Amino acid dipepetide frequency for Lachnospiraceae bacterium 5_1_57FAA

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.332AlaAla: 7.332 ± 0.135	1.312AlaCys: 1.312 ± 0.038	4.52AlaAsp: 4.52 ± 0.07	4.974AlaGlu: 4.974 ± 0.077	3.085AlaPhe: 3.085 ± 0.064	6.606AlaGly: 6.606 ± 0.109	1.134AlaHis: 1.134 ± 0.034	5.722AlaIle: 5.722 ± 0.081	5.058AlaLys: 5.058 ± 0.079	6.94AlaLeu: 6.94 ± 0.102	2.659AlaMet: 2.659 ± 0.052	2.56AlaAsn: 2.56 ± 0.052	2.051AlaPro: 2.051 ± 0.059	2.307AlaGln: 2.307 ± 0.049	3.536AlaArg: 3.536 ± 0.068	4.195AlaSer: 4.195 ± 0.083	3.255AlaThr: 3.255 ± 0.065	6.231AlaVal: 6.231 ± 0.098	0.641AlaTrp: 0.641 ± 0.027	2.893AlaTyr: 2.893 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.089CysAla: 1.089 ± 0.037	0.297CysCys: 0.297 ± 0.018	0.824CysAsp: 0.824 ± 0.03	0.934CysGlu: 0.934 ± 0.03	0.614CysPhe: 0.614 ± 0.025	1.583CysGly: 1.583 ± 0.049	0.359CysHis: 0.359 ± 0.018	1.209CysIle: 1.209 ± 0.037	0.882CysLys: 0.882 ± 0.029	1.214CysLeu: 1.214 ± 0.037	0.51CysMet: 0.51 ± 0.022	0.607CysAsn: 0.607 ± 0.026	0.692CysPro: 0.692 ± 0.031	0.497CysGln: 0.497 ± 0.019	0.769CysArg: 0.769 ± 0.025	0.853CysSer: 0.853 ± 0.032	0.796CysThr: 0.796 ± 0.032	0.988CysVal: 0.988 ± 0.032	0.125CysTrp: 0.125 ± 0.012	0.545CysTyr: 0.545 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.371AspAla: 4.371 ± 0.078	0.829AspCys: 0.829 ± 0.032	2.867AspAsp: 2.867 ± 0.058	4.617AspGlu: 4.617 ± 0.081	2.368AspPhe: 2.368 ± 0.058	4.413AspGly: 4.413 ± 0.066	0.814AspHis: 0.814 ± 0.027	4.788AspIle: 4.788 ± 0.073	3.762AspLys: 3.762 ± 0.063	4.385AspLeu: 4.385 ± 0.068	2.114AspMet: 2.114 ± 0.046	2.076AspAsn: 2.076 ± 0.047	1.708AspPro: 1.708 ± 0.04	1.417AspGln: 1.417 ± 0.038	2.519AspArg: 2.519 ± 0.051	2.948AspSer: 2.948 ± 0.057	2.92AspThr: 2.92 ± 0.064	4.025AspVal: 4.025 ± 0.07	0.564AspTrp: 0.564 ± 0.024	2.823AspTyr: 2.823 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.998GluAla: 5.998 ± 0.105	0.934GluCys: 0.934 ± 0.036	4.654GluAsp: 4.654 ± 0.069	8.081GluGlu: 8.081 ± 0.156	2.688GluPhe: 2.688 ± 0.051	5.076GluGly: 5.076 ± 0.083	1.341GluHis: 1.341 ± 0.039	5.478GluIle: 5.478 ± 0.08	6.275GluLys: 6.275 ± 0.088	6.897GluLeu: 6.897 ± 0.1	2.469GluMet: 2.469 ± 0.056	3.619GluAsn: 3.619 ± 0.064	1.947GluPro: 1.947 ± 0.047	2.905GluGln: 2.905 ± 0.059	3.675GluArg: 3.675 ± 0.067	3.359GluSer: 3.359 ± 0.062	3.51GluThr: 3.51 ± 0.065	4.957GluVal: 4.957 ± 0.092	0.667GluTrp: 0.667 ± 0.025	3.28GluTyr: 3.28 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	2.95PheAla: 2.95 ± 0.058	0.718PheCys: 0.718 ± 0.026	2.368PheAsp: 2.368 ± 0.052	2.595PheGlu: 2.595 ± 0.054	1.639PhePhe: 1.639 ± 0.05	3.051PheGly: 3.051 ± 0.066	0.76PheHis: 0.76 ± 0.028	2.753PheIle: 2.753 ± 0.062	2.004PheLys: 2.004 ± 0.044	3.811PheLeu: 3.811 ± 0.086	1.16PheMet: 1.16 ± 0.036	1.333PheAsn: 1.333 ± 0.035	1.368PhePro: 1.368 ± 0.035	1.371PheGln: 1.371 ± 0.042	1.669PheArg: 1.669 ± 0.042	2.533PheSer: 2.533 ± 0.052	2.143PheThr: 2.143 ± 0.051	2.559PheVal: 2.559 ± 0.05	0.368PheTrp: 0.368 ± 0.02	1.537PheTyr: 1.537 ± 0.042	0.002PheXaa: 0.002 ± 0.001
Gly	5.32GlyAla: 5.32 ± 0.096	1.358GlyCys: 1.358 ± 0.04	3.569GlyAsp: 3.569 ± 0.067	4.888GlyGlu: 4.888 ± 0.084	3.011GlyPhe: 3.011 ± 0.064	5.146GlyGly: 5.146 ± 0.097	1.289GlyHis: 1.289 ± 0.039	6.823GlyIle: 6.823 ± 0.097	5.747GlyLys: 5.747 ± 0.075	6.208GlyLeu: 6.208 ± 0.087	2.804GlyMet: 2.804 ± 0.055	3.043GlyAsn: 3.043 ± 0.067	1.429GlyPro: 1.429 ± 0.044	2.343GlyGln: 2.343 ± 0.046	3.655GlyArg: 3.655 ± 0.068	3.996GlySer: 3.996 ± 0.066	4.376GlyThr: 4.376 ± 0.075	4.978GlyVal: 4.978 ± 0.089	0.752GlyTrp: 0.752 ± 0.044	3.405GlyTyr: 3.405 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	1.218HisAla: 1.218 ± 0.036	0.302HisCys: 0.302 ± 0.017	0.904HisAsp: 0.904 ± 0.029	1.094HisGlu: 1.094 ± 0.034	0.753HisPhe: 0.753 ± 0.028	1.281HisGly: 1.281 ± 0.04	0.399HisHis: 0.399 ± 0.023	1.391HisIle: 1.391 ± 0.04	1.024HisLys: 1.024 ± 0.035	1.58HisLeu: 1.58 ± 0.042	0.601HisMet: 0.601 ± 0.023	0.689HisAsn: 0.689 ± 0.025	0.888HisPro: 0.888 ± 0.027	0.569HisGln: 0.569 ± 0.025	0.752HisArg: 0.752 ± 0.028	0.94HisSer: 0.94 ± 0.033	0.952HisThr: 0.952 ± 0.032	1.191HisVal: 1.191 ± 0.036	0.144HisTrp: 0.144 ± 0.012	0.772HisTyr: 0.772 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.981IleAla: 5.981 ± 0.086	1.382IleCys: 1.382 ± 0.04	4.183IleAsp: 4.183 ± 0.074	5.076IleGlu: 5.076 ± 0.078	2.984IlePhe: 2.984 ± 0.065	5.72IleGly: 5.72 ± 0.092	1.451IleHis: 1.451 ± 0.044	5.295IleIle: 5.295 ± 0.087	4.178IleLys: 4.178 ± 0.069	7.382IleLeu: 7.382 ± 0.122	2.178IleMet: 2.178 ± 0.052	2.544IleAsn: 2.544 ± 0.053	3.136IlePro: 3.136 ± 0.058	2.465IleGln: 2.465 ± 0.053	3.861IleArg: 3.861 ± 0.074	4.739IleSer: 4.739 ± 0.076	4.069IleThr: 4.069 ± 0.063	5.129IleVal: 5.129 ± 0.084	0.659IleTrp: 0.659 ± 0.029	2.757IleTyr: 2.757 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	5.375LysAla: 5.375 ± 0.08	0.734LysCys: 0.734 ± 0.032	4.37LysAsp: 4.37 ± 0.073	7.658LysGlu: 7.658 ± 0.088	1.756LysPhe: 1.756 ± 0.042	4.611LysGly: 4.611 ± 0.077	0.995LysHis: 0.995 ± 0.032	4.787LysIle: 4.787 ± 0.071	6.197LysLys: 6.197 ± 0.085	4.858LysLeu: 4.858 ± 0.069	2.354LysMet: 2.354 ± 0.048	3.184LysAsn: 3.184 ± 0.06	2.009LysPro: 2.009 ± 0.044	2.082LysGln: 2.082 ± 0.047	3.344LysArg: 3.344 ± 0.064	3.232LysSer: 3.232 ± 0.056	3.454LysThr: 3.454 ± 0.066	4.71LysVal: 4.71 ± 0.075	0.593LysTrp: 0.593 ± 0.023	2.845LysTyr: 2.845 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	7.234LeuAla: 7.234 ± 0.106	1.55LeuCys: 1.55 ± 0.046	5.097LeuAsp: 5.097 ± 0.079	6.573LeuGlu: 6.573 ± 0.098	3.513LeuPhe: 3.513 ± 0.071	6.246LeuGly: 6.246 ± 0.098	1.521LeuHis: 1.521 ± 0.041	6.016LeuIle: 6.016 ± 0.095	6.563LeuLys: 6.563 ± 0.087	8.228LeuLeu: 8.228 ± 0.125	2.684LeuMet: 2.684 ± 0.053	3.592LeuAsn: 3.592 ± 0.074	3.492LeuPro: 3.492 ± 0.076	2.634LeuGln: 2.634 ± 0.057	3.74LeuArg: 3.74 ± 0.075	5.903LeuSer: 5.903 ± 0.079	4.856LeuThr: 4.856 ± 0.07	5.371LeuVal: 5.371 ± 0.082	0.756LeuTrp: 0.756 ± 0.026	3.289LeuTyr: 3.289 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.743MetAla: 2.743 ± 0.06	0.373MetCys: 0.373 ± 0.021	1.992MetAsp: 1.992 ± 0.047	2.925MetGlu: 2.925 ± 0.056	1.02MetPhe: 1.02 ± 0.034	2.276MetGly: 2.276 ± 0.053	0.502MetHis: 0.502 ± 0.022	2.294MetIle: 2.294 ± 0.051	2.763MetLys: 2.763 ± 0.052	2.971MetLeu: 2.971 ± 0.057	1.023MetMet: 1.023 ± 0.036	1.572MetAsn: 1.572 ± 0.037	1.231MetPro: 1.231 ± 0.031	1.121MetGln: 1.121 ± 0.037	1.399MetArg: 1.399 ± 0.039	1.789MetSer: 1.789 ± 0.037	1.76MetThr: 1.76 ± 0.038	2.013MetVal: 2.013 ± 0.047	0.24MetTrp: 0.24 ± 0.015	0.966MetTyr: 0.966 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.889AsnAla: 2.889 ± 0.05	0.616AsnCys: 0.616 ± 0.025	1.948AsnAsp: 1.948 ± 0.049	2.557AsnGlu: 2.557 ± 0.054	1.366AsnPhe: 1.366 ± 0.038	3.123AsnGly: 3.123 ± 0.062	0.792AsnHis: 0.792 ± 0.027	3.163AsnIle: 3.163 ± 0.058	2.343AsnLys: 2.343 ± 0.05	3.587AsnLeu: 3.587 ± 0.063	1.394AsnMet: 1.394 ± 0.038	1.538AsnAsn: 1.538 ± 0.048	1.997AsnPro: 1.997 ± 0.048	1.358AsnGln: 1.358 ± 0.035	1.914AsnArg: 1.914 ± 0.053	2.041AsnSer: 2.041 ± 0.052	2.133AsnThr: 2.133 ± 0.052	2.691AsnVal: 2.691 ± 0.061	0.389AsnTrp: 0.389 ± 0.021	1.779AsnTyr: 1.779 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.502ProAla: 2.502 ± 0.057	0.513ProCys: 0.513 ± 0.026	2.282ProAsp: 2.282 ± 0.051	3.17ProGlu: 3.17 ± 0.062	1.496ProPhe: 1.496 ± 0.044	2.499ProGly: 2.499 ± 0.05	0.597ProHis: 0.597 ± 0.025	2.166ProIle: 2.166 ± 0.045	2.029ProLys: 2.029 ± 0.048	2.718ProLeu: 2.718 ± 0.064	0.943ProMet: 0.943 ± 0.028	1.182ProAsn: 1.182 ± 0.033	0.796ProPro: 0.796 ± 0.029	1.044ProGln: 1.044 ± 0.037	1.075ProArg: 1.075 ± 0.034	1.832ProSer: 1.832 ± 0.046	1.55ProThr: 1.55 ± 0.043	2.845ProVal: 2.845 ± 0.056	0.331ProTrp: 0.331 ± 0.018	1.539ProTyr: 1.539 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.538GlnAla: 2.538 ± 0.055	0.398GlnCys: 0.398 ± 0.02	1.629GlnAsp: 1.629 ± 0.039	2.948GlnGlu: 2.948 ± 0.062	1.136GlnPhe: 1.136 ± 0.032	2.109GlnGly: 2.109 ± 0.043	0.469GlnHis: 0.469 ± 0.022	2.687GlnIle: 2.687 ± 0.043	2.655GlnLys: 2.655 ± 0.058	2.69GlnLeu: 2.69 ± 0.052	1.3GlnMet: 1.3 ± 0.043	1.408GlnAsn: 1.408 ± 0.042	0.855GlnPro: 0.855 ± 0.028	1.136GlnGln: 1.136 ± 0.037	1.459GlnArg: 1.459 ± 0.041	1.64GlnSer: 1.64 ± 0.038	1.512GlnThr: 1.512 ± 0.041	2.261GlnVal: 2.261 ± 0.048	0.33GlnTrp: 0.33 ± 0.02	1.368GlnTyr: 1.368 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.711ArgAla: 2.711 ± 0.047	0.669ArgCys: 0.669 ± 0.028	2.169ArgAsp: 2.169 ± 0.047	3.887ArgGlu: 3.887 ± 0.074	1.883ArgPhe: 1.883 ± 0.044	2.639ArgGly: 2.639 ± 0.046	0.911ArgHis: 0.911 ± 0.031	3.803ArgIle: 3.803 ± 0.063	3.694ArgLys: 3.694 ± 0.069	4.43ArgLeu: 4.43 ± 0.074	1.795ArgMet: 1.795 ± 0.04	2.057ArgAsn: 2.057 ± 0.045	1.399ArgPro: 1.399 ± 0.041	1.982ArgGln: 1.982 ± 0.046	2.62ArgArg: 2.62 ± 0.058	2.164ArgSer: 2.164 ± 0.053	2.346ArgThr: 2.346 ± 0.051	2.608ArgVal: 2.608 ± 0.054	0.391ArgTrp: 0.391 ± 0.02	2.003ArgTyr: 2.003 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.892SerAla: 3.892 ± 0.071	0.812SerCys: 0.812 ± 0.029	3.007SerAsp: 3.007 ± 0.06	3.588SerGlu: 3.588 ± 0.068	2.357SerPhe: 2.357 ± 0.051	4.877SerGly: 4.877 ± 0.081	1.095SerHis: 1.095 ± 0.034	4.154SerIle: 4.154 ± 0.065	3.42SerLys: 3.42 ± 0.059	5.085SerLeu: 5.085 ± 0.07	1.802SerMet: 1.802 ± 0.047	1.985SerAsn: 1.985 ± 0.056	1.734SerPro: 1.734 ± 0.043	1.956SerGln: 1.956 ± 0.049	2.766SerArg: 2.766 ± 0.055	3.205SerSer: 3.205 ± 0.065	2.618SerThr: 2.618 ± 0.063	4.145SerVal: 4.145 ± 0.07	0.486SerTrp: 0.486 ± 0.026	2.27SerTyr: 2.27 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.138ThrAla: 4.138 ± 0.075	0.698ThrCys: 0.698 ± 0.029	3.027ThrAsp: 3.027 ± 0.062	3.463ThrGlu: 3.463 ± 0.06	2.086ThrPhe: 2.086 ± 0.045	4.622ThrGly: 4.622 ± 0.075	0.82ThrHis: 0.82 ± 0.031	3.744ThrIle: 3.744 ± 0.083	3.102ThrLys: 3.102 ± 0.057	4.84ThrLeu: 4.84 ± 0.072	1.511ThrMet: 1.511 ± 0.042	1.793ThrAsn: 1.793 ± 0.045	2.082ThrPro: 2.082 ± 0.05	1.558ThrGln: 1.558 ± 0.044	1.998ThrArg: 1.998 ± 0.044	2.842ThrSer: 2.842 ± 0.048	2.719ThrThr: 2.719 ± 0.057	4.118ThrVal: 4.118 ± 0.069	0.42ThrTrp: 0.42 ± 0.025	2.033ThrTyr: 2.033 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	5.246ValAla: 5.246 ± 0.084	1.147ValCys: 1.147 ± 0.038	3.888ValAsp: 3.888 ± 0.074	4.872ValGlu: 4.872 ± 0.076	2.838ValPhe: 2.838 ± 0.057	4.506ValGly: 4.506 ± 0.083	1.13ValHis: 1.13 ± 0.036	5.399ValIle: 5.399 ± 0.099	4.464ValLys: 4.464 ± 0.07	6.478ValLeu: 6.478 ± 0.084	2.129ValMet: 2.129 ± 0.05	2.703ValAsn: 2.703 ± 0.057	2.622ValPro: 2.622 ± 0.055	1.854ValGln: 1.854 ± 0.044	2.979ValArg: 2.979 ± 0.063	4.373ValSer: 4.373 ± 0.064	4.071ValThr: 4.071 ± 0.066	4.76ValVal: 4.76 ± 0.088	0.634ValTrp: 0.634 ± 0.025	2.62ValTyr: 2.62 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.572TrpAla: 0.572 ± 0.026	0.138TrpCys: 0.138 ± 0.013	0.526TrpAsp: 0.526 ± 0.024	0.697TrpGlu: 0.697 ± 0.027	0.368TrpPhe: 0.368 ± 0.021	0.656TrpGly: 0.656 ± 0.03	0.184TrpHis: 0.184 ± 0.015	0.652TrpIle: 0.652 ± 0.024	0.744TrpLys: 0.744 ± 0.027	0.804TrpLeu: 0.804 ± 0.028	0.357TrpMet: 0.357 ± 0.019	0.48TrpAsn: 0.48 ± 0.021	0.212TrpPro: 0.212 ± 0.016	0.346TrpGln: 0.346 ± 0.021	0.355TrpArg: 0.355 ± 0.021	0.443TrpSer: 0.443 ± 0.023	0.392TrpThr: 0.392 ± 0.02	0.537TrpVal: 0.537 ± 0.021	0.113TrpTrp: 0.113 ± 0.011	0.389TrpTyr: 0.389 ± 0.034	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.912TyrAla: 2.912 ± 0.058	0.606TyrCys: 0.606 ± 0.025	2.505TyrAsp: 2.505 ± 0.05	3.214TyrGlu: 3.214 ± 0.059	1.73TyrPhe: 1.73 ± 0.047	3.1TyrGly: 3.1 ± 0.06	0.883TyrHis: 0.883 ± 0.03	2.847TyrIle: 2.847 ± 0.059	2.242TyrLys: 2.242 ± 0.049	3.749TyrLeu: 3.749 ± 0.07	1.184TyrMet: 1.184 ± 0.031	1.654TyrAsn: 1.654 ± 0.043	1.461TyrPro: 1.461 ± 0.045	1.585TyrGln: 1.585 ± 0.042	2.074TyrArg: 2.074 ± 0.049	2.224TyrSer: 2.224 ± 0.052	2.183TyrThr: 2.183 ± 0.049	2.595TyrVal: 2.595 ± 0.051	0.363TyrTrp: 0.363 ± 0.023	1.971TyrTyr: 1.971 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.002XaaSer: 0.002 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3365 proteins (986099 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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