Amino acid dipepetide frequency for Ammonifex degensii (strain DSM 10501 / KC4)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.884AlaAla: 10.884 ± 0.162	1.407AlaCys: 1.407 ± 0.047	3.543AlaAsp: 3.543 ± 0.075	7.619AlaGlu: 7.619 ± 0.119	3.433AlaPhe: 3.433 ± 0.089	8.282AlaGly: 8.282 ± 0.139	1.602AlaHis: 1.602 ± 0.044	3.905AlaIle: 3.905 ± 0.1	3.966AlaLys: 3.966 ± 0.094	12.264AlaLeu: 12.264 ± 0.166	1.727AlaMet: 1.727 ± 0.045	1.989AlaAsn: 1.989 ± 0.06	3.671AlaPro: 3.671 ± 0.089	3.193AlaGln: 3.193 ± 0.077	8.4AlaArg: 8.4 ± 0.151	4.294AlaSer: 4.294 ± 0.086	3.934AlaThr: 3.934 ± 0.09	8.693AlaVal: 8.693 ± 0.159	1.39AlaTrp: 1.39 ± 0.052	2.798AlaTyr: 2.798 ± 0.075	0.0AlaXaa: 0.0 ± 0.0
Cys	0.982CysAla: 0.982 ± 0.046	0.244CysCys: 0.244 ± 0.022	0.486CysAsp: 0.486 ± 0.029	0.556CysGlu: 0.556 ± 0.029	0.508CysPhe: 0.508 ± 0.031	1.497CysGly: 1.497 ± 0.057	0.375CysHis: 0.375 ± 0.03	0.415CysIle: 0.415 ± 0.028	0.286CysLys: 0.286 ± 0.022	1.53CysLeu: 1.53 ± 0.05	0.176CysMet: 0.176 ± 0.016	0.232CysAsn: 0.232 ± 0.021	1.099CysPro: 1.099 ± 0.049	0.417CysGln: 0.417 ± 0.025	1.356CysArg: 1.356 ± 0.046	0.74CysSer: 0.74 ± 0.04	0.505CysThr: 0.505 ± 0.028	0.795CysVal: 0.795 ± 0.04	0.19CysTrp: 0.19 ± 0.017	0.393CysTyr: 0.393 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	3.088AspAla: 3.088 ± 0.073	0.529AspCys: 0.529 ± 0.032	1.374AspAsp: 1.374 ± 0.046	2.615AspGlu: 2.615 ± 0.063	1.958AspPhe: 1.958 ± 0.06	3.04AspGly: 3.04 ± 0.082	0.644AspHis: 0.644 ± 0.031	2.077AspIle: 2.077 ± 0.063	1.807AspLys: 1.807 ± 0.054	5.466AspLeu: 5.466 ± 0.091	0.695AspMet: 0.695 ± 0.035	0.811AspAsn: 0.811 ± 0.034	3.193AspPro: 3.193 ± 0.075	0.861AspGln: 0.861 ± 0.039	3.164AspArg: 3.164 ± 0.072	1.276AspSer: 1.276 ± 0.045	1.728AspThr: 1.728 ± 0.056	3.11AspVal: 3.11 ± 0.081	0.709AspTrp: 0.709 ± 0.035	1.423AspTyr: 1.423 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	8.748GluAla: 8.748 ± 0.156	0.661GluCys: 0.661 ± 0.033	3.084GluAsp: 3.084 ± 0.081	9.908GluGlu: 9.908 ± 0.168	2.292GluPhe: 2.292 ± 0.058	6.551GluGly: 6.551 ± 0.113	1.148GluHis: 1.148 ± 0.044	4.6GluIle: 4.6 ± 0.096	5.498GluLys: 5.498 ± 0.111	9.116GluLeu: 9.116 ± 0.136	1.549GluMet: 1.549 ± 0.054	1.791GluAsn: 1.791 ± 0.054	2.695GluPro: 2.695 ± 0.083	1.958GluGln: 1.958 ± 0.067	6.295GluArg: 6.295 ± 0.113	2.19GluSer: 2.19 ± 0.059	2.808GluThr: 2.808 ± 0.074	7.967GluVal: 7.967 ± 0.122	0.866GluTrp: 0.866 ± 0.04	1.749GluTyr: 1.749 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	3.313PheAla: 3.313 ± 0.073	0.712PheCys: 0.712 ± 0.037	1.687PheAsp: 1.687 ± 0.052	1.854PheGlu: 1.854 ± 0.062	2.056PhePhe: 2.056 ± 0.072	3.025PheGly: 3.025 ± 0.076	0.724PheHis: 0.724 ± 0.034	1.693PheIle: 1.693 ± 0.059	1.402PheLys: 1.402 ± 0.054	5.241PheLeu: 5.241 ± 0.13	0.623PheMet: 0.623 ± 0.035	0.912PheAsn: 0.912 ± 0.037	2.249PhePro: 2.249 ± 0.066	0.966PheGln: 0.966 ± 0.038	2.672PheArg: 2.672 ± 0.062	2.404PheSer: 2.404 ± 0.06	2.072PheThr: 2.072 ± 0.057	2.605PheVal: 2.605 ± 0.061	0.787PheTrp: 0.787 ± 0.038	1.337PheTyr: 1.337 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	6.595GlyAla: 6.595 ± 0.109	1.182GlyCys: 1.182 ± 0.042	3.207GlyAsp: 3.207 ± 0.079	6.744GlyGlu: 6.744 ± 0.112	3.346GlyPhe: 3.346 ± 0.088	6.557GlyGly: 6.557 ± 0.112	1.444GlyHis: 1.444 ± 0.053	4.704GlyIle: 4.704 ± 0.1	5.327GlyLys: 5.327 ± 0.098	8.584GlyLeu: 8.584 ± 0.139	1.867GlyMet: 1.867 ± 0.06	1.904GlyAsn: 1.904 ± 0.065	3.054GlyPro: 3.054 ± 0.073	2.353GlyGln: 2.353 ± 0.052	6.394GlyArg: 6.394 ± 0.118	3.853GlySer: 3.853 ± 0.088	3.83GlyThr: 3.83 ± 0.092	7.201GlyVal: 7.201 ± 0.127	1.22GlyTrp: 1.22 ± 0.054	2.516GlyTyr: 2.516 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	1.324HisAla: 1.324 ± 0.057	0.248HisCys: 0.248 ± 0.021	0.586HisAsp: 0.586 ± 0.03	0.871HisGlu: 0.871 ± 0.037	0.89HisPhe: 0.89 ± 0.036	1.348HisGly: 1.348 ± 0.046	0.423HisHis: 0.423 ± 0.029	0.811HisIle: 0.811 ± 0.036	0.585HisLys: 0.585 ± 0.03	2.532HisLeu: 2.532 ± 0.069	0.262HisMet: 0.262 ± 0.02	0.442HisAsn: 0.442 ± 0.029	1.492HisPro: 1.492 ± 0.046	0.557HisGln: 0.557 ± 0.028	1.57HisArg: 1.57 ± 0.049	0.744HisSer: 0.744 ± 0.034	0.775HisThr: 0.775 ± 0.039	1.15HisVal: 1.15 ± 0.046	0.259HisTrp: 0.259 ± 0.02	0.676HisTyr: 0.676 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	4.402IleAla: 4.402 ± 0.11	0.609IleCys: 0.609 ± 0.028	2.281IleAsp: 2.281 ± 0.066	3.115IleGlu: 3.115 ± 0.089	1.888IlePhe: 1.888 ± 0.056	3.415IleGly: 3.415 ± 0.083	0.717IleHis: 0.717 ± 0.034	2.449IleIle: 2.449 ± 0.068	2.605IleLys: 2.605 ± 0.076	5.233IleLeu: 5.233 ± 0.103	0.816IleMet: 0.816 ± 0.04	1.244IleAsn: 1.244 ± 0.049	2.715IlePro: 2.715 ± 0.062	1.064IleGln: 1.064 ± 0.041	3.1IleArg: 3.1 ± 0.074	2.228IleSer: 2.228 ± 0.062	2.473IleThr: 2.473 ± 0.066	3.383IleVal: 3.383 ± 0.093	0.559IleTrp: 0.559 ± 0.033	1.399IleTyr: 1.399 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.647LysAla: 4.647 ± 0.088	0.377LysCys: 0.377 ± 0.027	2.08LysAsp: 2.08 ± 0.062	5.479LysGlu: 5.479 ± 0.105	1.267LysPhe: 1.267 ± 0.05	3.888LysGly: 3.888 ± 0.083	0.792LysHis: 0.792 ± 0.034	2.452LysIle: 2.452 ± 0.073	2.826LysLys: 2.826 ± 0.071	5.22LysLeu: 5.22 ± 0.098	0.863LysMet: 0.863 ± 0.037	1.169LysAsn: 1.169 ± 0.048	2.037LysPro: 2.037 ± 0.059	1.144LysGln: 1.144 ± 0.044	3.602LysArg: 3.602 ± 0.075	1.727LysSer: 1.727 ± 0.052	2.045LysThr: 2.045 ± 0.064	4.758LysVal: 4.758 ± 0.084	0.442LysTrp: 0.442 ± 0.027	1.161LysTyr: 1.161 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	13.528LeuAla: 13.528 ± 0.207	1.425LeuCys: 1.425 ± 0.049	4.704LeuAsp: 4.704 ± 0.089	9.266LeuGlu: 9.266 ± 0.144	4.1LeuPhe: 4.1 ± 0.104	9.68LeuGly: 9.68 ± 0.145	1.789LeuHis: 1.789 ± 0.055	4.615LeuIle: 4.615 ± 0.088	6.281LeuLys: 6.281 ± 0.112	13.885LeuLeu: 13.885 ± 0.237	1.7LeuMet: 1.7 ± 0.054	2.781LeuAsn: 2.781 ± 0.07	7.017LeuPro: 7.017 ± 0.122	2.955LeuGln: 2.955 ± 0.085	9.308LeuArg: 9.308 ± 0.136	6.306LeuSer: 6.306 ± 0.12	5.423LeuThr: 5.423 ± 0.09	9.745LeuVal: 9.745 ± 0.139	1.409LeuTrp: 1.409 ± 0.056	3.233LeuTyr: 3.233 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	2.104MetAla: 2.104 ± 0.06	0.157MetCys: 0.157 ± 0.018	0.626MetAsp: 0.626 ± 0.035	1.375MetGlu: 1.375 ± 0.046	0.434MetPhe: 0.434 ± 0.026	1.524MetGly: 1.524 ± 0.059	0.259MetHis: 0.259 ± 0.021	0.768MetIle: 0.768 ± 0.037	0.829MetLys: 0.829 ± 0.036	1.717MetLeu: 1.717 ± 0.055	0.278MetMet: 0.278 ± 0.021	0.433MetAsn: 0.433 ± 0.029	0.909MetPro: 0.909 ± 0.043	0.511MetGln: 0.511 ± 0.028	1.525MetArg: 1.525 ± 0.047	0.811MetSer: 0.811 ± 0.034	0.832MetThr: 0.832 ± 0.033	1.569MetVal: 1.569 ± 0.054	0.163MetTrp: 0.163 ± 0.017	0.313MetTyr: 0.313 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	1.872AsnAla: 1.872 ± 0.058	0.303AsnCys: 0.303 ± 0.021	0.704AsnAsp: 0.704 ± 0.033	1.144AsnGlu: 1.144 ± 0.047	1.139AsnPhe: 1.139 ± 0.039	1.674AsnGly: 1.674 ± 0.059	0.396AsnHis: 0.396 ± 0.026	1.204AsnIle: 1.204 ± 0.047	0.647AsnLys: 0.647 ± 0.027	3.302AsnLeu: 3.302 ± 0.073	0.385AsnMet: 0.385 ± 0.027	0.476AsnAsn: 0.476 ± 0.031	1.896AsnPro: 1.896 ± 0.056	0.722AsnGln: 0.722 ± 0.035	1.853AsnArg: 1.853 ± 0.057	0.898AsnSer: 0.898 ± 0.035	1.008AsnThr: 1.008 ± 0.045	1.58AsnVal: 1.58 ± 0.052	0.436AsnTrp: 0.436 ± 0.025	0.744AsnTyr: 0.744 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	4.883ProAla: 4.883 ± 0.103	0.613ProCys: 0.613 ± 0.029	2.655ProAsp: 2.655 ± 0.07	5.623ProGlu: 5.623 ± 0.095	2.18ProPhe: 2.18 ± 0.06	5.11ProGly: 5.11 ± 0.109	1.094ProHis: 1.094 ± 0.038	1.634ProIle: 1.634 ± 0.053	1.831ProLys: 1.831 ± 0.059	5.23ProLeu: 5.23 ± 0.104	0.735ProMet: 0.735 ± 0.031	1.109ProAsn: 1.109 ± 0.043	3.437ProPro: 3.437 ± 0.079	1.728ProGln: 1.728 ± 0.058	3.597ProArg: 3.597 ± 0.076	2.66ProSer: 2.66 ± 0.079	2.124ProThr: 2.124 ± 0.064	4.833ProVal: 4.833 ± 0.095	0.765ProTrp: 0.765 ± 0.032	1.608ProTyr: 1.608 ± 0.055	0.0ProXaa: 0.0 ± 0.0
Gln	3.572GlnAla: 3.572 ± 0.086	0.244GlnCys: 0.244 ± 0.025	1.025GlnAsp: 1.025 ± 0.037	3.131GlnGlu: 3.131 ± 0.086	0.684GlnPhe: 0.684 ± 0.03	2.431GlnGly: 2.431 ± 0.058	0.482GlnHis: 0.482 ± 0.029	1.409GlnIle: 1.409 ± 0.05	1.562GlnLys: 1.562 ± 0.044	2.691GlnLeu: 2.691 ± 0.073	0.554GlnMet: 0.554 ± 0.026	0.69GlnAsn: 0.69 ± 0.029	1.144GlnPro: 1.144 ± 0.038	0.939GlnGln: 0.939 ± 0.047	2.037GlnArg: 2.037 ± 0.061	1.025GlnSer: 1.025 ± 0.041	1.032GlnThr: 1.032 ± 0.043	2.827GlnVal: 2.827 ± 0.064	0.291GlnTrp: 0.291 ± 0.023	0.655GlnTyr: 0.655 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	6.717ArgAla: 6.717 ± 0.117	0.99ArgCys: 0.99 ± 0.046	2.92ArgAsp: 2.92 ± 0.067	7.876ArgGlu: 7.876 ± 0.134	3.03ArgPhe: 3.03 ± 0.067	5.576ArgGly: 5.576 ± 0.115	1.672ArgHis: 1.672 ± 0.061	3.592ArgIle: 3.592 ± 0.08	3.645ArgLys: 3.645 ± 0.09	9.985ArgLeu: 9.985 ± 0.138	1.474ArgMet: 1.474 ± 0.053	1.556ArgAsn: 1.556 ± 0.056	3.752ArgPro: 3.752 ± 0.086	3.057ArgGln: 3.057 ± 0.071	7.399ArgArg: 7.399 ± 0.127	3.009ArgSer: 3.009 ± 0.073	2.971ArgThr: 2.971 ± 0.063	6.698ArgVal: 6.698 ± 0.115	1.372ArgTrp: 1.372 ± 0.048	2.549ArgTyr: 2.549 ± 0.066	0.0ArgXaa: 0.0 ± 0.0
Ser	3.562SerAla: 3.562 ± 0.077	0.728SerCys: 0.728 ± 0.035	1.409SerAsp: 1.409 ± 0.052	2.204SerGlu: 2.204 ± 0.064	2.453SerPhe: 2.453 ± 0.07	4.027SerGly: 4.027 ± 0.095	0.917SerHis: 0.917 ± 0.039	1.714SerIle: 1.714 ± 0.057	1.319SerLys: 1.319 ± 0.041	6.292SerLeu: 6.292 ± 0.127	0.851SerMet: 0.851 ± 0.041	0.8SerAsn: 0.8 ± 0.035	3.362SerPro: 3.362 ± 0.072	1.323SerGln: 1.323 ± 0.048	3.905SerArg: 3.905 ± 0.075	2.771SerSer: 2.771 ± 0.069	2.022SerThr: 2.022 ± 0.056	2.958SerVal: 2.958 ± 0.075	0.887SerTrp: 0.887 ± 0.037	1.391SerTyr: 1.391 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.247ThrAla: 4.247 ± 0.09	0.626ThrCys: 0.626 ± 0.031	1.773ThrAsp: 1.773 ± 0.06	2.422ThrGlu: 2.422 ± 0.057	1.783ThrPhe: 1.783 ± 0.053	4.517ThrGly: 4.517 ± 0.092	0.8ThrHis: 0.8 ± 0.035	1.99ThrIle: 1.99 ± 0.067	1.41ThrLys: 1.41 ± 0.048	5.0ThrLeu: 5.0 ± 0.091	0.664ThrMet: 0.664 ± 0.033	1.03ThrAsn: 1.03 ± 0.043	3.033ThrPro: 3.033 ± 0.07	0.987ThrGln: 0.987 ± 0.045	2.944ThrArg: 2.944 ± 0.068	2.195ThrSer: 2.195 ± 0.058	2.251ThrThr: 2.251 ± 0.071	4.223ThrVal: 4.223 ± 0.111	0.572ThrTrp: 0.572 ± 0.03	1.291ThrTyr: 1.291 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	8.975ValAla: 8.975 ± 0.131	1.077ValCys: 1.077 ± 0.048	3.588ValAsp: 3.588 ± 0.074	6.789ValGlu: 6.789 ± 0.125	3.105ValPhe: 3.105 ± 0.075	6.298ValGly: 6.298 ± 0.119	1.292ValHis: 1.292 ± 0.043	4.027ValIle: 4.027 ± 0.097	4.688ValLys: 4.688 ± 0.094	9.908ValLeu: 9.908 ± 0.157	1.409ValMet: 1.409 ± 0.049	2.056ValAsn: 2.056 ± 0.062	4.399ValPro: 4.399 ± 0.089	1.824ValGln: 1.824 ± 0.055	6.333ValArg: 6.333 ± 0.117	4.03ValSer: 4.03 ± 0.091	4.151ValThr: 4.151 ± 0.1	8.629ValVal: 8.629 ± 0.151	1.029ValTrp: 1.029 ± 0.044	2.172ValTyr: 2.172 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	1.109TrpAla: 1.109 ± 0.043	0.19TrpCys: 0.19 ± 0.017	0.623TrpAsp: 0.623 ± 0.035	1.262TrpGlu: 1.262 ± 0.049	0.479TrpPhe: 0.479 ± 0.03	1.152TrpGly: 1.152 ± 0.055	0.307TrpHis: 0.307 ± 0.022	0.556TrpIle: 0.556 ± 0.036	0.604TrpLys: 0.604 ± 0.034	1.845TrpLeu: 1.845 ± 0.062	0.248TrpMet: 0.248 ± 0.021	0.262TrpAsn: 0.262 ± 0.019	0.66TrpPro: 0.66 ± 0.032	0.732TrpGln: 0.732 ± 0.033	1.423TrpArg: 1.423 ± 0.054	0.534TrpSer: 0.534 ± 0.028	0.455TrpThr: 0.455 ± 0.029	1.053TrpVal: 1.053 ± 0.044	0.339TrpTrp: 0.339 ± 0.027	0.35TrpTyr: 0.35 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.442TyrAla: 2.442 ± 0.072	0.458TyrCys: 0.458 ± 0.027	1.212TyrAsp: 1.212 ± 0.043	1.624TyrGlu: 1.624 ± 0.057	1.31TyrPhe: 1.31 ± 0.046	2.292TyrGly: 2.292 ± 0.061	0.666TyrHis: 0.666 ± 0.035	1.08TyrIle: 1.08 ± 0.039	0.856TyrLys: 0.856 ± 0.04	4.108TyrLeu: 4.108 ± 0.084	0.26TyrMet: 0.26 ± 0.021	0.696TyrAsn: 0.696 ± 0.033	1.636TyrPro: 1.636 ± 0.045	1.134TyrGln: 1.134 ± 0.045	2.965TyrArg: 2.965 ± 0.068	1.203TyrSer: 1.203 ± 0.043	1.319TyrThr: 1.319 ± 0.054	2.001TyrVal: 2.001 ± 0.061	0.495TyrTrp: 0.495 ± 0.028	0.99TyrTyr: 0.99 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2077 proteins (626053 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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