Amino acid dipepetide frequency for Accumulibacter phosphatis (strain UW-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.582AlaAla: 17.582 ± 0.179	1.422AlaCys: 1.422 ± 0.036	7.019AlaAsp: 7.019 ± 0.12	7.161AlaGlu: 7.161 ± 0.096	4.076AlaPhe: 4.076 ± 0.059	11.048AlaGly: 11.048 ± 0.116	2.35AlaHis: 2.35 ± 0.043	5.816AlaIle: 5.816 ± 0.068	3.28AlaLys: 3.28 ± 0.063	14.1AlaLeu: 14.1 ± 0.149	2.926AlaMet: 2.926 ± 0.054	3.067AlaAsn: 3.067 ± 0.058	5.277AlaPro: 5.277 ± 0.084	4.462AlaGln: 4.462 ± 0.077	9.499AlaArg: 9.499 ± 0.101	6.775AlaSer: 6.775 ± 0.08	6.105AlaThr: 6.105 ± 0.075	8.675AlaVal: 8.675 ± 0.084	1.789AlaTrp: 1.789 ± 0.041	2.551AlaTyr: 2.551 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.185CysAla: 1.185 ± 0.029	0.158CysCys: 0.158 ± 0.01	0.56CysAsp: 0.56 ± 0.021	0.525CysGlu: 0.525 ± 0.02	0.378CysPhe: 0.378 ± 0.017	1.051CysGly: 1.051 ± 0.028	0.322CysHis: 0.322 ± 0.015	0.376CysIle: 0.376 ± 0.017	0.239CysLys: 0.239 ± 0.012	1.104CysLeu: 1.104 ± 0.026	0.182CysMet: 0.182 ± 0.012	0.243CysAsn: 0.243 ± 0.013	0.585CysPro: 0.585 ± 0.023	0.307CysGln: 0.307 ± 0.014	0.867CysArg: 0.867 ± 0.026	0.582CysSer: 0.582 ± 0.022	0.457CysThr: 0.457 ± 0.018	0.691CysVal: 0.691 ± 0.023	0.168CysTrp: 0.168 ± 0.011	0.252CysTyr: 0.252 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.501AspAla: 6.501 ± 0.095	0.55AspCys: 0.55 ± 0.02	3.287AspAsp: 3.287 ± 0.093	3.518AspGlu: 3.518 ± 0.053	2.275AspPhe: 2.275 ± 0.04	4.878AspGly: 4.878 ± 0.104	1.087AspHis: 1.087 ± 0.027	2.43AspIle: 2.43 ± 0.048	1.628AspLys: 1.628 ± 0.039	6.033AspLeu: 6.033 ± 0.071	0.956AspMet: 0.956 ± 0.03	1.343AspAsn: 1.343 ± 0.036	3.058AspPro: 3.058 ± 0.053	1.73AspGln: 1.73 ± 0.038	3.906AspArg: 3.906 ± 0.058	2.753AspSer: 2.753 ± 0.059	2.614AspThr: 2.614 ± 0.126	3.798AspVal: 3.798 ± 0.07	1.028AspTrp: 1.028 ± 0.028	1.526AspTyr: 1.526 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.954GluAla: 6.954 ± 0.082	0.462GluCys: 0.462 ± 0.018	2.269GluAsp: 2.269 ± 0.046	2.834GluGlu: 2.834 ± 0.056	1.867GluPhe: 1.867 ± 0.038	3.584GluGly: 3.584 ± 0.053	1.386GluHis: 1.386 ± 0.03	3.142GluIle: 3.142 ± 0.049	2.111GluLys: 2.111 ± 0.045	6.217GluLeu: 6.217 ± 0.081	1.416GluMet: 1.416 ± 0.033	1.392GluAsn: 1.392 ± 0.033	2.298GluPro: 2.298 ± 0.048	2.524GluGln: 2.524 ± 0.045	5.094GluArg: 5.094 ± 0.08	2.886GluSer: 2.886 ± 0.048	2.839GluThr: 2.839 ± 0.042	4.124GluVal: 4.124 ± 0.064	0.813GluTrp: 0.813 ± 0.023	1.17GluTyr: 1.17 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.719PheAla: 4.719 ± 0.061	0.426PheCys: 0.426 ± 0.016	2.356PheAsp: 2.356 ± 0.041	1.937PheGlu: 1.937 ± 0.044	1.509PhePhe: 1.509 ± 0.037	3.286PheGly: 3.286 ± 0.052	0.731PheHis: 0.731 ± 0.024	1.487PheIle: 1.487 ± 0.036	0.934PheLys: 0.934 ± 0.028	3.625PheLeu: 3.625 ± 0.048	0.702PheMet: 0.702 ± 0.021	1.031PheAsn: 1.031 ± 0.028	1.574PhePro: 1.574 ± 0.031	0.981PheGln: 0.981 ± 0.027	2.35PheArg: 2.35 ± 0.043	2.314PheSer: 2.314 ± 0.045	1.844PheThr: 1.844 ± 0.111	2.916PheVal: 2.916 ± 0.052	0.527PheTrp: 0.527 ± 0.02	0.89PheTyr: 0.89 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	8.143GlyAla: 8.143 ± 0.101	0.999GlyCys: 0.999 ± 0.03	4.556GlyAsp: 4.556 ± 0.118	5.064GlyGlu: 5.064 ± 0.066	3.268GlyPhe: 3.268 ± 0.066	6.824GlyGly: 6.824 ± 0.149	1.828GlyHis: 1.828 ± 0.041	4.05GlyIle: 4.05 ± 0.06	3.469GlyLys: 3.469 ± 0.05	8.524GlyLeu: 8.524 ± 0.093	2.088GlyMet: 2.088 ± 0.044	2.43GlyAsn: 2.43 ± 0.107	2.683GlyPro: 2.683 ± 0.053	3.16GlyGln: 3.16 ± 0.053	5.955GlyArg: 5.955 ± 0.06	5.111GlySer: 5.111 ± 0.087	3.965GlyThr: 3.965 ± 0.082	6.201GlyVal: 6.201 ± 0.079	1.314GlyTrp: 1.314 ± 0.031	2.172GlyTyr: 2.172 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.611HisAla: 2.611 ± 0.048	0.302HisCys: 0.302 ± 0.015	1.199HisAsp: 1.199 ± 0.03	1.092HisGlu: 1.092 ± 0.032	0.965HisPhe: 0.965 ± 0.029	1.932HisGly: 1.932 ± 0.038	0.618HisHis: 0.618 ± 0.023	0.819HisIle: 0.819 ± 0.022	0.515HisLys: 0.515 ± 0.019	2.551HisLeu: 2.551 ± 0.04	0.368HisMet: 0.368 ± 0.015	0.446HisAsn: 0.446 ± 0.018	1.404HisPro: 1.404 ± 0.035	0.767HisGln: 0.767 ± 0.025	1.667HisArg: 1.667 ± 0.037	1.112HisSer: 1.112 ± 0.028	0.888HisThr: 0.888 ± 0.024	1.464HisVal: 1.464 ± 0.029	0.342HisTrp: 0.342 ± 0.016	0.666HisTyr: 0.666 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.156IleAla: 6.156 ± 0.069	0.439IleCys: 0.439 ± 0.017	3.422IleAsp: 3.422 ± 0.052	3.276IleGlu: 3.276 ± 0.052	1.404IlePhe: 1.404 ± 0.031	4.342IleGly: 4.342 ± 0.061	0.92IleHis: 0.92 ± 0.026	1.782IleIle: 1.782 ± 0.04	1.429IleLys: 1.429 ± 0.034	4.029IleLeu: 4.029 ± 0.056	0.748IleMet: 0.748 ± 0.025	1.443IleAsn: 1.443 ± 0.032	2.108IlePro: 2.108 ± 0.038	1.162IleGln: 1.162 ± 0.031	3.087IleArg: 3.087 ± 0.048	2.537IleSer: 2.537 ± 0.046	2.296IleThr: 2.296 ± 0.039	3.84IleVal: 3.84 ± 0.056	0.5IleTrp: 0.5 ± 0.018	0.996IleTyr: 0.996 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.538LysAla: 3.538 ± 0.061	0.19LysCys: 0.19 ± 0.011	1.495LysAsp: 1.495 ± 0.036	1.58LysGlu: 1.58 ± 0.043	0.82LysPhe: 0.82 ± 0.025	2.18LysGly: 2.18 ± 0.05	0.604LysHis: 0.604 ± 0.024	1.401LysIle: 1.401 ± 0.033	1.201LysLys: 1.201 ± 0.039	3.32LysLeu: 3.32 ± 0.051	0.708LysMet: 0.708 ± 0.028	0.826LysAsn: 0.826 ± 0.024	1.889LysPro: 1.889 ± 0.038	1.125LysGln: 1.125 ± 0.031	2.286LysArg: 2.286 ± 0.045	1.652LysSer: 1.652 ± 0.033	1.735LysThr: 1.735 ± 0.035	2.29LysVal: 2.29 ± 0.057	0.323LysTrp: 0.323 ± 0.015	0.634LysTyr: 0.634 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	16.644LeuAla: 16.644 ± 0.132	1.174LeuCys: 1.174 ± 0.031	6.304LeuAsp: 6.304 ± 0.065	5.414LeuGlu: 5.414 ± 0.072	3.806LeuPhe: 3.806 ± 0.058	8.65LeuGly: 8.65 ± 0.096	2.324LeuHis: 2.324 ± 0.04	4.975LeuIle: 4.975 ± 0.071	3.309LeuLys: 3.309 ± 0.054	13.396LeuLeu: 13.396 ± 0.168	2.176LeuMet: 2.176 ± 0.045	2.611LeuAsn: 2.611 ± 0.048	6.568LeuPro: 6.568 ± 0.081	3.879LeuGln: 3.879 ± 0.052	8.529LeuArg: 8.529 ± 0.092	6.506LeuSer: 6.506 ± 0.073	5.738LeuThr: 5.738 ± 0.115	8.006LeuVal: 8.006 ± 0.081	1.406LeuTrp: 1.406 ± 0.037	2.17LeuTyr: 2.17 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.642MetAla: 2.642 ± 0.046	0.148MetCys: 0.148 ± 0.009	0.949MetAsp: 0.949 ± 0.026	0.916MetGlu: 0.916 ± 0.027	0.648MetPhe: 0.648 ± 0.023	1.416MetGly: 1.416 ± 0.034	0.488MetHis: 0.488 ± 0.019	1.039MetIle: 1.039 ± 0.028	0.89MetLys: 0.89 ± 0.025	2.461MetLeu: 2.461 ± 0.049	0.494MetMet: 0.494 ± 0.023	0.761MetAsn: 0.761 ± 0.023	1.23MetPro: 1.23 ± 0.031	0.859MetGln: 0.859 ± 0.029	1.608MetArg: 1.608 ± 0.035	1.465MetSer: 1.465 ± 0.031	1.32MetThr: 1.32 ± 0.031	1.482MetVal: 1.482 ± 0.036	0.185MetTrp: 0.185 ± 0.01	0.313MetTyr: 0.313 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.028AsnAla: 3.028 ± 0.061	0.294AsnCys: 0.294 ± 0.016	1.485AsnAsp: 1.485 ± 0.079	1.313AsnGlu: 1.313 ± 0.033	0.891AsnPhe: 0.891 ± 0.026	2.103AsnGly: 2.103 ± 0.048	0.521AsnHis: 0.521 ± 0.018	1.103AsnIle: 1.103 ± 0.032	0.746AsnLys: 0.746 ± 0.026	2.758AsnLeu: 2.758 ± 0.05	0.455AsnMet: 0.455 ± 0.017	0.717AsnAsn: 0.717 ± 0.028	1.765AsnPro: 1.765 ± 0.036	0.83AsnGln: 0.83 ± 0.025	1.898AsnArg: 1.898 ± 0.039	1.32AsnSer: 1.32 ± 0.047	1.248AsnThr: 1.248 ± 0.03	1.826AsnVal: 1.826 ± 0.054	0.424AsnTrp: 0.424 ± 0.015	0.654AsnTyr: 0.654 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.811ProAla: 6.811 ± 0.097	0.411ProCys: 0.411 ± 0.019	3.066ProAsp: 3.066 ± 0.053	3.388ProGlu: 3.388 ± 0.048	1.64ProPhe: 1.64 ± 0.033	4.485ProGly: 4.485 ± 0.065	0.983ProHis: 0.983 ± 0.028	2.003ProIle: 2.003 ± 0.044	1.308ProLys: 1.308 ± 0.037	5.528ProLeu: 5.528 ± 0.069	1.113ProMet: 1.113 ± 0.027	1.11ProAsn: 1.11 ± 0.029	2.814ProPro: 2.814 ± 0.061	1.807ProGln: 1.807 ± 0.038	2.977ProArg: 2.977 ± 0.048	2.508ProSer: 2.508 ± 0.05	2.494ProThr: 2.494 ± 0.046	4.087ProVal: 4.087 ± 0.06	0.727ProTrp: 0.727 ± 0.024	1.116ProTyr: 1.116 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.93GlnAla: 4.93 ± 0.065	0.307GlnCys: 0.307 ± 0.015	1.392GlnAsp: 1.392 ± 0.033	1.818GlnGlu: 1.818 ± 0.035	1.182GlnPhe: 1.182 ± 0.031	2.604GlnGly: 2.604 ± 0.039	0.9GlnHis: 0.9 ± 0.027	1.844GlnIle: 1.844 ± 0.04	1.094GlnLys: 1.094 ± 0.026	3.969GlnLeu: 3.969 ± 0.056	0.878GlnMet: 0.878 ± 0.022	0.761GlnAsn: 0.761 ± 0.023	1.947GlnPro: 1.947 ± 0.038	1.749GlnGln: 1.749 ± 0.04	3.249GlnArg: 3.249 ± 0.051	1.88GlnSer: 1.88 ± 0.039	1.738GlnThr: 1.738 ± 0.039	2.991GlnVal: 2.991 ± 0.071	0.502GlnTrp: 0.502 ± 0.02	0.735GlnTyr: 0.735 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.764ArgAla: 7.764 ± 0.082	0.721ArgCys: 0.721 ± 0.025	3.836ArgAsp: 3.836 ± 0.049	4.568ArgGlu: 4.568 ± 0.059	3.06ArgPhe: 3.06 ± 0.052	4.78ArgGly: 4.78 ± 0.063	2.059ArgHis: 2.059 ± 0.039	3.834ArgIle: 3.834 ± 0.056	2.197ArgLys: 2.197 ± 0.041	9.753ArgLeu: 9.753 ± 0.105	1.723ArgMet: 1.723 ± 0.036	1.939ArgAsn: 1.939 ± 0.039	3.562ArgPro: 3.562 ± 0.056	3.741ArgGln: 3.741 ± 0.059	6.346ArgArg: 6.346 ± 0.088	3.962ArgSer: 3.962 ± 0.054	3.189ArgThr: 3.189 ± 0.042	5.277ArgVal: 5.277 ± 0.059	1.172ArgTrp: 1.172 ± 0.03	2.029ArgTyr: 2.029 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.366SerAla: 6.366 ± 0.067	0.523SerCys: 0.523 ± 0.017	2.912SerAsp: 2.912 ± 0.062	3.082SerGlu: 3.082 ± 0.045	2.173SerPhe: 2.173 ± 0.042	5.562SerGly: 5.562 ± 0.082	1.152SerHis: 1.152 ± 0.026	2.485SerIle: 2.485 ± 0.04	1.394SerLys: 1.394 ± 0.032	6.498SerLeu: 6.498 ± 0.063	1.163SerMet: 1.163 ± 0.028	1.217SerAsn: 1.217 ± 0.037	3.093SerPro: 3.093 ± 0.053	1.839SerGln: 1.839 ± 0.042	4.035SerArg: 4.035 ± 0.053	3.085SerSer: 3.085 ± 0.059	2.729SerThr: 2.729 ± 0.05	4.089SerVal: 4.089 ± 0.071	0.729SerTrp: 0.729 ± 0.026	1.291SerTyr: 1.291 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.003ThrAla: 6.003 ± 0.129	0.448ThrCys: 0.448 ± 0.018	2.562ThrAsp: 2.562 ± 0.067	2.07ThrGlu: 2.07 ± 0.037	1.738ThrPhe: 1.738 ± 0.073	4.488ThrGly: 4.488 ± 0.093	1.064ThrHis: 1.064 ± 0.027	2.362ThrIle: 2.362 ± 0.045	0.983ThrLys: 0.983 ± 0.027	6.521ThrLeu: 6.521 ± 0.112	0.948ThrMet: 0.948 ± 0.023	1.132ThrAsn: 1.132 ± 0.029	3.15ThrPro: 3.15 ± 0.059	1.537ThrGln: 1.537 ± 0.033	3.49ThrArg: 3.49 ± 0.051	2.559ThrSer: 2.559 ± 0.051	2.776ThrThr: 2.776 ± 0.098	3.936ThrVal: 3.936 ± 0.086	0.674ThrTrp: 0.674 ± 0.024	1.068ThrTyr: 1.068 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.625ValAla: 9.625 ± 0.117	0.822ValCys: 0.822 ± 0.027	4.425ValAsp: 4.425 ± 0.066	4.129ValGlu: 4.129 ± 0.058	2.963ValPhe: 2.963 ± 0.049	5.786ValGly: 5.786 ± 0.075	1.436ValHis: 1.436 ± 0.029	3.6ValIle: 3.6 ± 0.057	2.13ValLys: 2.13 ± 0.047	8.271ValLeu: 8.271 ± 0.113	1.615ValMet: 1.615 ± 0.036	1.922ValAsn: 1.922 ± 0.047	3.521ValPro: 3.521 ± 0.061	2.201ValGln: 2.201 ± 0.044	5.219ValArg: 5.219 ± 0.067	4.319ValSer: 4.319 ± 0.063	3.812ValThr: 3.812 ± 0.058	6.348ValVal: 6.348 ± 0.076	0.98ValTrp: 0.98 ± 0.024	1.49ValTyr: 1.49 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.185TrpAla: 1.185 ± 0.032	0.166TrpCys: 0.166 ± 0.012	0.581TrpAsp: 0.581 ± 0.023	0.622TrpGlu: 0.622 ± 0.022	0.553TrpPhe: 0.553 ± 0.021	0.862TrpGly: 0.862 ± 0.027	0.377TrpHis: 0.377 ± 0.015	0.63TrpIle: 0.63 ± 0.022	0.393TrpLys: 0.393 ± 0.017	2.237TrpLeu: 2.237 ± 0.054	0.304TrpMet: 0.304 ± 0.014	0.418TrpAsn: 0.418 ± 0.016	0.679TrpPro: 0.679 ± 0.026	0.878TrpGln: 0.878 ± 0.025	1.394TrpArg: 1.394 ± 0.037	0.843TrpSer: 0.843 ± 0.024	0.627TrpThr: 0.627 ± 0.023	0.917TrpVal: 0.917 ± 0.029	0.264TrpTrp: 0.264 ± 0.013	0.326TrpTyr: 0.326 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.59TyrAla: 2.59 ± 0.046	0.27TyrCys: 0.27 ± 0.013	1.222TyrAsp: 1.222 ± 0.033	1.076TyrGlu: 1.076 ± 0.032	0.922TyrPhe: 0.922 ± 0.028	1.945TyrGly: 1.945 ± 0.04	0.576TyrHis: 0.576 ± 0.022	0.737TyrIle: 0.737 ± 0.021	0.549TyrLys: 0.549 ± 0.02	2.693TyrLeu: 2.693 ± 0.045	0.348TyrMet: 0.348 ± 0.016	0.572TyrAsn: 0.572 ± 0.021	1.17TyrPro: 1.17 ± 0.03	0.931TyrGln: 0.931 ± 0.027	2.057TyrArg: 2.057 ± 0.038	1.25TyrSer: 1.25 ± 0.029	1.096TyrThr: 1.096 ± 0.035	1.657TyrVal: 1.657 ± 0.039	0.388TyrTrp: 0.388 ± 0.018	0.638TyrTyr: 0.638 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4438 proteins (1504008 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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