 ± 0.453
2.614AspGln: 2.614 ± 0.5
4.146AspArg: 4.146 ± 0.45
4.867AspSer: 4.867 ± 0.463
3.47AspThr: 3.47 ± 0.389
4.146AspVal: 4.146 ± 0.351
1.037AspTrp: 1.037 ± 0.207
2.614AspTyr: 2.614 ± 0.311
0.0AspXaa: 0.0 ± 0.0
Glu
5.002GluAla: 5.002 ± 0.503
0.856GluCys: 0.856 ± 0.236
4.642GluAsp: 4.642 ± 0.678
2.253GluGlu: 2.253 ± 0.363
2.388GluPhe: 2.388 ± 0.337
3.831GluGly: 3.831 ± 0.346
1.442GluHis: 1.442 ± 0.195
4.101GluIle: 4.101 ± 0.61
3.425GluLys: 3.425 ± 0.469
5.137GluLeu: 5.137 ± 0.559
1.352GluMet: 1.352 ± 0.246
2.388GluAsn: 2.388 ± 0.299
2.479GluPro: 2.479 ± 0.414
2.884GluGln: 2.884 ± 0.364
4.912GluArg: 4.912 ± 0.715
4.416GluSer: 4.416 ± 0.431
3.831GluThr: 3.831 ± 0.435
3.74GluVal: 3.74 ± 0.435
1.262GluTrp: 1.262 ± 0.317
2.163GluTyr: 2.163 ± 0.365
0.0GluXaa: 0.0 ± 0.0
Phe
3.29PheAla: 3.29 ± 0.364
0.406PheCys: 0.406 ± 0.162
3.245PheAsp: 3.245 ± 0.354
2.163PheGlu: 2.163 ± 0.383
1.127PhePhe: 1.127 ± 0.241
3.695PheGly: 3.695 ± 0.408
0.766PheHis: 0.766 ± 0.197
1.397PheIle: 1.397 ± 0.235
1.487PheLys: 1.487 ± 0.25
2.388PheLeu: 2.388 ± 0.317
0.766PheMet: 0.766 ± 0.202
2.073PheAsn: 2.073 ± 0.25
1.262PhePro: 1.262 ± 0.217
1.532PheGln: 1.532 ± 0.36
1.803PheArg: 1.803 ± 0.323
2.298PheSer: 2.298 ± 0.309
2.253PheThr: 2.253 ± 0.298
2.343PheVal: 2.343 ± 0.362
0.27PheTrp: 0.27 ± 0.105
1.037PheTyr: 1.037 ± 0.225
0.0PheXaa: 0.0 ± 0.0
Gly
5.858GlyAla: 5.858 ± 1.043
0.676GlyCys: 0.676 ± 0.173
4.957GlyAsp: 4.957 ± 0.438
4.101GlyGlu: 4.101 ± 0.446
3.245GlyPhe: 3.245 ± 0.499
7.526GlyGly: 7.526 ± 1.354
1.758GlyHis: 1.758 ± 0.311
5.678GlyIle: 5.678 ± 0.666
4.146GlyLys: 4.146 ± 0.427
4.822GlyLeu: 4.822 ± 0.68
2.163GlyMet: 2.163 ± 0.346
4.552GlyAsn: 4.552 ± 0.503
3.245GlyPro: 3.245 ± 0.446
5.137GlyGln: 5.137 ± 0.818
3.831GlyArg: 3.831 ± 0.417
4.507GlySer: 4.507 ± 0.51
5.183GlyThr: 5.183 ± 0.679
5.183GlyVal: 5.183 ± 0.591
1.397GlyTrp: 1.397 ± 0.249
2.704GlyTyr: 2.704 ± 0.455
0.0GlyXaa: 0.0 ± 0.0
His
1.397HisAla: 1.397 ± 0.243
0.18HisCys: 0.18 ± 0.087
1.532HisAsp: 1.532 ± 0.32
1.307HisGlu: 1.307 ± 0.252
0.541HisPhe: 0.541 ± 0.163
1.622HisGly: 1.622 ± 0.262
0.451HisHis: 0.451 ± 0.168
1.442HisIle: 1.442 ± 0.26
0.721HisLys: 0.721 ± 0.171
0.991HisLeu: 0.991 ± 0.256
0.811HisMet: 0.811 ± 0.176
0.496HisAsn: 0.496 ± 0.136
1.487HisPro: 1.487 ± 0.254
0.315HisGln: 0.315 ± 0.108
1.082HisArg: 1.082 ± 0.24
1.172HisSer: 1.172 ± 0.285
0.901HisThr: 0.901 ± 0.209
1.442HisVal: 1.442 ± 0.238
0.496HisTrp: 0.496 ± 0.152
0.766HisTyr: 0.766 ± 0.18
0.0HisXaa: 0.0 ± 0.0
Ile
5.453IleAla: 5.453 ± 0.608
0.496IleCys: 0.496 ± 0.155
4.326IleAsp: 4.326 ± 0.509
4.011IleGlu: 4.011 ± 0.443
1.397IlePhe: 1.397 ± 0.238
4.912IleGly: 4.912 ± 0.598
1.082IleHis: 1.082 ± 0.231
1.983IleIle: 1.983 ± 0.406
2.208IleLys: 2.208 ± 0.319
3.515IleLeu: 3.515 ± 0.458
0.721IleMet: 0.721 ± 0.164
1.893IleAsn: 1.893 ± 0.29
3.921IlePro: 3.921 ± 0.476
2.884IleGln: 2.884 ± 0.32
3.019IleArg: 3.019 ± 0.4
2.884IleSer: 2.884 ± 0.403
2.614IleThr: 2.614 ± 0.443
4.236IleVal: 4.236 ± 0.391
1.127IleTrp: 1.127 ± 0.214
1.037IleTyr: 1.037 ± 0.183
0.0IleXaa: 0.0 ± 0.0
Lys
6.174LysAla: 6.174 ± 0.764
0.586LysCys: 0.586 ± 0.158
3.2LysAsp: 3.2 ± 0.43
2.929LysGlu: 2.929 ± 0.425
1.667LysPhe: 1.667 ± 0.256
4.011LysGly: 4.011 ± 0.437
1.082LysHis: 1.082 ± 0.247
2.839LysIle: 2.839 ± 0.39
3.29LysLys: 3.29 ± 0.51
4.416LysLeu: 4.416 ± 0.469
1.352LysMet: 1.352 ± 0.279
1.532LysAsn: 1.532 ± 0.205
2.929LysPro: 2.929 ± 0.455
2.659LysGln: 2.659 ± 0.357
3.74LysArg: 3.74 ± 0.536
3.245LysSer: 3.245 ± 0.402
2.884LysThr: 2.884 ± 0.395
3.245LysVal: 3.245 ± 0.405
0.856LysTrp: 0.856 ± 0.21
1.397LysTyr: 1.397 ± 0.247
0.0LysXaa: 0.0 ± 0.0
Leu
6.985LeuAla: 6.985 ± 0.475
0.496LeuCys: 0.496 ± 0.149
5.092LeuAsp: 5.092 ± 0.455
4.507LeuGlu: 4.507 ± 0.51
2.524LeuPhe: 2.524 ± 0.338
5.228LeuGly: 5.228 ± 0.631
1.217LeuHis: 1.217 ± 0.237
4.056LeuIle: 4.056 ± 0.4
4.732LeuLys: 4.732 ± 0.462
5.363LeuLeu: 5.363 ± 0.511
1.397LeuMet: 1.397 ± 0.247
3.74LeuAsn: 3.74 ± 0.502
4.236LeuPro: 4.236 ± 0.375
3.38LeuGln: 3.38 ± 0.436
4.191LeuArg: 4.191 ± 0.494
5.408LeuSer: 5.408 ± 0.543
3.921LeuThr: 3.921 ± 0.589
4.507LeuVal: 4.507 ± 0.449
1.397LeuTrp: 1.397 ± 0.253
1.397LeuTyr: 1.397 ± 0.223
0.0LeuXaa: 0.0 ± 0.0
Met
2.884MetAla: 2.884 ± 0.364
0.18MetCys: 0.18 ± 0.085
1.442MetAsp: 1.442 ± 0.238
1.082MetGlu: 1.082 ± 0.259
0.676MetPhe: 0.676 ± 0.183
1.532MetGly: 1.532 ± 0.233
0.315MetHis: 0.315 ± 0.113
1.442MetIle: 1.442 ± 0.279
1.667MetLys: 1.667 ± 0.261
1.622MetLeu: 1.622 ± 0.296
0.856MetMet: 0.856 ± 0.216
0.991MetAsn: 0.991 ± 0.22
1.352MetPro: 1.352 ± 0.198
0.811MetGln: 0.811 ± 0.196
1.397MetArg: 1.397 ± 0.292
1.712MetSer: 1.712 ± 0.301
1.938MetThr: 1.938 ± 0.298
1.082MetVal: 1.082 ± 0.216
0.18MetTrp: 0.18 ± 0.096
0.541MetTyr: 0.541 ± 0.151
0.0MetXaa: 0.0 ± 0.0
Asn
4.056AsnAla: 4.056 ± 0.465
0.451AsnCys: 0.451 ± 0.144
2.569AsnAsp: 2.569 ± 0.432
2.749AsnGlu: 2.749 ± 0.373
1.667AsnPhe: 1.667 ± 0.383
3.74AsnGly: 3.74 ± 0.471
0.946AsnHis: 0.946 ± 0.195
1.532AsnIle: 1.532 ± 0.294
1.893AsnLys: 1.893 ± 0.267
2.659AsnLeu: 2.659 ± 0.355
0.721AsnMet: 0.721 ± 0.148
1.577AsnAsn: 1.577 ± 0.397
3.921AsnPro: 3.921 ± 0.452
1.803AsnGln: 1.803 ± 0.299
3.064AsnArg: 3.064 ± 0.383
2.388AsnSer: 2.388 ± 0.317
2.479AsnThr: 2.479 ± 0.347
3.335AsnVal: 3.335 ± 0.428
1.442AsnTrp: 1.442 ± 0.252
1.217AsnTyr: 1.217 ± 0.237
0.0AsnXaa: 0.0 ± 0.0
Pro
3.966ProAla: 3.966 ± 0.608
0.361ProCys: 0.361 ± 0.136
3.695ProAsp: 3.695 ± 0.488
4.236ProGlu: 4.236 ± 0.593
1.983ProPhe: 1.983 ± 0.264
4.056ProGly: 4.056 ± 0.445
0.856ProHis: 0.856 ± 0.23
2.208ProIle: 2.208 ± 0.292
3.425ProLys: 3.425 ± 0.428
3.2ProLeu: 3.2 ± 0.344
1.082ProMet: 1.082 ± 0.206
2.704ProAsn: 2.704 ± 0.325
3.019ProPro: 3.019 ± 0.308
2.073ProGln: 2.073 ± 0.327
2.479ProArg: 2.479 ± 0.365
2.794ProSer: 2.794 ± 0.342
3.876ProThr: 3.876 ± 0.501
3.29ProVal: 3.29 ± 0.502
1.307ProTrp: 1.307 ± 0.235
1.532ProTyr: 1.532 ± 0.261
0.0ProXaa: 0.0 ± 0.0
Gln
4.101GlnAla: 4.101 ± 0.591
0.541GlnCys: 0.541 ± 0.138
2.073GlnAsp: 2.073 ± 0.397
2.208GlnGlu: 2.208 ± 0.376
2.073GlnPhe: 2.073 ± 0.269
3.74GlnGly: 3.74 ± 0.622
0.586GlnHis: 0.586 ± 0.152
2.343GlnIle: 2.343 ± 0.405
2.118GlnLys: 2.118 ± 0.339
3.605GlnLeu: 3.605 ± 0.458
0.811GlnMet: 0.811 ± 0.206
2.073GlnAsn: 2.073 ± 0.431
2.028GlnPro: 2.028 ± 0.262
2.298GlnGln: 2.298 ± 0.605
3.155GlnArg: 3.155 ± 0.47
2.208GlnSer: 2.208 ± 0.353
2.434GlnThr: 2.434 ± 0.337
2.749GlnVal: 2.749 ± 0.352
0.631GlnTrp: 0.631 ± 0.169
1.082GlnTyr: 1.082 ± 0.229
0.0GlnXaa: 0.0 ± 0.0
Arg
4.191ArgAla: 4.191 ± 0.532
1.127ArgCys: 1.127 ± 0.263
3.74ArgAsp: 3.74 ± 0.475
4.461ArgGlu: 4.461 ± 0.66
2.479ArgPhe: 2.479 ± 0.37
4.056ArgGly: 4.056 ± 0.399
1.532ArgHis: 1.532 ± 0.295
3.515ArgIle: 3.515 ± 0.446
3.695ArgLys: 3.695 ± 0.542
4.552ArgLeu: 4.552 ± 0.466
1.622ArgMet: 1.622 ± 0.311
3.019ArgAsn: 3.019 ± 0.385
2.163ArgPro: 2.163 ± 0.401
2.479ArgGln: 2.479 ± 0.321
3.785ArgArg: 3.785 ± 0.483
2.614ArgSer: 2.614 ± 0.349
2.434ArgThr: 2.434 ± 0.311
3.831ArgVal: 3.831 ± 0.309
1.037ArgTrp: 1.037 ± 0.252
2.208ArgTyr: 2.208 ± 0.333
0.0ArgXaa: 0.0 ± 0.0
Ser
5.318SerAla: 5.318 ± 0.665
0.315SerCys: 0.315 ± 0.151
5.002SerAsp: 5.002 ± 0.456
3.335SerGlu: 3.335 ± 0.491
1.532SerPhe: 1.532 ± 0.265
6.084SerGly: 6.084 ± 0.52
1.082SerHis: 1.082 ± 0.242
3.064SerIle: 3.064 ± 0.422
3.29SerLys: 3.29 ± 0.447
4.236SerLeu: 4.236 ± 0.393
1.532SerMet: 1.532 ± 0.242
2.704SerAsn: 2.704 ± 0.375
2.749SerPro: 2.749 ± 0.486
1.893SerGln: 1.893 ± 0.324
2.524SerArg: 2.524 ± 0.328
2.298SerSer: 2.298 ± 0.347
4.011SerThr: 4.011 ± 0.401
4.281SerVal: 4.281 ± 0.386
1.037SerTrp: 1.037 ± 0.218
1.983SerTyr: 1.983 ± 0.266
0.0SerXaa: 0.0 ± 0.0
Thr
5.498ThrAla: 5.498 ± 0.721
0.541ThrCys: 0.541 ± 0.157
3.47ThrAsp: 3.47 ± 0.35
3.245ThrGlu: 3.245 ± 0.423
2.749ThrPhe: 2.749 ± 0.42
5.543ThrGly: 5.543 ± 0.675
0.721ThrHis: 0.721 ± 0.22
2.974ThrIle: 2.974 ± 0.333
3.2ThrLys: 3.2 ± 0.413
5.183ThrLeu: 5.183 ± 0.446
1.442ThrMet: 1.442 ± 0.273
2.749ThrAsn: 2.749 ± 0.541
2.749ThrPro: 2.749 ± 0.38
1.893ThrGln: 1.893 ± 0.382
2.614ThrArg: 2.614 ± 0.461
2.749ThrSer: 2.749 ± 0.347
3.56ThrThr: 3.56 ± 0.443
3.47ThrVal: 3.47 ± 0.411
1.397ThrTrp: 1.397 ± 0.267
1.712ThrTyr: 1.712 ± 0.318
0.0ThrXaa: 0.0 ± 0.0
Val
5.678ValAla: 5.678 ± 0.523
0.676ValCys: 0.676 ± 0.208
5.183ValAsp: 5.183 ± 0.559
3.65ValGlu: 3.65 ± 0.532
1.983ValPhe: 1.983 ± 0.319
4.642ValGly: 4.642 ± 0.417
1.037ValHis: 1.037 ± 0.225
3.515ValIle: 3.515 ± 0.584
3.876ValLys: 3.876 ± 0.434
4.507ValLeu: 4.507 ± 0.456
1.848ValMet: 1.848 ± 0.298
2.974ValAsn: 2.974 ± 0.338
3.831ValPro: 3.831 ± 0.394
2.434ValGln: 2.434 ± 0.428
3.921ValArg: 3.921 ± 0.516
3.785ValSer: 3.785 ± 0.37
3.515ValThr: 3.515 ± 0.381
4.101ValVal: 4.101 ± 0.606
1.037ValTrp: 1.037 ± 0.184
2.343ValTyr: 2.343 ± 0.302
0.0ValXaa: 0.0 ± 0.0
Trp
1.262TrpAla: 1.262 ± 0.232
0.27TrpCys: 0.27 ± 0.116
1.622TrpAsp: 1.622 ± 0.271
1.037TrpGlu: 1.037 ± 0.255
0.676TrpPhe: 0.676 ± 0.153
1.217TrpGly: 1.217 ± 0.248
0.676TrpHis: 0.676 ± 0.214
0.856TrpIle: 0.856 ± 0.171
0.811TrpLys: 0.811 ± 0.205
1.487TrpLeu: 1.487 ± 0.249
0.406TrpMet: 0.406 ± 0.158
1.262TrpAsn: 1.262 ± 0.225
0.721TrpPro: 0.721 ± 0.173
0.766TrpGln: 0.766 ± 0.18
1.082TrpArg: 1.082 ± 0.166
1.037TrpSer: 1.037 ± 0.261
0.901TrpThr: 0.901 ± 0.198
1.217TrpVal: 1.217 ± 0.187
0.225TrpTrp: 0.225 ± 0.115
0.541TrpTyr: 0.541 ± 0.16
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.569TyrAla: 2.569 ± 0.332
0.18TyrCys: 0.18 ± 0.094
3.019TyrAsp: 3.019 ± 0.373
2.434TyrGlu: 2.434 ± 0.396
1.307TyrPhe: 1.307 ± 0.294
2.343TyrGly: 2.343 ± 0.317
0.631TyrHis: 0.631 ± 0.162
1.397TyrIle: 1.397 ± 0.289
1.262TyrLys: 1.262 ± 0.251
2.388TyrLeu: 2.388 ± 0.36
0.541TyrMet: 0.541 ± 0.158
1.082TyrAsn: 1.082 ± 0.193
1.487TyrPro: 1.487 ± 0.304
1.082TyrGln: 1.082 ± 0.215
2.073TyrArg: 2.073 ± 0.303
1.622TyrSer: 1.622 ± 0.245
1.622TyrThr: 1.622 ± 0.343
1.938TyrVal: 1.938 ± 0.241
0.676TyrTrp: 0.676 ± 0.162
1.037TyrTyr: 1.037 ± 0.227
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 111 proteins (22191 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski