Amino acid dipepetide frequency for Nematocida sp. 1 (strain ERTm2 / ATCC PRA-371) (Nematode killer fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.995AlaAla: 3.995 ± 0.088	1.142AlaCys: 1.142 ± 0.028	2.775AlaAsp: 2.775 ± 0.049	4.766AlaGlu: 4.766 ± 0.091	2.052AlaPhe: 2.052 ± 0.044	3.04AlaGly: 3.04 ± 0.067	1.394AlaHis: 1.394 ± 0.041	4.121AlaIle: 4.121 ± 0.067	3.861AlaLys: 3.861 ± 0.07	5.914AlaLeu: 5.914 ± 0.09	1.48AlaMet: 1.48 ± 0.038	2.261AlaAsn: 2.261 ± 0.058	2.14AlaPro: 2.14 ± 0.063	2.266AlaGln: 2.266 ± 0.051	2.544AlaArg: 2.544 ± 0.056	4.276AlaSer: 4.276 ± 0.084	2.386AlaThr: 2.386 ± 0.047	3.938AlaVal: 3.938 ± 0.066	0.42AlaTrp: 0.42 ± 0.022	2.416AlaTyr: 2.416 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.185CysAla: 1.185 ± 0.034	0.424CysCys: 0.424 ± 0.022	0.738CysAsp: 0.738 ± 0.027	0.934CysGlu: 0.934 ± 0.031	0.796CysPhe: 0.796 ± 0.029	0.879CysGly: 0.879 ± 0.032	0.27CysHis: 0.27 ± 0.017	1.697CysIle: 1.697 ± 0.043	1.461CysLys: 1.461 ± 0.036	1.802CysLeu: 1.802 ± 0.048	0.671CysMet: 0.671 ± 0.024	0.823CysAsn: 0.823 ± 0.029	0.615CysPro: 0.615 ± 0.029	0.394CysGln: 0.394 ± 0.019	0.863CysArg: 0.863 ± 0.034	1.586CysSer: 1.586 ± 0.043	1.266CysThr: 1.266 ± 0.031	1.121CysVal: 1.121 ± 0.035	0.103CysTrp: 0.103 ± 0.011	0.539CysTyr: 0.539 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	2.973AspAla: 2.973 ± 0.055	0.831AspCys: 0.831 ± 0.032	1.885AspAsp: 1.885 ± 0.046	3.61AspGlu: 3.61 ± 0.071	1.725AspPhe: 1.725 ± 0.041	2.356AspGly: 2.356 ± 0.056	0.827AspHis: 0.827 ± 0.034	4.732AspIle: 4.732 ± 0.079	3.73AspLys: 3.73 ± 0.057	4.652AspLeu: 4.652 ± 0.073	1.336AspMet: 1.336 ± 0.038	1.87AspAsn: 1.87 ± 0.047	1.725AspPro: 1.725 ± 0.054	1.217AspGln: 1.217 ± 0.032	2.547AspArg: 2.547 ± 0.061	3.778AspSer: 3.778 ± 0.069	2.889AspThr: 2.889 ± 0.059	2.829AspVal: 2.829 ± 0.056	0.319AspTrp: 0.319 ± 0.021	1.78AspTyr: 1.78 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	3.996GluAla: 3.996 ± 0.079	1.429GluCys: 1.429 ± 0.04	4.124GluAsp: 4.124 ± 0.076	8.509GluGlu: 8.509 ± 0.147	2.615GluPhe: 2.615 ± 0.056	3.506GluGly: 3.506 ± 0.061	1.491GluHis: 1.491 ± 0.042	7.381GluIle: 7.381 ± 0.104	8.169GluLys: 8.169 ± 0.11	5.71GluLeu: 5.71 ± 0.082	2.469GluMet: 2.469 ± 0.055	4.458GluAsn: 4.458 ± 0.078	1.714GluPro: 1.714 ± 0.059	2.334GluGln: 2.334 ± 0.055	3.828GluArg: 3.828 ± 0.09	5.581GluSer: 5.581 ± 0.082	4.338GluThr: 4.338 ± 0.092	4.463GluVal: 4.463 ± 0.081	0.532GluTrp: 0.532 ± 0.024	3.749GluTyr: 3.749 ± 0.069	0.0GluXaa: 0.0 ± 0.0
Phe	1.943PheAla: 1.943 ± 0.048	0.939PheCys: 0.939 ± 0.036	1.631PheAsp: 1.631 ± 0.043	2.192PheGlu: 2.192 ± 0.046	2.346PhePhe: 2.346 ± 0.051	1.945PheGly: 1.945 ± 0.048	0.707PheHis: 0.707 ± 0.027	3.737PheIle: 3.737 ± 0.062	2.73PheLys: 2.73 ± 0.055	4.567PheLeu: 4.567 ± 0.076	1.204PheMet: 1.204 ± 0.04	1.795PheAsn: 1.795 ± 0.043	1.482PhePro: 1.482 ± 0.038	1.1PheGln: 1.1 ± 0.036	1.473PheArg: 1.473 ± 0.041	3.866PheSer: 3.866 ± 0.065	2.344PheThr: 2.344 ± 0.05	2.292PheVal: 2.292 ± 0.049	0.32PheTrp: 0.32 ± 0.019	1.8PheTyr: 1.8 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	2.498GlyAla: 2.498 ± 0.062	0.867GlyCys: 0.867 ± 0.03	1.926GlyAsp: 1.926 ± 0.055	2.897GlyGlu: 2.897 ± 0.062	1.98GlyPhe: 1.98 ± 0.052	2.238GlyGly: 2.238 ± 0.074	1.057GlyHis: 1.057 ± 0.038	4.317GlyIle: 4.317 ± 0.078	3.666GlyLys: 3.666 ± 0.068	4.18GlyLeu: 4.18 ± 0.073	1.508GlyMet: 1.508 ± 0.052	2.012GlyAsn: 2.012 ± 0.045	1.276GlyPro: 1.276 ± 0.037	1.224GlyGln: 1.224 ± 0.046	2.202GlyArg: 2.202 ± 0.051	3.432GlySer: 3.432 ± 0.064	2.48GlyThr: 2.48 ± 0.059	3.227GlyVal: 3.227 ± 0.067	0.364GlyTrp: 0.364 ± 0.02	2.057GlyTyr: 2.057 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.47HisAla: 1.47 ± 0.032	0.359HisCys: 0.359 ± 0.017	0.629HisAsp: 0.629 ± 0.025	1.223HisGlu: 1.223 ± 0.032	0.776HisPhe: 0.776 ± 0.028	0.989HisGly: 0.989 ± 0.034	0.378HisHis: 0.378 ± 0.022	1.93HisIle: 1.93 ± 0.043	1.567HisLys: 1.567 ± 0.041	1.96HisLeu: 1.96 ± 0.044	0.74HisMet: 0.74 ± 0.027	0.97HisAsn: 0.97 ± 0.03	0.953HisPro: 0.953 ± 0.035	0.518HisGln: 0.518 ± 0.023	1.118HisArg: 1.118 ± 0.031	1.951HisSer: 1.951 ± 0.054	1.481HisThr: 1.481 ± 0.04	1.13HisVal: 1.13 ± 0.032	0.148HisTrp: 0.148 ± 0.013	0.715HisTyr: 0.715 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.21IleAla: 4.21 ± 0.072	1.557IleCys: 1.557 ± 0.04	4.635IleAsp: 4.635 ± 0.066	6.588IleGlu: 6.588 ± 0.094	3.86IlePhe: 3.86 ± 0.071	3.388IleGly: 3.388 ± 0.067	1.628IleHis: 1.628 ± 0.039	5.848IleIle: 5.848 ± 0.102	6.886IleLys: 6.886 ± 0.095	8.644IleLeu: 8.644 ± 0.091	1.751IleMet: 1.751 ± 0.048	4.112IleAsn: 4.112 ± 0.069	3.006IlePro: 3.006 ± 0.054	3.118IleGln: 3.118 ± 0.061	3.703IleArg: 3.703 ± 0.075	7.438IleSer: 7.438 ± 0.099	4.22IleThr: 4.22 ± 0.066	4.42IleVal: 4.42 ± 0.075	0.66IleTrp: 0.66 ± 0.029	3.458IleTyr: 3.458 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	4.214LysAla: 4.214 ± 0.07	1.192LysCys: 1.192 ± 0.031	4.563LysAsp: 4.563 ± 0.074	9.304LysGlu: 9.304 ± 0.143	1.901LysPhe: 1.901 ± 0.054	3.43LysGly: 3.43 ± 0.068	1.708LysHis: 1.708 ± 0.043	6.673LysIle: 6.673 ± 0.09	8.962LysLys: 8.962 ± 0.123	5.182LysLeu: 5.182 ± 0.078	2.372LysMet: 2.372 ± 0.05	4.93LysAsn: 4.93 ± 0.089	2.304LysPro: 2.304 ± 0.066	2.513LysGln: 2.513 ± 0.053	4.253LysArg: 4.253 ± 0.07	5.515LysSer: 5.515 ± 0.085	5.185LysThr: 5.185 ± 0.076	4.329LysVal: 4.329 ± 0.075	0.549LysTrp: 0.549 ± 0.022	3.772LysTyr: 3.772 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	5.264LeuAla: 5.264 ± 0.085	2.114LeuCys: 2.114 ± 0.049	4.377LeuAsp: 4.377 ± 0.076	6.697LeuGlu: 6.697 ± 0.092	5.148LeuPhe: 5.148 ± 0.088	4.111LeuGly: 4.111 ± 0.074	1.972LeuHis: 1.972 ± 0.045	6.211LeuIle: 6.211 ± 0.087	6.94LeuLys: 6.94 ± 0.093	10.421LeuLeu: 10.421 ± 0.128	2.12LeuMet: 2.12 ± 0.051	4.417LeuAsn: 4.417 ± 0.081	3.378LeuPro: 3.378 ± 0.07	3.454LeuGln: 3.454 ± 0.057	3.864LeuArg: 3.864 ± 0.065	8.466LeuSer: 8.466 ± 0.103	3.982LeuThr: 3.982 ± 0.058	5.365LeuVal: 5.365 ± 0.085	0.617LeuTrp: 0.617 ± 0.022	3.651LeuTyr: 3.651 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	1.532MetAla: 1.532 ± 0.042	0.571MetCys: 0.571 ± 0.024	1.577MetAsp: 1.577 ± 0.039	2.254MetGlu: 2.254 ± 0.052	1.049MetPhe: 1.049 ± 0.027	1.381MetGly: 1.381 ± 0.048	1.25MetHis: 1.25 ± 0.035	1.61MetIle: 1.61 ± 0.04	2.384MetLys: 2.384 ± 0.056	2.405MetLeu: 2.405 ± 0.049	0.501MetMet: 0.501 ± 0.021	1.441MetAsn: 1.441 ± 0.041	1.203MetPro: 1.203 ± 0.06	1.472MetGln: 1.472 ± 0.038	1.201MetArg: 1.201 ± 0.035	1.704MetSer: 1.704 ± 0.047	1.075MetThr: 1.075 ± 0.035	1.434MetVal: 1.434 ± 0.037	0.223MetTrp: 0.223 ± 0.015	1.19MetTyr: 1.19 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	2.637AsnAla: 2.637 ± 0.058	0.687AsnCys: 0.687 ± 0.031	1.944AsnAsp: 1.944 ± 0.051	3.512AsnGlu: 3.512 ± 0.069	1.491AsnPhe: 1.491 ± 0.041	2.345AsnGly: 2.345 ± 0.057	0.818AsnHis: 0.818 ± 0.028	5.138AsnIle: 5.138 ± 0.083	4.102AsnLys: 4.102 ± 0.07	4.02AsnLeu: 4.02 ± 0.065	1.625AsnMet: 1.625 ± 0.044	2.996AsnAsn: 2.996 ± 0.074	2.325AsnPro: 2.325 ± 0.063	1.506AsnGln: 1.506 ± 0.044	2.527AsnArg: 2.527 ± 0.052	4.214AsnSer: 4.214 ± 0.079	3.351AsnThr: 3.351 ± 0.076	2.297AsnVal: 2.297 ± 0.05	0.331AsnTrp: 0.331 ± 0.02	1.847AsnTyr: 1.847 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.453ProAla: 2.453 ± 0.074	0.591ProCys: 0.591 ± 0.026	1.616ProAsp: 1.616 ± 0.04	3.304ProGlu: 3.304 ± 0.068	1.499ProPhe: 1.499 ± 0.037	1.692ProGly: 1.692 ± 0.047	0.724ProHis: 0.724 ± 0.028	2.557ProIle: 2.557 ± 0.049	2.373ProLys: 2.373 ± 0.054	3.012ProLeu: 3.012 ± 0.064	0.858ProMet: 0.858 ± 0.038	1.704ProAsn: 1.704 ± 0.056	1.206ProPro: 1.206 ± 0.051	1.103ProGln: 1.103 ± 0.036	1.442ProArg: 1.442 ± 0.046	3.304ProSer: 3.304 ± 0.084	1.84ProThr: 1.84 ± 0.075	2.422ProVal: 2.422 ± 0.064	0.251ProTrp: 0.251 ± 0.016	1.229ProTyr: 1.229 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.989GlnAla: 1.989 ± 0.05	0.497GlnCys: 0.497 ± 0.024	1.499GlnAsp: 1.499 ± 0.042	3.285GlnGlu: 3.285 ± 0.065	0.967GlnPhe: 0.967 ± 0.029	1.321GlnGly: 1.321 ± 0.045	0.53GlnHis: 0.53 ± 0.023	2.69GlnIle: 2.69 ± 0.055	3.527GlnLys: 3.527 ± 0.065	2.245GlnLeu: 2.245 ± 0.053	1.063GlnMet: 1.063 ± 0.038	1.937GlnAsn: 1.937 ± 0.045	1.063GlnPro: 1.063 ± 0.042	1.102GlnGln: 1.102 ± 0.042	1.609GlnArg: 1.609 ± 0.037	2.428GlnSer: 2.428 ± 0.052	1.928GlnThr: 1.928 ± 0.045	1.619GlnVal: 1.619 ± 0.045	0.213GlnTrp: 0.213 ± 0.014	1.072GlnTyr: 1.072 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.582ArgAla: 2.582 ± 0.057	0.716ArgCys: 0.716 ± 0.027	2.126ArgAsp: 2.126 ± 0.047	3.585ArgGlu: 3.585 ± 0.072	1.738ArgPhe: 1.738 ± 0.041	1.766ArgGly: 1.766 ± 0.049	0.956ArgHis: 0.956 ± 0.031	4.311ArgIle: 4.311 ± 0.08	4.334ArgLys: 4.334 ± 0.079	3.911ArgLeu: 3.911 ± 0.067	1.416ArgMet: 1.416 ± 0.036	2.5ArgAsn: 2.5 ± 0.057	1.414ArgPro: 1.414 ± 0.041	1.419ArgGln: 1.419 ± 0.039	2.531ArgArg: 2.531 ± 0.07	3.0ArgSer: 3.0 ± 0.059	2.341ArgThr: 2.341 ± 0.053	3.028ArgVal: 3.028 ± 0.065	0.317ArgTrp: 0.317 ± 0.019	1.729ArgTyr: 1.729 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.0SerAla: 5.0 ± 0.082	1.147SerCys: 1.147 ± 0.04	3.684SerAsp: 3.684 ± 0.075	5.946SerGlu: 5.946 ± 0.083	3.252SerPhe: 3.252 ± 0.055	3.854SerGly: 3.854 ± 0.072	1.499SerHis: 1.499 ± 0.044	7.025SerIle: 7.025 ± 0.083	5.984SerLys: 5.984 ± 0.105	8.028SerLeu: 8.028 ± 0.11	2.321SerMet: 2.321 ± 0.057	3.715SerAsn: 3.715 ± 0.079	2.873SerPro: 2.873 ± 0.065	2.515SerGln: 2.515 ± 0.052	3.068SerArg: 3.068 ± 0.056	6.786SerSer: 6.786 ± 0.21	5.019SerThr: 5.019 ± 0.089	5.106SerVal: 5.106 ± 0.07	0.436SerTrp: 0.436 ± 0.022	2.587SerTyr: 2.587 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	3.532ThrAla: 3.532 ± 0.061	0.877ThrCys: 0.877 ± 0.031	2.814ThrAsp: 2.814 ± 0.055	4.96ThrGlu: 4.96 ± 0.087	1.838ThrPhe: 1.838 ± 0.045	2.928ThrGly: 2.928 ± 0.057	1.283ThrHis: 1.283 ± 0.04	3.814ThrIle: 3.814 ± 0.061	4.311ThrLys: 4.311 ± 0.073	5.161ThrLeu: 5.161 ± 0.073	1.238ThrMet: 1.238 ± 0.038	2.393ThrAsn: 2.393 ± 0.064	2.554ThrPro: 2.554 ± 0.067	1.973ThrGln: 1.973 ± 0.047	2.45ThrArg: 2.45 ± 0.05	3.922ThrSer: 3.922 ± 0.073	2.95ThrThr: 2.95 ± 0.077	3.655ThrVal: 3.655 ± 0.074	0.335ThrTrp: 0.335 ± 0.018	1.954ThrTyr: 1.954 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	2.918ValAla: 2.918 ± 0.061	1.406ValCys: 1.406 ± 0.042	3.083ValAsp: 3.083 ± 0.062	4.294ValGlu: 4.294 ± 0.077	3.131ValPhe: 3.131 ± 0.053	2.451ValGly: 2.451 ± 0.055	1.657ValHis: 1.657 ± 0.04	4.392ValIle: 4.392 ± 0.067	4.084ValLys: 4.084 ± 0.068	6.399ValLeu: 6.399 ± 0.087	1.222ValMet: 1.222 ± 0.046	2.576ValAsn: 2.576 ± 0.047	2.402ValPro: 2.402 ± 0.06	2.221ValGln: 2.221 ± 0.052	2.461ValArg: 2.461 ± 0.054	4.67ValSer: 4.67 ± 0.075	2.396ValThr: 2.396 ± 0.067	3.584ValVal: 3.584 ± 0.071	0.468ValTrp: 0.468 ± 0.025	2.824ValTyr: 2.824 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.429TrpAla: 0.429 ± 0.02	0.17TrpCys: 0.17 ± 0.014	0.352TrpAsp: 0.352 ± 0.019	0.396TrpGlu: 0.396 ± 0.023	0.284TrpPhe: 0.284 ± 0.018	0.301TrpGly: 0.301 ± 0.019	0.14TrpHis: 0.14 ± 0.013	0.609TrpIle: 0.609 ± 0.028	0.52TrpLys: 0.52 ± 0.023	0.639TrpLeu: 0.639 ± 0.029	0.252TrpMet: 0.252 ± 0.017	0.341TrpAsn: 0.341 ± 0.021	0.217TrpPro: 0.217 ± 0.013	0.225TrpGln: 0.225 ± 0.015	0.366TrpArg: 0.366 ± 0.018	0.582TrpSer: 0.582 ± 0.021	0.316TrpThr: 0.316 ± 0.017	0.437TrpVal: 0.437 ± 0.022	0.071TrpTrp: 0.071 ± 0.008	0.268TrpTyr: 0.268 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.368TyrAla: 2.368 ± 0.047	0.65TyrCys: 0.65 ± 0.024	1.636TyrAsp: 1.636 ± 0.039	2.139TyrGlu: 2.139 ± 0.043	1.964TyrPhe: 1.964 ± 0.046	1.485TyrGly: 1.485 ± 0.042	0.716TyrHis: 0.716 ± 0.027	4.336TyrIle: 4.336 ± 0.088	3.263TyrLys: 3.263 ± 0.063	3.717TyrLeu: 3.717 ± 0.071	1.31TyrMet: 1.31 ± 0.037	2.46TyrAsn: 2.46 ± 0.065	1.33TyrPro: 1.33 ± 0.04	0.908TyrGln: 0.908 ± 0.029	1.671TyrArg: 1.671 ± 0.041	3.346TyrSer: 3.346 ± 0.064	3.157TyrThr: 3.157 ± 0.059	1.945TyrVal: 1.945 ± 0.041	0.238TyrTrp: 0.238 ± 0.016	1.635TyrTyr: 1.635 ± 0.048	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2769 proteins (997577 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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