Amino acid dipepetide frequency for Burkholderia dabaoshanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.412AlaAla: 18.412 ± 0.148	1.423AlaCys: 1.423 ± 0.03	6.643AlaAsp: 6.643 ± 0.058	6.021AlaGlu: 6.021 ± 0.07	4.496AlaPhe: 4.496 ± 0.047	10.677AlaGly: 10.677 ± 0.087	3.096AlaHis: 3.096 ± 0.041	5.933AlaIle: 5.933 ± 0.061	3.788AlaLys: 3.788 ± 0.055	15.268AlaLeu: 15.268 ± 0.119	3.31AlaMet: 3.31 ± 0.041	3.236AlaAsn: 3.236 ± 0.044	6.327AlaPro: 6.327 ± 0.08	5.703AlaGln: 5.703 ± 0.067	10.07AlaArg: 10.07 ± 0.096	7.935AlaSer: 7.935 ± 0.081	6.302AlaThr: 6.302 ± 0.075	9.022AlaVal: 9.022 ± 0.081	1.787AlaTrp: 1.787 ± 0.034	2.842AlaTyr: 2.842 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.425CysAla: 1.425 ± 0.029	0.143CysCys: 0.143 ± 0.009	0.573CysAsp: 0.573 ± 0.015	0.552CysGlu: 0.552 ± 0.017	0.324CysPhe: 0.324 ± 0.013	0.999CysGly: 0.999 ± 0.028	0.235CysHis: 0.235 ± 0.012	0.382CysIle: 0.382 ± 0.012	0.213CysLys: 0.213 ± 0.011	0.783CysLeu: 0.783 ± 0.022	0.2CysMet: 0.2 ± 0.011	0.258CysAsn: 0.258 ± 0.01	0.476CysPro: 0.476 ± 0.015	0.221CysGln: 0.221 ± 0.011	0.626CysArg: 0.626 ± 0.017	0.52CysSer: 0.52 ± 0.016	0.492CysThr: 0.492 ± 0.018	0.829CysVal: 0.829 ± 0.022	0.117CysTrp: 0.117 ± 0.008	0.223CysTyr: 0.223 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.006AspAla: 8.006 ± 0.073	0.477AspCys: 0.477 ± 0.016	3.194AspAsp: 3.194 ± 0.044	3.614AspGlu: 3.614 ± 0.045	1.906AspPhe: 1.906 ± 0.03	4.714AspGly: 4.714 ± 0.046	1.073AspHis: 1.073 ± 0.023	2.434AspIle: 2.434 ± 0.04	1.43AspLys: 1.43 ± 0.029	5.009AspLeu: 5.009 ± 0.057	1.116AspMet: 1.116 ± 0.023	1.115AspAsn: 1.115 ± 0.027	2.985AspPro: 2.985 ± 0.04	1.463AspGln: 1.463 ± 0.031	3.586AspArg: 3.586 ± 0.046	2.454AspSer: 2.454 ± 0.041	2.852AspThr: 2.852 ± 0.041	4.237AspVal: 4.237 ± 0.038	0.93AspTrp: 0.93 ± 0.024	1.466AspTyr: 1.466 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.862GluAla: 6.862 ± 0.07	0.448GluCys: 0.448 ± 0.017	2.12GluAsp: 2.12 ± 0.037	2.253GluGlu: 2.253 ± 0.039	1.761GluPhe: 1.761 ± 0.032	3.432GluGly: 3.432 ± 0.044	1.579GluHis: 1.579 ± 0.027	2.71GluIle: 2.71 ± 0.04	1.662GluLys: 1.662 ± 0.039	5.525GluLeu: 5.525 ± 0.065	1.18GluMet: 1.18 ± 0.024	1.408GluAsn: 1.408 ± 0.029	2.74GluPro: 2.74 ± 0.046	2.564GluGln: 2.564 ± 0.047	5.563GluArg: 5.563 ± 0.071	2.771GluSer: 2.771 ± 0.033	2.908GluThr: 2.908 ± 0.043	3.451GluVal: 3.451 ± 0.046	0.713GluTrp: 0.713 ± 0.019	1.146GluTyr: 1.146 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.86PheAla: 4.86 ± 0.057	0.403PheCys: 0.403 ± 0.013	2.742PheAsp: 2.742 ± 0.041	2.168PheGlu: 2.168 ± 0.034	1.38PhePhe: 1.38 ± 0.029	3.555PheGly: 3.555 ± 0.049	0.718PheHis: 0.718 ± 0.02	1.497PheIle: 1.497 ± 0.032	1.03PheLys: 1.03 ± 0.025	2.836PheLeu: 2.836 ± 0.041	0.764PheMet: 0.764 ± 0.022	1.009PheAsn: 1.009 ± 0.025	1.504PhePro: 1.504 ± 0.031	0.931PheGln: 0.931 ± 0.021	1.917PheArg: 1.917 ± 0.036	2.319PheSer: 2.319 ± 0.036	1.858PheThr: 1.858 ± 0.03	3.201PheVal: 3.201 ± 0.042	0.482PheTrp: 0.482 ± 0.015	0.914PheTyr: 0.914 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	9.996GlyAla: 9.996 ± 0.081	0.887GlyCys: 0.887 ± 0.022	3.982GlyAsp: 3.982 ± 0.046	4.541GlyGlu: 4.541 ± 0.056	3.256GlyPhe: 3.256 ± 0.042	6.74GlyGly: 6.74 ± 0.087	1.93GlyHis: 1.93 ± 0.036	4.174GlyIle: 4.174 ± 0.044	3.073GlyLys: 3.073 ± 0.042	7.588GlyLeu: 7.588 ± 0.068	2.143GlyMet: 2.143 ± 0.034	2.397GlyAsn: 2.397 ± 0.05	3.021GlyPro: 3.021 ± 0.041	2.761GlyGln: 2.761 ± 0.047	5.363GlyArg: 5.363 ± 0.059	4.509GlySer: 4.509 ± 0.057	4.726GlyThr: 4.726 ± 0.072	6.467GlyVal: 6.467 ± 0.053	1.354GlyTrp: 1.354 ± 0.027	2.445GlyTyr: 2.445 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	3.265HisAla: 3.265 ± 0.045	0.285HisCys: 0.285 ± 0.012	1.306HisAsp: 1.306 ± 0.025	1.274HisGlu: 1.274 ± 0.027	0.924HisPhe: 0.924 ± 0.021	2.203HisGly: 2.203 ± 0.035	0.606HisHis: 0.606 ± 0.02	0.934HisIle: 0.934 ± 0.02	0.46HisLys: 0.46 ± 0.015	2.143HisLeu: 2.143 ± 0.03	0.502HisMet: 0.502 ± 0.017	0.487HisAsn: 0.487 ± 0.016	1.449HisPro: 1.449 ± 0.027	0.596HisGln: 0.596 ± 0.017	1.725HisArg: 1.725 ± 0.029	1.072HisSer: 1.072 ± 0.02	1.089HisThr: 1.089 ± 0.021	1.803HisVal: 1.803 ± 0.031	0.412HisTrp: 0.412 ± 0.015	0.679HisTyr: 0.679 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.114IleAla: 7.114 ± 0.059	0.423IleCys: 0.423 ± 0.014	3.714IleAsp: 3.714 ± 0.041	3.543IleGlu: 3.543 ± 0.045	1.299IlePhe: 1.299 ± 0.028	4.689IleGly: 4.689 ± 0.057	0.888IleHis: 0.888 ± 0.022	1.339IleIle: 1.339 ± 0.03	1.276IleLys: 1.276 ± 0.028	3.113IleLeu: 3.113 ± 0.047	0.7IleMet: 0.7 ± 0.02	1.228IleAsn: 1.228 ± 0.03	1.931IlePro: 1.931 ± 0.035	1.086IleGln: 1.086 ± 0.022	2.755IleArg: 2.755 ± 0.033	2.401IleSer: 2.401 ± 0.04	2.091IleThr: 2.091 ± 0.03	4.592IleVal: 4.592 ± 0.051	0.5IleTrp: 0.5 ± 0.015	0.966IleTyr: 0.966 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.441LysAla: 3.441 ± 0.049	0.166LysCys: 0.166 ± 0.01	1.354LysAsp: 1.354 ± 0.029	1.322LysGlu: 1.322 ± 0.028	0.845LysPhe: 0.845 ± 0.02	2.003LysGly: 2.003 ± 0.038	0.719LysHis: 0.719 ± 0.018	1.509LysIle: 1.509 ± 0.03	1.095LysLys: 1.095 ± 0.033	3.218LysLeu: 3.218 ± 0.041	0.714LysMet: 0.714 ± 0.019	0.826LysAsn: 0.826 ± 0.022	1.786LysPro: 1.786 ± 0.033	1.235LysGln: 1.235 ± 0.024	2.437LysArg: 2.437 ± 0.035	1.672LysSer: 1.672 ± 0.032	1.785LysThr: 1.785 ± 0.032	2.015LysVal: 2.015 ± 0.037	0.359LysTrp: 0.359 ± 0.013	0.653LysTyr: 0.653 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.675LeuAla: 14.675 ± 0.123	1.007LeuCys: 1.007 ± 0.026	5.967LeuAsp: 5.967 ± 0.061	5.189LeuGlu: 5.189 ± 0.061	3.442LeuPhe: 3.442 ± 0.046	8.022LeuGly: 8.022 ± 0.069	2.221LeuHis: 2.221 ± 0.037	4.388LeuIle: 4.388 ± 0.055	2.989LeuLys: 2.989 ± 0.043	9.555LeuLeu: 9.555 ± 0.095	2.167LeuMet: 2.167 ± 0.035	2.538LeuAsn: 2.538 ± 0.036	5.733LeuPro: 5.733 ± 0.057	3.07LeuGln: 3.07 ± 0.041	7.275LeuArg: 7.275 ± 0.064	6.327LeuSer: 6.327 ± 0.059	5.708LeuThr: 5.708 ± 0.056	7.68LeuVal: 7.68 ± 0.074	1.136LeuTrp: 1.136 ± 0.025	2.149LeuTyr: 2.149 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.441MetAla: 2.441 ± 0.035	0.173MetCys: 0.173 ± 0.009	0.921MetAsp: 0.921 ± 0.02	0.877MetGlu: 0.877 ± 0.017	0.717MetPhe: 0.717 ± 0.021	1.567MetGly: 1.567 ± 0.03	0.574MetHis: 0.574 ± 0.019	1.018MetIle: 1.018 ± 0.022	0.951MetLys: 0.951 ± 0.024	2.593MetLeu: 2.593 ± 0.036	0.564MetMet: 0.564 ± 0.018	0.837MetAsn: 0.837 ± 0.019	1.517MetPro: 1.517 ± 0.03	1.028MetGln: 1.028 ± 0.021	1.99MetArg: 1.99 ± 0.029	1.74MetSer: 1.74 ± 0.028	1.655MetThr: 1.655 ± 0.029	1.366MetVal: 1.366 ± 0.023	0.205MetTrp: 0.205 ± 0.009	0.36MetTyr: 0.36 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.588AsnAla: 3.588 ± 0.045	0.247AsnCys: 0.247 ± 0.013	1.459AsnAsp: 1.459 ± 0.028	1.368AsnGlu: 1.368 ± 0.027	0.924AsnPhe: 0.924 ± 0.021	2.574AsnGly: 2.574 ± 0.05	0.488AsnHis: 0.488 ± 0.017	1.109AsnIle: 1.109 ± 0.026	0.648AsnLys: 0.648 ± 0.02	2.509AsnLeu: 2.509 ± 0.036	0.539AsnMet: 0.539 ± 0.016	0.725AsnAsn: 0.725 ± 0.023	1.654AsnPro: 1.654 ± 0.029	0.822AsnGln: 0.822 ± 0.022	1.811AsnArg: 1.811 ± 0.032	1.255AsnSer: 1.255 ± 0.032	1.355AsnThr: 1.355 ± 0.028	2.249AsnVal: 2.249 ± 0.036	0.412AsnTrp: 0.412 ± 0.017	0.694AsnTyr: 0.694 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.705ProAla: 6.705 ± 0.059	0.383ProCys: 0.383 ± 0.015	3.092ProAsp: 3.092 ± 0.036	3.019ProGlu: 3.019 ± 0.041	1.911ProPhe: 1.911 ± 0.031	4.266ProGly: 4.266 ± 0.052	1.262ProHis: 1.262 ± 0.027	2.249ProIle: 2.249 ± 0.031	1.398ProLys: 1.398 ± 0.032	5.132ProLeu: 5.132 ± 0.058	1.152ProMet: 1.152 ± 0.024	1.504ProAsn: 1.504 ± 0.028	2.553ProPro: 2.553 ± 0.048	1.742ProGln: 1.742 ± 0.036	3.135ProArg: 3.135 ± 0.037	3.247ProSer: 3.247 ± 0.045	2.556ProThr: 2.556 ± 0.038	4.034ProVal: 4.034 ± 0.047	0.666ProTrp: 0.666 ± 0.018	1.222ProTyr: 1.222 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.981GlnAla: 4.981 ± 0.058	0.308GlnCys: 0.308 ± 0.014	1.285GlnAsp: 1.285 ± 0.029	1.346GlnGlu: 1.346 ± 0.03	1.257GlnPhe: 1.257 ± 0.025	2.414GlnGly: 2.414 ± 0.04	0.816GlnHis: 0.816 ± 0.02	1.788GlnIle: 1.788 ± 0.027	0.907GlnLys: 0.907 ± 0.023	3.636GlnLeu: 3.636 ± 0.048	0.931GlnMet: 0.931 ± 0.024	0.886GlnAsn: 0.886 ± 0.024	1.936GlnPro: 1.936 ± 0.037	1.592GlnGln: 1.592 ± 0.034	2.861GlnArg: 2.861 ± 0.038	2.085GlnSer: 2.085 ± 0.034	2.032GlnThr: 2.032 ± 0.032	2.454GlnVal: 2.454 ± 0.034	0.602GlnTrp: 0.602 ± 0.019	0.897GlnTyr: 0.897 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.272ArgAla: 9.272 ± 0.086	0.643ArgCys: 0.643 ± 0.022	3.86ArgAsp: 3.86 ± 0.05	4.629ArgGlu: 4.629 ± 0.06	3.124ArgPhe: 3.124 ± 0.043	4.85ArgGly: 4.85 ± 0.049	1.988ArgHis: 1.988 ± 0.031	3.768ArgIle: 3.768 ± 0.047	1.99ArgLys: 1.99 ± 0.034	7.726ArgLeu: 7.726 ± 0.085	1.903ArgMet: 1.903 ± 0.029	1.812ArgAsn: 1.812 ± 0.025	3.231ArgPro: 3.231 ± 0.048	2.509ArgGln: 2.509 ± 0.037	5.794ArgArg: 5.794 ± 0.064	3.75ArgSer: 3.75 ± 0.048	3.666ArgThr: 3.666 ± 0.044	5.344ArgVal: 5.344 ± 0.059	1.118ArgTrp: 1.118 ± 0.025	2.152ArgTyr: 2.152 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	7.334SerAla: 7.334 ± 0.079	0.49SerCys: 0.49 ± 0.016	2.902SerAsp: 2.902 ± 0.035	2.789SerGlu: 2.789 ± 0.039	2.152SerPhe: 2.152 ± 0.037	5.37SerGly: 5.37 ± 0.068	1.242SerHis: 1.242 ± 0.026	2.853SerIle: 2.853 ± 0.041	1.568SerLys: 1.568 ± 0.03	5.851SerLeu: 5.851 ± 0.057	1.467SerMet: 1.467 ± 0.023	1.643SerAsn: 1.643 ± 0.032	3.047SerPro: 3.047 ± 0.043	1.785SerGln: 1.785 ± 0.036	3.793SerArg: 3.793 ± 0.039	3.522SerSer: 3.522 ± 0.063	3.234SerThr: 3.234 ± 0.051	4.351SerVal: 4.351 ± 0.053	0.715SerTrp: 0.715 ± 0.021	1.348SerTyr: 1.348 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.085ThrAla: 6.085 ± 0.065	0.416ThrCys: 0.416 ± 0.016	2.616ThrAsp: 2.616 ± 0.044	2.373ThrGlu: 2.373 ± 0.033	2.01ThrPhe: 2.01 ± 0.03	4.737ThrGly: 4.737 ± 0.061	1.269ThrHis: 1.269 ± 0.023	2.683ThrIle: 2.683 ± 0.037	1.294ThrLys: 1.294 ± 0.029	6.416ThrLeu: 6.416 ± 0.062	1.192ThrMet: 1.192 ± 0.023	1.424ThrAsn: 1.424 ± 0.033	3.387ThrPro: 3.387 ± 0.038	1.947ThrGln: 1.947 ± 0.036	3.604ThrArg: 3.604 ± 0.039	3.041ThrSer: 3.041 ± 0.055	2.814ThrThr: 2.814 ± 0.056	4.352ThrVal: 4.352 ± 0.055	0.68ThrTrp: 0.68 ± 0.019	1.271ThrTyr: 1.271 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.713ValAla: 9.713 ± 0.078	0.84ValCys: 0.84 ± 0.022	4.31ValAsp: 4.31 ± 0.043	4.124ValGlu: 4.124 ± 0.05	2.773ValPhe: 2.773 ± 0.04	5.524ValGly: 5.524 ± 0.056	1.573ValHis: 1.573 ± 0.027	3.393ValIle: 3.393 ± 0.049	2.373ValLys: 2.373 ± 0.042	7.936ValLeu: 7.936 ± 0.074	1.753ValMet: 1.753 ± 0.032	2.066ValAsn: 2.066 ± 0.035	4.058ValPro: 4.058 ± 0.047	2.508ValGln: 2.508 ± 0.04	5.441ValArg: 5.441 ± 0.059	4.746ValSer: 4.746 ± 0.049	4.502ValThr: 4.502 ± 0.061	6.357ValVal: 6.357 ± 0.07	0.972ValTrp: 0.972 ± 0.022	1.707ValTyr: 1.707 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.243TrpAla: 1.243 ± 0.024	0.155TrpCys: 0.155 ± 0.008	0.627TrpAsp: 0.627 ± 0.018	0.501TrpGlu: 0.501 ± 0.016	0.567TrpPhe: 0.567 ± 0.018	0.849TrpGly: 0.849 ± 0.021	0.42TrpHis: 0.42 ± 0.012	0.708TrpIle: 0.708 ± 0.019	0.401TrpLys: 0.401 ± 0.015	1.934TrpLeu: 1.934 ± 0.03	0.366TrpMet: 0.366 ± 0.015	0.427TrpAsn: 0.427 ± 0.017	0.685TrpPro: 0.685 ± 0.021	0.645TrpGln: 0.645 ± 0.017	1.293TrpArg: 1.293 ± 0.026	0.818TrpSer: 0.818 ± 0.021	0.711TrpThr: 0.711 ± 0.024	0.907TrpVal: 0.907 ± 0.021	0.239TrpTrp: 0.239 ± 0.01	0.307TrpTyr: 0.307 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.877TyrAla: 2.877 ± 0.04	0.275TyrCys: 0.275 ± 0.013	1.397TyrAsp: 1.397 ± 0.033	1.293TyrGlu: 1.293 ± 0.027	1.017TyrPhe: 1.017 ± 0.022	2.166TyrGly: 2.166 ± 0.035	0.514TyrHis: 0.514 ± 0.016	0.779TyrIle: 0.779 ± 0.021	0.607TyrLys: 0.607 ± 0.018	2.468TyrLeu: 2.468 ± 0.037	0.432TyrMet: 0.432 ± 0.013	0.603TyrAsn: 0.603 ± 0.018	1.205TyrPro: 1.205 ± 0.024	0.807TyrGln: 0.807 ± 0.022	2.089TyrArg: 2.089 ± 0.032	1.272TyrSer: 1.272 ± 0.031	1.275TyrThr: 1.275 ± 0.032	1.956TyrVal: 1.956 ± 0.033	0.407TyrTrp: 0.407 ± 0.013	0.685TyrTyr: 0.685 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6323 proteins (2062746 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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