Amino acid dipepetide frequency for Salinicola sp. MIT1003

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.091AlaAla: 12.091 ± 0.16
1.15AlaCys: 1.15 ± 0.03
6.217AlaAsp: 6.217 ± 0.078
6.989AlaGlu: 6.989 ± 0.095
3.915AlaPhe: 3.915 ± 0.061
9.025AlaGly: 9.025 ± 0.105
2.217AlaHis: 2.217 ± 0.041
5.912AlaIle: 5.912 ± 0.073
2.935AlaLys: 2.935 ± 0.052
13.395AlaLeu: 13.395 ± 0.133
3.269AlaMet: 3.269 ± 0.056
2.88AlaAsn: 2.88 ± 0.059
4.658AlaPro: 4.658 ± 0.076
4.024AlaGln: 4.024 ± 0.074
7.824AlaArg: 7.824 ± 0.108
6.552AlaSer: 6.552 ± 0.082
5.341AlaThr: 5.341 ± 0.071
7.251AlaVal: 7.251 ± 0.092
1.752AlaTrp: 1.752 ± 0.045
2.315AlaTyr: 2.315 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.871CysAla: 0.871 ± 0.028
0.136CysCys: 0.136 ± 0.011
0.564CysAsp: 0.564 ± 0.024
0.551CysGlu: 0.551 ± 0.022
0.326CysPhe: 0.326 ± 0.017
0.933CysGly: 0.933 ± 0.03
0.341CysHis: 0.341 ± 0.021
0.375CysIle: 0.375 ± 0.019
0.177CysLys: 0.177 ± 0.011
1.025CysLeu: 1.025 ± 0.03
0.161CysMet: 0.161 ± 0.011
0.205CysAsn: 0.205 ± 0.012
0.45CysPro: 0.45 ± 0.022
0.381CysGln: 0.381 ± 0.019
0.793CysArg: 0.793 ± 0.03
0.47CysSer: 0.47 ± 0.021
0.38CysThr: 0.38 ± 0.017
0.613CysVal: 0.613 ± 0.026
0.129CysTrp: 0.129 ± 0.01
0.271CysTyr: 0.271 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
6.783AspAla: 6.783 ± 0.092
0.496AspCys: 0.496 ± 0.02
4.352AspAsp: 4.352 ± 0.071
4.086AspGlu: 4.086 ± 0.06
2.205AspPhe: 2.205 ± 0.048
4.928AspGly: 4.928 ± 0.075
1.473AspHis: 1.473 ± 0.035
3.164AspIle: 3.164 ± 0.05
1.718AspLys: 1.718 ± 0.041
5.518AspLeu: 5.518 ± 0.087
1.3AspMet: 1.3 ± 0.033
1.746AspAsn: 1.746 ± 0.039
3.103AspPro: 3.103 ± 0.061
2.114AspGln: 2.114 ± 0.044
4.159AspArg: 4.159 ± 0.066
3.344AspSer: 3.344 ± 0.06
2.96AspThr: 2.96 ± 0.057
4.193AspVal: 4.193 ± 0.065
1.081AspTrp: 1.081 ± 0.031
1.855AspTyr: 1.855 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
7.747GluAla: 7.747 ± 0.102
0.476GluCys: 0.476 ± 0.022
2.893GluAsp: 2.893 ± 0.056
3.401GluGlu: 3.401 ± 0.065
1.684GluPhe: 1.684 ± 0.036
4.468GluGly: 4.468 ± 0.073
1.61GluHis: 1.61 ± 0.038
3.179GluIle: 3.179 ± 0.058
1.951GluLys: 1.951 ± 0.049
6.318GluLeu: 6.318 ± 0.084
1.515GluMet: 1.515 ± 0.035
1.551GluAsn: 1.551 ± 0.04
2.784GluPro: 2.784 ± 0.055
3.002GluGln: 3.002 ± 0.056
5.901GluArg: 5.901 ± 0.082
3.642GluSer: 3.642 ± 0.062
3.553GluThr: 3.553 ± 0.059
4.012GluVal: 4.012 ± 0.07
0.915GluTrp: 0.915 ± 0.028
1.185GluTyr: 1.185 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.564PheAla: 3.564 ± 0.057
0.372PheCys: 0.372 ± 0.019
2.728PheAsp: 2.728 ± 0.054
2.338PheGlu: 2.338 ± 0.05
1.332PhePhe: 1.332 ± 0.038
3.306PheGly: 3.306 ± 0.059
0.832PheHis: 0.832 ± 0.03
1.662PheIle: 1.662 ± 0.04
0.942PheLys: 0.942 ± 0.03
3.195PheLeu: 3.195 ± 0.063
0.832PheMet: 0.832 ± 0.024
1.057PheAsn: 1.057 ± 0.032
1.438PhePro: 1.438 ± 0.041
1.17PheGln: 1.17 ± 0.029
1.969PheArg: 1.969 ± 0.046
2.345PheSer: 2.345 ± 0.05
1.889PheThr: 1.889 ± 0.047
2.636PheVal: 2.636 ± 0.052
0.518PheTrp: 0.518 ± 0.02
0.971PheTyr: 0.971 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
7.411GlyAla: 7.411 ± 0.096
0.925GlyCys: 0.925 ± 0.029
4.837GlyAsp: 4.837 ± 0.075
5.405GlyGlu: 5.405 ± 0.074
3.354GlyPhe: 3.354 ± 0.058
6.618GlyGly: 6.618 ± 0.11
2.017GlyHis: 2.017 ± 0.045
4.639GlyIle: 4.639 ± 0.074
2.931GlyLys: 2.931 ± 0.055
8.774GlyLeu: 8.774 ± 0.098
2.298GlyMet: 2.298 ± 0.05
2.313GlyAsn: 2.313 ± 0.05
2.661GlyPro: 2.661 ± 0.055
3.242GlyGln: 3.242 ± 0.059
5.443GlyArg: 5.443 ± 0.071
4.607GlySer: 4.607 ± 0.06
3.785GlyThr: 3.785 ± 0.065
6.244GlyVal: 6.244 ± 0.081
1.488GlyTrp: 1.488 ± 0.036
2.471GlyTyr: 2.471 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.517HisAla: 2.517 ± 0.054
0.305HisCys: 0.305 ± 0.018
1.541HisAsp: 1.541 ± 0.038
1.299HisGlu: 1.299 ± 0.036
1.02HisPhe: 1.02 ± 0.033
2.217HisGly: 2.217 ± 0.05
0.775HisHis: 0.775 ± 0.029
0.943HisIle: 0.943 ± 0.03
0.527HisLys: 0.527 ± 0.022
2.545HisLeu: 2.545 ± 0.046
0.477HisMet: 0.477 ± 0.019
0.567HisAsn: 0.567 ± 0.02
1.506HisPro: 1.506 ± 0.037
0.999HisGln: 0.999 ± 0.029
1.861HisArg: 1.861 ± 0.048
1.083HisSer: 1.083 ± 0.03
0.939HisThr: 0.939 ± 0.028
1.574HisVal: 1.574 ± 0.041
0.491HisTrp: 0.491 ± 0.023
0.8HisTyr: 0.8 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.223IleAla: 6.223 ± 0.083
0.449IleCys: 0.449 ± 0.02
4.03IleAsp: 4.03 ± 0.063
3.717IleGlu: 3.717 ± 0.061
1.526IlePhe: 1.526 ± 0.042
4.9IleGly: 4.9 ± 0.076
1.071IleHis: 1.071 ± 0.033
2.052IleIle: 2.052 ± 0.05
1.321IleLys: 1.321 ± 0.04
4.191IleLeu: 4.191 ± 0.069
0.921IleMet: 0.921 ± 0.027
1.556IleAsn: 1.556 ± 0.042
2.339IlePro: 2.339 ± 0.045
1.597IleGln: 1.597 ± 0.036
3.123IleArg: 3.123 ± 0.059
2.722IleSer: 2.722 ± 0.057
2.601IleThr: 2.601 ± 0.05
3.884IleVal: 3.884 ± 0.059
0.537IleTrp: 0.537 ± 0.021
1.101IleTyr: 1.101 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
3.242LysAla: 3.242 ± 0.069
0.148LysCys: 0.148 ± 0.012
1.308LysAsp: 1.308 ± 0.039
1.419LysGlu: 1.419 ± 0.038
0.608LysPhe: 0.608 ± 0.021
2.182LysGly: 2.182 ± 0.044
0.608LysHis: 0.608 ± 0.024
1.274LysIle: 1.274 ± 0.035
0.923LysLys: 0.923 ± 0.039
3.046LysLeu: 3.046 ± 0.057
0.613LysMet: 0.613 ± 0.024
0.687LysAsn: 0.687 ± 0.029
1.702LysPro: 1.702 ± 0.046
1.275LysGln: 1.275 ± 0.038
2.626LysArg: 2.626 ± 0.051
1.68LysSer: 1.68 ± 0.045
1.534LysThr: 1.534 ± 0.035
2.017LysVal: 2.017 ± 0.046
0.3LysTrp: 0.3 ± 0.017
0.513LysTyr: 0.513 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
13.594LeuAla: 13.594 ± 0.137
1.022LeuCys: 1.022 ± 0.031
7.232LeuAsp: 7.232 ± 0.086
7.132LeuGlu: 7.132 ± 0.098
3.815LeuPhe: 3.815 ± 0.067
8.94LeuGly: 8.94 ± 0.105
2.285LeuHis: 2.285 ± 0.045
5.712LeuIle: 5.712 ± 0.086
3.452LeuLys: 3.452 ± 0.059
11.266LeuLeu: 11.266 ± 0.143
2.755LeuMet: 2.755 ± 0.057
2.895LeuAsn: 2.895 ± 0.054
5.975LeuPro: 5.975 ± 0.079
3.393LeuGln: 3.393 ± 0.067
6.601LeuArg: 6.601 ± 0.083
6.883LeuSer: 6.883 ± 0.1
5.886LeuThr: 5.886 ± 0.076
7.606LeuVal: 7.606 ± 0.106
1.446LeuTrp: 1.446 ± 0.039
2.447LeuTyr: 2.447 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
3.124MetAla: 3.124 ± 0.05
0.152MetCys: 0.152 ± 0.012
1.093MetAsp: 1.093 ± 0.029
1.058MetGlu: 1.058 ± 0.033
0.659MetPhe: 0.659 ± 0.026
1.806MetGly: 1.806 ± 0.039
0.492MetHis: 0.492 ± 0.021
1.339MetIle: 1.339 ± 0.036
0.84MetLys: 0.84 ± 0.029
2.719MetLeu: 2.719 ± 0.05
0.676MetMet: 0.676 ± 0.025
0.773MetAsn: 0.773 ± 0.028
1.437MetPro: 1.437 ± 0.041
1.032MetGln: 1.032 ± 0.031
1.706MetArg: 1.706 ± 0.042
1.826MetSer: 1.826 ± 0.046
1.777MetThr: 1.777 ± 0.039
1.657MetVal: 1.657 ± 0.044
0.19MetTrp: 0.19 ± 0.014
0.335MetTyr: 0.335 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.136AsnAla: 3.136 ± 0.054
0.22AsnCys: 0.22 ± 0.015
1.742AsnAsp: 1.742 ± 0.046
1.391AsnGlu: 1.391 ± 0.036
0.897AsnPhe: 0.897 ± 0.027
2.416AsnGly: 2.416 ± 0.057
0.648AsnHis: 0.648 ± 0.026
1.238AsnIle: 1.238 ± 0.037
0.59AsnLys: 0.59 ± 0.026
2.784AsnLeu: 2.784 ± 0.053
0.585AsnMet: 0.585 ± 0.023
0.739AsnAsn: 0.739 ± 0.028
1.682AsnPro: 1.682 ± 0.042
0.97AsnGln: 0.97 ± 0.031
1.964AsnArg: 1.964 ± 0.039
1.236AsnSer: 1.236 ± 0.036
1.271AsnThr: 1.271 ± 0.043
1.994AsnVal: 1.994 ± 0.044
0.393AsnTrp: 0.393 ± 0.02
0.682AsnTyr: 0.682 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
5.313ProAla: 5.313 ± 0.083
0.347ProCys: 0.347 ± 0.017
3.355ProAsp: 3.355 ± 0.06
3.632ProGlu: 3.632 ± 0.055
1.745ProPhe: 1.745 ± 0.037
4.076ProGly: 4.076 ± 0.068
1.096ProHis: 1.096 ± 0.031
2.239ProIle: 2.239 ± 0.044
1.263ProLys: 1.263 ± 0.038
5.326ProLeu: 5.326 ± 0.076
1.25ProMet: 1.25 ± 0.03
1.294ProAsn: 1.294 ± 0.036
2.102ProPro: 2.102 ± 0.047
1.898ProGln: 1.898 ± 0.041
3.059ProArg: 3.059 ± 0.059
2.767ProSer: 2.767 ± 0.056
2.38ProThr: 2.38 ± 0.043
3.665ProVal: 3.665 ± 0.055
0.769ProTrp: 0.769 ± 0.027
1.182ProTyr: 1.182 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
5.205GlnAla: 5.205 ± 0.079
0.294GlnCys: 0.294 ± 0.019
1.721GlnAsp: 1.721 ± 0.04
2.0GlnGlu: 2.0 ± 0.047
1.132GlnPhe: 1.132 ± 0.034
2.957GlnGly: 2.957 ± 0.054
0.991GlnHis: 0.991 ± 0.029
1.752GlnIle: 1.752 ± 0.039
1.011GlnLys: 1.011 ± 0.031
4.41GlnLeu: 4.41 ± 0.068
0.878GlnMet: 0.878 ± 0.027
0.884GlnAsn: 0.884 ± 0.03
2.086GlnPro: 2.086 ± 0.048
2.278GlnGln: 2.278 ± 0.059
3.752GlnArg: 3.752 ± 0.064
2.162GlnSer: 2.162 ± 0.048
1.956GlnThr: 1.956 ± 0.043
2.74GlnVal: 2.74 ± 0.053
0.727GlnTrp: 0.727 ± 0.024
0.813GlnTyr: 0.813 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
6.392ArgAla: 6.392 ± 0.078
0.644ArgCys: 0.644 ± 0.026
4.353ArgAsp: 4.353 ± 0.079
5.245ArgGlu: 5.245 ± 0.087
3.086ArgPhe: 3.086 ± 0.063
4.65ArgGly: 4.65 ± 0.07
2.389ArgHis: 2.389 ± 0.054
3.611ArgIle: 3.611 ± 0.062
1.865ArgLys: 1.865 ± 0.048
9.294ArgLeu: 9.294 ± 0.107
1.706ArgMet: 1.706 ± 0.035
1.738ArgAsn: 1.738 ± 0.035
3.106ArgPro: 3.106 ± 0.052
3.921ArgGln: 3.921 ± 0.074
5.896ArgArg: 5.896 ± 0.099
3.342ArgSer: 3.342 ± 0.053
2.858ArgThr: 2.858 ± 0.053
4.812ArgVal: 4.812 ± 0.069
1.271ArgTrp: 1.271 ± 0.034
2.32ArgTyr: 2.32 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
5.78SerAla: 5.78 ± 0.082
0.477SerCys: 0.477 ± 0.022
3.403SerAsp: 3.403 ± 0.063
3.205SerGlu: 3.205 ± 0.055
2.005SerPhe: 2.005 ± 0.049
5.395SerGly: 5.395 ± 0.078
1.372SerHis: 1.372 ± 0.038
2.669SerIle: 2.669 ± 0.048
1.349SerLys: 1.349 ± 0.039
6.661SerLeu: 6.661 ± 0.089
1.537SerMet: 1.537 ± 0.039
1.475SerAsn: 1.475 ± 0.039
2.97SerPro: 2.97 ± 0.053
2.324SerGln: 2.324 ± 0.045
4.485SerArg: 4.485 ± 0.073
3.349SerSer: 3.349 ± 0.071
2.776SerThr: 2.776 ± 0.057
3.99SerVal: 3.99 ± 0.056
0.785SerTrp: 0.785 ± 0.03
1.321SerTyr: 1.321 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.102ThrAla: 5.102 ± 0.074
0.4ThrCys: 0.4 ± 0.019
2.626ThrAsp: 2.626 ± 0.051
2.375ThrGlu: 2.375 ± 0.043
1.907ThrPhe: 1.907 ± 0.045
4.299ThrGly: 4.299 ± 0.069
1.21ThrHis: 1.21 ± 0.031
2.265ThrIle: 2.265 ± 0.061
0.954ThrLys: 0.954 ± 0.036
7.43ThrLeu: 7.43 ± 0.087
1.05ThrMet: 1.05 ± 0.034
1.217ThrAsn: 1.217 ± 0.035
3.473ThrPro: 3.473 ± 0.055
1.944ThrGln: 1.944 ± 0.046
3.583ThrArg: 3.583 ± 0.063
2.75ThrSer: 2.75 ± 0.048
2.621ThrThr: 2.621 ± 0.059
3.528ThrVal: 3.528 ± 0.06
0.666ThrTrp: 0.666 ± 0.022
1.172ThrTyr: 1.172 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
7.967ValAla: 7.967 ± 0.095
0.69ValCys: 0.69 ± 0.024
4.532ValAsp: 4.532 ± 0.082
4.668ValGlu: 4.668 ± 0.056
2.41ValPhe: 2.41 ± 0.046
5.359ValGly: 5.359 ± 0.063
1.445ValHis: 1.445 ± 0.044
4.117ValIle: 4.117 ± 0.065
2.011ValLys: 2.011 ± 0.048
7.128ValLeu: 7.128 ± 0.093
2.027ValMet: 2.027 ± 0.047
1.965ValAsn: 1.965 ± 0.045
3.233ValPro: 3.233 ± 0.052
2.066ValGln: 2.066 ± 0.047
4.209ValArg: 4.209 ± 0.068
4.448ValSer: 4.448 ± 0.075
4.212ValThr: 4.212 ± 0.065
5.653ValVal: 5.653 ± 0.092
0.927ValTrp: 0.927 ± 0.03
1.585ValTyr: 1.585 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.14TrpAla: 1.14 ± 0.038
0.167TrpCys: 0.167 ± 0.012
0.599TrpAsp: 0.599 ± 0.021
0.707TrpGlu: 0.707 ± 0.025
0.549TrpPhe: 0.549 ± 0.021
0.921TrpGly: 0.921 ± 0.029
0.448TrpHis: 0.448 ± 0.02
0.796TrpIle: 0.796 ± 0.028
0.429TrpLys: 0.429 ± 0.017
2.462TrpLeu: 2.462 ± 0.06
0.412TrpMet: 0.412 ± 0.018
0.424TrpAsn: 0.424 ± 0.021
0.748TrpPro: 0.748 ± 0.025
1.021TrpGln: 1.021 ± 0.031
1.286TrpArg: 1.286 ± 0.041
0.798TrpSer: 0.798 ± 0.028
0.625TrpThr: 0.625 ± 0.026
0.942TrpVal: 0.942 ± 0.032
0.319TrpTrp: 0.319 ± 0.02
0.333TrpTyr: 0.333 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.511TyrAla: 2.511 ± 0.046
0.282TyrCys: 0.282 ± 0.015
1.456TyrAsp: 1.456 ± 0.04
1.172TyrGlu: 1.172 ± 0.036
0.919TyrPhe: 0.919 ± 0.031
2.067TyrGly: 2.067 ± 0.042
0.663TyrHis: 0.663 ± 0.024
0.923TyrIle: 0.923 ± 0.033
0.518TyrLys: 0.518 ± 0.022
2.848TyrLeu: 2.848 ± 0.052
0.425TyrMet: 0.425 ± 0.019
0.613TyrAsn: 0.613 ± 0.024
1.306TyrPro: 1.306 ± 0.037
1.099TyrGln: 1.099 ± 0.036
2.259TyrArg: 2.259 ± 0.045
1.322TyrSer: 1.322 ± 0.035
1.227TyrThr: 1.227 ± 0.037
1.641TyrVal: 1.641 ± 0.035
0.422TyrTrp: 0.422 ± 0.018
0.691TyrTyr: 0.691 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3468 proteins (1139571 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski