Amino acid dipepetide frequency for Halieaceae bacterium IMCC3088

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.457AlaAla: 10.457 ± 0.115
1.149AlaCys: 1.149 ± 0.04
5.864AlaAsp: 5.864 ± 0.086
6.516AlaGlu: 6.516 ± 0.09
3.717AlaPhe: 3.717 ± 0.07
7.587AlaGly: 7.587 ± 0.109
2.024AlaHis: 2.024 ± 0.046
5.986AlaIle: 5.986 ± 0.087
4.398AlaLys: 4.398 ± 0.073
12.11AlaLeu: 12.11 ± 0.134
3.041AlaMet: 3.041 ± 0.062
3.422AlaAsn: 3.422 ± 0.069
3.961AlaPro: 3.961 ± 0.073
4.667AlaGln: 4.667 ± 0.081
5.313AlaArg: 5.313 ± 0.087
6.257AlaSer: 6.257 ± 0.082
5.287AlaThr: 5.287 ± 0.093
6.901AlaVal: 6.901 ± 0.101
1.316AlaTrp: 1.316 ± 0.039
2.77AlaTyr: 2.77 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
1.054CysAla: 1.054 ± 0.037
0.158CysCys: 0.158 ± 0.014
0.661CysAsp: 0.661 ± 0.034
0.605CysGlu: 0.605 ± 0.025
0.375CysPhe: 0.375 ± 0.02
0.903CysGly: 0.903 ± 0.037
0.322CysHis: 0.322 ± 0.032
0.539CysIle: 0.539 ± 0.025
0.295CysLys: 0.295 ± 0.018
0.994CysLeu: 0.994 ± 0.035
0.209CysMet: 0.209 ± 0.017
0.292CysAsn: 0.292 ± 0.018
0.47CysPro: 0.47 ± 0.027
0.396CysGln: 0.396 ± 0.022
0.521CysArg: 0.521 ± 0.027
0.699CysSer: 0.699 ± 0.029
0.432CysThr: 0.432 ± 0.026
0.763CysVal: 0.763 ± 0.033
0.122CysTrp: 0.122 ± 0.012
0.3CysTyr: 0.3 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
6.002AspAla: 6.002 ± 0.092
0.605AspCys: 0.605 ± 0.029
3.448AspAsp: 3.448 ± 0.075
3.815AspGlu: 3.815 ± 0.071
2.457AspPhe: 2.457 ± 0.055
4.095AspGly: 4.095 ± 0.078
1.294AspHis: 1.294 ± 0.04
3.574AspIle: 3.574 ± 0.06
2.097AspLys: 2.097 ± 0.051
6.027AspLeu: 6.027 ± 0.073
1.35AspMet: 1.35 ± 0.036
1.919AspAsn: 1.919 ± 0.048
2.772AspPro: 2.772 ± 0.057
2.444AspGln: 2.444 ± 0.051
3.208AspArg: 3.208 ± 0.062
3.351AspSer: 3.351 ± 0.065
3.167AspThr: 3.167 ± 0.062
4.223AspVal: 4.223 ± 0.072
1.032AspTrp: 1.032 ± 0.034
2.168AspTyr: 2.168 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
6.399GluAla: 6.399 ± 0.094
0.522GluCys: 0.522 ± 0.028
2.998GluAsp: 2.998 ± 0.069
3.294GluGlu: 3.294 ± 0.085
2.336GluPhe: 2.336 ± 0.05
4.038GluGly: 4.038 ± 0.077
1.619GluHis: 1.619 ± 0.043
3.377GluIle: 3.377 ± 0.073
2.153GluLys: 2.153 ± 0.058
6.934GluLeu: 6.934 ± 0.098
1.364GluMet: 1.364 ± 0.044
1.868GluAsn: 1.868 ± 0.044
2.452GluPro: 2.452 ± 0.054
3.607GluGln: 3.607 ± 0.073
4.473GluArg: 4.473 ± 0.077
3.599GluSer: 3.599 ± 0.064
3.138GluThr: 3.138 ± 0.065
4.393GluVal: 4.393 ± 0.073
0.876GluTrp: 0.876 ± 0.031
1.65GluTyr: 1.65 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.839PheAla: 3.839 ± 0.064
0.475PheCys: 0.475 ± 0.024
2.808PheAsp: 2.808 ± 0.055
2.605PheGlu: 2.605 ± 0.055
1.543PhePhe: 1.543 ± 0.049
3.425PheGly: 3.425 ± 0.063
0.712PheHis: 0.712 ± 0.029
2.057PheIle: 2.057 ± 0.043
1.541PheLys: 1.541 ± 0.041
3.343PheLeu: 3.343 ± 0.081
0.97PheMet: 0.97 ± 0.033
1.583PheAsn: 1.583 ± 0.045
1.391PhePro: 1.391 ± 0.046
1.216PheGln: 1.216 ± 0.036
1.642PheArg: 1.642 ± 0.046
2.668PheSer: 2.668 ± 0.064
2.045PheThr: 2.045 ± 0.05
2.72PheVal: 2.72 ± 0.057
0.517PheTrp: 0.517 ± 0.027
1.184PheTyr: 1.184 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
7.153GlyAla: 7.153 ± 0.09
0.8GlyCys: 0.8 ± 0.028
4.353GlyAsp: 4.353 ± 0.077
4.327GlyGlu: 4.327 ± 0.071
3.499GlyPhe: 3.499 ± 0.069
5.802GlyGly: 5.802 ± 0.106
1.664GlyHis: 1.664 ± 0.044
4.415GlyIle: 4.415 ± 0.087
3.1GlyLys: 3.1 ± 0.068
8.164GlyLeu: 8.164 ± 0.108
2.011GlyMet: 2.011 ± 0.052
2.291GlyAsn: 2.291 ± 0.049
2.396GlyPro: 2.396 ± 0.053
2.873GlyGln: 2.873 ± 0.056
4.168GlyArg: 4.168 ± 0.063
4.551GlySer: 4.551 ± 0.079
3.774GlyThr: 3.774 ± 0.071
6.147GlyVal: 6.147 ± 0.088
1.114GlyTrp: 1.114 ± 0.036
2.479GlyTyr: 2.479 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.948HisAla: 1.948 ± 0.047
0.306HisCys: 0.306 ± 0.02
1.117HisAsp: 1.117 ± 0.036
1.215HisGlu: 1.215 ± 0.037
0.928HisPhe: 0.928 ± 0.027
1.665HisGly: 1.665 ± 0.052
0.622HisHis: 0.622 ± 0.029
1.172HisIle: 1.172 ± 0.037
0.794HisLys: 0.794 ± 0.028
2.155HisLeu: 2.155 ± 0.057
0.554HisMet: 0.554 ± 0.027
0.752HisAsn: 0.752 ± 0.026
1.259HisPro: 1.259 ± 0.039
0.941HisGln: 0.941 ± 0.032
1.39HisArg: 1.39 ± 0.042
1.331HisSer: 1.331 ± 0.04
1.198HisThr: 1.198 ± 0.042
1.337HisVal: 1.337 ± 0.038
0.391HisTrp: 0.391 ± 0.021
0.896HisTyr: 0.896 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.47IleAla: 6.47 ± 0.091
0.557IleCys: 0.557 ± 0.026
4.148IleAsp: 4.148 ± 0.067
4.231IleGlu: 4.231 ± 0.071
1.79IlePhe: 1.79 ± 0.051
4.371IleGly: 4.371 ± 0.074
1.169IleHis: 1.169 ± 0.034
2.776IleIle: 2.776 ± 0.067
2.292IleLys: 2.292 ± 0.052
4.436IleLeu: 4.436 ± 0.082
1.15IleMet: 1.15 ± 0.034
2.266IleAsn: 2.266 ± 0.046
2.598IlePro: 2.598 ± 0.056
2.002IleGln: 2.002 ± 0.052
2.936IleArg: 2.936 ± 0.062
3.461IleSer: 3.461 ± 0.068
3.192IleThr: 3.192 ± 0.063
3.926IleVal: 3.926 ± 0.063
0.607IleTrp: 0.607 ± 0.024
1.392IleTyr: 1.392 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
4.409LysAla: 4.409 ± 0.076
0.248LysCys: 0.248 ± 0.019
2.09LysAsp: 2.09 ± 0.044
2.073LysGlu: 2.073 ± 0.049
1.164LysPhe: 1.164 ± 0.04
2.588LysGly: 2.588 ± 0.06
1.007LysHis: 1.007 ± 0.033
2.039LysIle: 2.039 ± 0.046
1.551LysLys: 1.551 ± 0.052
3.714LysLeu: 3.714 ± 0.067
0.829LysMet: 0.829 ± 0.033
1.319LysAsn: 1.319 ± 0.041
2.02LysPro: 2.02 ± 0.044
1.938LysGln: 1.938 ± 0.052
2.655LysArg: 2.655 ± 0.06
2.296LysSer: 2.296 ± 0.046
2.336LysThr: 2.336 ± 0.052
2.81LysVal: 2.81 ± 0.063
0.389LysTrp: 0.389 ± 0.021
0.924LysTyr: 0.924 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
11.576LeuAla: 11.576 ± 0.136
1.07LeuCys: 1.07 ± 0.034
6.262LeuAsp: 6.262 ± 0.091
6.348LeuGlu: 6.348 ± 0.095
3.629LeuPhe: 3.629 ± 0.072
8.091LeuGly: 8.091 ± 0.115
2.07LeuHis: 2.07 ± 0.051
5.496LeuIle: 5.496 ± 0.098
4.144LeuLys: 4.144 ± 0.075
10.112LeuLeu: 10.112 ± 0.156
2.553LeuMet: 2.553 ± 0.057
3.904LeuAsn: 3.904 ± 0.073
4.945LeuPro: 4.945 ± 0.081
4.136LeuGln: 4.136 ± 0.071
5.845LeuArg: 5.845 ± 0.094
7.434LeuSer: 7.434 ± 0.095
5.721LeuThr: 5.721 ± 0.089
7.175LeuVal: 7.175 ± 0.109
1.281LeuTrp: 1.281 ± 0.046
2.474LeuTyr: 2.474 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.688MetAla: 2.688 ± 0.067
0.202MetCys: 0.202 ± 0.017
1.258MetAsp: 1.258 ± 0.04
1.083MetGlu: 1.083 ± 0.038
0.724MetPhe: 0.724 ± 0.031
2.0MetGly: 2.0 ± 0.049
0.565MetHis: 0.565 ± 0.026
1.345MetIle: 1.345 ± 0.04
0.977MetLys: 0.977 ± 0.034
2.428MetLeu: 2.428 ± 0.051
0.663MetMet: 0.663 ± 0.027
0.918MetAsn: 0.918 ± 0.031
1.245MetPro: 1.245 ± 0.037
1.031MetGln: 1.031 ± 0.034
1.442MetArg: 1.442 ± 0.042
1.953MetSer: 1.953 ± 0.042
1.633MetThr: 1.633 ± 0.045
1.634MetVal: 1.634 ± 0.039
0.204MetTrp: 0.204 ± 0.016
0.501MetTyr: 0.501 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.502AsnAla: 3.502 ± 0.07
0.381AsnCys: 0.381 ± 0.023
1.977AsnAsp: 1.977 ± 0.048
1.986AsnGlu: 1.986 ± 0.051
1.301AsnPhe: 1.301 ± 0.034
2.532AsnGly: 2.532 ± 0.054
0.706AsnHis: 0.706 ± 0.03
2.047AsnIle: 2.047 ± 0.044
1.311AsnLys: 1.311 ± 0.043
3.426AsnLeu: 3.426 ± 0.059
0.78AsnMet: 0.78 ± 0.029
1.258AsnAsn: 1.258 ± 0.042
2.123AsnPro: 2.123 ± 0.041
1.485AsnGln: 1.485 ± 0.043
1.985AsnArg: 1.985 ± 0.046
2.001AsnSer: 2.001 ± 0.055
2.102AsnThr: 2.102 ± 0.055
2.179AsnVal: 2.179 ± 0.054
0.487AsnTrp: 0.487 ± 0.024
1.054AsnTyr: 1.054 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
3.998ProAla: 3.998 ± 0.078
0.327ProCys: 0.327 ± 0.021
2.8ProAsp: 2.8 ± 0.063
3.621ProGlu: 3.621 ± 0.063
1.641ProPhe: 1.641 ± 0.041
3.152ProGly: 3.152 ± 0.058
0.915ProHis: 0.915 ± 0.033
2.47ProIle: 2.47 ± 0.054
2.017ProLys: 2.017 ± 0.048
4.336ProLeu: 4.336 ± 0.068
1.132ProMet: 1.132 ± 0.037
1.82ProAsn: 1.82 ± 0.044
1.508ProPro: 1.508 ± 0.038
1.563ProGln: 1.563 ± 0.041
1.935ProArg: 1.935 ± 0.046
2.884ProSer: 2.884 ± 0.059
2.341ProThr: 2.341 ± 0.05
3.285ProVal: 3.285 ± 0.066
0.587ProTrp: 0.587 ± 0.023
1.207ProTyr: 1.207 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
5.011GlnAla: 5.011 ± 0.082
0.385GlnCys: 0.385 ± 0.02
2.133GlnAsp: 2.133 ± 0.05
2.285GlnGlu: 2.285 ± 0.058
1.548GlnPhe: 1.548 ± 0.044
3.191GlnGly: 3.191 ± 0.059
1.033GlnHis: 1.033 ± 0.043
2.26GlnIle: 2.26 ± 0.052
1.429GlnLys: 1.429 ± 0.043
4.495GlnLeu: 4.495 ± 0.066
0.986GlnMet: 0.986 ± 0.033
1.294GlnAsn: 1.294 ± 0.041
1.629GlnPro: 1.629 ± 0.039
2.131GlnGln: 2.131 ± 0.059
2.837GlnArg: 2.837 ± 0.067
2.724GlnSer: 2.724 ± 0.055
2.415GlnThr: 2.415 ± 0.056
3.033GlnVal: 3.033 ± 0.06
0.738GlnTrp: 0.738 ± 0.028
1.127GlnTyr: 1.127 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
5.37ArgAla: 5.37 ± 0.075
0.571ArgCys: 0.571 ± 0.028
3.268ArgAsp: 3.268 ± 0.064
3.595ArgGlu: 3.595 ± 0.062
2.527ArgPhe: 2.527 ± 0.051
3.637ArgGly: 3.637 ± 0.066
1.288ArgHis: 1.288 ± 0.037
3.28ArgIle: 3.28 ± 0.067
2.11ArgLys: 2.11 ± 0.044
6.305ArgLeu: 6.305 ± 0.11
1.353ArgMet: 1.353 ± 0.036
1.827ArgAsn: 1.827 ± 0.04
2.21ArgPro: 2.21 ± 0.057
2.409ArgGln: 2.409 ± 0.054
3.082ArgArg: 3.082 ± 0.071
3.283ArgSer: 3.283 ± 0.06
2.596ArgThr: 2.596 ± 0.056
4.302ArgVal: 4.302 ± 0.07
0.931ArgTrp: 0.931 ± 0.035
2.038ArgTyr: 2.038 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
6.219SerAla: 6.219 ± 0.09
0.542SerCys: 0.542 ± 0.025
4.079SerAsp: 4.079 ± 0.074
3.909SerGlu: 3.909 ± 0.067
2.392SerPhe: 2.392 ± 0.053
5.339SerGly: 5.339 ± 0.085
1.229SerHis: 1.229 ± 0.039
3.661SerIle: 3.661 ± 0.068
2.407SerLys: 2.407 ± 0.049
6.643SerLeu: 6.643 ± 0.091
1.639SerMet: 1.639 ± 0.044
2.114SerAsn: 2.114 ± 0.046
2.549SerPro: 2.549 ± 0.063
2.563SerGln: 2.563 ± 0.05
3.148SerArg: 3.148 ± 0.062
3.965SerSer: 3.965 ± 0.064
3.277SerThr: 3.277 ± 0.057
4.844SerVal: 4.844 ± 0.079
0.839SerTrp: 0.839 ± 0.029
1.786SerTyr: 1.786 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
5.113ThrAla: 5.113 ± 0.08
0.488ThrCys: 0.488 ± 0.025
3.123ThrAsp: 3.123 ± 0.068
3.089ThrGlu: 3.089 ± 0.062
1.925ThrPhe: 1.925 ± 0.049
4.315ThrGly: 4.315 ± 0.068
1.239ThrHis: 1.239 ± 0.035
2.888ThrIle: 2.888 ± 0.057
1.776ThrLys: 1.776 ± 0.046
6.609ThrLeu: 6.609 ± 0.092
1.106ThrMet: 1.106 ± 0.033
1.677ThrAsn: 1.677 ± 0.044
2.974ThrPro: 2.974 ± 0.053
2.559ThrGln: 2.559 ± 0.055
2.784ThrArg: 2.784 ± 0.053
3.023ThrSer: 3.023 ± 0.061
2.868ThrThr: 2.868 ± 0.061
4.022ThrVal: 4.022 ± 0.064
0.676ThrTrp: 0.676 ± 0.03
1.552ThrTyr: 1.552 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
7.802ValAla: 7.802 ± 0.104
0.784ValCys: 0.784 ± 0.035
4.335ValAsp: 4.335 ± 0.069
4.214ValGlu: 4.214 ± 0.081
2.955ValPhe: 2.955 ± 0.061
5.164ValGly: 5.164 ± 0.088
1.397ValHis: 1.397 ± 0.037
4.385ValIle: 4.385 ± 0.071
2.715ValLys: 2.715 ± 0.058
7.205ValLeu: 7.205 ± 0.11
1.834ValMet: 1.834 ± 0.047
2.75ValAsn: 2.75 ± 0.057
3.072ValPro: 3.072 ± 0.064
2.379ValGln: 2.379 ± 0.052
3.606ValArg: 3.606 ± 0.069
4.957ValSer: 4.957 ± 0.083
4.128ValThr: 4.128 ± 0.073
5.903ValVal: 5.903 ± 0.105
0.89ValTrp: 0.89 ± 0.034
1.968ValTyr: 1.968 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
1.095TrpAla: 1.095 ± 0.041
0.165TrpCys: 0.165 ± 0.014
0.685TrpAsp: 0.685 ± 0.029
0.641TrpGlu: 0.641 ± 0.025
0.589TrpPhe: 0.589 ± 0.025
0.919TrpGly: 0.919 ± 0.035
0.352TrpHis: 0.352 ± 0.02
0.706TrpIle: 0.706 ± 0.03
0.349TrpLys: 0.349 ± 0.021
1.798TrpLeu: 1.798 ± 0.051
0.392TrpMet: 0.392 ± 0.02
0.481TrpAsn: 0.481 ± 0.026
0.56TrpPro: 0.56 ± 0.025
0.807TrpGln: 0.807 ± 0.028
0.979TrpArg: 0.979 ± 0.037
0.904TrpSer: 0.904 ± 0.035
0.6TrpThr: 0.6 ± 0.027
1.037TrpVal: 1.037 ± 0.04
0.237TrpTrp: 0.237 ± 0.017
0.404TrpTyr: 0.404 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.639TyrAla: 2.639 ± 0.057
0.375TyrCys: 0.375 ± 0.02
1.642TyrAsp: 1.642 ± 0.042
1.639TyrGlu: 1.639 ± 0.042
1.246TyrPhe: 1.246 ± 0.032
2.266TyrGly: 2.266 ± 0.052
0.742TyrHis: 0.742 ± 0.027
1.297TyrIle: 1.297 ± 0.036
0.946TyrLys: 0.946 ± 0.032
3.032TyrLeu: 3.032 ± 0.051
0.576TyrMet: 0.576 ± 0.024
0.867TyrAsn: 0.867 ± 0.034
1.408TyrPro: 1.408 ± 0.041
1.537TyrGln: 1.537 ± 0.041
2.03TyrArg: 2.03 ± 0.047
1.8TyrSer: 1.8 ± 0.045
1.555TyrThr: 1.555 ± 0.045
1.809TyrVal: 1.809 ± 0.043
0.468TyrTrp: 0.468 ± 0.023
0.946TyrTyr: 0.946 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2855 proteins (911031 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski