Amino acid dipepetide frequency for Oceanobacillus limi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.539AlaAla: 4.539 ± 0.079	0.529AlaCys: 0.529 ± 0.023	3.217AlaAsp: 3.217 ± 0.063	4.388AlaGlu: 4.388 ± 0.072	3.081AlaPhe: 3.081 ± 0.062	4.593AlaGly: 4.593 ± 0.076	1.133AlaHis: 1.133 ± 0.032	5.914AlaIle: 5.914 ± 0.085	4.341AlaLys: 4.341 ± 0.068	6.313AlaLeu: 6.313 ± 0.088	1.884AlaMet: 1.884 ± 0.046	2.887AlaAsn: 2.887 ± 0.055	1.844AlaPro: 1.844 ± 0.051	1.928AlaGln: 1.928 ± 0.048	2.281AlaArg: 2.281 ± 0.053	3.893AlaSer: 3.893 ± 0.063	3.604AlaThr: 3.604 ± 0.058	4.696AlaVal: 4.696 ± 0.071	0.623AlaTrp: 0.623 ± 0.028	2.319AlaTyr: 2.319 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.344CysAla: 0.344 ± 0.017	0.094CysCys: 0.094 ± 0.01	0.377CysAsp: 0.377 ± 0.02	0.363CysGlu: 0.363 ± 0.021	0.278CysPhe: 0.278 ± 0.018	0.553CysGly: 0.553 ± 0.026	0.163CysHis: 0.163 ± 0.013	0.455CysIle: 0.455 ± 0.022	0.343CysLys: 0.343 ± 0.022	0.557CysLeu: 0.557 ± 0.022	0.167CysMet: 0.167 ± 0.012	0.27CysAsn: 0.27 ± 0.016	0.297CysPro: 0.297 ± 0.018	0.206CysGln: 0.206 ± 0.014	0.224CysArg: 0.224 ± 0.015	0.457CysSer: 0.457 ± 0.021	0.357CysThr: 0.357 ± 0.018	0.375CysVal: 0.375 ± 0.018	0.06CysTrp: 0.06 ± 0.007	0.242CysTyr: 0.242 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.276AspAla: 3.276 ± 0.06	0.325AspCys: 0.325 ± 0.017	2.95AspAsp: 2.95 ± 0.057	4.98AspGlu: 4.98 ± 0.081	2.486AspPhe: 2.486 ± 0.051	3.536AspGly: 3.536 ± 0.067	1.32AspHis: 1.32 ± 0.035	4.438AspIle: 4.438 ± 0.064	3.392AspLys: 3.392 ± 0.056	5.164AspLeu: 5.164 ± 0.069	1.472AspMet: 1.472 ± 0.035	2.215AspAsn: 2.215 ± 0.053	2.208AspPro: 2.208 ± 0.045	2.369AspGln: 2.369 ± 0.057	2.496AspArg: 2.496 ± 0.052	2.851AspSer: 2.851 ± 0.055	2.748AspThr: 2.748 ± 0.054	4.013AspVal: 4.013 ± 0.067	0.664AspTrp: 0.664 ± 0.025	2.506AspTyr: 2.506 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	5.257GluAla: 5.257 ± 0.067	0.291GluCys: 0.291 ± 0.017	4.437GluAsp: 4.437 ± 0.071	7.736GluGlu: 7.736 ± 0.115	2.653GluPhe: 2.653 ± 0.053	4.301GluGly: 4.301 ± 0.068	1.527GluHis: 1.527 ± 0.039	5.997GluIle: 5.997 ± 0.088	6.687GluLys: 6.687 ± 0.106	7.327GluLeu: 7.327 ± 0.095	2.448GluMet: 2.448 ± 0.046	4.211GluAsn: 4.211 ± 0.069	2.012GluPro: 2.012 ± 0.047	3.49GluGln: 3.49 ± 0.062	3.397GluArg: 3.397 ± 0.057	4.0GluSer: 4.0 ± 0.062	3.951GluThr: 3.951 ± 0.065	5.501GluVal: 5.501 ± 0.081	0.853GluTrp: 0.853 ± 0.03	2.439GluTyr: 2.439 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.911PheAla: 2.911 ± 0.055	0.307PheCys: 0.307 ± 0.017	2.525PheAsp: 2.525 ± 0.053	2.82PheGlu: 2.82 ± 0.05	2.399PhePhe: 2.399 ± 0.06	3.231PheGly: 3.231 ± 0.064	1.097PheHis: 1.097 ± 0.032	4.216PheIle: 4.216 ± 0.079	2.241PheLys: 2.241 ± 0.044	4.582PheLeu: 4.582 ± 0.094	1.251PheMet: 1.251 ± 0.035	1.902PheAsn: 1.902 ± 0.039	1.646PhePro: 1.646 ± 0.041	1.726PheGln: 1.726 ± 0.044	1.556PheArg: 1.556 ± 0.038	3.226PheSer: 3.226 ± 0.056	2.633PheThr: 2.633 ± 0.051	3.214PheVal: 3.214 ± 0.058	0.491PheTrp: 0.491 ± 0.024	1.898PheTyr: 1.898 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.371GlyAla: 4.371 ± 0.076	0.507GlyCys: 0.507 ± 0.023	3.389GlyAsp: 3.389 ± 0.06	4.646GlyGlu: 4.646 ± 0.069	3.379GlyPhe: 3.379 ± 0.067	4.564GlyGly: 4.564 ± 0.092	1.243GlyHis: 1.243 ± 0.038	5.995GlyIle: 5.995 ± 0.085	4.746GlyLys: 4.746 ± 0.079	6.116GlyLeu: 6.116 ± 0.09	2.129GlyMet: 2.129 ± 0.051	2.923GlyAsn: 2.923 ± 0.056	1.608GlyPro: 1.608 ± 0.036	2.0GlyGln: 2.0 ± 0.043	2.419GlyArg: 2.419 ± 0.048	3.93GlySer: 3.93 ± 0.061	3.868GlyThr: 3.868 ± 0.063	4.892GlyVal: 4.892 ± 0.071	0.768GlyTrp: 0.768 ± 0.025	2.809GlyTyr: 2.809 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.348HisAla: 1.348 ± 0.036	0.179HisCys: 0.179 ± 0.012	1.124HisAsp: 1.124 ± 0.03	1.478HisGlu: 1.478 ± 0.045	1.05HisPhe: 1.05 ± 0.031	1.435HisGly: 1.435 ± 0.036	0.683HisHis: 0.683 ± 0.027	1.575HisIle: 1.575 ± 0.038	1.081HisLys: 1.081 ± 0.033	1.973HisLeu: 1.973 ± 0.042	0.547HisMet: 0.547 ± 0.02	0.892HisAsn: 0.892 ± 0.03	1.096HisPro: 1.096 ± 0.033	0.869HisGln: 0.869 ± 0.024	0.899HisArg: 0.899 ± 0.029	1.146HisSer: 1.146 ± 0.029	1.078HisThr: 1.078 ± 0.032	1.511HisVal: 1.511 ± 0.035	0.215HisTrp: 0.215 ± 0.015	0.873HisTyr: 0.873 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.874IleAla: 5.874 ± 0.088	0.59IleCys: 0.59 ± 0.025	4.876IleAsp: 4.876 ± 0.069	5.785IleGlu: 5.785 ± 0.082	3.518IlePhe: 3.518 ± 0.072	6.042IleGly: 6.042 ± 0.085	1.948IleHis: 1.948 ± 0.045	6.513IleIle: 6.513 ± 0.103	4.482IleLys: 4.482 ± 0.069	7.403IleLeu: 7.403 ± 0.113	1.9IleMet: 1.9 ± 0.04	3.715IleAsn: 3.715 ± 0.063	3.483IlePro: 3.483 ± 0.059	3.148IleGln: 3.148 ± 0.056	3.155IleArg: 3.155 ± 0.045	5.118IleSer: 5.118 ± 0.077	4.74IleThr: 4.74 ± 0.062	5.626IleVal: 5.626 ± 0.073	0.672IleTrp: 0.672 ± 0.025	2.6IleTyr: 2.6 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.173LysAla: 4.173 ± 0.081	0.277LysCys: 0.277 ± 0.017	3.962LysAsp: 3.962 ± 0.065	6.859LysGlu: 6.859 ± 0.101	1.945LysPhe: 1.945 ± 0.043	4.036LysGly: 4.036 ± 0.068	1.409LysHis: 1.409 ± 0.037	4.499LysIle: 4.499 ± 0.071	5.542LysLys: 5.542 ± 0.085	5.783LysLeu: 5.783 ± 0.072	2.024LysMet: 2.024 ± 0.048	3.464LysAsn: 3.464 ± 0.066	2.016LysPro: 2.016 ± 0.048	3.318LysGln: 3.318 ± 0.064	3.381LysArg: 3.381 ± 0.056	3.538LysSer: 3.538 ± 0.063	3.357LysThr: 3.357 ± 0.05	4.401LysVal: 4.401 ± 0.07	0.778LysTrp: 0.778 ± 0.025	2.196LysTyr: 2.196 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	6.507LeuAla: 6.507 ± 0.089	0.562LeuCys: 0.562 ± 0.021	5.105LeuAsp: 5.105 ± 0.068	6.936LeuGlu: 6.936 ± 0.08	5.087LeuPhe: 5.087 ± 0.104	6.154LeuGly: 6.154 ± 0.085	1.959LeuHis: 1.959 ± 0.042	7.366LeuIle: 7.366 ± 0.116	5.832LeuLys: 5.832 ± 0.077	9.875LeuLeu: 9.875 ± 0.15	2.339LeuMet: 2.339 ± 0.057	4.187LeuAsn: 4.187 ± 0.061	3.681LeuPro: 3.681 ± 0.064	3.643LeuGln: 3.643 ± 0.055	3.516LeuArg: 3.516 ± 0.053	6.453LeuSer: 6.453 ± 0.088	5.531LeuThr: 5.531 ± 0.07	6.27LeuVal: 6.27 ± 0.084	0.775LeuTrp: 0.775 ± 0.025	3.106LeuTyr: 3.106 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.808MetAla: 1.808 ± 0.039	0.131MetCys: 0.131 ± 0.011	1.696MetAsp: 1.696 ± 0.043	2.347MetGlu: 2.347 ± 0.047	1.089MetPhe: 1.089 ± 0.037	1.752MetGly: 1.752 ± 0.039	0.497MetHis: 0.497 ± 0.022	2.06MetIle: 2.06 ± 0.048	2.474MetLys: 2.474 ± 0.048	2.415MetLeu: 2.415 ± 0.052	0.813MetMet: 0.813 ± 0.026	1.669MetAsn: 1.669 ± 0.041	0.883MetPro: 0.883 ± 0.033	0.94MetGln: 0.94 ± 0.028	1.105MetArg: 1.105 ± 0.032	1.653MetSer: 1.653 ± 0.045	1.58MetThr: 1.58 ± 0.043	1.861MetVal: 1.861 ± 0.046	0.205MetTrp: 0.205 ± 0.015	0.816MetTyr: 0.816 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	2.663AsnAla: 2.663 ± 0.047	0.3AsnCys: 0.3 ± 0.016	2.711AsnAsp: 2.711 ± 0.055	4.015AsnGlu: 4.015 ± 0.061	1.81AsnPhe: 1.81 ± 0.038	3.398AsnGly: 3.398 ± 0.065	1.166AsnHis: 1.166 ± 0.033	3.427AsnIle: 3.427 ± 0.06	3.197AsnLys: 3.197 ± 0.061	4.128AsnLeu: 4.128 ± 0.061	1.257AsnMet: 1.257 ± 0.032	2.53AsnAsn: 2.53 ± 0.064	2.109AsnPro: 2.109 ± 0.041	2.251AsnGln: 2.251 ± 0.056	2.199AsnArg: 2.199 ± 0.046	2.438AsnSer: 2.438 ± 0.055	2.385AsnThr: 2.385 ± 0.051	3.336AsnVal: 3.336 ± 0.066	0.617AsnTrp: 0.617 ± 0.021	1.868AsnTyr: 1.868 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	1.934ProAla: 1.934 ± 0.049	0.192ProCys: 0.192 ± 0.014	1.987ProAsp: 1.987 ± 0.046	2.819ProGlu: 2.819 ± 0.059	1.885ProPhe: 1.885 ± 0.04	2.135ProGly: 2.135 ± 0.047	0.687ProHis: 0.687 ± 0.028	2.998ProIle: 2.998 ± 0.055	2.248ProLys: 2.248 ± 0.044	3.121ProLeu: 3.121 ± 0.056	0.797ProMet: 0.797 ± 0.027	1.859ProAsn: 1.859 ± 0.04	0.906ProPro: 0.906 ± 0.03	0.98ProGln: 0.98 ± 0.035	1.071ProArg: 1.071 ± 0.034	2.336ProSer: 2.336 ± 0.052	2.085ProThr: 2.085 ± 0.046	2.587ProVal: 2.587 ± 0.052	0.36ProTrp: 0.36 ± 0.021	1.42ProTyr: 1.42 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.591GlnAla: 2.591 ± 0.048	0.168GlnCys: 0.168 ± 0.011	1.965GlnAsp: 1.965 ± 0.045	3.279GlnGlu: 3.279 ± 0.059	1.611GlnPhe: 1.611 ± 0.039	2.249GlnGly: 2.249 ± 0.047	0.786GlnHis: 0.786 ± 0.027	2.669GlnIle: 2.669 ± 0.046	2.703GlnLys: 2.703 ± 0.055	4.153GlnLeu: 4.153 ± 0.07	1.167GlnMet: 1.167 ± 0.035	1.674GlnAsn: 1.674 ± 0.041	1.181GlnPro: 1.181 ± 0.04	1.939GlnGln: 1.939 ± 0.057	1.558GlnArg: 1.558 ± 0.043	2.259GlnSer: 2.259 ± 0.052	2.011GlnThr: 2.011 ± 0.044	2.483GlnVal: 2.483 ± 0.049	0.405GlnTrp: 0.405 ± 0.017	1.269GlnTyr: 1.269 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.257ArgAla: 2.257 ± 0.054	0.242ArgCys: 0.242 ± 0.017	2.141ArgAsp: 2.141 ± 0.046	3.213ArgGlu: 3.213 ± 0.049	1.864ArgPhe: 1.864 ± 0.04	2.251ArgGly: 2.251 ± 0.051	0.725ArgHis: 0.725 ± 0.026	3.263ArgIle: 3.263 ± 0.054	3.283ArgLys: 3.283 ± 0.06	3.711ArgLeu: 3.711 ± 0.055	1.318ArgMet: 1.318 ± 0.036	2.104ArgAsn: 2.104 ± 0.047	1.162ArgPro: 1.162 ± 0.035	1.408ArgGln: 1.408 ± 0.038	1.71ArgArg: 1.71 ± 0.048	2.318ArgSer: 2.318 ± 0.045	2.038ArgThr: 2.038 ± 0.042	2.606ArgVal: 2.606 ± 0.054	0.388ArgTrp: 0.388 ± 0.017	1.595ArgTyr: 1.595 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.377SerAla: 3.377 ± 0.059	0.333SerCys: 0.333 ± 0.02	3.264SerAsp: 3.264 ± 0.057	4.195SerGlu: 4.195 ± 0.058	3.313SerPhe: 3.313 ± 0.056	4.246SerGly: 4.246 ± 0.074	1.148SerHis: 1.148 ± 0.033	5.461SerIle: 5.461 ± 0.078	3.786SerLys: 3.786 ± 0.066	5.864SerLeu: 5.864 ± 0.068	1.729SerMet: 1.729 ± 0.043	3.057SerAsn: 3.057 ± 0.06	1.982SerPro: 1.982 ± 0.047	1.905SerGln: 1.905 ± 0.045	2.173SerArg: 2.173 ± 0.042	3.92SerSer: 3.92 ± 0.069	3.274SerThr: 3.274 ± 0.055	4.059SerVal: 4.059 ± 0.066	0.625SerTrp: 0.625 ± 0.027	2.493SerTyr: 2.493 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.531ThrAla: 3.531 ± 0.065	0.312ThrCys: 0.312 ± 0.02	3.008ThrAsp: 3.008 ± 0.056	3.823ThrGlu: 3.823 ± 0.06	2.734ThrPhe: 2.734 ± 0.06	3.874ThrGly: 3.874 ± 0.064	1.024ThrHis: 1.024 ± 0.029	4.973ThrIle: 4.973 ± 0.069	3.468ThrLys: 3.468 ± 0.058	5.109ThrLeu: 5.109 ± 0.073	1.404ThrMet: 1.404 ± 0.032	2.847ThrAsn: 2.847 ± 0.053	2.1ThrPro: 2.1 ± 0.042	1.444ThrGln: 1.444 ± 0.04	1.783ThrArg: 1.783 ± 0.038	3.412ThrSer: 3.412 ± 0.062	3.187ThrThr: 3.187 ± 0.064	4.035ThrVal: 4.035 ± 0.067	0.593ThrTrp: 0.593 ± 0.024	2.168ThrTyr: 2.168 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.636ValAla: 4.636 ± 0.059	0.478ValCys: 0.478 ± 0.021	4.016ValAsp: 4.016 ± 0.062	5.284ValGlu: 5.284 ± 0.078	3.186ValPhe: 3.186 ± 0.061	4.792ValGly: 4.792 ± 0.075	1.335ValHis: 1.335 ± 0.037	5.856ValIle: 5.856 ± 0.089	4.253ValLys: 4.253 ± 0.074	6.558ValLeu: 6.558 ± 0.085	1.878ValMet: 1.878 ± 0.045	3.204ValAsn: 3.204 ± 0.056	2.52ValPro: 2.52 ± 0.05	2.378ValGln: 2.378 ± 0.047	2.581ValArg: 2.581 ± 0.052	4.556ValSer: 4.556 ± 0.075	4.056ValThr: 4.056 ± 0.062	5.087ValVal: 5.087 ± 0.073	0.627ValTrp: 0.627 ± 0.025	2.373ValTyr: 2.373 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.534TrpAla: 0.534 ± 0.023	0.068TrpCys: 0.068 ± 0.008	0.577TrpAsp: 0.577 ± 0.025	0.747TrpGlu: 0.747 ± 0.028	0.545TrpPhe: 0.545 ± 0.026	0.664TrpGly: 0.664 ± 0.027	0.21TrpHis: 0.21 ± 0.014	0.875TrpIle: 0.875 ± 0.027	0.782TrpLys: 0.782 ± 0.027	1.085TrpLeu: 1.085 ± 0.032	0.341TrpMet: 0.341 ± 0.019	0.562TrpAsn: 0.562 ± 0.024	0.234TrpPro: 0.234 ± 0.015	0.37TrpGln: 0.37 ± 0.018	0.386TrpArg: 0.386 ± 0.02	0.585TrpSer: 0.585 ± 0.025	0.486TrpThr: 0.486 ± 0.019	0.692TrpVal: 0.692 ± 0.027	0.158TrpTrp: 0.158 ± 0.013	0.409TrpTyr: 0.409 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.074TyrAla: 2.074 ± 0.045	0.299TyrCys: 0.299 ± 0.019	2.084TyrAsp: 2.084 ± 0.043	2.803TyrGlu: 2.803 ± 0.051	1.958TyrPhe: 1.958 ± 0.045	2.496TyrGly: 2.496 ± 0.046	0.993TyrHis: 0.993 ± 0.033	2.637TyrIle: 2.637 ± 0.052	2.075TyrLys: 2.075 ± 0.047	3.649TyrLeu: 3.649 ± 0.065	0.927TyrMet: 0.927 ± 0.027	1.633TyrAsn: 1.633 ± 0.041	1.436TyrPro: 1.436 ± 0.036	1.806TyrGln: 1.806 ± 0.042	1.708TyrArg: 1.708 ± 0.04	2.117TyrSer: 2.117 ± 0.048	1.861TyrThr: 1.861 ± 0.042	2.409TyrVal: 2.409 ± 0.055	0.431TyrTrp: 0.431 ± 0.021	1.519TyrTyr: 1.519 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3982 proteins (1095241 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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