Amino acid dipepetide frequency for Faecalibacterium prausnitzii (strain DSM 17677 / JCM 31915 / A2-165)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.237AlaAla: 13.237 ± 0.194	1.541AlaCys: 1.541 ± 0.049	5.635AlaAsp: 5.635 ± 0.088	7.242AlaGlu: 7.242 ± 0.109	3.498AlaPhe: 3.498 ± 0.068	7.478AlaGly: 7.478 ± 0.103	1.671AlaHis: 1.671 ± 0.05	4.716AlaIle: 4.716 ± 0.081	5.044AlaLys: 5.044 ± 0.074	10.138AlaLeu: 10.138 ± 0.134	2.691AlaMet: 2.691 ± 0.06	2.807AlaAsn: 2.807 ± 0.052	3.623AlaPro: 3.623 ± 0.073	3.852AlaGln: 3.852 ± 0.078	4.82AlaArg: 4.82 ± 0.088	4.6AlaSer: 4.6 ± 0.079	3.696AlaThr: 3.696 ± 0.066	7.753AlaVal: 7.753 ± 0.117	0.875AlaTrp: 0.875 ± 0.029	2.682AlaTyr: 2.682 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.673CysAla: 1.673 ± 0.043	0.404CysCys: 0.404 ± 0.023	0.868CysAsp: 0.868 ± 0.033	1.042CysGlu: 1.042 ± 0.038	0.724CysPhe: 0.724 ± 0.029	1.823CysGly: 1.823 ± 0.054	0.329CysHis: 0.329 ± 0.021	1.041CysIle: 1.041 ± 0.038	0.841CysLys: 0.841 ± 0.031	1.29CysLeu: 1.29 ± 0.042	0.44CysMet: 0.44 ± 0.019	0.551CysAsn: 0.551 ± 0.025	0.866CysPro: 0.866 ± 0.032	0.484CysGln: 0.484 ± 0.023	1.053CysArg: 1.053 ± 0.032	1.047CysSer: 1.047 ± 0.039	0.986CysThr: 0.986 ± 0.035	1.209CysVal: 1.209 ± 0.042	0.196CysTrp: 0.196 ± 0.015	0.591CysTyr: 0.591 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	5.477AspAla: 5.477 ± 0.091	0.885AspCys: 0.885 ± 0.036	2.69AspAsp: 2.69 ± 0.057	4.098AspGlu: 4.098 ± 0.071	2.435AspPhe: 2.435 ± 0.052	4.48AspGly: 4.48 ± 0.082	0.946AspHis: 0.946 ± 0.032	3.081AspIle: 3.081 ± 0.068	2.647AspLys: 2.647 ± 0.056	4.977AspLeu: 4.977 ± 0.077	1.329AspMet: 1.329 ± 0.04	1.737AspAsn: 1.737 ± 0.047	2.618AspPro: 2.618 ± 0.058	1.315AspGln: 1.315 ± 0.039	2.62AspArg: 2.62 ± 0.057	2.687AspSer: 2.687 ± 0.061	3.24AspThr: 3.24 ± 0.063	3.552AspVal: 3.552 ± 0.063	0.667AspTrp: 0.667 ± 0.026	2.313AspTyr: 2.313 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	6.217GluAla: 6.217 ± 0.095	0.812GluCys: 0.812 ± 0.032	3.54GluAsp: 3.54 ± 0.064	5.16GluGlu: 5.16 ± 0.096	1.998GluPhe: 1.998 ± 0.049	4.167GluGly: 4.167 ± 0.075	1.346GluHis: 1.346 ± 0.039	3.813GluIle: 3.813 ± 0.069	5.027GluLys: 5.027 ± 0.077	6.767GluLeu: 6.767 ± 0.096	2.113GluMet: 2.113 ± 0.045	3.354GluAsn: 3.354 ± 0.064	2.274GluPro: 2.274 ± 0.06	3.513GluGln: 3.513 ± 0.068	3.795GluArg: 3.795 ± 0.071	2.943GluSer: 2.943 ± 0.061	3.507GluThr: 3.507 ± 0.074	4.006GluVal: 4.006 ± 0.073	0.671GluTrp: 0.671 ± 0.025	2.459GluTyr: 2.459 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.76PheAla: 3.76 ± 0.07	0.98PheCys: 0.98 ± 0.034	2.541PheAsp: 2.541 ± 0.055	2.229PheGlu: 2.229 ± 0.05	1.742PhePhe: 1.742 ± 0.049	2.987PheGly: 2.987 ± 0.06	0.825PheHis: 0.825 ± 0.03	1.995PheIle: 1.995 ± 0.051	1.559PheLys: 1.559 ± 0.045	3.903PheLeu: 3.903 ± 0.07	0.937PheMet: 0.937 ± 0.031	1.334PheAsn: 1.334 ± 0.04	1.448PhePro: 1.448 ± 0.04	1.206PheGln: 1.206 ± 0.034	2.006PheArg: 2.006 ± 0.045	2.719PheSer: 2.719 ± 0.057	2.352PheThr: 2.352 ± 0.053	2.796PheVal: 2.796 ± 0.056	0.494PheTrp: 0.494 ± 0.024	1.567PheTyr: 1.567 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	6.271GlyAla: 6.271 ± 0.102	1.451GlyCys: 1.451 ± 0.045	3.406GlyAsp: 3.406 ± 0.062	4.6GlyGlu: 4.6 ± 0.069	3.012GlyPhe: 3.012 ± 0.054	5.741GlyGly: 5.741 ± 0.11	1.433GlyHis: 1.433 ± 0.04	4.925GlyIle: 4.925 ± 0.072	4.86GlyLys: 4.86 ± 0.074	6.662GlyLeu: 6.662 ± 0.099	2.404GlyMet: 2.404 ± 0.059	2.467GlyAsn: 2.467 ± 0.055	1.777GlyPro: 1.777 ± 0.047	2.589GlyGln: 2.589 ± 0.048	4.082GlyArg: 4.082 ± 0.077	4.291GlySer: 4.291 ± 0.076	4.458GlyThr: 4.458 ± 0.07	5.44GlyVal: 5.44 ± 0.099	0.917GlyTrp: 0.917 ± 0.036	2.957GlyTyr: 2.957 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.451HisAla: 1.451 ± 0.036	0.444HisCys: 0.444 ± 0.022	1.01HisAsp: 1.01 ± 0.036	1.072HisGlu: 1.072 ± 0.043	0.903HisPhe: 0.903 ± 0.032	1.455HisGly: 1.455 ± 0.042	0.511HisHis: 0.511 ± 0.034	1.202HisIle: 1.202 ± 0.038	0.957HisLys: 0.957 ± 0.033	1.719HisLeu: 1.719 ± 0.045	0.441HisMet: 0.441 ± 0.024	0.758HisAsn: 0.758 ± 0.032	1.174HisPro: 1.174 ± 0.036	0.62HisGln: 0.62 ± 0.026	1.046HisArg: 1.046 ± 0.035	1.044HisSer: 1.044 ± 0.034	1.168HisThr: 1.168 ± 0.037	1.053HisVal: 1.053 ± 0.032	0.233HisTrp: 0.233 ± 0.015	0.752HisTyr: 0.752 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.164IleAla: 5.164 ± 0.078	1.048IleCys: 1.048 ± 0.033	3.221IleAsp: 3.221 ± 0.062	3.366IleGlu: 3.366 ± 0.069	2.169IlePhe: 2.169 ± 0.053	4.027IleGly: 4.027 ± 0.067	1.083IleHis: 1.083 ± 0.034	3.056IleIle: 3.056 ± 0.06	2.547IleLys: 2.547 ± 0.056	5.566IleLeu: 5.566 ± 0.09	1.34IleMet: 1.34 ± 0.039	1.885IleAsn: 1.885 ± 0.051	2.701IlePro: 2.701 ± 0.064	1.855IleGln: 1.855 ± 0.046	3.199IleArg: 3.199 ± 0.068	3.523IleSer: 3.523 ± 0.065	3.397IleThr: 3.397 ± 0.065	3.9IleVal: 3.9 ± 0.071	0.541IleTrp: 0.541 ± 0.02	1.884IleTyr: 1.884 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	5.301LysAla: 5.301 ± 0.089	0.662LysCys: 0.662 ± 0.027	2.802LysAsp: 2.802 ± 0.067	3.993LysGlu: 3.993 ± 0.081	1.599LysPhe: 1.599 ± 0.045	3.621LysGly: 3.621 ± 0.073	0.947LysHis: 0.947 ± 0.029	3.12LysIle: 3.12 ± 0.061	4.189LysLys: 4.189 ± 0.087	4.917LysLeu: 4.917 ± 0.072	1.719LysMet: 1.719 ± 0.045	2.48LysAsn: 2.48 ± 0.051	2.286LysPro: 2.286 ± 0.058	2.384LysGln: 2.384 ± 0.057	2.857LysArg: 2.857 ± 0.06	2.67LysSer: 2.67 ± 0.058	3.343LysThr: 3.343 ± 0.055	3.245LysVal: 3.245 ± 0.063	0.533LysTrp: 0.533 ± 0.025	1.991LysTyr: 1.991 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	9.375LeuAla: 9.375 ± 0.125	2.205LeuCys: 2.205 ± 0.055	5.487LeuAsp: 5.487 ± 0.081	5.843LeuGlu: 5.843 ± 0.086	4.121LeuPhe: 4.121 ± 0.078	6.49LeuGly: 6.49 ± 0.108	1.972LeuHis: 1.972 ± 0.043	4.714LeuIle: 4.714 ± 0.084	4.864LeuLys: 4.864 ± 0.079	10.188LeuLeu: 10.188 ± 0.159	2.677LeuMet: 2.677 ± 0.058	3.807LeuAsn: 3.807 ± 0.057	4.993LeuPro: 4.993 ± 0.075	3.224LeuGln: 3.224 ± 0.059	5.396LeuArg: 5.396 ± 0.091	6.009LeuSer: 6.009 ± 0.089	6.288LeuThr: 6.288 ± 0.09	6.073LeuVal: 6.073 ± 0.105	1.055LeuTrp: 1.055 ± 0.036	3.342LeuTyr: 3.342 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	2.688MetAla: 2.688 ± 0.054	0.301MetCys: 0.301 ± 0.02	1.585MetAsp: 1.585 ± 0.041	2.029MetGlu: 2.029 ± 0.049	0.899MetPhe: 0.899 ± 0.034	1.966MetGly: 1.966 ± 0.049	0.452MetHis: 0.452 ± 0.024	1.508MetIle: 1.508 ± 0.043	1.921MetLys: 1.921 ± 0.046	2.734MetLeu: 2.734 ± 0.057	0.841MetMet: 0.841 ± 0.033	1.288MetAsn: 1.288 ± 0.039	1.308MetPro: 1.308 ± 0.037	1.224MetGln: 1.224 ± 0.037	1.341MetArg: 1.341 ± 0.037	1.545MetSer: 1.545 ± 0.04	1.803MetThr: 1.803 ± 0.048	1.772MetVal: 1.772 ± 0.041	0.218MetTrp: 0.218 ± 0.016	0.677MetTyr: 0.677 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.617AsnAla: 3.617 ± 0.062	0.628AsnCys: 0.628 ± 0.024	1.845AsnAsp: 1.845 ± 0.047	2.135AsnGlu: 2.135 ± 0.052	1.472AsnPhe: 1.472 ± 0.042	3.294AsnGly: 3.294 ± 0.069	0.696AsnHis: 0.696 ± 0.029	2.338AsnIle: 2.338 ± 0.056	1.78AsnLys: 1.78 ± 0.042	3.377AsnLeu: 3.377 ± 0.066	1.024AsnMet: 1.024 ± 0.033	1.339AsnAsn: 1.339 ± 0.041	1.876AsnPro: 1.876 ± 0.058	1.195AsnGln: 1.195 ± 0.045	1.985AsnArg: 1.985 ± 0.04	1.788AsnSer: 1.788 ± 0.05	2.089AsnThr: 2.089 ± 0.047	2.451AsnVal: 2.451 ± 0.05	0.406AsnTrp: 0.406 ± 0.023	1.495AsnTyr: 1.495 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	4.62ProAla: 4.62 ± 0.081	0.642ProCys: 0.642 ± 0.032	2.741ProAsp: 2.741 ± 0.059	4.124ProGlu: 4.124 ± 0.083	1.691ProPhe: 1.691 ± 0.047	3.104ProGly: 3.104 ± 0.065	0.8ProHis: 0.8 ± 0.028	2.099ProIle: 2.099 ± 0.049	1.955ProLys: 1.955 ± 0.052	3.62ProLeu: 3.62 ± 0.067	1.047ProMet: 1.047 ± 0.034	1.326ProAsn: 1.326 ± 0.042	1.356ProPro: 1.356 ± 0.044	1.554ProGln: 1.554 ± 0.042	1.684ProArg: 1.684 ± 0.054	1.981ProSer: 1.981 ± 0.042	2.028ProThr: 2.028 ± 0.055	3.345ProVal: 3.345 ± 0.059	0.39ProTrp: 0.39 ± 0.021	1.452ProTyr: 1.452 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.296GlnAla: 3.296 ± 0.064	0.502GlnCys: 0.502 ± 0.022	1.572GlnAsp: 1.572 ± 0.044	2.476GlnGlu: 2.476 ± 0.058	1.273GlnPhe: 1.273 ± 0.04	2.258GlnGly: 2.258 ± 0.054	0.729GlnHis: 0.729 ± 0.032	2.131GlnIle: 2.131 ± 0.052	2.691GlnLys: 2.691 ± 0.074	3.811GlnLeu: 3.811 ± 0.071	1.234GlnMet: 1.234 ± 0.03	1.697GlnAsn: 1.697 ± 0.04	1.49GlnPro: 1.49 ± 0.042	1.847GlnGln: 1.847 ± 0.055	2.2GlnArg: 2.2 ± 0.059	1.968GlnSer: 1.968 ± 0.049	2.095GlnThr: 2.095 ± 0.046	2.147GlnVal: 2.147 ± 0.05	0.43GlnTrp: 0.43 ± 0.022	1.364GlnTyr: 1.364 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	4.611ArgAla: 4.611 ± 0.088	0.938ArgCys: 0.938 ± 0.034	2.518ArgAsp: 2.518 ± 0.05	3.778ArgGlu: 3.778 ± 0.075	2.207ArgPhe: 2.207 ± 0.049	3.114ArgGly: 3.114 ± 0.059	0.984ArgHis: 0.984 ± 0.032	3.109ArgIle: 3.109 ± 0.059	3.264ArgLys: 3.264 ± 0.069	5.228ArgLeu: 5.228 ± 0.09	1.77ArgMet: 1.77 ± 0.04	1.949ArgAsn: 1.949 ± 0.049	2.134ArgPro: 2.134 ± 0.049	2.378ArgGln: 2.378 ± 0.052	3.69ArgArg: 3.69 ± 0.075	2.84ArgSer: 2.84 ± 0.054	3.097ArgThr: 3.097 ± 0.064	3.286ArgVal: 3.286 ± 0.066	0.615ArgTrp: 0.615 ± 0.027	2.069ArgTyr: 2.069 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	5.299SerAla: 5.299 ± 0.101	0.906SerCys: 0.906 ± 0.039	2.713SerAsp: 2.713 ± 0.054	3.252SerGlu: 3.252 ± 0.067	2.509SerPhe: 2.509 ± 0.053	4.836SerGly: 4.836 ± 0.074	1.014SerHis: 1.014 ± 0.036	3.26SerIle: 3.26 ± 0.066	2.377SerLys: 2.377 ± 0.052	5.09SerLeu: 5.09 ± 0.079	1.627SerMet: 1.627 ± 0.042	1.804SerAsn: 1.804 ± 0.049	2.112SerPro: 2.112 ± 0.046	1.695SerGln: 1.695 ± 0.041	2.988SerArg: 2.988 ± 0.059	3.372SerSer: 3.372 ± 0.083	3.09SerThr: 3.09 ± 0.064	4.002SerVal: 4.002 ± 0.069	0.569SerTrp: 0.569 ± 0.022	1.989SerTyr: 1.989 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	6.16ThrAla: 6.16 ± 0.101	0.762ThrCys: 0.762 ± 0.031	3.121ThrAsp: 3.121 ± 0.06	3.733ThrGlu: 3.733 ± 0.065	2.153ThrPhe: 2.153 ± 0.05	4.756ThrGly: 4.756 ± 0.078	1.035ThrHis: 1.035 ± 0.033	3.253ThrIle: 3.253 ± 0.069	2.407ThrLys: 2.407 ± 0.055	5.872ThrLeu: 5.872 ± 0.09	1.499ThrMet: 1.499 ± 0.043	1.757ThrAsn: 1.757 ± 0.042	2.839ThrPro: 2.839 ± 0.062	1.789ThrGln: 1.789 ± 0.043	2.659ThrArg: 2.659 ± 0.056	2.787ThrSer: 2.787 ± 0.056	3.143ThrThr: 3.143 ± 0.071	4.885ThrVal: 4.885 ± 0.089	0.471ThrTrp: 0.471 ± 0.028	1.772ThrTyr: 1.772 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	5.454ValAla: 5.454 ± 0.088	1.49ValCys: 1.49 ± 0.042	3.763ValAsp: 3.763 ± 0.053	4.437ValGlu: 4.437 ± 0.084	2.95ValPhe: 2.95 ± 0.06	4.546ValGly: 4.546 ± 0.087	1.196ValHis: 1.196 ± 0.036	3.696ValIle: 3.696 ± 0.062	3.449ValLys: 3.449 ± 0.073	7.533ValLeu: 7.533 ± 0.122	1.868ValMet: 1.868 ± 0.045	2.432ValAsn: 2.432 ± 0.057	2.939ValPro: 2.939 ± 0.061	2.571ValGln: 2.571 ± 0.053	3.639ValArg: 3.639 ± 0.07	4.317ValSer: 4.317 ± 0.076	4.22ValThr: 4.22 ± 0.077	4.947ValVal: 4.947 ± 0.082	0.756ValTrp: 0.756 ± 0.027	2.31ValTyr: 2.31 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.855TrpAla: 0.855 ± 0.031	0.219TrpCys: 0.219 ± 0.017	0.561TrpAsp: 0.561 ± 0.028	0.706TrpGlu: 0.706 ± 0.029	0.468TrpPhe: 0.468 ± 0.025	0.774TrpGly: 0.774 ± 0.032	0.22TrpHis: 0.22 ± 0.016	0.442TrpIle: 0.442 ± 0.022	0.66TrpLys: 0.66 ± 0.026	1.189TrpLeu: 1.189 ± 0.043	0.318TrpMet: 0.318 ± 0.02	0.527TrpAsn: 0.527 ± 0.023	0.339TrpPro: 0.339 ± 0.02	0.516TrpGln: 0.516 ± 0.025	0.537TrpArg: 0.537 ± 0.024	0.489TrpSer: 0.489 ± 0.023	0.495TrpThr: 0.495 ± 0.024	0.682TrpVal: 0.682 ± 0.026	0.115TrpTrp: 0.115 ± 0.01	0.405TrpTyr: 0.405 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.072TyrAla: 3.072 ± 0.065	0.634TyrCys: 0.634 ± 0.025	2.173TyrAsp: 2.173 ± 0.051	2.166TyrGlu: 2.166 ± 0.045	1.556TyrPhe: 1.556 ± 0.044	2.827TyrGly: 2.827 ± 0.056	0.824TyrHis: 0.824 ± 0.029	1.974TyrIle: 1.974 ± 0.05	1.619TyrLys: 1.619 ± 0.038	3.542TyrLeu: 3.542 ± 0.065	0.78TyrMet: 0.78 ± 0.027	1.53TyrAsn: 1.53 ± 0.043	1.405TyrPro: 1.405 ± 0.041	1.402TyrGln: 1.402 ± 0.041	1.984TyrArg: 1.984 ± 0.048	1.886TyrSer: 1.886 ± 0.05	2.36TyrThr: 2.36 ± 0.048	1.971TyrVal: 1.971 ± 0.044	0.366TyrTrp: 0.366 ± 0.019	1.54TyrTyr: 1.54 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3472 proteins (930013 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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