Amino acid dipepetide frequency for Orientia chuto str. Dubai

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.648AlaAla: 4.648 ± 0.178
0.857AlaCys: 0.857 ± 0.054
2.552AlaAsp: 2.552 ± 0.105
3.267AlaGlu: 3.267 ± 0.109
2.283AlaPhe: 2.283 ± 0.11
3.421AlaGly: 3.421 ± 0.106
0.977AlaHis: 0.977 ± 0.058
7.066AlaIle: 7.066 ± 0.214
5.139AlaLys: 5.139 ± 0.147
6.243AlaLeu: 6.243 ± 0.198
1.557AlaMet: 1.557 ± 0.08
3.642AlaAsn: 3.642 ± 0.121
1.463AlaPro: 1.463 ± 0.081
2.523AlaGln: 2.523 ± 0.122
2.358AlaArg: 2.358 ± 0.092
4.094AlaSer: 4.094 ± 0.131
3.279AlaThr: 3.279 ± 0.107
3.997AlaVal: 3.997 ± 0.12
0.509AlaTrp: 0.509 ± 0.051
2.043AlaTyr: 2.043 ± 0.095
0.0AlaXaa: 0.0 ± 0.0
Cys
0.692CysAla: 0.692 ± 0.058
0.292CysCys: 0.292 ± 0.036
0.569CysAsp: 0.569 ± 0.042
0.505CysGlu: 0.505 ± 0.046
0.618CysPhe: 0.618 ± 0.053
0.868CysGly: 0.868 ± 0.054
0.322CysHis: 0.322 ± 0.037
1.392CysIle: 1.392 ± 0.078
1.074CysLys: 1.074 ± 0.08
1.25CysLeu: 1.25 ± 0.069
0.333CysMet: 0.333 ± 0.036
1.22CysAsn: 1.22 ± 0.064
0.427CysPro: 0.427 ± 0.046
0.561CysGln: 0.561 ± 0.05
0.505CysArg: 0.505 ± 0.037
1.269CysSer: 1.269 ± 0.065
0.775CysThr: 0.775 ± 0.058
0.573CysVal: 0.573 ± 0.053
0.146CysTrp: 0.146 ± 0.021
0.778CysTyr: 0.778 ± 0.056
0.0CysXaa: 0.0 ± 0.0
Asp
2.238AspAla: 2.238 ± 0.098
0.689AspCys: 0.689 ± 0.056
2.287AspAsp: 2.287 ± 0.108
2.365AspGlu: 2.365 ± 0.123
2.448AspPhe: 2.448 ± 0.12
1.984AspGly: 1.984 ± 0.09
0.939AspHis: 0.939 ± 0.057
5.434AspIle: 5.434 ± 0.172
3.578AspLys: 3.578 ± 0.136
4.798AspLeu: 4.798 ± 0.127
0.846AspMet: 0.846 ± 0.055
3.222AspAsn: 3.222 ± 0.135
1.261AspPro: 1.261 ± 0.073
1.808AspGln: 1.808 ± 0.087
1.411AspArg: 1.411 ± 0.07
3.305AspSer: 3.305 ± 0.118
2.276AspThr: 2.276 ± 0.094
2.489AspVal: 2.489 ± 0.092
0.382AspTrp: 0.382 ± 0.037
2.182AspTyr: 2.182 ± 0.091
0.0AspXaa: 0.0 ± 0.0
Glu
3.428GluAla: 3.428 ± 0.166
0.67GluCys: 0.67 ± 0.049
2.433GluAsp: 2.433 ± 0.129
3.286GluGlu: 3.286 ± 0.133
2.313GluPhe: 2.313 ± 0.095
2.036GluGly: 2.036 ± 0.101
1.119GluHis: 1.119 ± 0.064
5.303GluIle: 5.303 ± 0.147
4.214GluLys: 4.214 ± 0.139
5.928GluLeu: 5.928 ± 0.139
1.168GluMet: 1.168 ± 0.068
3.279GluAsn: 3.279 ± 0.126
1.149GluPro: 1.149 ± 0.079
2.511GluGln: 2.511 ± 0.109
1.823GluArg: 1.823 ± 0.09
3.118GluSer: 3.118 ± 0.102
2.047GluThr: 2.047 ± 0.086
3.458GluVal: 3.458 ± 0.137
0.427GluTrp: 0.427 ± 0.041
2.324GluTyr: 2.324 ± 0.102
0.0GluXaa: 0.0 ± 0.0
Phe
2.515PheAla: 2.515 ± 0.104
0.741PheCys: 0.741 ± 0.056
2.392PheAsp: 2.392 ± 0.098
1.811PheGlu: 1.811 ± 0.094
2.642PhePhe: 2.642 ± 0.127
2.339PheGly: 2.339 ± 0.108
0.853PheHis: 0.853 ± 0.052
4.981PheIle: 4.981 ± 0.156
3.163PheLys: 3.163 ± 0.099
4.188PheLeu: 4.188 ± 0.164
0.932PheMet: 0.932 ± 0.059
3.308PheAsn: 3.308 ± 0.13
1.284PhePro: 1.284 ± 0.076
1.482PheGln: 1.482 ± 0.075
1.224PheArg: 1.224 ± 0.063
3.963PheSer: 3.963 ± 0.147
2.287PheThr: 2.287 ± 0.099
2.174PheVal: 2.174 ± 0.088
0.427PheTrp: 0.427 ± 0.041
1.849PheTyr: 1.849 ± 0.089
0.0PheXaa: 0.0 ± 0.0
Gly
3.357GlyAla: 3.357 ± 0.131
0.737GlyCys: 0.737 ± 0.053
2.197GlyAsp: 2.197 ± 0.096
2.481GlyGlu: 2.481 ± 0.109
2.137GlyPhe: 2.137 ± 0.105
3.256GlyGly: 3.256 ± 0.168
0.958GlyHis: 0.958 ± 0.061
5.756GlyIle: 5.756 ± 0.184
4.308GlyLys: 4.308 ± 0.157
4.311GlyLeu: 4.311 ± 0.135
1.145GlyMet: 1.145 ± 0.073
2.736GlyAsn: 2.736 ± 0.101
1.156GlyPro: 1.156 ± 0.065
1.793GlyGln: 1.793 ± 0.073
1.868GlyArg: 1.868 ± 0.103
3.451GlySer: 3.451 ± 0.127
2.594GlyThr: 2.594 ± 0.113
3.061GlyVal: 3.061 ± 0.125
0.528GlyTrp: 0.528 ± 0.048
2.047GlyTyr: 2.047 ± 0.093
0.0GlyXaa: 0.0 ± 0.0
His
1.127HisAla: 1.127 ± 0.072
0.374HisCys: 0.374 ± 0.037
1.044HisAsp: 1.044 ± 0.065
0.906HisGlu: 0.906 ± 0.059
0.891HisPhe: 0.891 ± 0.065
1.168HisGly: 1.168 ± 0.062
0.513HisHis: 0.513 ± 0.05
1.961HisIle: 1.961 ± 0.085
1.475HisLys: 1.475 ± 0.073
1.931HisLeu: 1.931 ± 0.104
0.378HisMet: 0.378 ± 0.042
1.471HisAsn: 1.471 ± 0.077
0.666HisPro: 0.666 ± 0.053
0.898HisGln: 0.898 ± 0.055
0.786HisArg: 0.786 ± 0.051
1.531HisSer: 1.531 ± 0.083
0.981HisThr: 0.981 ± 0.065
1.011HisVal: 1.011 ± 0.063
0.213HisTrp: 0.213 ± 0.027
0.962HisTyr: 0.962 ± 0.065
0.0HisXaa: 0.0 ± 0.0
Ile
7.407IleAla: 7.407 ± 0.202
1.448IleCys: 1.448 ± 0.076
5.393IleAsp: 5.393 ± 0.164
5.734IleGlu: 5.734 ± 0.145
4.783IlePhe: 4.783 ± 0.173
5.49IleGly: 5.49 ± 0.181
1.804IleHis: 1.804 ± 0.076
11.232IleIle: 11.232 ± 0.309
8.724IleLys: 8.724 ± 0.197
10.273IleLeu: 10.273 ± 0.258
2.066IleMet: 2.066 ± 0.102
7.403IleAsn: 7.403 ± 0.187
3.413IlePro: 3.413 ± 0.117
3.496IleGln: 3.496 ± 0.123
3.185IleArg: 3.185 ± 0.116
8.23IleSer: 8.23 ± 0.203
6.145IleThr: 6.145 ± 0.155
6.377IleVal: 6.377 ± 0.163
0.793IleTrp: 0.793 ± 0.054
3.559IleTyr: 3.559 ± 0.119
0.0IleXaa: 0.0 ± 0.0
Lys
4.566LysAla: 4.566 ± 0.142
0.902LysCys: 0.902 ± 0.063
3.507LysAsp: 3.507 ± 0.11
4.356LysGlu: 4.356 ± 0.173
3.743LysPhe: 3.743 ± 0.139
3.02LysGly: 3.02 ± 0.109
1.714LysHis: 1.714 ± 0.078
8.874LysIle: 8.874 ± 0.211
5.996LysLys: 5.996 ± 0.163
8.941LysLeu: 8.941 ± 0.213
1.688LysMet: 1.688 ± 0.092
5.651LysAsn: 5.651 ± 0.148
1.935LysPro: 1.935 ± 0.086
3.357LysGln: 3.357 ± 0.117
2.418LysArg: 2.418 ± 0.105
5.131LysSer: 5.131 ± 0.136
3.724LysThr: 3.724 ± 0.112
4.757LysVal: 4.757 ± 0.148
0.569LysTrp: 0.569 ± 0.053
3.555LysTyr: 3.555 ± 0.112
0.0LysXaa: 0.0 ± 0.0
Leu
6.77LeuAla: 6.77 ± 0.153
1.527LeuCys: 1.527 ± 0.082
4.311LeuAsp: 4.311 ± 0.139
5.431LeuGlu: 5.431 ± 0.163
4.035LeuPhe: 4.035 ± 0.153
5.389LeuGly: 5.389 ± 0.169
2.328LeuHis: 2.328 ± 0.095
9.458LeuIle: 9.458 ± 0.248
7.631LeuLys: 7.631 ± 0.174
11.19LeuLeu: 11.19 ± 0.264
2.212LeuMet: 2.212 ± 0.087
6.377LeuAsn: 6.377 ± 0.15
3.81LeuPro: 3.81 ± 0.118
4.476LeuGln: 4.476 ± 0.141
3.428LeuArg: 3.428 ± 0.113
8.376LeuSer: 8.376 ± 0.193
5.232LeuThr: 5.232 ± 0.148
5.595LeuVal: 5.595 ± 0.164
0.846LeuTrp: 0.846 ± 0.065
3.612LeuTyr: 3.612 ± 0.132
0.0LeuXaa: 0.0 ± 0.0
Met
1.115MetAla: 1.115 ± 0.068
0.266MetCys: 0.266 ± 0.037
0.842MetAsp: 0.842 ± 0.058
1.029MetGlu: 1.029 ± 0.067
0.831MetPhe: 0.831 ± 0.064
0.928MetGly: 0.928 ± 0.059
0.561MetHis: 0.561 ± 0.043
2.152MetIle: 2.152 ± 0.09
1.49MetLys: 1.49 ± 0.073
2.923MetLeu: 2.923 ± 0.113
0.494MetMet: 0.494 ± 0.039
1.28MetAsn: 1.28 ± 0.078
0.984MetPro: 0.984 ± 0.057
1.194MetGln: 1.194 ± 0.065
0.842MetArg: 0.842 ± 0.053
1.516MetSer: 1.516 ± 0.076
0.936MetThr: 0.936 ± 0.056
1.299MetVal: 1.299 ± 0.074
0.176MetTrp: 0.176 ± 0.031
0.606MetTyr: 0.606 ± 0.052
0.0MetXaa: 0.0 ± 0.0
Asn
3.402AsnAla: 3.402 ± 0.106
0.951AsnCys: 0.951 ± 0.056
2.99AsnAsp: 2.99 ± 0.106
3.177AsnGlu: 3.177 ± 0.115
3.365AsnPhe: 3.365 ± 0.121
2.605AsnGly: 2.605 ± 0.104
1.43AsnHis: 1.43 ± 0.08
8.425AsnIle: 8.425 ± 0.22
5.764AsnLys: 5.764 ± 0.155
6.972AsnLeu: 6.972 ± 0.163
1.49AsnMet: 1.49 ± 0.071
6.497AsnAsn: 6.497 ± 0.2
2.021AsnPro: 2.021 ± 0.1
2.99AsnGln: 2.99 ± 0.111
1.77AsnArg: 1.77 ± 0.077
5.337AsnSer: 5.337 ± 0.167
3.323AsnThr: 3.323 ± 0.123
3.17AsnVal: 3.17 ± 0.106
0.457AsnTrp: 0.457 ± 0.044
3.245AsnTyr: 3.245 ± 0.123
0.0AsnXaa: 0.0 ± 0.0
Pro
1.636ProAla: 1.636 ± 0.08
0.367ProCys: 0.367 ± 0.039
1.385ProAsp: 1.385 ± 0.085
1.924ProGlu: 1.924 ± 0.086
1.321ProPhe: 1.321 ± 0.079
1.654ProGly: 1.654 ± 0.104
0.588ProHis: 0.588 ± 0.05
3.046ProIle: 3.046 ± 0.107
2.028ProLys: 2.028 ± 0.091
2.871ProLeu: 2.871 ± 0.107
0.576ProMet: 0.576 ± 0.044
1.927ProAsn: 1.927 ± 0.085
0.906ProPro: 0.906 ± 0.064
1.153ProGln: 1.153 ± 0.061
0.816ProArg: 0.816 ± 0.06
2.111ProSer: 2.111 ± 0.088
1.534ProThr: 1.534 ± 0.082
1.781ProVal: 1.781 ± 0.09
0.24ProTrp: 0.24 ± 0.034
1.183ProTyr: 1.183 ± 0.069
0.0ProXaa: 0.0 ± 0.0
Gln
2.668GlnAla: 2.668 ± 0.106
0.561GlnCys: 0.561 ± 0.04
1.916GlnAsp: 1.916 ± 0.088
2.781GlnGlu: 2.781 ± 0.117
1.594GlnPhe: 1.594 ± 0.081
1.699GlnGly: 1.699 ± 0.081
1.048GlnHis: 1.048 ± 0.06
3.563GlnIle: 3.563 ± 0.101
3.32GlnLys: 3.32 ± 0.12
4.128GlnLeu: 4.128 ± 0.158
0.883GlnMet: 0.883 ± 0.064
2.968GlnAsn: 2.968 ± 0.116
1.007GlnPro: 1.007 ± 0.066
2.481GlnGln: 2.481 ± 0.114
1.284GlnArg: 1.284 ± 0.079
2.975GlnSer: 2.975 ± 0.114
1.549GlnThr: 1.549 ± 0.075
2.38GlnVal: 2.38 ± 0.088
0.247GlnTrp: 0.247 ± 0.032
1.8GlnTyr: 1.8 ± 0.081
0.0GlnXaa: 0.0 ± 0.0
Arg
2.077ArgAla: 2.077 ± 0.103
0.494ArgCys: 0.494 ± 0.043
1.422ArgAsp: 1.422 ± 0.08
1.737ArgGlu: 1.737 ± 0.085
1.546ArgPhe: 1.546 ± 0.08
1.752ArgGly: 1.752 ± 0.098
0.625ArgHis: 0.625 ± 0.051
3.413ArgIle: 3.413 ± 0.119
2.552ArgLys: 2.552 ± 0.109
3.342ArgLeu: 3.342 ± 0.117
0.782ArgMet: 0.782 ± 0.054
1.905ArgAsn: 1.905 ± 0.092
0.891ArgPro: 0.891 ± 0.063
1.239ArgGln: 1.239 ± 0.069
1.572ArgArg: 1.572 ± 0.084
2.294ArgSer: 2.294 ± 0.093
1.527ArgThr: 1.527 ± 0.083
1.95ArgVal: 1.95 ± 0.094
0.288ArgTrp: 0.288 ± 0.031
1.512ArgTyr: 1.512 ± 0.079
0.0ArgXaa: 0.0 ± 0.0
Ser
4.394SerAla: 4.394 ± 0.136
1.16SerCys: 1.16 ± 0.067
3.286SerAsp: 3.286 ± 0.114
3.679SerGlu: 3.679 ± 0.131
3.301SerPhe: 3.301 ± 0.118
3.956SerGly: 3.956 ± 0.149
1.381SerHis: 1.381 ± 0.073
8.256SerIle: 8.256 ± 0.213
6.145SerLys: 6.145 ± 0.155
7.276SerLeu: 7.276 ± 0.17
1.606SerMet: 1.606 ± 0.069
5.704SerAsn: 5.704 ± 0.175
1.916SerPro: 1.916 ± 0.083
2.665SerGln: 2.665 ± 0.105
2.347SerArg: 2.347 ± 0.092
6.374SerSer: 6.374 ± 0.211
3.896SerThr: 3.896 ± 0.129
3.844SerVal: 3.844 ± 0.133
0.554SerTrp: 0.554 ± 0.049
3.121SerTyr: 3.121 ± 0.112
0.0SerXaa: 0.0 ± 0.0
Thr
3.544ThrAla: 3.544 ± 0.125
0.633ThrCys: 0.633 ± 0.051
2.216ThrAsp: 2.216 ± 0.089
2.496ThrGlu: 2.496 ± 0.102
1.95ThrPhe: 1.95 ± 0.091
2.796ThrGly: 2.796 ± 0.108
0.868ThrHis: 0.868 ± 0.068
5.629ThrIle: 5.629 ± 0.164
3.997ThrLys: 3.997 ± 0.125
4.615ThrLeu: 4.615 ± 0.133
1.04ThrMet: 1.04 ± 0.069
3.365ThrAsn: 3.365 ± 0.139
1.725ThrPro: 1.725 ± 0.075
1.804ThrGln: 1.804 ± 0.081
1.501ThrArg: 1.501 ± 0.08
3.705ThrSer: 3.705 ± 0.133
2.994ThrThr: 2.994 ± 0.096
3.185ThrVal: 3.185 ± 0.11
0.333ThrTrp: 0.333 ± 0.044
1.549ThrTyr: 1.549 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
3.657ValAla: 3.657 ± 0.132
0.711ValCys: 0.711 ± 0.058
2.792ValAsp: 2.792 ± 0.104
3.155ValGlu: 3.155 ± 0.123
2.35ValPhe: 2.35 ± 0.109
3.017ValGly: 3.017 ± 0.116
1.033ValHis: 1.033 ± 0.056
6.422ValIle: 6.422 ± 0.166
4.442ValLys: 4.442 ± 0.152
5.696ValLeu: 5.696 ± 0.161
1.374ValMet: 1.374 ± 0.077
3.604ValAsn: 3.604 ± 0.115
1.669ValPro: 1.669 ± 0.067
1.98ValGln: 1.98 ± 0.086
1.95ValArg: 1.95 ± 0.08
4.311ValSer: 4.311 ± 0.125
2.915ValThr: 2.915 ± 0.106
3.701ValVal: 3.701 ± 0.132
0.442ValTrp: 0.442 ± 0.043
1.86ValTyr: 1.86 ± 0.082
0.0ValXaa: 0.0 ± 0.0
Trp
0.412TrpAla: 0.412 ± 0.047
0.127TrpCys: 0.127 ± 0.023
0.299TrpAsp: 0.299 ± 0.035
0.251TrpGlu: 0.251 ± 0.032
0.378TrpPhe: 0.378 ± 0.042
0.43TrpGly: 0.43 ± 0.046
0.243TrpHis: 0.243 ± 0.031
0.689TrpIle: 0.689 ± 0.063
0.52TrpLys: 0.52 ± 0.05
1.029TrpLeu: 1.029 ± 0.058
0.153TrpMet: 0.153 ± 0.029
0.55TrpAsn: 0.55 ± 0.046
0.284TrpPro: 0.284 ± 0.036
0.569TrpGln: 0.569 ± 0.05
0.382TrpArg: 0.382 ± 0.04
0.58TrpSer: 0.58 ± 0.043
0.258TrpThr: 0.258 ± 0.034
0.397TrpVal: 0.397 ± 0.038
0.094TrpTrp: 0.094 ± 0.019
0.404TrpTyr: 0.404 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.264TyrAla: 2.264 ± 0.121
0.662TyrCys: 0.662 ± 0.051
2.107TyrAsp: 2.107 ± 0.108
1.662TyrGlu: 1.662 ± 0.074
2.028TyrPhe: 2.028 ± 0.104
2.07TyrGly: 2.07 ± 0.081
0.981TyrHis: 0.981 ± 0.06
3.904TyrIle: 3.904 ± 0.124
2.844TyrLys: 2.844 ± 0.092
4.128TyrLeu: 4.128 ± 0.112
0.737TyrMet: 0.737 ± 0.05
3.271TyrAsn: 3.271 ± 0.125
1.078TyrPro: 1.078 ± 0.06
1.875TyrGln: 1.875 ± 0.085
1.452TyrArg: 1.452 ± 0.083
3.192TyrSer: 3.192 ± 0.122
1.673TyrThr: 1.673 ± 0.081
1.883TyrVal: 1.883 ± 0.074
0.382TyrTrp: 0.382 ± 0.042
2.028TyrTyr: 2.028 ± 0.106
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1067 proteins (267194 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski