Amino acid dipepetide frequency for Moraxella atlantae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.566AlaAla: 10.566 ± 0.22
1.114AlaCys: 1.114 ± 0.044
7.13AlaAsp: 7.13 ± 0.113
5.117AlaGlu: 5.117 ± 0.114
3.37AlaPhe: 3.37 ± 0.073
6.919AlaGly: 6.919 ± 0.131
2.56AlaHis: 2.56 ± 0.077
5.914AlaIle: 5.914 ± 0.103
5.369AlaLys: 5.369 ± 0.115
11.654AlaLeu: 11.654 ± 0.22
3.055AlaMet: 3.055 ± 0.072
4.904AlaAsn: 4.904 ± 0.106
4.281AlaPro: 4.281 ± 0.095
6.672AlaGln: 6.672 ± 0.134
5.279AlaArg: 5.279 ± 0.114
5.826AlaSer: 5.826 ± 0.086
5.935AlaThr: 5.935 ± 0.113
7.212AlaVal: 7.212 ± 0.141
1.267AlaTrp: 1.267 ± 0.057
2.815AlaTyr: 2.815 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.8CysAla: 0.8 ± 0.045
0.106CysCys: 0.106 ± 0.015
0.539CysAsp: 0.539 ± 0.03
0.38CysGlu: 0.38 ± 0.029
0.326CysPhe: 0.326 ± 0.022
0.697CysGly: 0.697 ± 0.036
0.337CysHis: 0.337 ± 0.024
0.466CysIle: 0.466 ± 0.032
0.22CysLys: 0.22 ± 0.023
0.886CysLeu: 0.886 ± 0.038
0.185CysMet: 0.185 ± 0.018
0.292CysAsn: 0.292 ± 0.021
0.448CysPro: 0.448 ± 0.033
0.726CysGln: 0.726 ± 0.039
0.485CysArg: 0.485 ± 0.028
0.414CysSer: 0.414 ± 0.026
0.358CysThr: 0.358 ± 0.027
0.734CysVal: 0.734 ± 0.034
0.092CysTrp: 0.092 ± 0.011
0.273CysTyr: 0.273 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
6.122AspAla: 6.122 ± 0.122
0.505AspCys: 0.505 ± 0.034
4.102AspAsp: 4.102 ± 0.098
3.394AspGlu: 3.394 ± 0.079
2.483AspPhe: 2.483 ± 0.059
4.219AspGly: 4.219 ± 0.12
1.172AspHis: 1.172 ± 0.048
4.096AspIle: 4.096 ± 0.1
3.211AspLys: 3.211 ± 0.078
5.674AspLeu: 5.674 ± 0.109
1.521AspMet: 1.521 ± 0.05
2.937AspAsn: 2.937 ± 0.083
2.204AspPro: 2.204 ± 0.067
1.971AspGln: 1.971 ± 0.054
2.323AspArg: 2.323 ± 0.058
3.53AspSer: 3.53 ± 0.086
3.989AspThr: 3.989 ± 0.098
4.034AspVal: 4.034 ± 0.084
1.074AspTrp: 1.074 ± 0.042
2.242AspTyr: 2.242 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
4.338GluAla: 4.338 ± 0.098
0.353GluCys: 0.353 ± 0.026
2.074GluAsp: 2.074 ± 0.071
1.714GluGlu: 1.714 ± 0.07
1.86GluPhe: 1.86 ± 0.062
2.411GluGly: 2.411 ± 0.074
1.329GluHis: 1.329 ± 0.042
2.76GluIle: 2.76 ± 0.073
2.023GluLys: 2.023 ± 0.074
5.149GluLeu: 5.149 ± 0.11
0.997GluMet: 0.997 ± 0.035
1.787GluAsn: 1.787 ± 0.052
1.957GluPro: 1.957 ± 0.064
3.859GluGln: 3.859 ± 0.101
3.376GluArg: 3.376 ± 0.099
1.873GluSer: 1.873 ± 0.062
2.308GluThr: 2.308 ± 0.074
3.101GluVal: 3.101 ± 0.079
0.547GluTrp: 0.547 ± 0.032
1.393GluTyr: 1.393 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
4.455PheAla: 4.455 ± 0.096
0.458PheCys: 0.458 ± 0.027
3.042PheAsp: 3.042 ± 0.068
1.862PheGlu: 1.862 ± 0.064
1.326PhePhe: 1.326 ± 0.057
3.139PheGly: 3.139 ± 0.077
0.661PheHis: 0.661 ± 0.035
2.06PheIle: 2.06 ± 0.068
1.388PheLys: 1.388 ± 0.049
2.89PheLeu: 2.89 ± 0.069
0.844PheMet: 0.844 ± 0.042
1.752PheAsn: 1.752 ± 0.053
0.913PhePro: 0.913 ± 0.045
0.8PheGln: 0.8 ± 0.042
1.348PheArg: 1.348 ± 0.043
2.405PheSer: 2.405 ± 0.065
1.92PheThr: 1.92 ± 0.065
2.742PheVal: 2.742 ± 0.066
0.488PheTrp: 0.488 ± 0.029
1.272PheTyr: 1.272 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
5.52GlyAla: 5.52 ± 0.119
0.708GlyCys: 0.708 ± 0.033
3.741GlyAsp: 3.741 ± 0.123
3.687GlyGlu: 3.687 ± 0.075
2.966GlyPhe: 2.966 ± 0.083
4.75GlyGly: 4.75 ± 0.13
1.404GlyHis: 1.404 ± 0.054
4.078GlyIle: 4.078 ± 0.092
4.004GlyLys: 4.004 ± 0.092
6.884GlyLeu: 6.884 ± 0.11
2.044GlyMet: 2.044 ± 0.061
2.598GlyAsn: 2.598 ± 0.111
0.76GlyPro: 0.76 ± 0.04
3.647GlyGln: 3.647 ± 0.087
3.058GlyArg: 3.058 ± 0.07
3.422GlySer: 3.422 ± 0.109
3.478GlyThr: 3.478 ± 0.102
5.559GlyVal: 5.559 ± 0.136
0.966GlyTrp: 0.966 ± 0.044
2.565GlyTyr: 2.565 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
2.836HisAla: 2.836 ± 0.094
0.238HisCys: 0.238 ± 0.022
1.57HisAsp: 1.57 ± 0.066
1.06HisGlu: 1.06 ± 0.047
0.837HisPhe: 0.837 ± 0.038
1.865HisGly: 1.865 ± 0.07
0.825HisHis: 0.825 ± 0.045
1.413HisIle: 1.413 ± 0.059
0.81HisLys: 0.81 ± 0.044
2.177HisLeu: 2.177 ± 0.072
0.485HisMet: 0.485 ± 0.023
0.97HisAsn: 0.97 ± 0.044
1.16HisPro: 1.16 ± 0.045
1.247HisGln: 1.247 ± 0.049
1.111HisArg: 1.111 ± 0.054
1.317HisSer: 1.317 ± 0.043
1.607HisThr: 1.607 ± 0.06
1.496HisVal: 1.496 ± 0.052
0.385HisTrp: 0.385 ± 0.025
0.814HisTyr: 0.814 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.794IleAla: 6.794 ± 0.099
0.574IleCys: 0.574 ± 0.031
4.511IleAsp: 4.511 ± 0.089
3.642IleGlu: 3.642 ± 0.092
1.824IlePhe: 1.824 ± 0.055
4.561IleGly: 4.561 ± 0.106
1.245IleHis: 1.245 ± 0.043
3.058IleIle: 3.058 ± 0.085
2.692IleLys: 2.692 ± 0.067
4.452IleLeu: 4.452 ± 0.105
1.229IleMet: 1.229 ± 0.05
2.898IleAsn: 2.898 ± 0.085
2.093IlePro: 2.093 ± 0.075
2.02IleGln: 2.02 ± 0.067
2.575IleArg: 2.575 ± 0.063
3.501IleSer: 3.501 ± 0.082
3.557IleThr: 3.557 ± 0.1
3.847IleVal: 3.847 ± 0.085
0.543IleTrp: 0.543 ± 0.027
1.45IleTyr: 1.45 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.346LysAla: 4.346 ± 0.091
0.189LysCys: 0.189 ± 0.019
2.603LysAsp: 2.603 ± 0.076
1.6LysGlu: 1.6 ± 0.064
1.31LysPhe: 1.31 ± 0.048
2.422LysGly: 2.422 ± 0.065
1.077LysHis: 1.077 ± 0.052
2.761LysIle: 2.761 ± 0.077
2.19LysLys: 2.19 ± 0.072
4.528LysLeu: 4.528 ± 0.091
1.014LysMet: 1.014 ± 0.046
2.112LysAsn: 2.112 ± 0.08
2.478LysPro: 2.478 ± 0.074
2.853LysGln: 2.853 ± 0.079
2.586LysArg: 2.586 ± 0.069
2.362LysSer: 2.362 ± 0.066
3.205LysThr: 3.205 ± 0.081
2.665LysVal: 2.665 ± 0.073
0.388LysTrp: 0.388 ± 0.024
1.163LysTyr: 1.163 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
13.584LeuAla: 13.584 ± 0.209
0.889LeuCys: 0.889 ± 0.037
6.065LeuAsp: 6.065 ± 0.101
3.912LeuGlu: 3.912 ± 0.089
3.254LeuPhe: 3.254 ± 0.084
6.873LeuGly: 6.873 ± 0.114
2.332LeuHis: 2.332 ± 0.075
5.341LeuIle: 5.341 ± 0.093
4.268LeuLys: 4.268 ± 0.096
10.593LeuLeu: 10.593 ± 0.206
2.476LeuMet: 2.476 ± 0.07
4.157LeuAsn: 4.157 ± 0.11
6.054LeuPro: 6.054 ± 0.114
4.891LeuGln: 4.891 ± 0.1
5.01LeuArg: 5.01 ± 0.101
6.627LeuSer: 6.627 ± 0.122
7.001LeuThr: 7.001 ± 0.148
7.0LeuVal: 7.0 ± 0.128
1.25LeuTrp: 1.25 ± 0.05
2.704LeuTyr: 2.704 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.722MetAla: 2.722 ± 0.076
0.165MetCys: 0.165 ± 0.016
1.076MetAsp: 1.076 ± 0.045
0.627MetGlu: 0.627 ± 0.034
0.675MetPhe: 0.675 ± 0.035
1.79MetGly: 1.79 ± 0.063
0.499MetHis: 0.499 ± 0.033
1.275MetIle: 1.275 ± 0.045
0.917MetLys: 0.917 ± 0.047
2.647MetLeu: 2.647 ± 0.067
0.667MetMet: 0.667 ± 0.038
1.001MetAsn: 1.001 ± 0.041
1.599MetPro: 1.599 ± 0.049
1.516MetGln: 1.516 ± 0.048
1.255MetArg: 1.255 ± 0.052
1.408MetSer: 1.408 ± 0.051
1.779MetThr: 1.779 ± 0.06
1.755MetVal: 1.755 ± 0.058
0.198MetTrp: 0.198 ± 0.019
0.501MetTyr: 0.501 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
4.793AsnAla: 4.793 ± 0.104
0.349AsnCys: 0.349 ± 0.025
2.518AsnAsp: 2.518 ± 0.072
1.643AsnGlu: 1.643 ± 0.054
1.576AsnPhe: 1.576 ± 0.052
2.755AsnGly: 2.755 ± 0.097
1.107AsnHis: 1.107 ± 0.044
2.521AsnIle: 2.521 ± 0.072
1.69AsnLys: 1.69 ± 0.06
4.322AsnLeu: 4.322 ± 0.09
0.768AsnMet: 0.768 ± 0.035
2.012AsnAsn: 2.012 ± 0.12
2.487AsnPro: 2.487 ± 0.059
2.654AsnGln: 2.654 ± 0.112
2.37AsnArg: 2.37 ± 0.062
2.163AsnSer: 2.163 ± 0.095
2.838AsnThr: 2.838 ± 0.105
2.744AsnVal: 2.744 ± 0.092
0.58AsnTrp: 0.58 ± 0.036
1.283AsnTyr: 1.283 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
4.382ProAla: 4.382 ± 0.107
0.287ProCys: 0.287 ± 0.024
2.929ProAsp: 2.929 ± 0.076
2.359ProGlu: 2.359 ± 0.07
1.553ProPhe: 1.553 ± 0.061
1.081ProGly: 1.081 ± 0.054
1.0ProHis: 1.0 ± 0.039
2.76ProIle: 2.76 ± 0.073
2.183ProLys: 2.183 ± 0.064
4.376ProLeu: 4.376 ± 0.098
1.199ProMet: 1.199 ± 0.041
2.709ProAsn: 2.709 ± 0.074
1.836ProPro: 1.836 ± 0.075
1.998ProGln: 1.998 ± 0.056
1.7ProArg: 1.7 ± 0.06
2.823ProSer: 2.823 ± 0.07
3.783ProThr: 3.783 ± 0.078
3.384ProVal: 3.384 ± 0.08
0.404ProTrp: 0.404 ± 0.028
1.415ProTyr: 1.415 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
7.492GlnAla: 7.492 ± 0.153
0.33GlnCys: 0.33 ± 0.027
2.768GlnAsp: 2.768 ± 0.082
1.668GlnGlu: 1.668 ± 0.053
1.82GlnPhe: 1.82 ± 0.063
3.314GlnGly: 3.314 ± 0.108
1.6GlnHis: 1.6 ± 0.055
3.232GlnIle: 3.232 ± 0.077
2.033GlnLys: 2.033 ± 0.066
5.8GlnLeu: 5.8 ± 0.117
1.241GlnMet: 1.241 ± 0.052
2.223GlnAsn: 2.223 ± 0.068
2.781GlnPro: 2.781 ± 0.075
4.037GlnGln: 4.037 ± 0.121
3.124GlnArg: 3.124 ± 0.094
2.723GlnSer: 2.723 ± 0.072
3.869GlnThr: 3.869 ± 0.114
3.928GlnVal: 3.928 ± 0.089
0.54GlnTrp: 0.54 ± 0.031
1.489GlnTyr: 1.489 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
4.745ArgAla: 4.745 ± 0.103
0.398ArgCys: 0.398 ± 0.026
2.777ArgAsp: 2.777 ± 0.076
2.75ArgGlu: 2.75 ± 0.082
2.247ArgPhe: 2.247 ± 0.057
2.872ArgGly: 2.872 ± 0.076
1.404ArgHis: 1.404 ± 0.058
2.82ArgIle: 2.82 ± 0.067
1.972ArgLys: 1.972 ± 0.066
6.154ArgLeu: 6.154 ± 0.125
1.283ArgMet: 1.283 ± 0.046
1.602ArgAsn: 1.602 ± 0.054
2.047ArgPro: 2.047 ± 0.055
3.368ArgGln: 3.368 ± 0.087
2.847ArgArg: 2.847 ± 0.084
2.182ArgSer: 2.182 ± 0.061
2.332ArgThr: 2.332 ± 0.052
3.715ArgVal: 3.715 ± 0.091
0.692ArgTrp: 0.692 ± 0.034
2.102ArgTyr: 2.102 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
5.475SerAla: 5.475 ± 0.106
0.407SerCys: 0.407 ± 0.027
3.411SerAsp: 3.411 ± 0.081
2.57SerGlu: 2.57 ± 0.079
2.022SerPhe: 2.022 ± 0.071
3.833SerGly: 3.833 ± 0.094
1.44SerHis: 1.44 ± 0.044
2.852SerIle: 2.852 ± 0.072
2.367SerLys: 2.367 ± 0.061
5.759SerLeu: 5.759 ± 0.101
1.315SerMet: 1.315 ± 0.045
2.343SerAsn: 2.343 ± 0.089
2.441SerPro: 2.441 ± 0.07
3.287SerGln: 3.287 ± 0.089
2.917SerArg: 2.917 ± 0.068
3.131SerSer: 3.131 ± 0.09
3.154SerThr: 3.154 ± 0.103
3.985SerVal: 3.985 ± 0.095
0.627SerTrp: 0.627 ± 0.037
1.66SerTyr: 1.66 ± 0.078
0.0SerXaa: 0.0 ± 0.0
Thr
6.767ThrAla: 6.767 ± 0.127
0.478ThrCys: 0.478 ± 0.031
3.863ThrAsp: 3.863 ± 0.09
2.307ThrGlu: 2.307 ± 0.065
1.908ThrPhe: 1.908 ± 0.057
4.579ThrGly: 4.579 ± 0.111
1.572ThrHis: 1.572 ± 0.044
3.2ThrIle: 3.2 ± 0.091
2.05ThrLys: 2.05 ± 0.067
7.549ThrLeu: 7.549 ± 0.14
1.073ThrMet: 1.073 ± 0.042
2.575ThrAsn: 2.575 ± 0.109
3.956ThrPro: 3.956 ± 0.096
3.324ThrGln: 3.324 ± 0.091
2.814ThrArg: 2.814 ± 0.081
3.11ThrSer: 3.11 ± 0.078
4.237ThrThr: 4.237 ± 0.115
4.208ThrVal: 4.208 ± 0.123
0.627ThrTrp: 0.627 ± 0.037
1.527ThrTyr: 1.527 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
7.239ValAla: 7.239 ± 0.113
0.778ValCys: 0.778 ± 0.034
3.684ValAsp: 3.684 ± 0.08
3.3ValGlu: 3.3 ± 0.078
2.614ValPhe: 2.614 ± 0.073
4.987ValGly: 4.987 ± 0.091
1.32ValHis: 1.32 ± 0.05
4.428ValIle: 4.428 ± 0.09
3.188ValLys: 3.188 ± 0.076
7.388ValLeu: 7.388 ± 0.129
1.957ValMet: 1.957 ± 0.056
2.83ValAsn: 2.83 ± 0.078
3.047ValPro: 3.047 ± 0.087
3.234ValGln: 3.234 ± 0.07
3.379ValArg: 3.379 ± 0.077
4.175ValSer: 4.175 ± 0.106
4.29ValThr: 4.29 ± 0.126
5.563ValVal: 5.563 ± 0.119
0.925ValTrp: 0.925 ± 0.042
2.129ValTyr: 2.129 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
1.003TrpAla: 1.003 ± 0.042
0.135TrpCys: 0.135 ± 0.016
0.453TrpAsp: 0.453 ± 0.029
0.317TrpGlu: 0.317 ± 0.024
0.502TrpPhe: 0.502 ± 0.032
0.643TrpGly: 0.643 ± 0.037
0.383TrpHis: 0.383 ± 0.025
0.531TrpIle: 0.531 ± 0.034
0.276TrpLys: 0.276 ± 0.026
2.281TrpLeu: 2.281 ± 0.073
0.214TrpMet: 0.214 ± 0.019
0.255TrpAsn: 0.255 ± 0.02
0.139TrpPro: 0.139 ± 0.015
1.779TrpGln: 1.779 ± 0.067
0.743TrpArg: 0.743 ± 0.033
0.458TrpSer: 0.458 ± 0.026
0.502TrpThr: 0.502 ± 0.039
0.957TrpVal: 0.957 ± 0.044
0.189TrpTrp: 0.189 ± 0.019
0.399TrpTyr: 0.399 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.98TyrAla: 2.98 ± 0.072
0.304TyrCys: 0.304 ± 0.023
1.949TyrAsp: 1.949 ± 0.06
1.299TyrGlu: 1.299 ± 0.052
1.293TyrPhe: 1.293 ± 0.05
2.128TyrGly: 2.128 ± 0.06
0.951TyrHis: 0.951 ± 0.043
1.499TyrIle: 1.499 ± 0.044
1.001TyrLys: 1.001 ± 0.047
3.12TyrLeu: 3.12 ± 0.067
0.505TyrMet: 0.505 ± 0.027
1.217TyrAsn: 1.217 ± 0.061
1.481TyrPro: 1.481 ± 0.049
2.129TyrGln: 2.129 ± 0.074
2.012TyrArg: 2.012 ± 0.057
1.548TyrSer: 1.548 ± 0.057
1.58TyrThr: 1.58 ± 0.061
1.827TyrVal: 1.827 ± 0.055
0.375TyrTrp: 0.375 ± 0.027
0.982TyrTyr: 0.982 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1904 proteins (631180 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski