Amino acid dipepetide frequency for Photobacterium damselae subsp. piscicida DI21

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.457AlaAla: 5.457 ± 0.593
0.968AlaCys: 0.968 ± 0.188
3.345AlaAsp: 3.345 ± 0.285
3.55AlaGlu: 3.55 ± 0.365
3.257AlaPhe: 3.257 ± 0.297
3.579AlaGly: 3.579 ± 0.383
2.171AlaHis: 2.171 ± 0.322
5.956AlaIle: 5.956 ± 0.474
4.342AlaLys: 4.342 ± 0.413
8.127AlaLeu: 8.127 ± 0.632
1.614AlaMet: 1.614 ± 0.213
3.051AlaAsn: 3.051 ± 0.375
3.11AlaPro: 3.11 ± 0.47
4.019AlaGln: 4.019 ± 0.637
2.23AlaArg: 2.23 ± 0.27
4.9AlaSer: 4.9 ± 0.38
4.988AlaThr: 4.988 ± 0.535
3.726AlaVal: 3.726 ± 0.368
1.027AlaTrp: 1.027 ± 0.165
2.523AlaTyr: 2.523 ± 0.306
0.0AlaXaa: 0.0 ± 0.0
Cys
1.174CysAla: 1.174 ± 0.185
0.293CysCys: 0.293 ± 0.116
0.763CysAsp: 0.763 ± 0.144
0.792CysGlu: 0.792 ± 0.165
0.44CysPhe: 0.44 ± 0.125
0.91CysGly: 0.91 ± 0.194
0.411CysHis: 0.411 ± 0.113
0.998CysIle: 0.998 ± 0.167
0.557CysLys: 0.557 ± 0.124
1.115CysLeu: 1.115 ± 0.223
0.235CysMet: 0.235 ± 0.069
0.411CysAsn: 0.411 ± 0.131
0.528CysPro: 0.528 ± 0.128
0.616CysGln: 0.616 ± 0.171
0.792CysArg: 0.792 ± 0.161
1.115CysSer: 1.115 ± 0.156
0.44CysThr: 0.44 ± 0.138
0.821CysVal: 0.821 ± 0.154
0.088CysTrp: 0.088 ± 0.045
0.499CysTyr: 0.499 ± 0.122
0.0CysXaa: 0.0 ± 0.0
Asp
3.462AspAla: 3.462 ± 0.316
0.587AspCys: 0.587 ± 0.137
2.435AspAsp: 2.435 ± 0.239
2.699AspGlu: 2.699 ± 0.291
2.288AspPhe: 2.288 ± 0.298
3.169AspGly: 3.169 ± 0.319
1.438AspHis: 1.438 ± 0.196
3.902AspIle: 3.902 ± 0.358
3.462AspLys: 3.462 ± 0.418
5.017AspLeu: 5.017 ± 0.471
1.35AspMet: 1.35 ± 0.214
3.139AspAsn: 3.139 ± 0.334
2.2AspPro: 2.2 ± 0.243
2.2AspGln: 2.2 ± 0.252
1.995AspArg: 1.995 ± 0.277
4.372AspSer: 4.372 ± 0.419
2.934AspThr: 2.934 ± 0.292
3.11AspVal: 3.11 ± 0.348
0.88AspTrp: 0.88 ± 0.162
1.819AspTyr: 1.819 ± 0.312
0.0AspXaa: 0.0 ± 0.0
Glu
3.579GluAla: 3.579 ± 0.375
0.733GluCys: 0.733 ± 0.201
1.878GluAsp: 1.878 ± 0.249
3.022GluGlu: 3.022 ± 0.406
1.995GluPhe: 1.995 ± 0.301
2.083GluGly: 2.083 ± 0.216
1.379GluHis: 1.379 ± 0.239
3.521GluIle: 3.521 ± 0.337
4.225GluLys: 4.225 ± 0.456
6.719GluLeu: 6.719 ± 0.478
1.907GluMet: 1.907 ± 0.302
2.376GluAsn: 2.376 ± 0.306
1.76GluPro: 1.76 ± 0.232
3.491GluGln: 3.491 ± 0.461
2.729GluArg: 2.729 ± 0.254
3.315GluSer: 3.315 ± 0.321
3.198GluThr: 3.198 ± 0.301
2.67GluVal: 2.67 ± 0.276
0.733GluTrp: 0.733 ± 0.12
1.467GluTyr: 1.467 ± 0.231
0.0GluXaa: 0.0 ± 0.0
Phe
2.729PheAla: 2.729 ± 0.253
0.792PheCys: 0.792 ± 0.134
2.464PheAsp: 2.464 ± 0.277
2.347PheGlu: 2.347 ± 0.255
1.643PhePhe: 1.643 ± 0.254
3.081PheGly: 3.081 ± 0.235
0.91PheHis: 0.91 ± 0.132
2.875PheIle: 2.875 ± 0.359
2.817PheLys: 2.817 ± 0.386
3.521PheLeu: 3.521 ± 0.493
0.704PheMet: 0.704 ± 0.173
2.083PheAsn: 2.083 ± 0.251
1.027PhePro: 1.027 ± 0.156
0.968PheGln: 0.968 ± 0.161
1.76PheArg: 1.76 ± 0.299
3.521PheSer: 3.521 ± 0.381
2.23PheThr: 2.23 ± 0.305
2.406PheVal: 2.406 ± 0.264
0.381PheTrp: 0.381 ± 0.095
1.232PheTyr: 1.232 ± 0.255
0.0PheXaa: 0.0 ± 0.0
Gly
3.726GlyAla: 3.726 ± 0.381
0.733GlyCys: 0.733 ± 0.144
3.345GlyAsp: 3.345 ± 0.354
3.286GlyGlu: 3.286 ± 0.327
2.318GlyPhe: 2.318 ± 0.279
3.902GlyGly: 3.902 ± 0.369
1.35GlyHis: 1.35 ± 0.208
4.078GlyIle: 4.078 ± 0.415
3.638GlyLys: 3.638 ± 0.472
5.78GlyLeu: 5.78 ± 0.581
1.467GlyMet: 1.467 ± 0.219
3.433GlyAsn: 3.433 ± 0.318
1.027GlyPro: 1.027 ± 0.161
2.817GlyGln: 2.817 ± 0.335
3.051GlyArg: 3.051 ± 0.25
3.726GlySer: 3.726 ± 0.376
2.993GlyThr: 2.993 ± 0.3
3.697GlyVal: 3.697 ± 0.355
1.086GlyTrp: 1.086 ± 0.155
2.641GlyTyr: 2.641 ± 0.262
0.0GlyXaa: 0.0 ± 0.0
His
1.819HisAla: 1.819 ± 0.343
0.469HisCys: 0.469 ± 0.123
1.496HisAsp: 1.496 ± 0.205
0.968HisGlu: 0.968 ± 0.17
1.526HisPhe: 1.526 ± 0.205
1.467HisGly: 1.467 ± 0.212
1.144HisHis: 1.144 ± 0.194
1.848HisIle: 1.848 ± 0.23
1.027HisLys: 1.027 ± 0.181
3.227HisLeu: 3.227 ± 0.324
0.499HisMet: 0.499 ± 0.117
1.467HisAsn: 1.467 ± 0.2
0.998HisPro: 0.998 ± 0.182
1.32HisGln: 1.32 ± 0.338
1.35HisArg: 1.35 ± 0.219
2.024HisSer: 2.024 ± 0.269
1.379HisThr: 1.379 ± 0.211
1.291HisVal: 1.291 ± 0.201
0.704HisTrp: 0.704 ± 0.151
1.496HisTyr: 1.496 ± 0.254
0.0HisXaa: 0.0 ± 0.0
Ile
5.809IleAla: 5.809 ± 0.507
0.616IleCys: 0.616 ± 0.136
4.753IleAsp: 4.753 ± 0.357
5.017IleGlu: 5.017 ± 0.431
2.582IlePhe: 2.582 ± 0.323
4.284IleGly: 4.284 ± 0.438
1.32IleHis: 1.32 ± 0.173
3.814IleIle: 3.814 ± 0.532
3.902IleLys: 3.902 ± 0.469
5.076IleLeu: 5.076 ± 0.47
1.262IleMet: 1.262 ± 0.165
4.489IleAsn: 4.489 ± 0.399
2.435IlePro: 2.435 ± 0.22
2.905IleGln: 2.905 ± 0.323
2.875IleArg: 2.875 ± 0.301
5.545IleSer: 5.545 ± 0.552
3.931IleThr: 3.931 ± 0.422
3.697IleVal: 3.697 ± 0.394
0.557IleTrp: 0.557 ± 0.128
2.142IleTyr: 2.142 ± 0.278
0.0IleXaa: 0.0 ± 0.0
Lys
4.078LysAla: 4.078 ± 0.348
0.792LysCys: 0.792 ± 0.181
2.905LysAsp: 2.905 ± 0.356
3.374LysGlu: 3.374 ± 0.372
1.819LysPhe: 1.819 ± 0.315
3.609LysGly: 3.609 ± 0.439
1.496LysHis: 1.496 ± 0.185
3.433LysIle: 3.433 ± 0.428
5.105LysLys: 5.105 ± 0.735
5.574LysLeu: 5.574 ± 0.562
1.555LysMet: 1.555 ± 0.253
3.257LysAsn: 3.257 ± 0.452
3.257LysPro: 3.257 ± 0.411
3.374LysGln: 3.374 ± 0.216
4.489LysArg: 4.489 ± 0.664
3.55LysSer: 3.55 ± 0.35
3.902LysThr: 3.902 ± 0.442
3.374LysVal: 3.374 ± 0.42
0.792LysTrp: 0.792 ± 0.178
1.907LysTyr: 1.907 ± 0.288
0.0LysXaa: 0.0 ± 0.0
Leu
8.831LeuAla: 8.831 ± 0.849
1.614LeuCys: 1.614 ± 0.221
5.662LeuAsp: 5.662 ± 0.418
5.105LeuGlu: 5.105 ± 0.422
4.196LeuPhe: 4.196 ± 0.422
5.574LeuGly: 5.574 ± 0.471
1.995LeuHis: 1.995 ± 0.268
6.631LeuIle: 6.631 ± 0.51
5.574LeuLys: 5.574 ± 0.484
10.474LeuLeu: 10.474 ± 0.668
2.494LeuMet: 2.494 ± 0.371
5.398LeuAsn: 5.398 ± 0.508
4.812LeuPro: 4.812 ± 0.54
3.374LeuGln: 3.374 ± 0.409
5.017LeuArg: 5.017 ± 0.395
10.386LeuSer: 10.386 ± 0.772
6.543LeuThr: 6.543 ± 0.502
6.308LeuVal: 6.308 ± 0.57
1.115LeuTrp: 1.115 ± 0.19
2.963LeuTyr: 2.963 ± 0.331
0.0LeuXaa: 0.0 ± 0.0
Met
1.672MetAla: 1.672 ± 0.22
0.411MetCys: 0.411 ± 0.094
1.056MetAsp: 1.056 ± 0.209
1.027MetGlu: 1.027 ± 0.151
0.733MetPhe: 0.733 ± 0.136
1.614MetGly: 1.614 ± 0.183
0.792MetHis: 0.792 ± 0.166
1.614MetIle: 1.614 ± 0.256
1.555MetLys: 1.555 ± 0.308
2.083MetLeu: 2.083 ± 0.248
0.675MetMet: 0.675 ± 0.104
1.086MetAsn: 1.086 ± 0.179
0.91MetPro: 0.91 ± 0.188
0.733MetGln: 0.733 ± 0.179
0.851MetArg: 0.851 ± 0.147
1.848MetSer: 1.848 ± 0.246
1.907MetThr: 1.907 ± 0.236
1.174MetVal: 1.174 ± 0.249
0.117MetTrp: 0.117 ± 0.041
0.499MetTyr: 0.499 ± 0.136
0.0MetXaa: 0.0 ± 0.0
Asn
2.993AsnAla: 2.993 ± 0.312
0.821AsnCys: 0.821 ± 0.163
3.081AsnAsp: 3.081 ± 0.307
2.787AsnGlu: 2.787 ± 0.335
1.76AsnPhe: 1.76 ± 0.213
3.198AsnGly: 3.198 ± 0.427
1.232AsnHis: 1.232 ± 0.203
3.433AsnIle: 3.433 ± 0.424
3.638AsnLys: 3.638 ± 0.521
4.9AsnLeu: 4.9 ± 0.361
0.88AsnMet: 0.88 ± 0.168
2.67AsnAsn: 2.67 ± 0.425
2.347AsnPro: 2.347 ± 0.275
2.523AsnGln: 2.523 ± 0.275
1.79AsnArg: 1.79 ± 0.216
3.286AsnSer: 3.286 ± 0.367
3.315AsnThr: 3.315 ± 0.422
2.905AsnVal: 2.905 ± 0.215
0.763AsnTrp: 0.763 ± 0.121
1.995AsnTyr: 1.995 ± 0.314
0.0AsnXaa: 0.0 ± 0.0
Pro
2.758ProAla: 2.758 ± 0.471
0.528ProCys: 0.528 ± 0.118
2.523ProAsp: 2.523 ± 0.282
2.406ProGlu: 2.406 ± 0.27
1.086ProPhe: 1.086 ± 0.199
1.115ProGly: 1.115 ± 0.176
1.056ProHis: 1.056 ± 0.169
2.875ProIle: 2.875 ± 0.256
2.67ProLys: 2.67 ± 0.241
4.342ProLeu: 4.342 ± 0.39
0.763ProMet: 0.763 ± 0.144
1.878ProAsn: 1.878 ± 0.227
1.584ProPro: 1.584 ± 0.269
2.171ProGln: 2.171 ± 0.418
1.496ProArg: 1.496 ± 0.278
2.817ProSer: 2.817 ± 0.337
3.022ProThr: 3.022 ± 0.237
2.67ProVal: 2.67 ± 0.283
0.704ProTrp: 0.704 ± 0.165
1.467ProTyr: 1.467 ± 0.19
0.0ProXaa: 0.0 ± 0.0
Gln
4.049GlnAla: 4.049 ± 0.542
0.557GlnCys: 0.557 ± 0.143
2.553GlnAsp: 2.553 ± 0.414
2.23GlnGlu: 2.23 ± 0.233
2.112GlnPhe: 2.112 ± 0.211
2.817GlnGly: 2.817 ± 0.335
2.083GlnHis: 2.083 ± 0.322
3.227GlnIle: 3.227 ± 0.324
1.995GlnLys: 1.995 ± 0.299
5.574GlnLeu: 5.574 ± 0.585
0.968GlnMet: 0.968 ± 0.142
1.995GlnAsn: 1.995 ± 0.255
2.2GlnPro: 2.2 ± 0.407
4.372GlnGln: 4.372 ± 0.712
2.582GlnArg: 2.582 ± 0.314
3.667GlnSer: 3.667 ± 0.599
2.523GlnThr: 2.523 ± 0.312
3.081GlnVal: 3.081 ± 0.375
0.88GlnTrp: 0.88 ± 0.165
2.112GlnTyr: 2.112 ± 0.269
0.0GlnXaa: 0.0 ± 0.0
Arg
2.963ArgAla: 2.963 ± 0.356
0.763ArgCys: 0.763 ± 0.132
2.699ArgAsp: 2.699 ± 0.315
2.406ArgGlu: 2.406 ± 0.263
1.643ArgPhe: 1.643 ± 0.227
2.582ArgGly: 2.582 ± 0.386
1.819ArgHis: 1.819 ± 0.212
3.286ArgIle: 3.286 ± 0.31
3.345ArgLys: 3.345 ± 0.423
5.809ArgLeu: 5.809 ± 0.48
0.968ArgMet: 0.968 ± 0.191
1.819ArgAsn: 1.819 ± 0.197
1.614ArgPro: 1.614 ± 0.202
2.67ArgGln: 2.67 ± 0.303
1.643ArgArg: 1.643 ± 0.274
2.171ArgSer: 2.171 ± 0.246
2.112ArgThr: 2.112 ± 0.28
2.318ArgVal: 2.318 ± 0.314
0.616ArgTrp: 0.616 ± 0.131
2.905ArgTyr: 2.905 ± 0.464
0.0ArgXaa: 0.0 ± 0.0
Ser
5.252SerAla: 5.252 ± 0.458
0.645SerCys: 0.645 ± 0.152
3.227SerAsp: 3.227 ± 0.304
3.081SerGlu: 3.081 ± 0.335
3.667SerPhe: 3.667 ± 0.335
4.841SerGly: 4.841 ± 0.39
2.523SerHis: 2.523 ± 0.305
4.724SerIle: 4.724 ± 0.392
4.019SerLys: 4.019 ± 0.52
8.039SerLeu: 8.039 ± 0.74
1.408SerMet: 1.408 ± 0.188
3.521SerAsn: 3.521 ± 0.408
3.315SerPro: 3.315 ± 0.424
4.548SerGln: 4.548 ± 0.392
3.697SerArg: 3.697 ± 0.326
5.809SerSer: 5.809 ± 0.432
4.284SerThr: 4.284 ± 0.339
4.782SerVal: 4.782 ± 0.332
0.851SerTrp: 0.851 ± 0.139
2.787SerTyr: 2.787 ± 0.305
0.0SerXaa: 0.0 ± 0.0
Thr
3.814ThrAla: 3.814 ± 0.387
0.469ThrCys: 0.469 ± 0.115
2.875ThrAsp: 2.875 ± 0.301
3.286ThrGlu: 3.286 ± 0.309
2.083ThrPhe: 2.083 ± 0.253
3.873ThrGly: 3.873 ± 0.437
1.438ThrHis: 1.438 ± 0.221
3.315ThrIle: 3.315 ± 0.356
3.579ThrLys: 3.579 ± 0.384
7.628ThrLeu: 7.628 ± 0.503
1.467ThrMet: 1.467 ± 0.276
2.875ThrAsn: 2.875 ± 0.316
2.875ThrPro: 2.875 ± 0.391
3.315ThrGln: 3.315 ± 0.349
2.611ThrArg: 2.611 ± 0.267
4.372ThrSer: 4.372 ± 0.312
3.726ThrThr: 3.726 ± 0.428
3.873ThrVal: 3.873 ± 0.391
0.499ThrTrp: 0.499 ± 0.131
1.584ThrTyr: 1.584 ± 0.266
0.0ThrXaa: 0.0 ± 0.0
Val
4.665ValAla: 4.665 ± 0.422
0.557ValCys: 0.557 ± 0.097
2.905ValAsp: 2.905 ± 0.278
3.609ValGlu: 3.609 ± 0.347
2.406ValPhe: 2.406 ± 0.309
3.433ValGly: 3.433 ± 0.303
1.702ValHis: 1.702 ± 0.223
4.489ValIle: 4.489 ± 0.294
2.875ValLys: 2.875 ± 0.321
5.398ValLeu: 5.398 ± 0.461
1.115ValMet: 1.115 ± 0.165
3.139ValAsn: 3.139 ± 0.328
1.79ValPro: 1.79 ± 0.198
2.464ValGln: 2.464 ± 0.293
2.347ValArg: 2.347 ± 0.258
4.9ValSer: 4.9 ± 0.455
3.961ValThr: 3.961 ± 0.355
3.931ValVal: 3.931 ± 0.311
0.733ValTrp: 0.733 ± 0.154
1.907ValTyr: 1.907 ± 0.273
0.0ValXaa: 0.0 ± 0.0
Trp
0.616TrpAla: 0.616 ± 0.133
0.147TrpCys: 0.147 ± 0.064
0.645TrpAsp: 0.645 ± 0.137
0.499TrpGlu: 0.499 ± 0.14
0.352TrpPhe: 0.352 ± 0.088
0.733TrpGly: 0.733 ± 0.131
0.381TrpHis: 0.381 ± 0.102
0.587TrpIle: 0.587 ± 0.131
0.91TrpLys: 0.91 ± 0.154
1.966TrpLeu: 1.966 ± 0.255
0.352TrpMet: 0.352 ± 0.106
0.704TrpAsn: 0.704 ± 0.135
0.616TrpPro: 0.616 ± 0.118
1.203TrpGln: 1.203 ± 0.262
0.763TrpArg: 0.763 ± 0.149
1.144TrpSer: 1.144 ± 0.188
0.645TrpThr: 0.645 ± 0.138
0.675TrpVal: 0.675 ± 0.115
0.059TrpTrp: 0.059 ± 0.035
0.264TrpTyr: 0.264 ± 0.074
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.494TyrAla: 2.494 ± 0.256
0.499TyrCys: 0.499 ± 0.148
1.848TyrAsp: 1.848 ± 0.264
1.291TyrGlu: 1.291 ± 0.207
1.584TyrPhe: 1.584 ± 0.266
2.23TyrGly: 2.23 ± 0.286
0.88TyrHis: 0.88 ± 0.176
2.406TyrIle: 2.406 ± 0.404
2.435TyrLys: 2.435 ± 0.371
3.697TyrLeu: 3.697 ± 0.403
0.645TyrMet: 0.645 ± 0.158
1.526TyrAsn: 1.526 ± 0.323
1.526TyrPro: 1.526 ± 0.221
2.494TyrGln: 2.494 ± 0.256
2.083TyrArg: 2.083 ± 0.273
2.553TyrSer: 2.553 ± 0.321
1.526TyrThr: 1.526 ± 0.283
1.819TyrVal: 1.819 ± 0.204
0.675TyrTrp: 0.675 ± 0.2
1.291TyrTyr: 1.291 ± 0.227
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 110 proteins (34085 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski