Amino acid dipepetide frequency for Caenispirillum bisanense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.252AlaAla: 24.252 ± 0.253	1.354AlaCys: 1.354 ± 0.037	8.208AlaAsp: 8.208 ± 0.093	9.278AlaGlu: 9.278 ± 0.099	4.42AlaPhe: 4.42 ± 0.056	12.331AlaGly: 12.331 ± 0.097	2.341AlaHis: 2.341 ± 0.039	4.624AlaIle: 4.624 ± 0.055	3.226AlaLys: 3.226 ± 0.051	14.909AlaLeu: 14.909 ± 0.138	3.578AlaMet: 3.578 ± 0.049	2.293AlaAsn: 2.293 ± 0.047	6.914AlaPro: 6.914 ± 0.103	3.685AlaGln: 3.685 ± 0.052	9.847AlaArg: 9.847 ± 0.093	5.025AlaSer: 5.025 ± 0.062	6.413AlaThr: 6.413 ± 0.074	12.249AlaVal: 12.249 ± 0.101	1.811AlaTrp: 1.811 ± 0.04	2.455AlaTyr: 2.455 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.055CysAla: 1.055 ± 0.027	0.098CysCys: 0.098 ± 0.008	0.596CysAsp: 0.596 ± 0.018	0.413CysGlu: 0.413 ± 0.017	0.284CysPhe: 0.284 ± 0.013	0.959CysGly: 0.959 ± 0.024	0.244CysHis: 0.244 ± 0.014	0.377CysIle: 0.377 ± 0.014	0.198CysLys: 0.198 ± 0.012	0.788CysLeu: 0.788 ± 0.023	0.165CysMet: 0.165 ± 0.011	0.168CysAsn: 0.168 ± 0.011	0.522CysPro: 0.522 ± 0.02	0.197CysGln: 0.197 ± 0.012	0.791CysArg: 0.791 ± 0.025	0.359CysSer: 0.359 ± 0.016	0.455CysThr: 0.455 ± 0.019	0.63CysVal: 0.63 ± 0.02	0.129CysTrp: 0.129 ± 0.009	0.194CysTyr: 0.194 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.002AspAla: 8.002 ± 0.081	0.484AspCys: 0.484 ± 0.016	3.86AspAsp: 3.86 ± 0.058	3.42AspGlu: 3.42 ± 0.049	1.97AspPhe: 1.97 ± 0.034	6.1AspGly: 6.1 ± 0.095	1.389AspHis: 1.389 ± 0.029	2.518AspIle: 2.518 ± 0.042	1.422AspLys: 1.422 ± 0.034	6.794AspLeu: 6.794 ± 0.079	1.385AspMet: 1.385 ± 0.028	1.027AspAsn: 1.027 ± 0.034	3.777AspPro: 3.777 ± 0.052	1.558AspGln: 1.558 ± 0.033	5.175AspArg: 5.175 ± 0.064	2.039AspSer: 2.039 ± 0.04	2.845AspThr: 2.845 ± 0.049	4.742AspVal: 4.742 ± 0.062	0.994AspTrp: 0.994 ± 0.021	1.351AspTyr: 1.351 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	8.665GluAla: 8.665 ± 0.099	0.341GluCys: 0.341 ± 0.015	3.344GluAsp: 3.344 ± 0.056	3.377GluGlu: 3.377 ± 0.064	1.471GluPhe: 1.471 ± 0.031	4.529GluGly: 4.529 ± 0.054	1.205GluHis: 1.205 ± 0.028	2.793GluIle: 2.793 ± 0.045	1.915GluLys: 1.915 ± 0.041	4.828GluLeu: 4.828 ± 0.068	1.575GluMet: 1.575 ± 0.03	1.222GluAsn: 1.222 ± 0.028	3.032GluPro: 3.032 ± 0.061	2.105GluGln: 2.105 ± 0.042	5.075GluArg: 5.075 ± 0.074	2.169GluSer: 2.169 ± 0.036	3.501GluThr: 3.501 ± 0.049	4.524GluVal: 4.524 ± 0.056	0.661GluTrp: 0.661 ± 0.018	0.966GluTyr: 0.966 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.274PheAla: 4.274 ± 0.057	0.357PheCys: 0.357 ± 0.016	2.368PheAsp: 2.368 ± 0.044	1.836PheGlu: 1.836 ± 0.036	1.169PhePhe: 1.169 ± 0.032	3.423PheGly: 3.423 ± 0.054	0.752PheHis: 0.752 ± 0.023	1.214PheIle: 1.214 ± 0.032	0.859PheLys: 0.859 ± 0.026	3.28PheLeu: 3.28 ± 0.053	0.703PheMet: 0.703 ± 0.022	0.755PheAsn: 0.755 ± 0.022	1.462PhePro: 1.462 ± 0.032	0.928PheGln: 0.928 ± 0.026	2.224PheArg: 2.224 ± 0.035	1.546PheSer: 1.546 ± 0.035	1.946PheThr: 1.946 ± 0.041	2.735PheVal: 2.735 ± 0.046	0.495PheTrp: 0.495 ± 0.017	0.812PheTyr: 0.812 ± 0.023	0.001PheXaa: 0.001 ± 0.001
Gly	9.952GlyAla: 9.952 ± 0.094	0.921GlyCys: 0.921 ± 0.028	4.97GlyAsp: 4.97 ± 0.069	4.767GlyGlu: 4.767 ± 0.055	3.292GlyPhe: 3.292 ± 0.053	8.511GlyGly: 8.511 ± 0.113	1.904GlyHis: 1.904 ± 0.035	4.059GlyIle: 4.059 ± 0.052	2.698GlyLys: 2.698 ± 0.048	9.662GlyLeu: 9.662 ± 0.092	2.47GlyMet: 2.47 ± 0.043	1.721GlyAsn: 1.721 ± 0.036	3.907GlyPro: 3.907 ± 0.058	2.545GlyGln: 2.545 ± 0.043	7.411GlyArg: 7.411 ± 0.075	4.142GlySer: 4.142 ± 0.067	4.969GlyThr: 4.969 ± 0.08	6.83GlyVal: 6.83 ± 0.068	1.5GlyTrp: 1.5 ± 0.039	2.091GlyTyr: 2.091 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.503HisAla: 2.503 ± 0.043	0.235HisCys: 0.235 ± 0.013	1.34HisAsp: 1.34 ± 0.027	1.03HisGlu: 1.03 ± 0.026	0.706HisPhe: 0.706 ± 0.022	2.099HisGly: 2.099 ± 0.042	0.59HisHis: 0.59 ± 0.02	0.78HisIle: 0.78 ± 0.025	0.413HisLys: 0.413 ± 0.015	2.13HisLeu: 2.13 ± 0.038	0.506HisMet: 0.506 ± 0.02	0.379HisAsn: 0.379 ± 0.017	1.417HisPro: 1.417 ± 0.031	0.514HisGln: 0.514 ± 0.017	1.633HisArg: 1.633 ± 0.034	0.739HisSer: 0.739 ± 0.02	0.941HisThr: 0.941 ± 0.024	1.636HisVal: 1.636 ± 0.033	0.309HisTrp: 0.309 ± 0.015	0.506HisTyr: 0.506 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.866IleAla: 5.866 ± 0.07	0.362IleCys: 0.362 ± 0.015	2.912IleAsp: 2.912 ± 0.044	2.574IleGlu: 2.574 ± 0.047	1.151IlePhe: 1.151 ± 0.03	4.169IleGly: 4.169 ± 0.061	0.782IleHis: 0.782 ± 0.023	1.463IleIle: 1.463 ± 0.042	1.042IleLys: 1.042 ± 0.029	3.848IleLeu: 3.848 ± 0.061	0.767IleMet: 0.767 ± 0.024	0.957IleAsn: 0.957 ± 0.027	1.931IlePro: 1.931 ± 0.038	0.985IleGln: 0.985 ± 0.025	2.621IleArg: 2.621 ± 0.045	1.81IleSer: 1.81 ± 0.032	2.246IleThr: 2.246 ± 0.046	3.616IleVal: 3.616 ± 0.052	0.413IleTrp: 0.413 ± 0.016	0.835IleTyr: 0.835 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.822LysAla: 3.822 ± 0.061	0.134LysCys: 0.134 ± 0.009	1.576LysAsp: 1.576 ± 0.034	1.401LysGlu: 1.401 ± 0.036	0.671LysPhe: 0.671 ± 0.022	2.329LysGly: 2.329 ± 0.045	0.473LysHis: 0.473 ± 0.017	1.196LysIle: 1.196 ± 0.032	1.032LysLys: 1.032 ± 0.034	2.453LysLeu: 2.453 ± 0.041	0.644LysMet: 0.644 ± 0.025	0.581LysAsn: 0.581 ± 0.021	1.73LysPro: 1.73 ± 0.04	0.847LysGln: 0.847 ± 0.024	1.949LysArg: 1.949 ± 0.042	1.233LysSer: 1.233 ± 0.028	1.632LysThr: 1.632 ± 0.033	2.274LysVal: 2.274 ± 0.044	0.289LysTrp: 0.289 ± 0.017	0.507LysTyr: 0.507 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.434LeuAla: 15.434 ± 0.137	0.922LeuCys: 0.922 ± 0.024	6.514LeuAsp: 6.514 ± 0.075	5.314LeuGlu: 5.314 ± 0.063	3.536LeuPhe: 3.536 ± 0.057	8.635LeuGly: 8.635 ± 0.083	2.06LeuHis: 2.06 ± 0.04	3.777LeuIle: 3.777 ± 0.058	3.065LeuLys: 3.065 ± 0.046	10.38LeuLeu: 10.38 ± 0.121	2.297LeuMet: 2.297 ± 0.043	2.105LeuAsn: 2.105 ± 0.041	6.328LeuPro: 6.328 ± 0.079	2.575LeuGln: 2.575 ± 0.046	8.066LeuArg: 8.066 ± 0.08	5.332LeuSer: 5.332 ± 0.06	6.17LeuThr: 6.17 ± 0.067	8.548LeuVal: 8.548 ± 0.081	1.328LeuTrp: 1.328 ± 0.036	1.978LeuTyr: 1.978 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.429MetAla: 3.429 ± 0.051	0.134MetCys: 0.134 ± 0.011	1.268MetAsp: 1.268 ± 0.032	1.19MetGlu: 1.19 ± 0.027	0.581MetPhe: 0.581 ± 0.019	1.829MetGly: 1.829 ± 0.043	0.442MetHis: 0.442 ± 0.017	1.144MetIle: 1.144 ± 0.031	0.826MetLys: 0.826 ± 0.025	2.303MetLeu: 2.303 ± 0.039	0.559MetMet: 0.559 ± 0.021	0.6MetAsn: 0.6 ± 0.02	1.526MetPro: 1.526 ± 0.033	0.77MetGln: 0.77 ± 0.024	1.666MetArg: 1.666 ± 0.032	1.351MetSer: 1.351 ± 0.033	2.056MetThr: 2.056 ± 0.033	1.948MetVal: 1.948 ± 0.038	0.2MetTrp: 0.2 ± 0.012	0.287MetTyr: 0.287 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.483AsnAla: 2.483 ± 0.045	0.18AsnCys: 0.18 ± 0.011	1.122AsnAsp: 1.122 ± 0.028	0.976AsnGlu: 0.976 ± 0.027	0.646AsnPhe: 0.646 ± 0.022	1.822AsnGly: 1.822 ± 0.045	0.41AsnHis: 0.41 ± 0.017	0.966AsnIle: 0.966 ± 0.025	0.511AsnLys: 0.511 ± 0.02	2.063AsnLeu: 2.063 ± 0.034	0.503AsnMet: 0.503 ± 0.017	0.459AsnAsn: 0.459 ± 0.019	1.491AsnPro: 1.491 ± 0.033	0.585AsnGln: 0.585 ± 0.021	1.557AsnArg: 1.557 ± 0.036	0.784AsnSer: 0.784 ± 0.025	1.1AsnThr: 1.1 ± 0.026	1.553AsnVal: 1.553 ± 0.036	0.251AsnTrp: 0.251 ± 0.014	0.464AsnTyr: 0.464 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	8.17ProAla: 8.17 ± 0.115	0.359ProCys: 0.359 ± 0.017	4.099ProAsp: 4.099 ± 0.056	4.094ProGlu: 4.094 ± 0.059	1.915ProPhe: 1.915 ± 0.038	4.76ProGly: 4.76 ± 0.062	1.126ProHis: 1.126 ± 0.029	1.673ProIle: 1.673 ± 0.028	1.392ProLys: 1.392 ± 0.029	5.485ProLeu: 5.485 ± 0.069	1.205ProMet: 1.205 ± 0.027	0.997ProAsn: 0.997 ± 0.027	3.706ProPro: 3.706 ± 0.086	1.766ProGln: 1.766 ± 0.032	3.378ProArg: 3.378 ± 0.055	2.299ProSer: 2.299 ± 0.04	2.743ProThr: 2.743 ± 0.047	4.891ProVal: 4.891 ± 0.051	0.816ProTrp: 0.816 ± 0.021	1.118ProTyr: 1.118 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.322GlnAla: 4.322 ± 0.055	0.205GlnCys: 0.205 ± 0.012	1.425GlnAsp: 1.425 ± 0.036	1.543GlnGlu: 1.543 ± 0.035	0.834GlnPhe: 0.834 ± 0.023	2.409GlnGly: 2.409 ± 0.046	0.56GlnHis: 0.56 ± 0.02	1.294GlnIle: 1.294 ± 0.031	0.808GlnLys: 0.808 ± 0.023	2.349GlnLeu: 2.349 ± 0.049	0.8GlnMet: 0.8 ± 0.026	0.588GlnAsn: 0.588 ± 0.021	1.744GlnPro: 1.744 ± 0.036	1.098GlnGln: 1.098 ± 0.037	2.245GlnArg: 2.245 ± 0.039	1.283GlnSer: 1.283 ± 0.03	1.636GlnThr: 1.636 ± 0.033	2.477GlnVal: 2.477 ± 0.036	0.418GlnTrp: 0.418 ± 0.017	0.557GlnTyr: 0.557 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.873ArgAla: 8.873 ± 0.104	0.598ArgCys: 0.598 ± 0.02	4.744ArgAsp: 4.744 ± 0.059	4.254ArgGlu: 4.254 ± 0.06	2.799ArgPhe: 2.799 ± 0.043	5.226ArgGly: 5.226 ± 0.055	1.902ArgHis: 1.902 ± 0.037	3.555ArgIle: 3.555 ± 0.052	2.097ArgLys: 2.097 ± 0.041	9.469ArgLeu: 9.469 ± 0.105	2.009ArgMet: 2.009 ± 0.04	1.494ArgAsn: 1.494 ± 0.032	4.33ArgPro: 4.33 ± 0.06	2.517ArgGln: 2.517 ± 0.042	7.48ArgArg: 7.48 ± 0.101	3.181ArgSer: 3.181 ± 0.049	3.844ArgThr: 3.844 ± 0.051	5.499ArgVal: 5.499 ± 0.07	1.148ArgTrp: 1.148 ± 0.031	1.609ArgTyr: 1.609 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.113SerAla: 5.113 ± 0.069	0.384SerCys: 0.384 ± 0.016	2.466SerAsp: 2.466 ± 0.045	2.032SerGlu: 2.032 ± 0.041	1.68SerPhe: 1.68 ± 0.032	4.499SerGly: 4.499 ± 0.068	0.915SerHis: 0.915 ± 0.026	1.877SerIle: 1.877 ± 0.037	1.03SerLys: 1.03 ± 0.027	4.787SerLeu: 4.787 ± 0.061	1.044SerMet: 1.044 ± 0.024	0.904SerAsn: 0.904 ± 0.025	2.444SerPro: 2.444 ± 0.043	1.165SerGln: 1.165 ± 0.029	3.231SerArg: 3.231 ± 0.045	1.966SerSer: 1.966 ± 0.043	2.176SerThr: 2.176 ± 0.043	3.503SerVal: 3.503 ± 0.052	0.571SerTrp: 0.571 ± 0.021	1.028SerTyr: 1.028 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	7.809ThrAla: 7.809 ± 0.086	0.438ThrCys: 0.438 ± 0.021	3.1ThrAsp: 3.1 ± 0.054	2.877ThrGlu: 2.877 ± 0.053	1.876ThrPhe: 1.876 ± 0.038	5.319ThrGly: 5.319 ± 0.073	0.968ThrHis: 0.968 ± 0.031	2.292ThrIle: 2.292 ± 0.046	1.132ThrLys: 1.132 ± 0.032	6.347ThrLeu: 6.347 ± 0.071	1.096ThrMet: 1.096 ± 0.028	1.032ThrAsn: 1.032 ± 0.031	3.535ThrPro: 3.535 ± 0.053	1.297ThrGln: 1.297 ± 0.03	3.302ThrArg: 3.302 ± 0.048	2.169ThrSer: 2.169 ± 0.045	3.016ThrThr: 3.016 ± 0.058	5.37ThrVal: 5.37 ± 0.082	0.793ThrTrp: 0.793 ± 0.021	1.164ThrTyr: 1.164 ± 0.03	0.001ThrXaa: 0.001 ± 0.001
Val	11.436ValAla: 11.436 ± 0.091	0.771ValCys: 0.771 ± 0.025	4.782ValAsp: 4.782 ± 0.066	5.196ValGlu: 5.196 ± 0.06	2.913ValPhe: 2.913 ± 0.04	6.365ValGly: 6.365 ± 0.075	1.533ValHis: 1.533 ± 0.034	3.448ValIle: 3.448 ± 0.054	2.169ValLys: 2.169 ± 0.04	8.705ValLeu: 8.705 ± 0.08	1.992ValMet: 1.992 ± 0.036	1.793ValAsn: 1.793 ± 0.031	4.508ValPro: 4.508 ± 0.051	2.258ValGln: 2.258 ± 0.043	5.881ValArg: 5.881 ± 0.064	3.822ValSer: 3.822 ± 0.052	5.373ValThr: 5.373 ± 0.084	7.96ValVal: 7.96 ± 0.08	1.008ValTrp: 1.008 ± 0.028	1.637ValTyr: 1.637 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.348TrpAla: 1.348 ± 0.03	0.146TrpCys: 0.146 ± 0.009	0.708TrpAsp: 0.708 ± 0.023	0.637TrpGlu: 0.637 ± 0.019	0.48TrpPhe: 0.48 ± 0.018	0.933TrpGly: 0.933 ± 0.026	0.342TrpHis: 0.342 ± 0.015	0.552TrpIle: 0.552 ± 0.016	0.392TrpLys: 0.392 ± 0.014	1.752TrpLeu: 1.752 ± 0.039	0.378TrpMet: 0.378 ± 0.015	0.35TrpAsn: 0.35 ± 0.016	0.701TrpPro: 0.701 ± 0.022	0.601TrpGln: 0.601 ± 0.02	1.392TrpArg: 1.392 ± 0.031	0.684TrpSer: 0.684 ± 0.023	0.821TrpThr: 0.821 ± 0.024	0.949TrpVal: 0.949 ± 0.024	0.246TrpTrp: 0.246 ± 0.013	0.294TrpTyr: 0.294 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.401TyrAla: 2.401 ± 0.035	0.2TyrCys: 0.2 ± 0.011	1.454TyrAsp: 1.454 ± 0.035	1.087TyrGlu: 1.087 ± 0.03	0.744TyrPhe: 0.744 ± 0.026	2.074TyrGly: 2.074 ± 0.04	0.469TyrHis: 0.469 ± 0.017	0.748TyrIle: 0.748 ± 0.022	0.547TyrLys: 0.547 ± 0.021	2.03TyrLeu: 2.03 ± 0.037	0.436TyrMet: 0.436 ± 0.017	0.503TyrAsn: 0.503 ± 0.019	0.986TyrPro: 0.986 ± 0.025	0.601TyrGln: 0.601 ± 0.019	1.703TyrArg: 1.703 ± 0.032	0.885TyrSer: 0.885 ± 0.023	1.048TyrThr: 1.048 ± 0.03	1.614TyrVal: 1.614 ± 0.034	0.325TyrTrp: 0.325 ± 0.015	0.55TyrTyr: 0.55 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.003

Statistics based on 4942 proteins (1577073 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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