Amino acid dipepetide frequency for Afipia sp. GAS231

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.08AlaAla: 17.08 ± 0.137
1.129AlaCys: 1.129 ± 0.027
6.488AlaAsp: 6.488 ± 0.068
6.604AlaGlu: 6.604 ± 0.066
4.481AlaPhe: 4.481 ± 0.053
10.371AlaGly: 10.371 ± 0.1
2.165AlaHis: 2.165 ± 0.03
6.679AlaIle: 6.679 ± 0.062
4.969AlaLys: 4.969 ± 0.064
12.406AlaLeu: 12.406 ± 0.096
3.481AlaMet: 3.481 ± 0.051
3.426AlaAsn: 3.426 ± 0.072
5.715AlaPro: 5.715 ± 0.066
4.029AlaGln: 4.029 ± 0.048
7.971AlaArg: 7.971 ± 0.082
7.035AlaSer: 7.035 ± 0.077
6.6AlaThr: 6.6 ± 0.077
8.914AlaVal: 8.914 ± 0.069
1.47AlaTrp: 1.47 ± 0.025
2.605AlaTyr: 2.605 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
0.983CysAla: 0.983 ± 0.023
0.122CysCys: 0.122 ± 0.008
0.531CysAsp: 0.531 ± 0.015
0.448CysGlu: 0.448 ± 0.014
0.338CysPhe: 0.338 ± 0.012
0.93CysGly: 0.93 ± 0.022
0.246CysHis: 0.246 ± 0.01
0.404CysIle: 0.404 ± 0.014
0.242CysLys: 0.242 ± 0.011
0.732CysLeu: 0.732 ± 0.018
0.187CysMet: 0.187 ± 0.008
0.242CysAsn: 0.242 ± 0.011
0.416CysPro: 0.416 ± 0.016
0.244CysGln: 0.244 ± 0.01
0.625CysArg: 0.625 ± 0.019
0.487CysSer: 0.487 ± 0.015
0.433CysThr: 0.433 ± 0.015
0.67CysVal: 0.67 ± 0.016
0.132CysTrp: 0.132 ± 0.009
0.216CysTyr: 0.216 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.485AspAla: 6.485 ± 0.057
0.452AspCys: 0.452 ± 0.015
2.998AspAsp: 2.998 ± 0.045
3.034AspGlu: 3.034 ± 0.036
2.184AspPhe: 2.184 ± 0.03
4.887AspGly: 4.887 ± 0.072
1.272AspHis: 1.272 ± 0.026
3.085AspIle: 3.085 ± 0.041
1.954AspLys: 1.954 ± 0.035
5.393AspLeu: 5.393 ± 0.052
1.217AspMet: 1.217 ± 0.025
1.44AspAsn: 1.44 ± 0.035
3.289AspPro: 3.289 ± 0.041
1.715AspGln: 1.715 ± 0.03
3.954AspArg: 3.954 ± 0.047
2.295AspSer: 2.295 ± 0.038
2.613AspThr: 2.613 ± 0.057
4.226AspVal: 4.226 ± 0.044
0.872AspTrp: 0.872 ± 0.02
1.46AspTyr: 1.46 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
6.606GluAla: 6.606 ± 0.063
0.375GluCys: 0.375 ± 0.014
2.295GluAsp: 2.295 ± 0.035
2.441GluGlu: 2.441 ± 0.043
1.89GluPhe: 1.89 ± 0.032
3.615GluGly: 3.615 ± 0.045
1.121GluHis: 1.121 ± 0.025
3.366GluIle: 3.366 ± 0.044
2.286GluLys: 2.286 ± 0.037
5.115GluLeu: 5.115 ± 0.062
1.427GluMet: 1.427 ± 0.027
1.492GluAsn: 1.492 ± 0.03
2.499GluPro: 2.499 ± 0.04
2.112GluGln: 2.112 ± 0.038
4.306GluArg: 4.306 ± 0.051
2.238GluSer: 2.238 ± 0.034
3.088GluThr: 3.088 ± 0.041
3.58GluVal: 3.58 ± 0.046
0.681GluTrp: 0.681 ± 0.017
0.981GluTyr: 0.981 ± 0.023
0.0GluXaa: 0.0 ± 0.0
Phe
4.965PheAla: 4.965 ± 0.056
0.418PheCys: 0.418 ± 0.015
2.579PheAsp: 2.579 ± 0.038
2.075PheGlu: 2.075 ± 0.03
1.484PhePhe: 1.484 ± 0.031
3.922PheGly: 3.922 ± 0.049
0.746PheHis: 0.746 ± 0.02
1.803PheIle: 1.803 ± 0.034
1.238PheLys: 1.238 ± 0.027
3.271PheLeu: 3.271 ± 0.043
0.824PheMet: 0.824 ± 0.021
1.256PheAsn: 1.256 ± 0.027
1.681PhePro: 1.681 ± 0.027
1.021PheGln: 1.021 ± 0.024
2.299PheArg: 2.299 ± 0.035
2.355PheSer: 2.355 ± 0.033
2.095PheThr: 2.095 ± 0.037
3.056PheVal: 3.056 ± 0.044
0.519PheTrp: 0.519 ± 0.015
0.941PheTyr: 0.941 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
9.139GlyAla: 9.139 ± 0.104
0.837GlyCys: 0.837 ± 0.02
4.321GlyAsp: 4.321 ± 0.057
4.242GlyGlu: 4.242 ± 0.051
3.773GlyPhe: 3.773 ± 0.051
7.642GlyGly: 7.642 ± 0.151
1.894GlyHis: 1.894 ± 0.033
4.88GlyIle: 4.88 ± 0.059
3.574GlyLys: 3.574 ± 0.051
8.407GlyLeu: 8.407 ± 0.072
2.236GlyMet: 2.236 ± 0.033
2.456GlyAsn: 2.456 ± 0.063
3.576GlyPro: 3.576 ± 0.041
2.737GlyGln: 2.737 ± 0.045
5.496GlyArg: 5.496 ± 0.059
5.008GlySer: 5.008 ± 0.088
4.939GlyThr: 4.939 ± 0.123
6.161GlyVal: 6.161 ± 0.058
1.345GlyTrp: 1.345 ± 0.028
2.411GlyTyr: 2.411 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
2.308HisAla: 2.308 ± 0.034
0.209HisCys: 0.209 ± 0.009
1.202HisAsp: 1.202 ± 0.027
0.974HisGlu: 0.974 ± 0.024
0.886HisPhe: 0.886 ± 0.022
1.968HisGly: 1.968 ± 0.032
0.578HisHis: 0.578 ± 0.022
1.001HisIle: 1.001 ± 0.019
0.51HisLys: 0.51 ± 0.015
1.959HisLeu: 1.959 ± 0.033
0.471HisMet: 0.471 ± 0.015
0.504HisAsn: 0.504 ± 0.015
1.361HisPro: 1.361 ± 0.025
0.564HisGln: 0.564 ± 0.018
1.434HisArg: 1.434 ± 0.033
1.003HisSer: 1.003 ± 0.024
0.846HisThr: 0.846 ± 0.022
1.491HisVal: 1.491 ± 0.029
0.334HisTrp: 0.334 ± 0.013
0.562HisTyr: 0.562 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
7.66IleAla: 7.66 ± 0.065
0.547IleCys: 0.547 ± 0.017
3.708IleAsp: 3.708 ± 0.048
3.482IleGlu: 3.482 ± 0.046
1.81IlePhe: 1.81 ± 0.031
5.292IleGly: 5.292 ± 0.061
0.933IleHis: 0.933 ± 0.022
2.35IleIle: 2.35 ± 0.034
1.893IleLys: 1.893 ± 0.032
4.338IleLeu: 4.338 ± 0.042
1.048IleMet: 1.048 ± 0.022
1.615IleAsn: 1.615 ± 0.035
2.453IlePro: 2.453 ± 0.034
1.288IleGln: 1.288 ± 0.027
3.16IleArg: 3.16 ± 0.039
3.254IleSer: 3.254 ± 0.046
2.931IleThr: 2.931 ± 0.052
4.534IleVal: 4.534 ± 0.052
0.635IleTrp: 0.635 ± 0.016
1.24IleTyr: 1.24 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
4.61LysAla: 4.61 ± 0.053
0.208LysCys: 0.208 ± 0.01
1.948LysAsp: 1.948 ± 0.035
1.693LysGlu: 1.693 ± 0.033
1.287LysPhe: 1.287 ± 0.024
2.786LysGly: 2.786 ± 0.042
0.716LysHis: 0.716 ± 0.019
2.156LysIle: 2.156 ± 0.036
1.655LysLys: 1.655 ± 0.043
3.918LysLeu: 3.918 ± 0.043
0.984LysMet: 0.984 ± 0.023
1.105LysAsn: 1.105 ± 0.023
2.558LysPro: 2.558 ± 0.041
1.299LysGln: 1.299 ± 0.023
2.58LysArg: 2.58 ± 0.038
2.243LysSer: 2.243 ± 0.035
2.216LysThr: 2.216 ± 0.037
2.693LysVal: 2.693 ± 0.045
0.469LysTrp: 0.469 ± 0.018
0.817LysTyr: 0.817 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
12.87LeuAla: 12.87 ± 0.091
0.856LeuCys: 0.856 ± 0.022
5.399LeuAsp: 5.399 ± 0.056
4.56LeuGlu: 4.56 ± 0.055
3.595LeuPhe: 3.595 ± 0.048
7.999LeuGly: 7.999 ± 0.07
1.793LeuHis: 1.793 ± 0.032
5.077LeuIle: 5.077 ± 0.053
3.913LeuLys: 3.913 ± 0.051
8.924LeuLeu: 8.924 ± 0.094
2.313LeuMet: 2.313 ± 0.037
2.825LeuAsn: 2.825 ± 0.044
5.236LeuPro: 5.236 ± 0.05
2.82LeuGln: 2.82 ± 0.04
6.384LeuArg: 6.384 ± 0.07
6.232LeuSer: 6.232 ± 0.06
5.749LeuThr: 5.749 ± 0.076
7.183LeuVal: 7.183 ± 0.069
1.072LeuTrp: 1.072 ± 0.023
1.98LeuTyr: 1.98 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
2.968MetAla: 2.968 ± 0.042
0.166MetCys: 0.166 ± 0.009
1.06MetAsp: 1.06 ± 0.022
0.995MetGlu: 0.995 ± 0.022
0.852MetPhe: 0.852 ± 0.019
1.655MetGly: 1.655 ± 0.032
0.448MetHis: 0.448 ± 0.013
1.444MetIle: 1.444 ± 0.029
1.097MetLys: 1.097 ± 0.025
2.512MetLeu: 2.512 ± 0.04
0.693MetMet: 0.693 ± 0.018
0.79MetAsn: 0.79 ± 0.02
1.534MetPro: 1.534 ± 0.032
0.844MetGln: 0.844 ± 0.02
1.76MetArg: 1.76 ± 0.03
1.725MetSer: 1.725 ± 0.028
1.935MetThr: 1.935 ± 0.03
1.727MetVal: 1.727 ± 0.028
0.227MetTrp: 0.227 ± 0.012
0.381MetTyr: 0.381 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
3.51AsnAla: 3.51 ± 0.06
0.261AsnCys: 0.261 ± 0.012
1.561AsnAsp: 1.561 ± 0.04
1.377AsnGlu: 1.377 ± 0.023
1.182AsnPhe: 1.182 ± 0.026
2.754AsnGly: 2.754 ± 0.084
0.554AsnHis: 0.554 ± 0.018
1.611AsnIle: 1.611 ± 0.031
0.945AsnLys: 0.945 ± 0.022
2.714AsnLeu: 2.714 ± 0.045
0.652AsnMet: 0.652 ± 0.017
0.975AsnAsn: 0.975 ± 0.045
1.948AsnPro: 1.948 ± 0.034
0.816AsnGln: 0.816 ± 0.021
1.83AsnArg: 1.83 ± 0.028
1.618AsnSer: 1.618 ± 0.045
1.487AsnThr: 1.487 ± 0.044
2.259AsnVal: 2.259 ± 0.051
0.502AsnTrp: 0.502 ± 0.014
0.792AsnTyr: 0.792 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
6.465ProAla: 6.465 ± 0.062
0.317ProCys: 0.317 ± 0.013
3.561ProAsp: 3.561 ± 0.045
3.194ProGlu: 3.194 ± 0.04
2.026ProPhe: 2.026 ± 0.03
4.47ProGly: 4.47 ± 0.052
1.068ProHis: 1.068 ± 0.022
2.432ProIle: 2.432 ± 0.031
2.191ProLys: 2.191 ± 0.04
4.601ProLeu: 4.601 ± 0.055
1.221ProMet: 1.221 ± 0.028
1.632ProAsn: 1.632 ± 0.024
2.889ProPro: 2.889 ± 0.06
1.708ProGln: 1.708 ± 0.032
2.977ProArg: 2.977 ± 0.049
2.99ProSer: 2.99 ± 0.046
2.694ProThr: 2.694 ± 0.037
4.157ProVal: 4.157 ± 0.049
0.707ProTrp: 0.707 ± 0.018
1.191ProTyr: 1.191 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
3.977GlnAla: 3.977 ± 0.048
0.249GlnCys: 0.249 ± 0.011
1.349GlnAsp: 1.349 ± 0.023
1.291GlnGlu: 1.291 ± 0.025
1.233GlnPhe: 1.233 ± 0.024
2.334GlnGly: 2.334 ± 0.031
0.635GlnHis: 0.635 ± 0.018
1.904GlnIle: 1.904 ± 0.029
1.225GlnLys: 1.225 ± 0.026
3.018GlnLeu: 3.018 ± 0.041
0.899GlnMet: 0.899 ± 0.019
0.94GlnAsn: 0.94 ± 0.026
1.826GlnPro: 1.826 ± 0.033
1.264GlnGln: 1.264 ± 0.027
2.377GlnArg: 2.377 ± 0.036
1.863GlnSer: 1.863 ± 0.027
1.79GlnThr: 1.79 ± 0.039
2.231GlnVal: 2.231 ± 0.034
0.44GlnTrp: 0.44 ± 0.014
0.68GlnTyr: 0.68 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
7.476ArgAla: 7.476 ± 0.083
0.533ArgCys: 0.533 ± 0.017
3.816ArgAsp: 3.816 ± 0.047
3.822ArgGlu: 3.822 ± 0.047
2.662ArgPhe: 2.662 ± 0.036
4.649ArgGly: 4.649 ± 0.049
1.536ArgHis: 1.536 ± 0.028
3.858ArgIle: 3.858 ± 0.044
2.56ArgLys: 2.56 ± 0.04
7.12ArgLeu: 7.12 ± 0.07
1.743ArgMet: 1.743 ± 0.028
1.999ArgAsn: 1.999 ± 0.03
3.383ArgPro: 3.383 ± 0.051
2.316ArgGln: 2.316 ± 0.033
4.931ArgArg: 4.931 ± 0.066
3.764ArgSer: 3.764 ± 0.045
3.23ArgThr: 3.23 ± 0.039
4.471ArgVal: 4.471 ± 0.048
0.948ArgTrp: 0.948 ± 0.023
1.649ArgTyr: 1.649 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
6.74SerAla: 6.74 ± 0.066
0.458SerCys: 0.458 ± 0.016
3.138SerAsp: 3.138 ± 0.041
2.917SerGlu: 2.917 ± 0.043
2.37SerPhe: 2.37 ± 0.036
5.862SerGly: 5.862 ± 0.093
1.152SerHis: 1.152 ± 0.025
3.138SerIle: 3.138 ± 0.043
1.972SerLys: 1.972 ± 0.033
5.431SerLeu: 5.431 ± 0.06
1.414SerMet: 1.414 ± 0.031
1.671SerAsn: 1.671 ± 0.04
3.06SerPro: 3.06 ± 0.04
1.744SerGln: 1.744 ± 0.031
3.658SerArg: 3.658 ± 0.046
3.488SerSer: 3.488 ± 0.061
2.974SerThr: 2.974 ± 0.056
4.253SerVal: 4.253 ± 0.055
0.772SerTrp: 0.772 ± 0.021
1.447SerTyr: 1.447 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.638ThrAla: 6.638 ± 0.089
0.44ThrCys: 0.44 ± 0.017
2.88ThrAsp: 2.88 ± 0.047
2.645ThrGlu: 2.645 ± 0.036
2.215ThrPhe: 2.215 ± 0.044
5.169ThrGly: 5.169 ± 0.087
1.032ThrHis: 1.032 ± 0.026
3.178ThrIle: 3.178 ± 0.063
1.844ThrLys: 1.844 ± 0.03
5.703ThrLeu: 5.703 ± 0.078
1.312ThrMet: 1.312 ± 0.024
1.599ThrAsn: 1.599 ± 0.047
3.374ThrPro: 3.374 ± 0.037
1.542ThrGln: 1.542 ± 0.029
3.187ThrArg: 3.187 ± 0.039
3.324ThrSer: 3.324 ± 0.054
3.155ThrThr: 3.155 ± 0.066
4.38ThrVal: 4.38 ± 0.077
0.656ThrTrp: 0.656 ± 0.018
1.191ThrTyr: 1.191 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
9.43ValAla: 9.43 ± 0.068
0.65ValCys: 0.65 ± 0.016
3.955ValAsp: 3.955 ± 0.054
4.1ValGlu: 4.1 ± 0.047
2.732ValPhe: 2.732 ± 0.04
5.707ValGly: 5.707 ± 0.055
1.449ValHis: 1.449 ± 0.03
4.127ValIle: 4.127 ± 0.049
2.649ValLys: 2.649 ± 0.038
7.223ValLeu: 7.223 ± 0.067
1.885ValMet: 1.885 ± 0.034
2.273ValAsn: 2.273 ± 0.056
3.818ValPro: 3.818 ± 0.048
2.112ValGln: 2.112 ± 0.028
4.689ValArg: 4.689 ± 0.057
4.519ValSer: 4.519 ± 0.055
4.737ValThr: 4.737 ± 0.068
6.14ValVal: 6.14 ± 0.06
0.926ValTrp: 0.926 ± 0.022
1.525ValTyr: 1.525 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.14TrpAla: 1.14 ± 0.021
0.144TrpCys: 0.144 ± 0.008
0.594TrpAsp: 0.594 ± 0.02
0.504TrpGlu: 0.504 ± 0.017
0.535TrpPhe: 0.535 ± 0.017
0.93TrpGly: 0.93 ± 0.021
0.359TrpHis: 0.359 ± 0.014
0.744TrpIle: 0.744 ± 0.02
0.52TrpLys: 0.52 ± 0.017
1.598TrpLeu: 1.598 ± 0.028
0.372TrpMet: 0.372 ± 0.013
0.493TrpAsn: 0.493 ± 0.014
0.698TrpPro: 0.698 ± 0.019
0.564TrpGln: 0.564 ± 0.017
1.119TrpArg: 1.119 ± 0.025
0.89TrpSer: 0.89 ± 0.019
0.822TrpThr: 0.822 ± 0.022
0.786TrpVal: 0.786 ± 0.019
0.234TrpTrp: 0.234 ± 0.011
0.285TrpTyr: 0.285 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.569TyrAla: 2.569 ± 0.04
0.258TyrCys: 0.258 ± 0.011
1.445TyrAsp: 1.445 ± 0.028
1.117TyrGlu: 1.117 ± 0.025
1.014TyrPhe: 1.014 ± 0.024
2.13TyrGly: 2.13 ± 0.032
0.468TyrHis: 0.468 ± 0.016
0.935TyrIle: 0.935 ± 0.023
0.704TyrLys: 0.704 ± 0.02
2.394TyrLeu: 2.394 ± 0.037
0.431TyrMet: 0.431 ± 0.013
0.611TyrAsn: 0.611 ± 0.017
1.177TyrPro: 1.177 ± 0.025
0.785TyrGln: 0.785 ± 0.023
1.728TyrArg: 1.728 ± 0.032
1.331TyrSer: 1.331 ± 0.03
1.128TyrThr: 1.128 ± 0.027
1.737TyrVal: 1.737 ± 0.03
0.392TyrTrp: 0.392 ± 0.012
0.638TyrTyr: 0.638 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6976 proteins (2166649 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski