Amino acid dipepetide frequency for Bovine ephemeral fever virus (BEFV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.832AlaAla: 0.832 ± 0.66
0.624AlaCys: 0.624 ± 0.393
1.248AlaAsp: 1.248 ± 0.628
1.04AlaGlu: 1.04 ± 0.352
1.04AlaPhe: 1.04 ± 0.455
1.248AlaGly: 1.248 ± 0.537
0.832AlaHis: 0.832 ± 0.347
3.328AlaIle: 3.328 ± 0.907
1.872AlaLys: 1.872 ± 0.538
2.288AlaLeu: 2.288 ± 0.849
0.832AlaMet: 0.832 ± 0.461
2.496AlaAsn: 2.496 ± 0.564
1.04AlaPro: 1.04 ± 0.603
0.832AlaGln: 0.832 ± 0.528
1.456AlaArg: 1.456 ± 0.542
2.288AlaSer: 2.288 ± 0.886
0.832AlaThr: 0.832 ± 0.323
2.704AlaVal: 2.704 ± 0.957
0.208AlaTrp: 0.208 ± 0.198
1.04AlaTyr: 1.04 ± 0.456
0.0AlaXaa: 0.0 ± 0.0
Cys
0.208CysAla: 0.208 ± 0.228
0.0CysCys: 0.0 ± 0.0
0.624CysAsp: 0.624 ± 0.286
0.416CysGlu: 0.416 ± 0.204
0.832CysPhe: 0.832 ± 0.404
1.248CysGly: 1.248 ± 0.392
1.248CysHis: 1.248 ± 0.657
0.624CysIle: 0.624 ± 0.209
1.248CysLys: 1.248 ± 0.805
3.12CysLeu: 3.12 ± 0.841
0.416CysMet: 0.416 ± 0.453
1.456CysAsn: 1.456 ± 0.937
0.832CysPro: 0.832 ± 0.558
0.624CysGln: 0.624 ± 0.235
1.04CysArg: 1.04 ± 0.413
1.456CysSer: 1.456 ± 0.644
1.456CysThr: 1.456 ± 0.678
1.04CysVal: 1.04 ± 0.34
1.04CysTrp: 1.04 ± 0.429
0.832CysTyr: 0.832 ± 0.347
0.0CysXaa: 0.0 ± 0.0
Asp
1.872AspAla: 1.872 ± 0.906
0.624AspCys: 0.624 ± 0.274
3.328AspAsp: 3.328 ± 1.641
5.2AspGlu: 5.2 ± 1.176
1.872AspPhe: 1.872 ± 0.433
2.704AspGly: 2.704 ± 0.733
0.832AspHis: 0.832 ± 0.375
3.12AspIle: 3.12 ± 1.024
4.992AspLys: 4.992 ± 1.178
7.696AspLeu: 7.696 ± 1.532
2.08AspMet: 2.08 ± 0.577
3.12AspAsn: 3.12 ± 0.662
1.456AspPro: 1.456 ± 0.493
2.704AspGln: 2.704 ± 0.478
1.664AspArg: 1.664 ± 0.416
2.496AspSer: 2.496 ± 0.599
1.456AspThr: 1.456 ± 1.087
3.744AspVal: 3.744 ± 1.182
1.248AspTrp: 1.248 ± 0.444
3.952AspTyr: 3.952 ± 0.638
0.0AspXaa: 0.0 ± 0.0
Glu
1.04GluAla: 1.04 ± 0.443
1.456GluCys: 1.456 ± 0.377
6.032GluAsp: 6.032 ± 0.903
7.903GluGlu: 7.903 ± 0.963
4.368GluPhe: 4.368 ± 0.48
4.992GluGly: 4.992 ± 0.852
1.248GluHis: 1.248 ± 0.533
8.111GluIle: 8.111 ± 1.542
6.864GluLys: 6.864 ± 1.416
8.111GluLeu: 8.111 ± 0.867
1.04GluMet: 1.04 ± 0.647
3.952GluAsn: 3.952 ± 1.23
1.456GluPro: 1.456 ± 0.385
1.04GluGln: 1.04 ± 0.463
4.16GluArg: 4.16 ± 0.753
6.656GluSer: 6.656 ± 0.907
2.08GluThr: 2.08 ± 0.848
3.328GluVal: 3.328 ± 0.811
0.832GluTrp: 0.832 ± 0.258
3.12GluTyr: 3.12 ± 0.851
0.208GluXaa: 0.208 ± 0.228
Phe
0.416PheAla: 0.416 ± 0.25
1.248PheCys: 1.248 ± 0.522
1.872PheAsp: 1.872 ± 0.407
2.912PheGlu: 2.912 ± 1.114
2.912PhePhe: 2.912 ± 0.674
3.328PheGly: 3.328 ± 1.171
0.416PheHis: 0.416 ± 0.472
3.328PheIle: 3.328 ± 0.6
4.16PheLys: 4.16 ± 1.272
3.744PheLeu: 3.744 ± 0.908
0.832PheMet: 0.832 ± 0.341
1.456PheAsn: 1.456 ± 0.52
1.04PhePro: 1.04 ± 0.625
1.456PheGln: 1.456 ± 0.349
2.288PheArg: 2.288 ± 0.656
2.288PheSer: 2.288 ± 0.601
2.496PheThr: 2.496 ± 0.71
2.08PheVal: 2.08 ± 0.697
0.832PheTrp: 0.832 ± 0.563
1.248PheTyr: 1.248 ± 0.346
0.0PheXaa: 0.0 ± 0.0
Gly
1.248GlyAla: 1.248 ± 0.441
1.664GlyCys: 1.664 ± 0.795
2.704GlyAsp: 2.704 ± 1.117
4.992GlyGlu: 4.992 ± 0.921
2.704GlyPhe: 2.704 ± 0.633
3.536GlyGly: 3.536 ± 0.603
1.664GlyHis: 1.664 ± 0.487
4.992GlyIle: 4.992 ± 0.864
3.744GlyLys: 3.744 ± 0.812
6.864GlyLeu: 6.864 ± 1.565
1.664GlyMet: 1.664 ± 0.568
2.08GlyAsn: 2.08 ± 0.673
0.416GlyPro: 0.416 ± 0.25
0.624GlyGln: 0.624 ± 0.375
3.328GlyArg: 3.328 ± 1.38
3.952GlySer: 3.952 ± 0.7
3.536GlyThr: 3.536 ± 0.68
2.704GlyVal: 2.704 ± 0.615
0.832GlyTrp: 0.832 ± 0.374
1.872GlyTyr: 1.872 ± 0.295
0.0GlyXaa: 0.0 ± 0.0
His
1.04HisAla: 1.04 ± 0.489
0.208HisCys: 0.208 ± 0.198
0.832HisAsp: 0.832 ± 0.401
1.664HisGlu: 1.664 ± 0.709
1.04HisPhe: 1.04 ± 0.63
1.456HisGly: 1.456 ± 0.443
1.04HisHis: 1.04 ± 0.3
1.872HisIle: 1.872 ± 0.508
2.08HisLys: 2.08 ± 0.471
1.872HisLeu: 1.872 ± 0.378
0.624HisMet: 0.624 ± 0.239
2.288HisAsn: 2.288 ± 0.826
1.248HisPro: 1.248 ± 0.258
0.208HisGln: 0.208 ± 0.35
1.456HisArg: 1.456 ± 0.423
1.04HisSer: 1.04 ± 0.37
0.624HisThr: 0.624 ± 0.563
1.456HisVal: 1.456 ± 0.551
0.416HisTrp: 0.416 ± 0.204
1.248HisTyr: 1.248 ± 0.392
0.0HisXaa: 0.0 ± 0.0
Ile
1.664IleAla: 1.664 ± 0.503
2.496IleCys: 2.496 ± 0.578
4.576IleAsp: 4.576 ± 0.489
5.616IleGlu: 5.616 ± 1.299
2.496IlePhe: 2.496 ± 0.717
3.744IleGly: 3.744 ± 0.701
1.664IleHis: 1.664 ± 1.08
8.735IleIle: 8.735 ± 0.988
11.023IleLys: 11.023 ± 1.223
7.696IleLeu: 7.696 ± 1.218
1.456IleMet: 1.456 ± 0.482
7.488IleAsn: 7.488 ± 1.15
2.912IlePro: 2.912 ± 0.558
2.496IleGln: 2.496 ± 0.489
4.992IleArg: 4.992 ± 0.843
5.616IleSer: 5.616 ± 0.875
2.704IleThr: 2.704 ± 0.955
2.912IleVal: 2.912 ± 0.705
0.832IleTrp: 0.832 ± 0.233
4.16IleTyr: 4.16 ± 0.763
0.0IleXaa: 0.0 ± 0.0
Lys
2.912LysAla: 2.912 ± 0.539
2.288LysCys: 2.288 ± 0.644
5.408LysAsp: 5.408 ± 0.662
7.072LysGlu: 7.072 ± 1.017
2.704LysPhe: 2.704 ± 0.729
6.032LysGly: 6.032 ± 1.571
1.664LysHis: 1.664 ± 0.342
7.28LysIle: 7.28 ± 0.804
7.072LysLys: 7.072 ± 1.222
9.151LysLeu: 9.151 ± 1.261
1.664LysMet: 1.664 ± 0.344
6.656LysAsn: 6.656 ± 1.04
3.536LysPro: 3.536 ± 0.658
2.08LysGln: 2.08 ± 0.665
4.368LysArg: 4.368 ± 0.98
7.28LysSer: 7.28 ± 0.87
3.744LysThr: 3.744 ± 1.031
2.704LysVal: 2.704 ± 0.778
0.832LysTrp: 0.832 ± 0.233
2.496LysTyr: 2.496 ± 0.938
0.0LysXaa: 0.0 ± 0.0
Leu
4.16LeuAla: 4.16 ± 0.534
1.456LeuCys: 1.456 ± 0.789
7.903LeuAsp: 7.903 ± 1.668
8.735LeuGlu: 8.735 ± 1.748
3.536LeuPhe: 3.536 ± 0.655
5.408LeuGly: 5.408 ± 1.25
2.08LeuHis: 2.08 ± 0.552
8.527LeuIle: 8.527 ± 1.269
7.072LeuLys: 7.072 ± 1.212
7.903LeuLeu: 7.903 ± 1.468
3.12LeuMet: 3.12 ± 1.049
6.032LeuAsn: 6.032 ± 1.109
2.08LeuPro: 2.08 ± 0.568
4.992LeuGln: 4.992 ± 0.838
5.824LeuArg: 5.824 ± 1.868
7.072LeuSer: 7.072 ± 0.881
5.616LeuThr: 5.616 ± 1.173
4.16LeuVal: 4.16 ± 0.683
1.456LeuTrp: 1.456 ± 0.432
2.704LeuTyr: 2.704 ± 0.577
0.0LeuXaa: 0.0 ± 0.0
Met
1.04MetAla: 1.04 ± 0.506
0.416MetCys: 0.416 ± 0.25
1.872MetAsp: 1.872 ± 0.531
2.288MetGlu: 2.288 ± 0.842
1.872MetPhe: 1.872 ± 0.722
1.248MetGly: 1.248 ± 0.472
0.208MetHis: 0.208 ± 0.198
2.288MetIle: 2.288 ± 0.748
1.456MetLys: 1.456 ± 0.364
1.664MetLeu: 1.664 ± 0.745
1.664MetMet: 1.664 ± 0.598
1.872MetAsn: 1.872 ± 0.398
1.248MetPro: 1.248 ± 0.449
0.416MetGln: 0.416 ± 0.319
0.624MetArg: 0.624 ± 0.36
2.288MetSer: 2.288 ± 0.556
1.248MetThr: 1.248 ± 0.431
1.664MetVal: 1.664 ± 0.418
0.208MetTrp: 0.208 ± 0.125
0.416MetTyr: 0.416 ± 0.376
0.0MetXaa: 0.0 ± 0.0
Asn
1.872AsnAla: 1.872 ± 0.917
1.248AsnCys: 1.248 ± 0.294
3.952AsnAsp: 3.952 ± 0.639
2.704AsnGlu: 2.704 ± 0.557
3.536AsnPhe: 3.536 ± 0.43
3.12AsnGly: 3.12 ± 1.029
1.872AsnHis: 1.872 ± 0.517
5.2AsnIle: 5.2 ± 0.533
6.032AsnLys: 6.032 ± 0.626
8.735AsnLeu: 8.735 ± 1.032
1.456AsnMet: 1.456 ± 0.422
5.2AsnAsn: 5.2 ± 1.073
2.288AsnPro: 2.288 ± 0.487
3.536AsnGln: 3.536 ± 0.504
2.496AsnArg: 2.496 ± 0.907
3.12AsnSer: 3.12 ± 0.76
2.912AsnThr: 2.912 ± 0.489
2.704AsnVal: 2.704 ± 1.164
2.288AsnTrp: 2.288 ± 0.623
3.328AsnTyr: 3.328 ± 1.009
0.0AsnXaa: 0.0 ± 0.0
Pro
1.04ProAla: 1.04 ± 0.466
0.624ProCys: 0.624 ± 0.224
2.288ProAsp: 2.288 ± 0.578
2.08ProGlu: 2.08 ± 0.636
0.832ProPhe: 0.832 ± 0.407
1.04ProGly: 1.04 ± 0.844
1.04ProHis: 1.04 ± 0.3
2.08ProIle: 2.08 ± 0.586
2.496ProLys: 2.496 ± 0.604
2.496ProLeu: 2.496 ± 0.53
0.832ProMet: 0.832 ± 0.343
1.456ProAsn: 1.456 ± 0.542
1.664ProPro: 1.664 ± 0.727
1.248ProGln: 1.248 ± 0.546
1.04ProArg: 1.04 ± 0.392
1.664ProSer: 1.664 ± 0.569
2.288ProThr: 2.288 ± 0.654
2.08ProVal: 2.08 ± 0.527
0.624ProTrp: 0.624 ± 0.336
2.08ProTyr: 2.08 ± 0.522
0.0ProXaa: 0.0 ± 0.0
Gln
1.248GlnAla: 1.248 ± 0.676
0.624GlnCys: 0.624 ± 0.315
0.832GlnAsp: 0.832 ± 0.323
3.744GlnGlu: 3.744 ± 1.169
1.248GlnPhe: 1.248 ± 0.492
1.456GlnGly: 1.456 ± 0.311
0.416GlnHis: 0.416 ± 0.408
2.704GlnIle: 2.704 ± 0.746
2.288GlnLys: 2.288 ± 0.719
1.872GlnLeu: 1.872 ± 0.496
0.624GlnMet: 0.624 ± 0.296
3.12GlnAsn: 3.12 ± 0.948
0.624GlnPro: 0.624 ± 0.375
0.624GlnGln: 0.624 ± 0.375
1.456GlnArg: 1.456 ± 0.471
2.08GlnSer: 2.08 ± 0.682
2.288GlnThr: 2.288 ± 0.482
0.624GlnVal: 0.624 ± 0.309
0.416GlnTrp: 0.416 ± 0.346
0.624GlnTyr: 0.624 ± 0.257
0.0GlnXaa: 0.0 ± 0.0
Arg
1.664ArgAla: 1.664 ± 0.801
1.664ArgCys: 1.664 ± 0.79
2.08ArgAsp: 2.08 ± 0.627
4.784ArgGlu: 4.784 ± 1.294
2.704ArgPhe: 2.704 ± 0.441
4.368ArgGly: 4.368 ± 1.446
0.624ArgHis: 0.624 ± 0.375
2.912ArgIle: 2.912 ± 0.765
2.912ArgLys: 2.912 ± 0.596
3.744ArgLeu: 3.744 ± 0.935
1.04ArgMet: 1.04 ± 0.695
3.536ArgAsn: 3.536 ± 0.561
2.496ArgPro: 2.496 ± 0.671
0.832ArgGln: 0.832 ± 0.27
2.912ArgArg: 2.912 ± 0.775
4.368ArgSer: 4.368 ± 0.659
2.08ArgThr: 2.08 ± 0.704
3.744ArgVal: 3.744 ± 0.664
0.832ArgTrp: 0.832 ± 0.31
1.04ArgTyr: 1.04 ± 0.466
0.208ArgXaa: 0.208 ± 0.125
Ser
1.872SerAla: 1.872 ± 0.438
1.248SerCys: 1.248 ± 0.374
3.536SerAsp: 3.536 ± 0.773
4.784SerGlu: 4.784 ± 0.94
2.496SerPhe: 2.496 ± 0.605
3.12SerGly: 3.12 ± 1.041
2.704SerHis: 2.704 ± 0.337
7.28SerIle: 7.28 ± 1.31
6.448SerLys: 6.448 ± 1.344
7.28SerLeu: 7.28 ± 1.812
1.664SerMet: 1.664 ± 0.546
4.992SerAsn: 4.992 ± 1.258
1.664SerPro: 1.664 ± 0.476
2.08SerGln: 2.08 ± 1.089
2.496SerArg: 2.496 ± 0.371
7.28SerSer: 7.28 ± 1.366
3.536SerThr: 3.536 ± 1.176
2.288SerVal: 2.288 ± 0.779
1.664SerTrp: 1.664 ± 0.418
3.744SerTyr: 3.744 ± 1.509
0.0SerXaa: 0.0 ± 0.0
Thr
1.04ThrAla: 1.04 ± 0.51
0.208ThrCys: 0.208 ± 0.228
2.496ThrAsp: 2.496 ± 0.91
4.368ThrGlu: 4.368 ± 0.85
0.624ThrPhe: 0.624 ± 0.209
2.288ThrGly: 2.288 ± 0.546
0.832ThrHis: 0.832 ± 0.292
3.536ThrIle: 3.536 ± 0.619
4.368ThrLys: 4.368 ± 1.017
3.744ThrLeu: 3.744 ± 1.14
1.04ThrMet: 1.04 ± 0.502
2.704ThrAsn: 2.704 ± 0.827
1.04ThrPro: 1.04 ± 0.486
0.208ThrGln: 0.208 ± 0.125
1.872ThrArg: 1.872 ± 0.638
4.16ThrSer: 4.16 ± 0.717
1.248ThrThr: 1.248 ± 0.374
3.744ThrVal: 3.744 ± 0.613
1.664ThrTrp: 1.664 ± 0.54
2.912ThrTyr: 2.912 ± 0.701
0.0ThrXaa: 0.0 ± 0.0
Val
1.248ValAla: 1.248 ± 0.727
0.416ValCys: 0.416 ± 0.25
2.08ValAsp: 2.08 ± 0.682
2.288ValGlu: 2.288 ± 0.492
1.872ValPhe: 1.872 ± 0.531
2.496ValGly: 2.496 ± 0.528
1.248ValHis: 1.248 ± 0.326
3.952ValIle: 3.952 ± 0.748
5.616ValLys: 5.616 ± 1.191
4.368ValLeu: 4.368 ± 0.734
2.496ValMet: 2.496 ± 0.812
3.12ValAsn: 3.12 ± 0.827
1.664ValPro: 1.664 ± 0.505
0.832ValGln: 0.832 ± 0.423
3.328ValArg: 3.328 ± 0.75
3.536ValSer: 3.536 ± 0.746
2.912ValThr: 2.912 ± 0.594
0.832ValVal: 0.832 ± 0.522
1.248ValTrp: 1.248 ± 0.522
1.04ValTyr: 1.04 ± 0.725
0.0ValXaa: 0.0 ± 0.0
Trp
0.416TrpAla: 0.416 ± 0.372
0.832TrpCys: 0.832 ± 0.233
0.624TrpAsp: 0.624 ± 0.309
2.288TrpGlu: 2.288 ± 0.643
0.832TrpPhe: 0.832 ± 0.226
1.04TrpGly: 1.04 ± 0.324
0.208TrpHis: 0.208 ± 0.125
2.704TrpIle: 2.704 ± 0.417
1.248TrpLys: 1.248 ± 0.41
1.248TrpLeu: 1.248 ± 0.563
0.208TrpMet: 0.208 ± 0.125
1.872TrpAsn: 1.872 ± 0.371
0.416TrpPro: 0.416 ± 0.25
0.416TrpGln: 0.416 ± 0.204
0.416TrpArg: 0.416 ± 0.204
1.456TrpSer: 1.456 ± 0.635
0.208TrpThr: 0.208 ± 0.198
0.832TrpVal: 0.832 ± 0.424
0.416TrpTrp: 0.416 ± 0.349
1.04TrpTyr: 1.04 ± 0.616
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.248TyrAla: 1.248 ± 0.307
0.416TyrCys: 0.416 ± 0.348
1.872TyrAsp: 1.872 ± 0.639
3.12TyrGlu: 3.12 ± 0.681
0.832TyrPhe: 0.832 ± 0.374
1.04TyrGly: 1.04 ± 0.309
1.872TyrHis: 1.872 ± 0.376
2.496TyrIle: 2.496 ± 1.125
3.952TyrLys: 3.952 ± 0.645
6.448TyrLeu: 6.448 ± 1.118
1.04TyrMet: 1.04 ± 0.554
2.704TyrAsn: 2.704 ± 0.899
1.872TyrPro: 1.872 ± 0.654
1.664TyrGln: 1.664 ± 0.395
3.328TyrArg: 3.328 ± 0.675
2.08TyrSer: 2.08 ± 0.517
0.832TyrThr: 0.832 ± 0.27
1.248TyrVal: 1.248 ± 0.497
0.832TyrTrp: 0.832 ± 0.39
1.664TyrTyr: 1.664 ± 0.365
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.208XaaGly: 0.208 ± 0.228
0.0XaaHis: 0.0 ± 0.0
0.208XaaIle: 0.208 ± 0.125
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.208XaaXaa: 0.208 ± 0.228
Statistics based on 12 proteins (4809 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski