Amino acid dipepetide frequency for Sulfolobus ellipsoid virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.289AlaCys: 0.289 ± 0.167
1.446AlaAsp: 1.446 ± 0.512
1.012AlaGlu: 1.012 ± 0.362
2.892AlaPhe: 2.892 ± 0.541
2.313AlaGly: 2.313 ± 0.517
0.723AlaHis: 0.723 ± 0.348
6.217AlaIle: 6.217 ± 0.774
2.892AlaLys: 2.892 ± 0.905
4.772AlaLeu: 4.772 ± 0.981
1.301AlaMet: 1.301 ± 0.449
3.759AlaAsn: 3.759 ± 0.867
1.301AlaPro: 1.301 ± 0.513
1.012AlaGln: 1.012 ± 0.431
0.868AlaArg: 0.868 ± 0.508
3.904AlaSer: 3.904 ± 0.799
3.181AlaThr: 3.181 ± 0.705
2.603AlaVal: 2.603 ± 0.631
0.434AlaTrp: 0.434 ± 0.199
3.759AlaTyr: 3.759 ± 0.792
0.0AlaXaa: 0.0 ± 0.0
Cys
0.289CysAla: 0.289 ± 0.19
0.0CysCys: 0.0 ± 0.0
0.145CysAsp: 0.145 ± 0.149
0.868CysGlu: 0.868 ± 0.437
0.434CysPhe: 0.434 ± 0.245
0.868CysGly: 0.868 ± 0.38
0.0CysHis: 0.0 ± 0.0
0.434CysIle: 0.434 ± 0.232
1.012CysLys: 1.012 ± 0.402
0.868CysLeu: 0.868 ± 0.358
0.0CysMet: 0.0 ± 0.0
1.157CysAsn: 1.157 ± 0.403
1.012CysPro: 1.012 ± 0.58
0.434CysGln: 0.434 ± 0.203
0.145CysArg: 0.145 ± 0.146
0.723CysSer: 0.723 ± 0.452
0.578CysThr: 0.578 ± 0.303
0.434CysVal: 0.434 ± 0.278
0.0CysTrp: 0.0 ± 0.0
1.446CysTyr: 1.446 ± 0.498
0.0CysXaa: 0.0 ± 0.0
Asp
2.603AspAla: 2.603 ± 0.428
0.868AspCys: 0.868 ± 0.481
1.591AspAsp: 1.591 ± 0.485
2.603AspGlu: 2.603 ± 0.821
2.458AspPhe: 2.458 ± 0.87
2.747AspGly: 2.747 ± 0.596
0.868AspHis: 0.868 ± 0.382
4.772AspIle: 4.772 ± 0.613
2.313AspLys: 2.313 ± 0.716
4.193AspLeu: 4.193 ± 1.044
1.301AspMet: 1.301 ± 0.434
3.036AspAsn: 3.036 ± 0.507
2.747AspPro: 2.747 ± 0.668
0.434AspGln: 0.434 ± 0.217
0.868AspArg: 0.868 ± 0.354
1.88AspSer: 1.88 ± 0.499
2.892AspThr: 2.892 ± 0.689
2.892AspVal: 2.892 ± 0.548
0.289AspTrp: 0.289 ± 0.198
2.747AspTyr: 2.747 ± 0.71
0.0AspXaa: 0.0 ± 0.0
Glu
1.446GluAla: 1.446 ± 0.562
1.157GluCys: 1.157 ± 0.435
2.603GluAsp: 2.603 ± 0.653
3.036GluGlu: 3.036 ± 0.786
1.157GluPhe: 1.157 ± 0.358
2.458GluGly: 2.458 ± 0.494
0.434GluHis: 0.434 ± 0.239
5.205GluIle: 5.205 ± 1.061
5.061GluLys: 5.061 ± 1.344
4.916GluLeu: 4.916 ± 0.893
1.591GluMet: 1.591 ± 0.555
3.759GluAsn: 3.759 ± 0.602
1.012GluPro: 1.012 ± 0.391
1.446GluGln: 1.446 ± 0.6
2.458GluArg: 2.458 ± 0.774
2.747GluSer: 2.747 ± 0.603
1.88GluThr: 1.88 ± 0.55
3.326GluVal: 3.326 ± 0.915
1.012GluTrp: 1.012 ± 0.423
2.313GluTyr: 2.313 ± 0.869
0.0GluXaa: 0.0 ± 0.0
Phe
1.735PheAla: 1.735 ± 0.35
0.434PheCys: 0.434 ± 0.268
2.458PheAsp: 2.458 ± 0.489
1.012PheGlu: 1.012 ± 0.442
3.181PhePhe: 3.181 ± 0.99
2.313PheGly: 2.313 ± 0.495
0.723PheHis: 0.723 ± 0.246
4.627PheIle: 4.627 ± 0.768
3.47PheLys: 3.47 ± 1.019
5.061PheLeu: 5.061 ± 0.974
0.868PheMet: 0.868 ± 0.388
2.603PheAsn: 2.603 ± 0.713
1.591PhePro: 1.591 ± 0.493
1.735PheGln: 1.735 ± 0.519
1.157PheArg: 1.157 ± 0.587
3.036PheSer: 3.036 ± 0.693
3.326PheThr: 3.326 ± 0.584
2.169PheVal: 2.169 ± 0.414
0.578PheTrp: 0.578 ± 0.23
4.338PheTyr: 4.338 ± 0.691
0.0PheXaa: 0.0 ± 0.0
Gly
3.181GlyAla: 3.181 ± 0.64
0.578GlyCys: 0.578 ± 0.303
1.88GlyAsp: 1.88 ± 0.457
3.181GlyGlu: 3.181 ± 0.724
3.181GlyPhe: 3.181 ± 0.87
3.326GlyGly: 3.326 ± 0.657
0.723GlyHis: 0.723 ± 0.324
5.495GlyIle: 5.495 ± 0.835
4.049GlyLys: 4.049 ± 1.14
4.627GlyLeu: 4.627 ± 0.875
0.868GlyMet: 0.868 ± 0.338
4.193GlyAsn: 4.193 ± 0.804
0.578GlyPro: 0.578 ± 0.266
2.169GlyGln: 2.169 ± 0.759
0.723GlyArg: 0.723 ± 0.239
4.482GlySer: 4.482 ± 0.842
2.024GlyThr: 2.024 ± 0.596
5.061GlyVal: 5.061 ± 0.699
0.289GlyTrp: 0.289 ± 0.161
4.627GlyTyr: 4.627 ± 0.924
0.0GlyXaa: 0.0 ± 0.0
His
0.723HisAla: 0.723 ± 0.216
0.145HisCys: 0.145 ± 0.12
0.434HisAsp: 0.434 ± 0.273
0.723HisGlu: 0.723 ± 0.305
0.434HisPhe: 0.434 ± 0.216
0.145HisGly: 0.145 ± 0.12
0.289HisHis: 0.289 ± 0.194
1.591HisIle: 1.591 ± 0.522
1.012HisLys: 1.012 ± 0.442
0.723HisLeu: 0.723 ± 0.339
0.289HisMet: 0.289 ± 0.205
0.434HisAsn: 0.434 ± 0.208
0.434HisPro: 0.434 ± 0.257
0.0HisGln: 0.0 ± 0.0
0.289HisArg: 0.289 ± 0.198
0.578HisSer: 0.578 ± 0.4
1.157HisThr: 1.157 ± 0.416
1.157HisVal: 1.157 ± 0.595
0.145HisTrp: 0.145 ± 0.161
0.578HisTyr: 0.578 ± 0.278
0.0HisXaa: 0.0 ± 0.0
Ile
4.916IleAla: 4.916 ± 0.854
0.578IleCys: 0.578 ± 0.329
4.338IleAsp: 4.338 ± 0.98
4.916IleGlu: 4.916 ± 0.947
4.049IlePhe: 4.049 ± 0.75
5.784IleGly: 5.784 ± 1.166
1.157IleHis: 1.157 ± 0.426
6.94IleIle: 6.94 ± 0.912
6.651IleLys: 6.651 ± 1.171
8.82IleLeu: 8.82 ± 1.08
2.313IleMet: 2.313 ± 0.557
5.495IleAsn: 5.495 ± 0.973
4.338IlePro: 4.338 ± 0.629
2.747IleGln: 2.747 ± 0.702
3.326IleArg: 3.326 ± 0.711
6.217IleSer: 6.217 ± 0.813
6.362IleThr: 6.362 ± 1.198
5.784IleVal: 5.784 ± 0.778
0.723IleTrp: 0.723 ± 0.326
5.784IleTyr: 5.784 ± 0.954
0.0IleXaa: 0.0 ± 0.0
Lys
2.603LysAla: 2.603 ± 0.865
0.434LysCys: 0.434 ± 0.291
3.326LysAsp: 3.326 ± 0.877
4.772LysGlu: 4.772 ± 1.153
2.892LysPhe: 2.892 ± 0.765
4.627LysGly: 4.627 ± 1.025
1.446LysHis: 1.446 ± 0.495
6.073LysIle: 6.073 ± 1.156
6.073LysLys: 6.073 ± 1.489
6.651LysLeu: 6.651 ± 1.529
2.169LysMet: 2.169 ± 0.728
3.181LysAsn: 3.181 ± 0.58
1.735LysPro: 1.735 ± 0.527
2.024LysGln: 2.024 ± 0.592
3.47LysArg: 3.47 ± 0.844
3.326LysSer: 3.326 ± 0.756
2.892LysThr: 2.892 ± 0.688
3.759LysVal: 3.759 ± 0.882
1.012LysTrp: 1.012 ± 0.462
3.904LysTyr: 3.904 ± 0.829
0.0LysXaa: 0.0 ± 0.0
Leu
5.061LeuAla: 5.061 ± 0.994
1.591LeuCys: 1.591 ± 0.609
4.049LeuAsp: 4.049 ± 0.827
5.35LeuGlu: 5.35 ± 1.266
4.482LeuPhe: 4.482 ± 0.575
4.193LeuGly: 4.193 ± 0.731
0.145LeuHis: 0.145 ± 0.133
7.808LeuIle: 7.808 ± 1.012
6.94LeuLys: 6.94 ± 1.41
7.23LeuLeu: 7.23 ± 1.197
2.747LeuMet: 2.747 ± 0.657
7.23LeuAsn: 7.23 ± 1.522
5.061LeuPro: 5.061 ± 0.721
2.169LeuGln: 2.169 ± 0.531
3.181LeuArg: 3.181 ± 0.842
8.82LeuSer: 8.82 ± 1.098
4.772LeuThr: 4.772 ± 0.716
6.217LeuVal: 6.217 ± 0.975
0.723LeuTrp: 0.723 ± 0.305
6.651LeuTyr: 6.651 ± 0.662
0.0LeuXaa: 0.0 ± 0.0
Met
1.301MetAla: 1.301 ± 0.438
0.0MetCys: 0.0 ± 0.0
1.301MetAsp: 1.301 ± 0.546
0.723MetGlu: 0.723 ± 0.37
0.723MetPhe: 0.723 ± 0.294
1.591MetGly: 1.591 ± 0.513
0.0MetHis: 0.0 ± 0.0
2.747MetIle: 2.747 ± 0.662
1.301MetLys: 1.301 ± 0.419
2.169MetLeu: 2.169 ± 0.596
0.434MetMet: 0.434 ± 0.215
1.591MetAsn: 1.591 ± 0.442
1.446MetPro: 1.446 ± 0.364
0.434MetGln: 0.434 ± 0.256
0.434MetArg: 0.434 ± 0.228
1.735MetSer: 1.735 ± 0.435
1.591MetThr: 1.591 ± 0.559
0.578MetVal: 0.578 ± 0.282
0.289MetTrp: 0.289 ± 0.217
1.446MetTyr: 1.446 ± 0.432
0.0MetXaa: 0.0 ± 0.0
Asn
4.772AsnAla: 4.772 ± 0.828
0.434AsnCys: 0.434 ± 0.193
2.747AsnAsp: 2.747 ± 0.567
2.603AsnGlu: 2.603 ± 0.593
3.036AsnPhe: 3.036 ± 0.602
5.928AsnGly: 5.928 ± 0.969
0.434AsnHis: 0.434 ± 0.296
3.904AsnIle: 3.904 ± 0.477
3.759AsnLys: 3.759 ± 0.837
7.085AsnLeu: 7.085 ± 0.891
0.434AsnMet: 0.434 ± 0.244
7.23AsnAsn: 7.23 ± 2.018
5.639AsnPro: 5.639 ± 1.22
3.759AsnGln: 3.759 ± 0.69
1.88AsnArg: 1.88 ± 0.577
4.772AsnSer: 4.772 ± 0.924
4.627AsnThr: 4.627 ± 1.151
5.639AsnVal: 5.639 ± 1.591
0.289AsnTrp: 0.289 ± 0.19
5.205AsnTyr: 5.205 ± 0.771
0.0AsnXaa: 0.0 ± 0.0
Pro
1.446ProAla: 1.446 ± 0.489
0.578ProCys: 0.578 ± 0.258
2.169ProAsp: 2.169 ± 0.68
1.591ProGlu: 1.591 ± 0.565
1.591ProPhe: 1.591 ± 0.363
0.145ProGly: 0.145 ± 0.155
1.012ProHis: 1.012 ± 0.436
5.639ProIle: 5.639 ± 0.853
2.892ProLys: 2.892 ± 0.637
3.47ProLeu: 3.47 ± 0.879
0.578ProMet: 0.578 ± 0.267
5.784ProAsn: 5.784 ± 1.24
1.735ProPro: 1.735 ± 0.44
1.735ProGln: 1.735 ± 0.397
0.434ProArg: 0.434 ± 0.237
5.35ProSer: 5.35 ± 1.251
3.326ProThr: 3.326 ± 0.717
3.181ProVal: 3.181 ± 0.944
0.145ProTrp: 0.145 ± 0.155
2.892ProTyr: 2.892 ± 0.601
0.0ProXaa: 0.0 ± 0.0
Gln
1.012GlnAla: 1.012 ± 0.317
0.289GlnCys: 0.289 ± 0.27
1.301GlnAsp: 1.301 ± 0.306
0.434GlnGlu: 0.434 ± 0.251
1.88GlnPhe: 1.88 ± 0.563
1.591GlnGly: 1.591 ± 0.492
0.723GlnHis: 0.723 ± 0.267
2.892GlnIle: 2.892 ± 0.654
1.88GlnLys: 1.88 ± 0.56
3.759GlnLeu: 3.759 ± 1.052
0.578GlnMet: 0.578 ± 0.272
3.326GlnAsn: 3.326 ± 0.82
1.591GlnPro: 1.591 ± 0.609
0.868GlnGln: 0.868 ± 0.443
0.578GlnArg: 0.578 ± 0.292
3.47GlnSer: 3.47 ± 1.199
3.181GlnThr: 3.181 ± 0.739
2.313GlnVal: 2.313 ± 0.507
0.289GlnTrp: 0.289 ± 0.157
1.591GlnTyr: 1.591 ± 0.507
0.0GlnXaa: 0.0 ± 0.0
Arg
1.446ArgAla: 1.446 ± 0.54
0.145ArgCys: 0.145 ± 0.154
1.446ArgAsp: 1.446 ± 0.47
1.735ArgGlu: 1.735 ± 0.714
0.434ArgPhe: 0.434 ± 0.23
1.446ArgGly: 1.446 ± 0.506
0.434ArgHis: 0.434 ± 0.257
2.024ArgIle: 2.024 ± 0.602
3.036ArgLys: 3.036 ± 0.93
3.615ArgLeu: 3.615 ± 0.999
1.157ArgMet: 1.157 ± 0.512
0.868ArgAsn: 0.868 ± 0.534
0.868ArgPro: 0.868 ± 0.454
1.157ArgGln: 1.157 ± 0.467
1.012ArgArg: 1.012 ± 0.468
1.157ArgSer: 1.157 ± 0.493
0.868ArgThr: 0.868 ± 0.261
2.313ArgVal: 2.313 ± 0.648
0.434ArgTrp: 0.434 ± 0.216
1.735ArgTyr: 1.735 ± 0.616
0.0ArgXaa: 0.0 ± 0.0
Ser
2.313SerAla: 2.313 ± 0.536
1.301SerCys: 1.301 ± 0.373
3.326SerAsp: 3.326 ± 0.554
2.169SerGlu: 2.169 ± 0.424
3.615SerPhe: 3.615 ± 0.87
4.916SerGly: 4.916 ± 1.145
0.145SerHis: 0.145 ± 0.133
6.796SerIle: 6.796 ± 0.776
3.759SerLys: 3.759 ± 0.854
6.362SerLeu: 6.362 ± 0.918
1.591SerMet: 1.591 ± 0.421
5.784SerAsn: 5.784 ± 1.308
3.181SerPro: 3.181 ± 0.707
3.615SerGln: 3.615 ± 0.812
1.012SerArg: 1.012 ± 0.399
8.242SerSer: 8.242 ± 1.52
5.928SerThr: 5.928 ± 1.497
6.507SerVal: 6.507 ± 1.461
0.578SerTrp: 0.578 ± 0.303
5.061SerTyr: 5.061 ± 0.788
0.0SerXaa: 0.0 ± 0.0
Thr
2.603ThrAla: 2.603 ± 0.688
1.157ThrCys: 1.157 ± 0.41
2.603ThrAsp: 2.603 ± 0.774
3.615ThrGlu: 3.615 ± 0.777
3.759ThrPhe: 3.759 ± 0.574
3.47ThrGly: 3.47 ± 0.659
0.868ThrHis: 0.868 ± 0.391
5.784ThrIle: 5.784 ± 1.316
2.313ThrLys: 2.313 ± 0.646
4.916ThrLeu: 4.916 ± 0.615
0.434ThrMet: 0.434 ± 0.261
3.759ThrAsn: 3.759 ± 0.701
4.049ThrPro: 4.049 ± 0.864
3.326ThrGln: 3.326 ± 0.98
0.868ThrArg: 0.868 ± 0.457
4.916ThrSer: 4.916 ± 1.097
5.061ThrThr: 5.061 ± 0.899
5.639ThrVal: 5.639 ± 0.788
0.723ThrTrp: 0.723 ± 0.305
3.759ThrTyr: 3.759 ± 0.816
0.0ThrXaa: 0.0 ± 0.0
Val
3.615ValAla: 3.615 ± 1.066
0.434ValCys: 0.434 ± 0.266
2.892ValAsp: 2.892 ± 0.752
3.904ValGlu: 3.904 ± 0.693
3.036ValPhe: 3.036 ± 0.518
3.181ValGly: 3.181 ± 0.688
1.012ValHis: 1.012 ± 0.379
5.784ValIle: 5.784 ± 0.796
4.049ValLys: 4.049 ± 1.045
7.374ValLeu: 7.374 ± 0.996
1.735ValMet: 1.735 ± 0.415
6.073ValAsn: 6.073 ± 1.158
3.904ValPro: 3.904 ± 0.618
1.301ValGln: 1.301 ± 0.382
3.181ValArg: 3.181 ± 1.048
4.916ValSer: 4.916 ± 0.789
5.35ValThr: 5.35 ± 1.067
4.772ValVal: 4.772 ± 1.271
0.0ValTrp: 0.0 ± 0.0
3.036ValTyr: 3.036 ± 0.506
0.0ValXaa: 0.0 ± 0.0
Trp
0.434TrpAla: 0.434 ± 0.163
0.0TrpCys: 0.0 ± 0.0
0.434TrpAsp: 0.434 ± 0.275
0.289TrpGlu: 0.289 ± 0.234
0.723TrpPhe: 0.723 ± 0.28
0.578TrpGly: 0.578 ± 0.392
0.0TrpHis: 0.0 ± 0.0
1.012TrpIle: 1.012 ± 0.308
0.289TrpLys: 0.289 ± 0.253
0.868TrpLeu: 0.868 ± 0.31
0.145TrpMet: 0.145 ± 0.133
0.578TrpAsn: 0.578 ± 0.236
0.0TrpPro: 0.0 ± 0.0
0.145TrpGln: 0.145 ± 0.148
0.434TrpArg: 0.434 ± 0.315
0.723TrpSer: 0.723 ± 0.162
0.145TrpThr: 0.145 ± 0.163
1.012TrpVal: 1.012 ± 0.501
0.0TrpTrp: 0.0 ± 0.0
0.723TrpTyr: 0.723 ± 0.316
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.181TyrAla: 3.181 ± 0.476
0.434TyrCys: 0.434 ± 0.245
3.615TyrAsp: 3.615 ± 0.833
4.482TyrGlu: 4.482 ± 1.047
2.458TyrPhe: 2.458 ± 0.379
3.615TyrGly: 3.615 ± 0.603
0.145TyrHis: 0.145 ± 0.133
5.495TyrIle: 5.495 ± 0.956
3.615TyrLys: 3.615 ± 1.026
6.94TyrLeu: 6.94 ± 0.901
1.157TyrMet: 1.157 ± 0.503
4.338TyrAsn: 4.338 ± 0.769
3.47TyrPro: 3.47 ± 0.522
3.036TyrGln: 3.036 ± 0.556
1.012TyrArg: 1.012 ± 0.367
5.205TyrSer: 5.205 ± 0.896
4.627TyrThr: 4.627 ± 0.622
4.193TyrVal: 4.193 ± 0.659
0.578TyrTrp: 0.578 ± 0.315
4.338TyrTyr: 4.338 ± 0.841
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 38 proteins (6917 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski