Amino acid dipepetide frequency for Polaribacter reichenbachii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.931AlaAla: 3.931 ± 0.071	0.45AlaCys: 0.45 ± 0.022	3.379AlaAsp: 3.379 ± 0.058	3.562AlaGlu: 3.562 ± 0.064	3.153AlaPhe: 3.153 ± 0.054	3.663AlaGly: 3.663 ± 0.061	0.959AlaHis: 0.959 ± 0.027	5.47AlaIle: 5.47 ± 0.069	5.01AlaLys: 5.01 ± 0.068	5.358AlaLeu: 5.358 ± 0.078	1.26AlaMet: 1.26 ± 0.038	3.748AlaAsn: 3.748 ± 0.069	1.636AlaPro: 1.636 ± 0.035	2.074AlaGln: 2.074 ± 0.038	1.687AlaArg: 1.687 ± 0.038	3.935AlaSer: 3.935 ± 0.063	3.749AlaThr: 3.749 ± 0.064	3.65AlaVal: 3.65 ± 0.066	0.582AlaTrp: 0.582 ± 0.021	2.298AlaTyr: 2.298 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.381CysAla: 0.381 ± 0.018	0.073CysCys: 0.073 ± 0.008	0.404CysAsp: 0.404 ± 0.02	0.372CysGlu: 0.372 ± 0.017	0.393CysPhe: 0.393 ± 0.018	0.487CysGly: 0.487 ± 0.023	0.156CysHis: 0.156 ± 0.014	0.549CysIle: 0.549 ± 0.025	0.548CysLys: 0.548 ± 0.021	0.548CysLeu: 0.548 ± 0.021	0.107CysMet: 0.107 ± 0.009	0.396CysAsn: 0.396 ± 0.022	0.236CysPro: 0.236 ± 0.016	0.185CysGln: 0.185 ± 0.013	0.152CysArg: 0.152 ± 0.01	0.496CysSer: 0.496 ± 0.022	0.378CysThr: 0.378 ± 0.018	0.367CysVal: 0.367 ± 0.017	0.063CysTrp: 0.063 ± 0.007	0.263CysTyr: 0.263 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.714AspAla: 3.714 ± 0.063	0.369AspCys: 0.369 ± 0.018	3.182AspAsp: 3.182 ± 0.063	3.871AspGlu: 3.871 ± 0.068	3.982AspPhe: 3.982 ± 0.069	3.686AspGly: 3.686 ± 0.073	0.724AspHis: 0.724 ± 0.027	4.526AspIle: 4.526 ± 0.062	4.892AspLys: 4.892 ± 0.073	5.346AspLeu: 5.346 ± 0.074	0.918AspMet: 0.918 ± 0.026	3.481AspAsn: 3.481 ± 0.061	1.441AspPro: 1.441 ± 0.043	1.256AspGln: 1.256 ± 0.032	1.636AspArg: 1.636 ± 0.04	3.015AspSer: 3.015 ± 0.054	2.581AspThr: 2.581 ± 0.045	3.872AspVal: 3.872 ± 0.052	0.801AspTrp: 0.801 ± 0.028	2.806AspTyr: 2.806 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	3.825GluAla: 3.825 ± 0.064	0.297GluCys: 0.297 ± 0.016	3.465GluAsp: 3.465 ± 0.059	4.519GluGlu: 4.519 ± 0.079	3.195GluPhe: 3.195 ± 0.053	3.395GluGly: 3.395 ± 0.061	0.989GluHis: 0.989 ± 0.034	6.146GluIle: 6.146 ± 0.081	6.35GluLys: 6.35 ± 0.091	5.915GluLeu: 5.915 ± 0.092	1.414GluMet: 1.414 ± 0.036	5.465GluAsn: 5.465 ± 0.068	1.455GluPro: 1.455 ± 0.034	2.0GluGln: 2.0 ± 0.038	2.157GluArg: 2.157 ± 0.044	3.256GluSer: 3.256 ± 0.046	3.808GluThr: 3.808 ± 0.057	4.1GluVal: 4.1 ± 0.062	0.625GluTrp: 0.625 ± 0.026	2.413GluTyr: 2.413 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	2.893PheAla: 2.893 ± 0.051	0.412PheCys: 0.412 ± 0.018	3.438PheAsp: 3.438 ± 0.062	3.209PheGlu: 3.209 ± 0.053	2.974PhePhe: 2.974 ± 0.065	3.672PheGly: 3.672 ± 0.072	0.779PheHis: 0.779 ± 0.024	4.367PheIle: 4.367 ± 0.076	4.473PheLys: 4.473 ± 0.061	5.011PheLeu: 5.011 ± 0.083	1.069PheMet: 1.069 ± 0.03	3.891PheAsn: 3.891 ± 0.067	1.597PhePro: 1.597 ± 0.034	1.42PheGln: 1.42 ± 0.036	1.517PheArg: 1.517 ± 0.037	4.424PheSer: 4.424 ± 0.065	3.39PheThr: 3.39 ± 0.054	2.977PheVal: 2.977 ± 0.053	0.643PheTrp: 0.643 ± 0.024	2.44PheTyr: 2.44 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	3.926GlyAla: 3.926 ± 0.064	0.473GlyCys: 0.473 ± 0.021	3.266GlyAsp: 3.266 ± 0.059	3.329GlyGlu: 3.329 ± 0.059	3.813GlyPhe: 3.813 ± 0.055	4.336GlyGly: 4.336 ± 0.087	0.947GlyHis: 0.947 ± 0.029	5.402GlyIle: 5.402 ± 0.083	5.223GlyLys: 5.223 ± 0.079	5.385GlyLeu: 5.385 ± 0.076	1.359GlyMet: 1.359 ± 0.036	3.859GlyAsn: 3.859 ± 0.074	1.212GlyPro: 1.212 ± 0.031	1.663GlyGln: 1.663 ± 0.042	1.93GlyArg: 1.93 ± 0.044	3.835GlySer: 3.835 ± 0.078	3.802GlyThr: 3.802 ± 0.064	4.226GlyVal: 4.226 ± 0.06	0.742GlyTrp: 0.742 ± 0.029	2.695GlyTyr: 2.695 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	0.746HisAla: 0.746 ± 0.025	0.134HisCys: 0.134 ± 0.01	0.694HisAsp: 0.694 ± 0.023	0.77HisGlu: 0.77 ± 0.03	1.128HisPhe: 1.128 ± 0.032	0.825HisGly: 0.825 ± 0.027	0.445HisHis: 0.445 ± 0.024	1.397HisIle: 1.397 ± 0.037	1.419HisLys: 1.419 ± 0.034	1.589HisLeu: 1.589 ± 0.034	0.267HisMet: 0.267 ± 0.016	1.055HisAsn: 1.055 ± 0.035	0.843HisPro: 0.843 ± 0.032	0.809HisGln: 0.809 ± 0.027	0.605HisArg: 0.605 ± 0.024	1.005HisSer: 1.005 ± 0.031	0.894HisThr: 0.894 ± 0.029	0.657HisVal: 0.657 ± 0.024	0.216HisTrp: 0.216 ± 0.012	0.739HisTyr: 0.739 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.492IleAla: 5.492 ± 0.088	0.62IleCys: 0.62 ± 0.023	5.301IleAsp: 5.301 ± 0.074	5.534IleGlu: 5.534 ± 0.075	3.944IlePhe: 3.944 ± 0.066	4.988IleGly: 4.988 ± 0.075	1.363IleHis: 1.363 ± 0.035	6.814IleIle: 6.814 ± 0.105	7.031IleLys: 7.031 ± 0.081	7.425IleLeu: 7.425 ± 0.096	1.3IleMet: 1.3 ± 0.035	5.711IleAsn: 5.711 ± 0.084	3.215IlePro: 3.215 ± 0.06	2.559IleGln: 2.559 ± 0.048	2.428IleArg: 2.428 ± 0.05	6.134IleSer: 6.134 ± 0.078	5.144IleThr: 5.144 ± 0.071	4.786IleVal: 4.786 ± 0.065	0.757IleTrp: 0.757 ± 0.028	3.083IleTyr: 3.083 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.812LysAla: 4.812 ± 0.072	0.336LysCys: 0.336 ± 0.018	4.842LysAsp: 4.842 ± 0.072	7.325LysGlu: 7.325 ± 0.103	3.451LysPhe: 3.451 ± 0.059	4.992LysGly: 4.992 ± 0.064	1.454LysHis: 1.454 ± 0.034	7.504LysIle: 7.504 ± 0.096	8.578LysLys: 8.578 ± 0.125	6.998LysLeu: 6.998 ± 0.082	2.076LysMet: 2.076 ± 0.041	6.941LysAsn: 6.941 ± 0.097	2.596LysPro: 2.596 ± 0.049	2.801LysGln: 2.801 ± 0.054	2.909LysArg: 2.909 ± 0.063	5.245LysSer: 5.245 ± 0.064	5.38LysThr: 5.38 ± 0.073	5.189LysVal: 5.189 ± 0.067	0.909LysTrp: 0.909 ± 0.029	3.414LysTyr: 3.414 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	5.351LeuAla: 5.351 ± 0.091	0.579LeuCys: 0.579 ± 0.022	4.928LeuAsp: 4.928 ± 0.069	6.287LeuGlu: 6.287 ± 0.083	4.871LeuPhe: 4.871 ± 0.078	5.642LeuGly: 5.642 ± 0.077	1.41LeuHis: 1.41 ± 0.039	7.068LeuIle: 7.068 ± 0.102	8.524LeuLys: 8.524 ± 0.113	8.186LeuLeu: 8.186 ± 0.095	1.868LeuMet: 1.868 ± 0.041	6.202LeuAsn: 6.202 ± 0.081	3.184LeuPro: 3.184 ± 0.051	3.093LeuGln: 3.093 ± 0.054	2.769LeuArg: 2.769 ± 0.052	6.575LeuSer: 6.575 ± 0.077	4.909LeuThr: 4.909 ± 0.068	5.058LeuVal: 5.058 ± 0.07	0.782LeuTrp: 0.782 ± 0.028	3.096LeuTyr: 3.096 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.329MetAla: 1.329 ± 0.037	0.124MetCys: 0.124 ± 0.01	0.954MetAsp: 0.954 ± 0.028	1.085MetGlu: 1.085 ± 0.034	0.834MetPhe: 0.834 ± 0.026	1.182MetGly: 1.182 ± 0.035	0.363MetHis: 0.363 ± 0.019	1.49MetIle: 1.49 ± 0.034	2.09MetLys: 2.09 ± 0.037	1.771MetLeu: 1.771 ± 0.043	0.503MetMet: 0.503 ± 0.02	1.27MetAsn: 1.27 ± 0.029	0.739MetPro: 0.739 ± 0.026	0.742MetGln: 0.742 ± 0.022	0.726MetArg: 0.726 ± 0.027	1.287MetSer: 1.287 ± 0.027	0.946MetThr: 0.946 ± 0.027	1.145MetVal: 1.145 ± 0.031	0.174MetTrp: 0.174 ± 0.012	0.723MetTyr: 0.723 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.923AsnAla: 3.923 ± 0.06	0.447AsnCys: 0.447 ± 0.02	3.635AsnAsp: 3.635 ± 0.07	3.914AsnGlu: 3.914 ± 0.062	3.642AsnPhe: 3.642 ± 0.065	4.408AsnGly: 4.408 ± 0.085	1.205AsnHis: 1.205 ± 0.03	5.672AsnIle: 5.672 ± 0.071	5.507AsnLys: 5.507 ± 0.087	6.384AsnLeu: 6.384 ± 0.081	1.186AsnMet: 1.186 ± 0.03	5.094AsnAsn: 5.094 ± 0.093	2.885AsnPro: 2.885 ± 0.053	2.453AsnGln: 2.453 ± 0.052	2.101AsnArg: 2.101 ± 0.04	4.697AsnSer: 4.697 ± 0.083	4.139AsnThr: 4.139 ± 0.08	3.832AsnVal: 3.832 ± 0.061	0.964AsnTrp: 0.964 ± 0.029	3.427AsnTyr: 3.427 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	1.635ProAla: 1.635 ± 0.045	0.17ProCys: 0.17 ± 0.011	1.841ProAsp: 1.841 ± 0.041	2.556ProGlu: 2.556 ± 0.053	1.837ProPhe: 1.837 ± 0.035	1.637ProGly: 1.637 ± 0.041	0.559ProHis: 0.559 ± 0.024	2.713ProIle: 2.713 ± 0.042	2.828ProLys: 2.828 ± 0.057	2.655ProLeu: 2.655 ± 0.045	0.583ProMet: 0.583 ± 0.022	2.321ProAsn: 2.321 ± 0.044	0.627ProPro: 0.627 ± 0.024	0.899ProGln: 0.899 ± 0.031	0.864ProArg: 0.864 ± 0.026	1.965ProSer: 1.965 ± 0.046	1.983ProThr: 1.983 ± 0.046	1.988ProVal: 1.988 ± 0.046	0.367ProTrp: 0.367 ± 0.017	1.271ProTyr: 1.271 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.575GlnAla: 1.575 ± 0.037	0.146GlnCys: 0.146 ± 0.011	1.521GlnAsp: 1.521 ± 0.036	2.416GlnGlu: 2.416 ± 0.048	1.746GlnPhe: 1.746 ± 0.04	1.626GlnGly: 1.626 ± 0.038	0.538GlnHis: 0.538 ± 0.019	2.649GlnIle: 2.649 ± 0.048	3.016GlnLys: 3.016 ± 0.048	3.165GlnLeu: 3.165 ± 0.058	0.728GlnMet: 0.728 ± 0.026	2.27GlnAsn: 2.27 ± 0.048	0.965GlnPro: 0.965 ± 0.029	1.358GlnGln: 1.358 ± 0.04	1.045GlnArg: 1.045 ± 0.03	1.719GlnSer: 1.719 ± 0.034	1.764GlnThr: 1.764 ± 0.036	1.749GlnVal: 1.749 ± 0.039	0.325GlnTrp: 0.325 ± 0.017	1.242GlnTyr: 1.242 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	1.871ArgAla: 1.871 ± 0.049	0.151ArgCys: 0.151 ± 0.012	1.554ArgAsp: 1.554 ± 0.036	1.903ArgGlu: 1.903 ± 0.043	1.804ArgPhe: 1.804 ± 0.041	1.837ArgGly: 1.837 ± 0.044	0.49ArgHis: 0.49 ± 0.02	2.76ArgIle: 2.76 ± 0.052	2.913ArgLys: 2.913 ± 0.054	2.766ArgLeu: 2.766 ± 0.053	0.743ArgMet: 0.743 ± 0.022	2.063ArgAsn: 2.063 ± 0.037	0.952ArgPro: 0.952 ± 0.028	0.878ArgGln: 0.878 ± 0.03	1.172ArgArg: 1.172 ± 0.034	1.679ArgSer: 1.679 ± 0.036	1.807ArgThr: 1.807 ± 0.044	1.847ArgVal: 1.847 ± 0.039	0.36ArgTrp: 0.36 ± 0.019	1.3ArgTyr: 1.3 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	3.609SerAla: 3.609 ± 0.065	0.592SerCys: 0.592 ± 0.021	3.645SerAsp: 3.645 ± 0.057	4.248SerGlu: 4.248 ± 0.067	4.083SerPhe: 4.083 ± 0.059	4.316SerGly: 4.316 ± 0.069	0.965SerHis: 0.965 ± 0.032	5.59SerIle: 5.59 ± 0.069	5.602SerLys: 5.602 ± 0.077	6.066SerLeu: 6.066 ± 0.079	1.117SerMet: 1.117 ± 0.03	4.14SerAsn: 4.14 ± 0.067	1.946SerPro: 1.946 ± 0.046	1.885SerGln: 1.885 ± 0.042	1.999SerArg: 1.999 ± 0.046	4.512SerSer: 4.512 ± 0.066	3.782SerThr: 3.782 ± 0.065	3.935SerVal: 3.935 ± 0.055	0.803SerTrp: 0.803 ± 0.028	2.862SerTyr: 2.862 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.545ThrAla: 3.545 ± 0.061	0.325ThrCys: 0.325 ± 0.017	3.408ThrAsp: 3.408 ± 0.064	3.6ThrGlu: 3.6 ± 0.06	3.208ThrPhe: 3.208 ± 0.059	3.857ThrGly: 3.857 ± 0.059	0.962ThrHis: 0.962 ± 0.028	5.206ThrIle: 5.206 ± 0.075	4.656ThrLys: 4.656 ± 0.071	5.188ThrLeu: 5.188 ± 0.064	0.865ThrMet: 0.865 ± 0.026	3.829ThrAsn: 3.829 ± 0.067	2.18ThrPro: 2.18 ± 0.043	1.727ThrGln: 1.727 ± 0.038	1.518ThrArg: 1.518 ± 0.036	4.16ThrSer: 4.16 ± 0.063	3.657ThrThr: 3.657 ± 0.064	3.602ThrVal: 3.602 ± 0.058	0.681ThrTrp: 0.681 ± 0.028	2.392ThrTyr: 2.392 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	3.959ValAla: 3.959 ± 0.064	0.467ValCys: 0.467 ± 0.018	3.739ValAsp: 3.739 ± 0.063	3.506ValGlu: 3.506 ± 0.059	3.366ValPhe: 3.366 ± 0.067	3.593ValGly: 3.593 ± 0.062	0.913ValHis: 0.913 ± 0.029	4.695ValIle: 4.695 ± 0.066	4.644ValLys: 4.644 ± 0.074	5.838ValLeu: 5.838 ± 0.077	1.135ValMet: 1.135 ± 0.034	3.906ValAsn: 3.906 ± 0.062	1.885ValPro: 1.885 ± 0.041	1.58ValGln: 1.58 ± 0.039	1.773ValArg: 1.773 ± 0.044	4.331ValSer: 4.331 ± 0.058	3.399ValThr: 3.399 ± 0.05	3.895ValVal: 3.895 ± 0.064	0.663ValTrp: 0.663 ± 0.023	2.379ValTyr: 2.379 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.634TrpAla: 0.634 ± 0.027	0.088TrpCys: 0.088 ± 0.009	0.637TrpAsp: 0.637 ± 0.026	0.647TrpGlu: 0.647 ± 0.027	0.649TrpPhe: 0.649 ± 0.026	0.724TrpGly: 0.724 ± 0.026	0.214TrpHis: 0.214 ± 0.015	0.767TrpIle: 0.767 ± 0.027	0.869TrpLys: 0.869 ± 0.027	0.97TrpLeu: 0.97 ± 0.031	0.315TrpMet: 0.315 ± 0.018	0.831TrpAsn: 0.831 ± 0.028	0.244TrpPro: 0.244 ± 0.016	0.502TrpGln: 0.502 ± 0.021	0.408TrpArg: 0.408 ± 0.019	0.748TrpSer: 0.748 ± 0.03	0.574TrpThr: 0.574 ± 0.024	0.654TrpVal: 0.654 ± 0.027	0.183TrpTrp: 0.183 ± 0.013	0.488TrpTyr: 0.488 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.402TyrAla: 2.402 ± 0.048	0.304TyrCys: 0.304 ± 0.016	2.267TyrAsp: 2.267 ± 0.047	2.136TyrGlu: 2.136 ± 0.047	2.522TyrPhe: 2.522 ± 0.05	2.556TyrGly: 2.556 ± 0.055	0.8TyrHis: 0.8 ± 0.025	2.85TyrIle: 2.85 ± 0.05	3.579TyrLys: 3.579 ± 0.061	3.816TyrLeu: 3.816 ± 0.061	0.661TyrMet: 0.661 ± 0.023	3.042TyrAsn: 3.042 ± 0.059	1.463TyrPro: 1.463 ± 0.03	1.68TyrGln: 1.68 ± 0.045	1.453TyrArg: 1.453 ± 0.035	2.679TyrSer: 2.679 ± 0.053	2.48TyrThr: 2.48 ± 0.049	2.136TyrVal: 2.136 ± 0.043	0.506TyrTrp: 0.506 ± 0.021	1.872TyrTyr: 1.872 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3418 proteins (1227233 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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