Amino acid dipepetide frequency for Escherichia phage Mu (Bacteriophage Mu)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.305AlaAla: 11.305 ± 1.245
0.665AlaCys: 0.665 ± 0.239
6.318AlaAsp: 6.318 ± 0.698
6.733AlaGlu: 6.733 ± 0.652
2.993AlaPhe: 2.993 ± 0.573
8.978AlaGly: 8.978 ± 1.114
1.247AlaHis: 1.247 ± 0.345
5.237AlaIle: 5.237 ± 0.576
3.491AlaLys: 3.491 ± 0.566
12.219AlaLeu: 12.219 ± 1.097
2.909AlaMet: 2.909 ± 0.553
3.076AlaAsn: 3.076 ± 0.551
3.242AlaPro: 3.242 ± 0.517
4.572AlaGln: 4.572 ± 0.611
7.564AlaArg: 7.564 ± 0.729
5.486AlaSer: 5.486 ± 0.635
4.572AlaThr: 4.572 ± 0.624
8.146AlaVal: 8.146 ± 0.89
1.579AlaTrp: 1.579 ± 0.331
1.663AlaTyr: 1.663 ± 0.473
0.0AlaXaa: 0.0 ± 0.0
Cys
1.164CysAla: 1.164 ± 0.329
0.333CysCys: 0.333 ± 0.16
0.333CysAsp: 0.333 ± 0.146
0.665CysGlu: 0.665 ± 0.245
0.333CysPhe: 0.333 ± 0.146
1.413CysGly: 1.413 ± 0.328
0.416CysHis: 0.416 ± 0.194
0.998CysIle: 0.998 ± 0.331
0.499CysLys: 0.499 ± 0.263
0.748CysLeu: 0.748 ± 0.219
0.416CysMet: 0.416 ± 0.166
0.582CysAsn: 0.582 ± 0.246
0.499CysPro: 0.499 ± 0.301
0.416CysGln: 0.416 ± 0.191
1.081CysArg: 1.081 ± 0.255
0.665CysSer: 0.665 ± 0.255
0.249CysThr: 0.249 ± 0.154
0.582CysVal: 0.582 ± 0.227
0.083CysTrp: 0.083 ± 0.079
0.416CysTyr: 0.416 ± 0.178
0.0CysXaa: 0.0 ± 0.0
Asp
6.733AspAla: 6.733 ± 0.838
0.748AspCys: 0.748 ± 0.251
3.99AspAsp: 3.99 ± 0.685
4.904AspGlu: 4.904 ± 0.625
1.912AspPhe: 1.912 ± 0.477
5.32AspGly: 5.32 ± 0.723
0.914AspHis: 0.914 ± 0.257
3.824AspIle: 3.824 ± 0.665
2.577AspLys: 2.577 ± 0.372
4.156AspLeu: 4.156 ± 0.722
1.247AspMet: 1.247 ± 0.398
2.743AspAsn: 2.743 ± 0.495
1.579AspPro: 1.579 ± 0.364
0.914AspGln: 0.914 ± 0.258
2.411AspArg: 2.411 ± 0.484
3.907AspSer: 3.907 ± 0.742
3.491AspThr: 3.491 ± 0.682
4.406AspVal: 4.406 ± 0.541
0.831AspTrp: 0.831 ± 0.277
1.579AspTyr: 1.579 ± 0.339
0.0AspXaa: 0.0 ± 0.0
Glu
5.071GluAla: 5.071 ± 0.869
1.081GluCys: 1.081 ± 0.297
2.993GluAsp: 2.993 ± 0.461
3.159GluGlu: 3.159 ± 0.563
1.413GluPhe: 1.413 ± 0.266
3.076GluGly: 3.076 ± 0.532
1.413GluHis: 1.413 ± 0.339
3.824GluIle: 3.824 ± 0.472
4.738GluLys: 4.738 ± 0.734
7.481GluLeu: 7.481 ± 0.821
3.491GluMet: 3.491 ± 0.83
2.909GluAsn: 2.909 ± 0.471
1.33GluPro: 1.33 ± 0.395
4.988GluGln: 4.988 ± 0.852
4.156GluArg: 4.156 ± 0.614
3.408GluSer: 3.408 ± 0.556
3.159GluThr: 3.159 ± 0.491
2.743GluVal: 2.743 ± 0.512
1.496GluTrp: 1.496 ± 0.379
1.995GluTyr: 1.995 ± 0.447
0.0GluXaa: 0.0 ± 0.0
Phe
2.244PheAla: 2.244 ± 0.437
0.249PheCys: 0.249 ± 0.191
1.995PheAsp: 1.995 ± 0.485
2.494PheGlu: 2.494 ± 0.525
0.748PhePhe: 0.748 ± 0.259
1.912PheGly: 1.912 ± 0.336
0.499PheHis: 0.499 ± 0.164
2.161PheIle: 2.161 ± 0.403
1.829PheLys: 1.829 ± 0.327
1.579PheLeu: 1.579 ± 0.364
0.748PheMet: 0.748 ± 0.284
1.746PheAsn: 1.746 ± 0.401
1.081PhePro: 1.081 ± 0.346
0.831PheGln: 0.831 ± 0.301
1.663PheArg: 1.663 ± 0.371
2.909PheSer: 2.909 ± 0.509
1.995PheThr: 1.995 ± 0.407
1.33PheVal: 1.33 ± 0.294
0.582PheTrp: 0.582 ± 0.187
0.831PheTyr: 0.831 ± 0.235
0.0PheXaa: 0.0 ± 0.0
Gly
5.736GlyAla: 5.736 ± 1.004
0.998GlyCys: 0.998 ± 0.285
5.486GlyAsp: 5.486 ± 0.64
4.073GlyGlu: 4.073 ± 0.567
2.244GlyPhe: 2.244 ± 0.416
6.567GlyGly: 6.567 ± 0.891
1.247GlyHis: 1.247 ± 0.347
3.907GlyIle: 3.907 ± 0.45
4.073GlyLys: 4.073 ± 0.455
6.318GlyLeu: 6.318 ± 0.789
1.746GlyMet: 1.746 ± 0.404
2.66GlyAsn: 2.66 ± 0.571
2.244GlyPro: 2.244 ± 0.523
3.076GlyGln: 3.076 ± 0.574
5.237GlyArg: 5.237 ± 0.662
3.907GlySer: 3.907 ± 0.734
4.073GlyThr: 4.073 ± 0.715
6.068GlyVal: 6.068 ± 0.887
2.993GlyTrp: 2.993 ± 0.523
2.411GlyTyr: 2.411 ± 0.454
0.0GlyXaa: 0.0 ± 0.0
His
0.998HisAla: 0.998 ± 0.254
0.582HisCys: 0.582 ± 0.276
1.247HisAsp: 1.247 ± 0.364
0.998HisGlu: 0.998 ± 0.267
0.416HisPhe: 0.416 ± 0.181
1.496HisGly: 1.496 ± 0.372
0.416HisHis: 0.416 ± 0.179
1.164HisIle: 1.164 ± 0.308
0.333HisLys: 0.333 ± 0.157
1.496HisLeu: 1.496 ± 0.365
0.166HisMet: 0.166 ± 0.111
0.665HisAsn: 0.665 ± 0.222
0.748HisPro: 0.748 ± 0.184
0.665HisGln: 0.665 ± 0.262
1.081HisArg: 1.081 ± 0.331
0.499HisSer: 0.499 ± 0.198
0.416HisThr: 0.416 ± 0.192
0.998HisVal: 0.998 ± 0.347
0.333HisTrp: 0.333 ± 0.156
0.499HisTyr: 0.499 ± 0.18
0.0HisXaa: 0.0 ± 0.0
Ile
4.904IleAla: 4.904 ± 0.575
0.831IleCys: 0.831 ± 0.342
3.574IleAsp: 3.574 ± 0.575
2.577IleGlu: 2.577 ± 0.53
1.663IlePhe: 1.663 ± 0.389
2.66IleGly: 2.66 ± 0.52
0.582IleHis: 0.582 ± 0.227
2.743IleIle: 2.743 ± 0.453
2.66IleLys: 2.66 ± 0.494
3.076IleLeu: 3.076 ± 0.401
0.914IleMet: 0.914 ± 0.28
3.159IleAsn: 3.159 ± 0.575
3.159IlePro: 3.159 ± 0.523
2.078IleGln: 2.078 ± 0.387
4.156IleArg: 4.156 ± 0.545
3.325IleSer: 3.325 ± 0.546
4.904IleThr: 4.904 ± 0.603
2.66IleVal: 2.66 ± 0.484
1.164IleTrp: 1.164 ± 0.35
1.663IleTyr: 1.663 ± 0.288
0.0IleXaa: 0.0 ± 0.0
Lys
5.154LysAla: 5.154 ± 0.675
0.416LysCys: 0.416 ± 0.205
2.244LysAsp: 2.244 ± 0.416
2.743LysGlu: 2.743 ± 0.483
1.164LysPhe: 1.164 ± 0.295
4.489LysGly: 4.489 ± 0.484
0.998LysHis: 0.998 ± 0.337
2.078LysIle: 2.078 ± 0.398
2.244LysLys: 2.244 ± 0.406
3.907LysLeu: 3.907 ± 0.61
1.33LysMet: 1.33 ± 0.424
2.411LysAsn: 2.411 ± 0.592
2.494LysPro: 2.494 ± 0.465
2.826LysGln: 2.826 ± 0.552
2.909LysArg: 2.909 ± 0.512
2.577LysSer: 2.577 ± 0.38
3.658LysThr: 3.658 ± 0.572
2.161LysVal: 2.161 ± 0.383
0.831LysTrp: 0.831 ± 0.331
1.33LysTyr: 1.33 ± 0.342
0.0LysXaa: 0.0 ± 0.0
Leu
9.227LeuAla: 9.227 ± 0.87
0.998LeuCys: 0.998 ± 0.275
4.988LeuAsp: 4.988 ± 0.558
5.902LeuGlu: 5.902 ± 0.864
2.494LeuPhe: 2.494 ± 0.495
6.151LeuGly: 6.151 ± 0.749
1.663LeuHis: 1.663 ± 0.412
3.99LeuIle: 3.99 ± 0.606
4.572LeuLys: 4.572 ± 0.585
7.897LeuLeu: 7.897 ± 0.726
2.494LeuMet: 2.494 ± 0.429
3.907LeuAsn: 3.907 ± 0.529
4.156LeuPro: 4.156 ± 0.53
3.408LeuGln: 3.408 ± 0.502
6.733LeuArg: 6.733 ± 0.763
7.897LeuSer: 7.897 ± 1.016
6.733LeuThr: 6.733 ± 0.731
4.323LeuVal: 4.323 ± 0.745
1.496LeuTrp: 1.496 ± 0.304
1.829LeuTyr: 1.829 ± 0.386
0.0LeuXaa: 0.0 ± 0.0
Met
3.491MetAla: 3.491 ± 0.664
0.416MetCys: 0.416 ± 0.173
1.746MetAsp: 1.746 ± 0.348
1.579MetGlu: 1.579 ± 0.323
0.914MetPhe: 0.914 ± 0.238
2.078MetGly: 2.078 ± 0.441
0.499MetHis: 0.499 ± 0.18
1.164MetIle: 1.164 ± 0.288
1.496MetLys: 1.496 ± 0.342
2.411MetLeu: 2.411 ± 0.412
0.499MetMet: 0.499 ± 0.179
2.328MetAsn: 2.328 ± 0.409
1.413MetPro: 1.413 ± 0.359
1.247MetGln: 1.247 ± 0.331
1.579MetArg: 1.579 ± 0.374
0.998MetSer: 0.998 ± 0.34
2.328MetThr: 2.328 ± 0.447
0.914MetVal: 0.914 ± 0.271
0.499MetTrp: 0.499 ± 0.18
0.333MetTyr: 0.333 ± 0.159
0.0MetXaa: 0.0 ± 0.0
Asn
4.738AsnAla: 4.738 ± 0.712
0.333AsnCys: 0.333 ± 0.188
2.244AsnAsp: 2.244 ± 0.43
2.577AsnGlu: 2.577 ± 0.489
0.748AsnPhe: 0.748 ± 0.249
4.323AsnGly: 4.323 ± 0.812
0.665AsnHis: 0.665 ± 0.283
2.743AsnIle: 2.743 ± 0.554
2.494AsnLys: 2.494 ± 0.369
2.743AsnLeu: 2.743 ± 0.455
1.413AsnMet: 1.413 ± 0.349
1.912AsnAsn: 1.912 ± 0.634
1.496AsnPro: 1.496 ± 0.352
1.746AsnGln: 1.746 ± 0.39
3.076AsnArg: 3.076 ± 0.472
1.995AsnSer: 1.995 ± 0.419
2.577AsnThr: 2.577 ± 0.567
3.076AsnVal: 3.076 ± 0.418
0.831AsnTrp: 0.831 ± 0.249
1.164AsnTyr: 1.164 ± 0.316
0.0AsnXaa: 0.0 ± 0.0
Pro
4.323ProAla: 4.323 ± 0.697
0.249ProCys: 0.249 ± 0.156
3.159ProAsp: 3.159 ± 0.43
3.491ProGlu: 3.491 ± 0.517
1.164ProPhe: 1.164 ± 0.341
2.743ProGly: 2.743 ± 0.458
0.083ProHis: 0.083 ± 0.077
0.748ProIle: 0.748 ± 0.228
2.078ProLys: 2.078 ± 0.407
3.242ProLeu: 3.242 ± 0.512
0.665ProMet: 0.665 ± 0.256
1.164ProAsn: 1.164 ± 0.358
1.746ProPro: 1.746 ± 0.325
1.829ProGln: 1.829 ± 0.351
3.159ProArg: 3.159 ± 0.561
3.159ProSer: 3.159 ± 0.387
1.413ProThr: 1.413 ± 0.369
3.741ProVal: 3.741 ± 0.503
0.416ProTrp: 0.416 ± 0.178
1.081ProTyr: 1.081 ± 0.304
0.0ProXaa: 0.0 ± 0.0
Gln
5.32GlnAla: 5.32 ± 0.529
0.249GlnCys: 0.249 ± 0.202
1.496GlnAsp: 1.496 ± 0.365
3.741GlnGlu: 3.741 ± 0.723
1.33GlnPhe: 1.33 ± 0.369
2.244GlnGly: 2.244 ± 0.399
0.166GlnHis: 0.166 ± 0.114
2.826GlnIle: 2.826 ± 0.528
2.577GlnLys: 2.577 ± 0.508
3.99GlnLeu: 3.99 ± 0.621
1.912GlnMet: 1.912 ± 0.335
1.912GlnAsn: 1.912 ± 0.372
2.494GlnPro: 2.494 ± 0.49
1.912GlnGln: 1.912 ± 0.412
3.242GlnArg: 3.242 ± 0.332
1.746GlnSer: 1.746 ± 0.381
2.161GlnThr: 2.161 ± 0.533
1.829GlnVal: 1.829 ± 0.307
0.748GlnTrp: 0.748 ± 0.222
1.413GlnTyr: 1.413 ± 0.308
0.0GlnXaa: 0.0 ± 0.0
Arg
6.65ArgAla: 6.65 ± 0.737
0.831ArgCys: 0.831 ± 0.362
4.489ArgAsp: 4.489 ± 0.598
5.902ArgGlu: 5.902 ± 0.927
2.577ArgPhe: 2.577 ± 0.48
3.159ArgGly: 3.159 ± 0.628
1.413ArgHis: 1.413 ± 0.436
3.824ArgIle: 3.824 ± 0.635
3.491ArgLys: 3.491 ± 0.553
7.149ArgLeu: 7.149 ± 0.68
1.912ArgMet: 1.912 ± 0.418
3.076ArgAsn: 3.076 ± 0.525
2.993ArgPro: 2.993 ± 0.465
3.658ArgGln: 3.658 ± 0.697
6.151ArgArg: 6.151 ± 0.742
2.826ArgSer: 2.826 ± 0.517
4.239ArgThr: 4.239 ± 0.609
4.239ArgVal: 4.239 ± 0.533
1.496ArgTrp: 1.496 ± 0.254
1.579ArgTyr: 1.579 ± 0.396
0.0ArgXaa: 0.0 ± 0.0
Ser
6.401SerAla: 6.401 ± 0.972
0.665SerCys: 0.665 ± 0.227
2.909SerAsp: 2.909 ± 0.535
2.66SerGlu: 2.66 ± 0.387
1.496SerPhe: 1.496 ± 0.343
5.736SerGly: 5.736 ± 0.863
0.499SerHis: 0.499 ± 0.201
3.076SerIle: 3.076 ± 0.449
2.078SerLys: 2.078 ± 0.428
5.819SerLeu: 5.819 ± 0.708
1.081SerMet: 1.081 ± 0.298
1.995SerAsn: 1.995 ± 0.417
1.746SerPro: 1.746 ± 0.312
2.328SerGln: 2.328 ± 0.358
5.819SerArg: 5.819 ± 0.599
2.826SerSer: 2.826 ± 0.502
4.073SerThr: 4.073 ± 0.439
4.323SerVal: 4.323 ± 0.569
1.081SerTrp: 1.081 ± 0.319
1.496SerTyr: 1.496 ± 0.326
0.0SerXaa: 0.0 ± 0.0
Thr
8.063ThrAla: 8.063 ± 1.251
0.582ThrCys: 0.582 ± 0.258
3.741ThrAsp: 3.741 ± 0.574
3.824ThrGlu: 3.824 ± 0.657
1.995ThrPhe: 1.995 ± 0.339
5.819ThrGly: 5.819 ± 0.702
0.748ThrHis: 0.748 ± 0.224
2.411ThrIle: 2.411 ± 0.452
2.494ThrLys: 2.494 ± 0.444
6.234ThrLeu: 6.234 ± 0.538
0.582ThrMet: 0.582 ± 0.196
1.413ThrAsn: 1.413 ± 0.334
2.66ThrPro: 2.66 ± 0.48
1.496ThrGln: 1.496 ± 0.406
3.99ThrArg: 3.99 ± 0.775
3.159ThrSer: 3.159 ± 0.486
3.741ThrThr: 3.741 ± 0.64
4.988ThrVal: 4.988 ± 0.773
1.247ThrTrp: 1.247 ± 0.321
1.579ThrTyr: 1.579 ± 0.31
0.0ThrXaa: 0.0 ± 0.0
Val
6.899ValAla: 6.899 ± 0.659
0.416ValCys: 0.416 ± 0.189
3.076ValAsp: 3.076 ± 0.531
3.907ValGlu: 3.907 ± 0.578
2.161ValPhe: 2.161 ± 0.353
3.408ValGly: 3.408 ± 0.553
0.748ValHis: 0.748 ± 0.214
3.491ValIle: 3.491 ± 0.569
2.826ValLys: 2.826 ± 0.531
5.32ValLeu: 5.32 ± 0.746
2.244ValMet: 2.244 ± 0.349
2.993ValAsn: 2.993 ± 0.506
2.494ValPro: 2.494 ± 0.473
2.244ValGln: 2.244 ± 0.426
4.073ValArg: 4.073 ± 0.432
4.406ValSer: 4.406 ± 0.598
4.988ValThr: 4.988 ± 0.876
4.323ValVal: 4.323 ± 0.605
0.914ValTrp: 0.914 ± 0.289
2.411ValTyr: 2.411 ± 0.407
0.0ValXaa: 0.0 ± 0.0
Trp
1.081TrpAla: 1.081 ± 0.249
0.831TrpCys: 0.831 ± 0.231
0.665TrpAsp: 0.665 ± 0.197
0.914TrpGlu: 0.914 ± 0.226
1.081TrpPhe: 1.081 ± 0.347
0.914TrpGly: 0.914 ± 0.232
0.333TrpHis: 0.333 ± 0.158
0.582TrpIle: 0.582 ± 0.281
0.665TrpLys: 0.665 ± 0.276
2.494TrpLeu: 2.494 ± 0.43
1.081TrpMet: 1.081 ± 0.319
0.998TrpAsn: 0.998 ± 0.334
0.914TrpPro: 0.914 ± 0.322
1.746TrpGln: 1.746 ± 0.353
1.247TrpArg: 1.247 ± 0.235
0.831TrpSer: 0.831 ± 0.274
0.998TrpThr: 0.998 ± 0.26
0.748TrpVal: 0.748 ± 0.226
0.166TrpTrp: 0.166 ± 0.113
0.665TrpTyr: 0.665 ± 0.194
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.494TyrAla: 2.494 ± 0.436
0.416TyrCys: 0.416 ± 0.173
1.496TyrAsp: 1.496 ± 0.396
1.081TyrGlu: 1.081 ± 0.294
0.582TyrPhe: 0.582 ± 0.217
2.577TyrGly: 2.577 ± 0.385
0.665TyrHis: 0.665 ± 0.198
1.663TyrIle: 1.663 ± 0.34
0.831TyrLys: 0.831 ± 0.275
2.577TyrLeu: 2.577 ± 0.468
0.998TyrMet: 0.998 ± 0.333
1.247TyrAsn: 1.247 ± 0.381
1.164TyrPro: 1.164 ± 0.361
1.33TyrGln: 1.33 ± 0.359
2.328TyrArg: 2.328 ± 0.414
1.579TyrSer: 1.579 ± 0.332
0.998TyrThr: 0.998 ± 0.295
1.746TyrVal: 1.746 ± 0.285
0.166TyrTrp: 0.166 ± 0.118
0.499TyrTyr: 0.499 ± 0.197
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (12031 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski